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Association of Genetic Variation in the Promoter Region of OXTR with Differences in Social Affective Neural Processing

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Journal of Behavioral and Brain Science 2012年第1期2卷 60-66页

作者： Garret O’Connell Heather C. Whalley Prerona Mukherjee andrew C. Stanfield Christian Montag Jeremy Hall Martin Reuter Center for Economics and Neuroscience University of Bonn Bonn Germany Department of Psychology University of Bonn Bonn Germany Division of Psychiatry University of Edinburgh Scotland UK

Evidence supports the involvement of oxytocin in social behavior. The oxytocin receptor gene (OXTR) has been associated with differences in social brain function and risk for autism. Motivated by recent work, we investigated the effect of variation in the common functional rs2268498 T/C polymorphism in the promoter region of OXTR on neural responses to fear expressions. 46 healthy subjects were divided into genotype groups of C carriers (n = 32) and TT ho-mozygous (n = 14) and neural activity was measured during the recognition of fear and neutral expressions. Results showed that during the recognition of fear expressions, the TT genotype group exhibited increased responding in the inferior occipital gyrus, considered important for face processing, compared to carriers of the C allele (P hole brain), an effect not found for neutral faces. These results indicate the impact of this OXTR genetic variant on individual differences in social affective neural processing.

关键词： OXTR Promoter Region Inferior Occipital Gyrus fMRI Emotional Facial Processing

不同多焦视网膜电图系统在评估视网膜功能上的比较

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中华眼视光学与视觉科学杂志 2011年第6期13卷 410-415页

作者：满晓飞叶皇莹霍颂天蚁颖生赖旭佑香港中文大学眼科及视觉科学学系香港眼科医院

目的评估VERIS mfERG （EDI Inc）和Espion multifocal imager （Diagnosys）两种不同系统测量正常眼多焦视网膜电图（mfERG）的电位波反应的差异及其相关性,并用两个不同系统分别测量黄斑前膜患眼的mfERG并进行分析.方法这是一项横... 详细信息

目的评估VERIS mfERG （EDI Inc）和Espion multifocal imager （Diagnosys）两种不同系统测量正常眼多焦视网膜电图（mfERG）的电位波反应的差异及其相关性,并用两个不同系统分别测量黄斑前膜患眼的mfERG并进行分析.方法这是一项横断面研究,在VERIS系统使用Burian-Allen （BA）电极,Espion系统使用BA和DTL电极分别测量25只正常眼的mfERG,将3次测得的一阶反应的相应数据进行配对t检验及Pearson相关分析.两个系统用BA电极分别测量19只黄斑前膜患眼的mfERG,对一阶反应的相应数据进行Fisher＇s exact test分析.结果 VERIS BA测得正常眼N1波、P1波振幅密度值最大,其次为Espion BA,Espion DTL最小;VERIS BA测得N1波、P1波潜伏期最长,Espion BA与Espion DTL差异无统计学意义.Espion BA与VERIS BA测得的P1波振幅密度、潜伏期皆有明显的相关性.黄斑前膜患眼中,VERIS BA比Espion BA能检测到更多P1波振幅密度和P1波潜伏期的异常.结论不论VERIS或Espion系统都能成功记录多焦视网膜电图,当两种系统都使用Burian-Allen电极时,两者mfERG一阶反应P1波振幅密度及潜伏期有着良好的相关性.

关键词：视网膜电描记术,多焦视网膜功能黄斑前膜

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印尼大选让投资者紧张

商业周刊（中文版） 2014年第14期 22-22页

作者： Bruce Einhorn andrew Janes Yudith ho 融汐

执政党候选人的胜利可能削弱投资者的收益从而引发抛售

关键词：投资者大选印尼候选人执政党

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Cracking the LSAT

ho HEY!THE LUMINEERS'QUIET STORM

2007年

作者： Adam Robinson and Kevin Blemel updated by Mindy Eve Myers Bob Spruill and andrew Brody.

ISBN: (纸本)9780375766138;0375766138

Cracking the LSAT offers major features on DVD, including engaging video tutorials from The Princeton Review’s top instructors. We also bring you full length practice tests in the book and exclusive free access to additional practice exams and expert advice online. Of course, you’ll also get all the test-prep techniques you expect from The Princeton Review. In Cracking the LSAT, we’ll teach you ho

关键词： LawUnited StatesEntrance examinations.Law School Admission Test.

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城市漫步（上海版、英文） 2014年第2期 46-46页

作者： andrew CHIN 不详

While the record in-dustry continues to adjust to the digital age,Colorado in die-folk rockers the Lumineers can attest to the power of one song.A video of their performance of ho Hey'in a small apartment caught the eyes of their future managers,who would help bankroll their 2012 self-titled *** song was used on an episode of Hart of Dixie,causing social media buzz.

关键词： record continue adjust

Prehospital system delay in patients with ST-segment elevation myocardial infarction in Singapore

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World Journal of Emergency Medicine 2015年第4期6卷 277-282页

作者： andrew Fu Wah ho Pin Pin Pek Stephanie Fook-Chong Ting Hway Wong Yih Yng Ng Aaron Sung Lung Wong Marcus Eng hock Ong Singhealth Emergency Medicine Residency Program Singapore Health Services Department of Emergency Medicine Singapore General Hospital Division of Research Singapore General Hospital Department of General Surgery Singapore General Hospital Medical Department Singapore Civil Defence Force Department of Cardiology National Heart Centre

BACKGROUND: Timely reperfusion in ST-segment elevation myocardial infarction(STEMI)improves outcomes. System delay is that between first medical contact and reperfusion therapy,comprising prehospital and hospital components. This study aimed to characterize prehospital system delay in ***: A retrospective chart review was performed for 462 consecutive STEMI patients presenting to a tertiary hospital from December 2006 to April 2008. Patients with cardiac arrest secondarily presented were excluded. For those who received emergency medical services(EMS),ambulance records were reviewed. Time intervals in the hospital were collected prospectively. The patients were divided into two equal groups of high/low prehospital system delay using visual binning ***: Of 462 patients, 76 received EMS and 52 of the 76 patients were analyzed. The median system delay was 125.5 minutes and the median prehospital system delay was 33.5minutes(interquartile range [IQR]=27.0, 42.0). Delay between call-received-by-ambulance and ambulance-dispatched was 2.48 minutes(IQR=1.47, 16.55); between ambulance-dispatch and arrival-at-patient-location was 8.07 minutes(IQR=1.30, 22.13); between arrival-at- and departurefrom-patient-location was 13.12 minutes(IQR=3.12, 32.2); and between leaving-patient-location to ED-registration was 9.90 minutes(IQR=1.62, 32.92). Comparing patients with prehospital system delay of less than 35.5 minutes versus more showed that the median delay between ambulancedispatch and arrival-at-patient-location was shorter(5.75 vs. 9.37 minutes, Phorter(10.78 vs.14.37 minutes, Phospital system delay in our patients was suboptimal. This is the first attempt at characterizing prehospital system delay in Singapore and forms the basis for improving efficiency of STEMI care.

关键词： Myocardial infarction Emergency medical services Delay First medical contact Door to balloon

From the Poles to the Tropics:Novel chemistry in the atmosphere probed using field measurements of OH and ho2 radicals

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From the Poles to the Tropics:Novel chemistry in the atmosph...

Evaluating the yield of systematic screening for tuberculosis among three priority groups in ho Chi Minh City,Viet Nam

中国化学会第27届学术年会

作者： Dwayne Heard Roisin Commane Peter Edwards Mathew Evans Kate Furneaux andrew Goddard Trevor Ingham Daniel Stone Stewart Vaughan Lisa Whalley School of Chemistry University of Leeds

＜正＞Atmospheric oxidation processes are largely controlled by the OH radical. Field measurements of OH, and the closely related radical ho2, are essential to understanding the rapid photochemical processes involved

关键词： Hydroxyl radical field measurements atmospheric chemistry

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Infectious Diseases of Poverty 2020年第6期9卷 16-28页

作者： Luan Nguyen Quang Vo andrew James Codlin Rachel Jeanette Forse NgaThuy Nguyen Thanh Nguyen Vu Giang Truong Le Vinh Van Truong Giang Chau Do Ha Minh Dang Lan Huu Nguyen hoa Binh Nguyen Nhung Viet Nguyen Jens Levy Knut Lonnroth SBertel Squire Maxine Caws Friends for International TB Relief 68B Nguyen Van Troi8Phu NhuanHo Chi Minh CityViet Nam Interactive Research and Development Ho Chi Minh CityViet Nam ho Chi Minh City Public Health Association Ho Chi Minh CityViet Nam Pham Ngoc Thach hospital Ho Chi Minh CityViet Nam National Lung hospital Ha NoiViet Nam KNCV Tuberculosefonds The HagueThe Netherlands Department of Global Public Health Karolinska InstitutetStockholmSweden Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpoolUK Birat Nepal Medical Trust LazimpatKathmanduNepal

Background: In order to end tuberculosis(TB),it is necessary to expand coverage of TB care services,including systematic screening ***,more evidence is needed for groups among whom systematic screening is only conditionally recommended by the World Health *** study evaluated concurrent screening in multiple target groups using community health workers(CHW).Methods:: In our two-year intervention study lasting from October 2017 to September 2019,CHWs in six districts of ho Chi Minh City,Viet Nam verbally screened three urban priority groups:(1)household TB contacts;(2)close TB contacts;and(3)residents of urban priority areas without clear documented exposure to TB including hotspots,boarding homes and urban *** persons were referred for further screening with chest radiography and follow-on testing with the Xpert MTB/RIF *** individuals with normal or without radiography results were tested on smear *** described the TB care cascade and characteristics for each priority group,and calculated yield and number needed to ***,we fitted a mixed-effect logistic regression to identify the association of these target groups and secondary patient covariates with TB treatment ***: We verbally screened 321020 people including 24232 household contacts,3182 social and close contacts and 293606 residents of urban priority *** resulted in 1138 persons treated for TB,of whom 85 were household contacts,39 were close contacts and 1014 belonged to urban priority area *** yield of active TB in these groups was 351,1226 and 345 per 100000,respectively,corresponding to numbers needed to screen of 285,82 and *** fitted model showed that close contacts[adjusted odds ratio(aOR)=2.07;95%CI:1.38–3.11;Phousehold ***: The study detected a large number of un

关键词： Case detection Tuberculosis Active case finding Urban Viet nam

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial

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Stroke & Vascular Neurology 2022年第2期7卷 158-165页

作者： Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis Department of Medicine and Neurology Melbourne Brain Centre at The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Population Health and Immunity Division Walter and Eliza Hall Institute of Medical ResearchParkvilleVictoriaAustralia Ambulance Victoria MelbourneVictoriaAustralia Melbourne Medical School The University of MelbourneMelbourneVictoriaAustralia Stroke Division The Florey Institute of Neuroscience and Mental HealthParkvilleVictoriaAustralia Department of Neurology Christchurch HospitalChristchurchNew Zealand Department of Neurology Monash Medical CentreMonash UniversityClaytonVictoriaAustralia Department of Interventional Neuroradiology Liverpool HospitalLiverpoolNew South WalesAustralia Department of Neurology Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Neurology Princess Alexandra HospitalWoolloongabbaQueenslandAustralia Department of Neurology Box Hill HospitalEastern HealthBox HillVictoriaAustralia Stroke Centre and Department of Neurology National Taiwan University HospitalTaipeiTaiwan Department of Medicine Dunedin School of MedicineUniversity of OtagoWellingtonNew Zealand Department of Neurosurgery E-Da HospitalYanchaoKaohsiungTaiwan Department of Neurology Alfred HospitalMelbourneVictoriaAustralia Department of Clinical Neuroscience Monash University Central Clinical SchoolMelbourneVictoriaAustralia Department of Medicine Sunshine Coast University HospitalNambourQueenslandAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia Department of Neurology John Hunter HospitalThe University of NewcastleNewcastleNew South WalesAustralia Department of Neurosurgery China Medical University HospitalTaichungTaiwan Department of Internal Medicine Palmerston North HospitalPalmerston NorthNew Zealand Department of Neurology St Vincent's HospitalFitzroyVictoriaAustralia Department of Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustra

Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of *** acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma *** and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical *** In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with *** size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of *** adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 *** Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching *** efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT *** We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments.

关键词： placebo centre absolute