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Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients

World Journal of Gastroenterology 2013年第48期19卷 9156-9173页

作者： Alessio Provenzani andrew santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro Department of Clinical Pharmacy Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) 90127 Palermo Italy School of Pharmacy University of Pittsburgh Pittsburgh PA 15261 United States G. D’Alessandro Department of Health Promotion Sciences Section of Pharmacology P Benigno University of Palermo 90127 Palermo Italy National Institute of Social Security (INPS) 90143 Palermo Italy School of Pharmacy University of Camerino 62032 Camerino Italy Department of Medicine Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT) 90127 Palermo Italy

The introduction of tacrolimus in clinical practice has improved patient survival after organ ***,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense *** start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the *** variability seems to be correlated with the presence of genetic *** is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given ***,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that *** present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of ***,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and *** these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing.

关键词： Pharmacogenetics Calcineurin inhibitors Tacrolimus Liver transplant Kidney transplant Single nucleotide polymorphisms CYP3A4 CYP3A5 ABCB1

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Pulmonary Immunohistochemical Detection of Surfactant Protein A (SP-A) in Fatal Drowning

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Forensic Medicine and Anatomy Research 2016年第3期4卷 33-36页

作者： Enrico De Dominicis Giuseppe santeusanio Filippo Milano Luigi Tonino Marsella Department of Biomedicine and Prevention Medical Faculty of Tor Vergata University Rome Italy Department of Experimental Medicine and Surgery Medical Faculty of Tor Vergata University Rome Italy

Drowning still remains one of the most difficult diagnoses in forensic pathology because macroscopic and microscopic autopsy findings are unspecific. An ideal diagnostic marker for drowning still needs to be developed, but some authors have recently studied SP-A as a marker of asphyxiation and drowning. The aim of this study is to compare the histopathological features and the SP-A immunohistochemical expression in lung tissue in the case of drowning with those determined by other causes to discriminate between cadaver submersion and drowning.

关键词： Drowning Autopsy Immunohistochemistry Surfactant Protein A Pathology

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