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Combined treatment of 3-hydroxypyridine-4-one derivatives and green tea extract to induce hepcidin expression in iron-overloaded b-thalassemic mice

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Asian Pacific Journal of tropical Biomedicine 2015年第12期5卷 1010-1017页

作者： Supranee Upanan Kanjana Pangjit Chairat Uthaipibull Suthat Fucharoen andrew t.mc kie Somdet Srichairatanakool Department of Biochemistry Faculty of Medicine Chiang Mai University College of Medicine and Public Health Ubon Ratchathani University National Center for Genetic Engineering and Biotechnology National Science and Technology Development AgencyThailand Science Park thalassemia Research Center Institute of Molecular Biosciences Mahidol University Salaya Campus Division of Diabetes and Nutritional Sciences School of Medicine King's College London

Objective:to evaluate the efficacy of deferiprone(DFP),1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one(CM1)or green tea extract(GtE)in enhancing expression of hepatic hepcidin1(Hamp1)m RNA and relieving iron overload in b-globin knockout thalassemic ***:the b-globin knockout thalassemic mice were fed with a ferrocenesupplemented diet for 2 months and oral administration of deionized water,DFP(50 mg/kg),CM1(50 mg/kg),GtE(50 mg epigallocatechin 3-gallate equivalent/kg),GtE along with DFP(50 mg/kg),and GtE along with CM1(50 mg/kg)every day for *** of hepatic Hamp1 m RNA,plasma non-transferrin bound iron,plasma alanine aminotransferase activity and tissue iron content were ***:All chelation treatments could reduce plasma non-transferrin bound iron ***,hepatic Hamp1 m RNA expression was significantly upregulated in the mice in a GtE+DFP combined treatment,correlating with a decrease in the plasma alanine aminotransferase activity and tissue iron ***:the GtE+DFP treatment could ameliorate iron overload and liver oxidative damage in non-transfusion dependent b-thalassemic mice,by chelating toxic iron in plasma and tissues,and increasing hepcidin expression to inhibit duodenal iron absorption and iron release from hepatocytes and macrophages in the *** is probably an advantage in giving GtE with DFP when treating patients with iron overload.

关键词： thalassemia Iron overload Hepcidin Iron chelator G

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CO2-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng Xiong Donghuan Wu Haonan Li andrew Li Qikun Hu Siyao Song Bingjun Xu Qi Lu State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University College of Chemistry and Molecular Engineering Peking University Ordos Laboratory

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO2emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO2using alkaline solutions with reactive *** this work,we present a CO2-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm2electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis techno-economic assessments Electrochemistry Flow electrolyzer

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Evaluation of natural goethite on the removal of arsenate and selenite from water

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Journal of Environmental Sciences 2019年第2期31卷 133-141页

作者： andrew t.Jacobson Maohong Fan Department of Chemical Engineering University of Wyoming

Elevated arsenic and selenium concentrations in water cause health problems to both humans and wildlife. Natural and anthropogenic activities have caused contamination of these elements in waters worldwide, making the development of efficient cost-effective methods in their removal essential. In this work, removal of arsenate and selenite from water by adsorption onto a natural goethite(α-FeO OH) sample was studied at varying conditions. the data was then compared with other arsenate, selenite/goethite adsorption systems as much of literature shows discrepancies due to varying adsorption conditions. Characterization of the goethite was completed using inductively coupled plasma mass spectrometry, X-ray diffraction, Fouriertransform infrared spectroscopy, scanning electron microscopy, and Brunauer–Emmett–teller surface area analysis. Pseudo-first order(PFO) and pseudo-second order(PSO) kinetic models were applied; including comparisons of different regression methods. Various adsorption isotherm models were applied to determine the best fitting model and to compare adsorption capacitates with other works. Desorption/leaching of arsenate and selenite was studied though the addition of phosphate and hydroxyl ions. Langmuir isotherm modeling resulted in maximum adsorption capacities of 6.204 and 7.740 mg/g for arsenate and selenite adsorption,respectively. the PSO model applied with a non-linear regression resulted in the best kinetic fits for both adsorption and desorption of arsenate and selenite. Adsorption decreased with increasing pH. Phosphate induced desorption resulted in the highest percentage of arsenate and selenite desorbed, while hydroxide induced resulted in the fastest desorption kinetics.

关键词： Arsenic Selenium Adsorption Desorption FeOOH Water treatment

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Serrated neoplasia of the colorectum

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World Journal of Gastroenterology 2007年第28期13卷 3792-3798页

作者： Nathan t Harvey andrew Ruszkiewicz Division of tissue Pathology Institute of Medical and Veterinary ScienceFrome RdAdelaideAustralia

Serrated polyps of the colorectum form a group of related lesions which include aberrant crypt foci (ACF), conventional hyperplastic polyps, mixed (admixed) polyps, serrated adenomas and sessile serrated adenomas. In recent years the molecular differences between these morphologically similar lesions have been highlighted, and their differing biological potential has been realised. In particular, the sessile serrated adenoma has become recognised as the precursor lesion to a group of sporadic colorectal carcinomas characterised by morphological and molecular features distinct from conventional adenomas. these recent findings have challenged the long held paradigm that all colorectal carcinomas arise via the traditional adenoma-carcinoma sequence. In addition, they present a major challenge for the early detection and management of colorectal cancer, which is no longer regarded as a homogeneous entity.

关键词： Serrated adenoma Serrated neoplasia Serrated adenocarcinoma Hyperplastic polyps Microsatellite instability

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Synthesis and characterisation of potassium polytitanate for photocatalytic degradation of crystal violet

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Journal of Environmental Sciences 2014年第11期26卷 2348-2354页

作者： Mohammad Shahid Ibrahim El Saliby andrew mc Donagh Leonard D.tijing Jong-Ho Kim Ho Kyong Shon School of Civil and Environmental Engineering University of Technology Sydney (UTS) P.O. Box 123 Broadway Sydney NSW 2007Australia School of Chemistry and Forensic Science University of Technology Sydney (UTS) P.O. Box 123 Broadway Sydney NSW 2007 Australia School of Applied Chemical Engineering The Research Institute for Catalysis Chonnam National University Gwangju 500-757 South Korea Photo & Environmental technology Co. Ltd. Gwangju 500-460 South Korea

Potassium titanate nanostructures were synthesised by hydrothermal treatment of tiO2 （P25） in KOH and H2O2. As-produced powders were characterised by scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, X-ray diffraction, and nitrogen adsorption-desorption methods. Longitudinally-oriented-wire-like structures with a length up to several micrometres and diameters ranging from 10 to 30 nm were obtained. Larger size fibrous nanowires resulting from the hydrotherrnal treatment showed high affinity in adsorbing crystal violet （CV）, which was mainly due to their high surface area. the photocatalytic bleaching of CV solution revealed that the wires are photoactive under ultraviolet light irradiation. Macroporous nanowires are considered as effective adsorbents of CV, capable of photocatalvtic degradation, and they can be easily separated from the solution by settling.

关键词： Potassium titanate Adsorption Crystal violet Macroporous titanium dioxide Photocatalysis

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Novel ecosystems created by coal mines in central Queensland’s Bowen Basin

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Ecological Processes 2013年第1期2卷 368-379页

作者： Peter D Erskine andrew t Fletcher Centre for Mined Land Rehabilitation The University of QueenslandBrisbane QLD 4072Australia

Introduction:Open-cut coal mining began in central Queensland’s Bowen Basin approximately 50 years *** this period of time,mine rehabilitators have used a variety of tree,shrub,and groundcover species to create‘novel ecosystems’to stabilise soils and provide vegetative cover for pre-supposed final end-land *** examine post-mining rehabilitation from multiple soil and vegetation monitoring activities in the Bowen Basin to assess the similarity of landforms,plant composition,and trends in plant diversity compared to unmined reference ***:Rehabilitated spoil dumps and reference sites were assessed using soil and vegetation data contained in compliance monitoring reports from Goonyella Riverside,Moura,Oaky Creek,Rolleston,and Blackwater ***,soil chemistry,and plant species mixes of rehabilitation aged from 2 to 22 years were compared to selected reference ***:Mines in this region have generally proposed one of two post-rehabilitation end-land uses:either pasture for cattle grazing or reconstructed native communities which potentially provide native fauna *** data from a selection of these mine sites suggest that when their rehabilitation was compared to nearby reference sites median slope values were between 2.5 and 7 times steeper and soil pH,electrical conductivity,and phosphorus levels were significantly *** steeply sloped landforms,poor soil characteristics,depauperate native species pool,and uniform presence of exotic pasture grasses in the rehabilitation indicate that most of these newly created ecosystems should not be used for cattle grazing and also have few natural ***:Legislative and community expectations have changed progressively over time and,although much of the rehabilitation is currently dominated by an assemblage of exotic buffel grass(Cenchrus ciliaris)and Acacia spp.,recent environmental authorities suggest these‘novel ecosystems’will be judged against native refere

关键词： Coal mining Completion criteria Environmental conditions Novel ecosystems

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Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt

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World Journal of Gastroenterology 2016年第25期22卷 5780-5789页

作者： Edward Wolfgang Lee andrew Kuei Sammy Saab Ronald W Busuttil Francisco Durazo Steven-Huy Han Mohamed M El-Kabany Justin P mc Williams Stephen t Kee Department of Radiology Division of Interventional Radiology Ronald Reagan Medical Center at UCLA David Geffen School of Medicine at UCLA Department of Medicine Division of Hepatology Pfleger Liver Institute University of California at Los Angeles Dumont-UCLA transplant Center Pfleger Liver Institute Division of Liver and Pancreas Transplantation Department of Surgery David Geffen School of Medicine at University of California Los Angeles

AIM: to evaluate and validate the national trends and predictors of in-patient mortality of transjugular intrahepatic portosystemic shunt (tIPS) in 15 ***: Using the National Inpatient Sample which is a part of Health Cost and Utilization Project, we identified a discharge-weighted national estimate of 83884 tIPS procedures performed in the United States from 1998 to 2012 using international classification of diseases-9 procedural code 39.1. the demographic, hospital and co-morbility data were analyzed using a multivariant analysis. Using multi-nominal logistic regression analysis, we determined predictive factors related to increases in-hospital mortality. Comorbidity measures are in accordance to the Comorbidity Software designed by the Agency for Healthcare Research and ***: Overall, 12.3% of patients died during hospitalization with downward trend in-hospital mortality with the mean length of stay of 10.8 ± 13.1 d. Notable, African American patients (OR = 1.809 vs Caucasian patients, P transferred patients (OR = 1.347 vs non-transferred, P tive cases, P tients in the Northeast region (OR = 1.449 vs West, P tly higher odds of in-hospital mortality. Number of diagnoses and number of procedures showed positive correlations with in-hospital death (OR = 1.249 per one increase in number of procedures). Patients diagnosed with acute respiratory failure (OR = 8.246), acute kidney failure (OR = 4.359), hepatic encephalopathy (OR = 2.217) and esophageal variceal bleeding (OR = 2.187) were at considerably higher odds of in-hospital death compared with ascites (OR = 0.136, P ty measures with the highest odds of in-hospital death were fluid and electrolyte disorders (OR = 2.823), coagulopathy (OR = 2.016), and lymphoma (OR = 1.842).CONCLUSION: the overall mortality of the tIPS procedure is stea

关键词： transjugular intrahepatic portosystemic shunt Mortality Inpatient United States National Inpatient Sample database Health Cost and Utilization Project

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Pseudouridines in spliceosomal snRNAs

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Protein & Cell 2011年第9期2卷 712-725页

作者： andrew t.Yu Junhui Ge Yi-tao Yu Department of Biochemistry and Biophysics Center for RNA BiologyUniversity of Rochester Medical Center601 Elmwood AvenueRochesterNY 14642USA Department of Pathology Changzheng HospitalSecond Military Medical UniversityShanghai 200003China

Spliceosomal RNAs are a family of small nuclear RNAs(snRNAs)that are essential for pre-mRNA *** vertebrate spliceosomal snRNAs are extensively pseudouridylated after *** in spliceosomal snRNAs are generally clustered in regions that are functionally important during *** of these modified nucleotides are conserved across species *** studies have demonstrated that spliceosomal snRNA pseudouridylation is catalyzed by two different mechanisms:an RNA-dependent mechanism and an RNA-independent *** functions of the pseudouridines in spliceosomal snRNAs(U2 snRNA in particular)have also been extensively *** data indicate that virtually all pseudouridines in U2 snRNA are functionally *** the currently known pseudouridines(constitutive modifications),recent work has also indicated that pseudouridylation can be induced at novel positions under stress conditions,thus strongly suggesting that pseudouridylation is also a regulatory modification.

关键词： small nuclear RNAs(snRNAs) pseudouridine spliceosome small nuclear ribonucleoproteins(snRNPs)

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ANALYSIS OF SINGLE PANE WINDOW REPLACEMENt

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Journal of Green Building 2014年第3期9卷 50-59页

作者： Dr.Paul t.Daniell andrew Grimm Department of Petroleum Engineering Marietta CollegeMariettaOH.

An engineering and economic analysis of energy loss through single paned windows in a large college building is *** goal of this work was to determine an economically viable solution for Marietta College to save on energy *** on the model presented,the economics of double paned window installation are *** alternative solution employing the addition of storm windows to the existing single paned windows has yielded very exciting *** double paned windows are generally the first thought when it comes to energy efficient windows,this work shows that storm window addition yields a much lower investment and quicker payback period for this specific *** engineering analysis and experimental technique presented can be used to investigate the cost benefit of single paned window upgrades for other buildings.

关键词： energy savings single pane windows conduction convection

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AFast Solver for an H_(1) Regularized PDE-Constrained Optimization Problem

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Communications in Computational Physics 2016年第1期19卷 143-167页

作者： andrew t.Barker tyrone Rees Martin Stoll Center for Applied Scientific Computing Lawrence Livermore National LaboratoryMail Stop L-561LivermoreCA 94551USA Numerical Analysis Group Scientific Computing DepartmentRutherford Appleton LaboratoryChiltonDidcotOxfordshireOX110QXUnited Kingdom Computational Methods in Systems and Control theory Max Planck Institute for Dynamics of Complex Technical SystemsSandtorstr.139106MagdeburgGermany

In this paperwe consider PDE-constrained optimization problemswhich incorporate an H_(1)regularization control *** focus on a time-dependent PDE,and consider both distributed and boundary *** problems we consider include bound constraints on the state,and we use a Moreau-Yosida penalty function to handle *** propose Krylov solvers and Schur complement preconditioning strategies for the different problems and illustrate their performance with numerical examples.

关键词： Preconditioning Krylov methods PDE-constrained optimization optimal control of PDEs

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