检索结果-南通市图书馆

Advances in diagnostic testing for gastroesophageal reflux disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第30期16卷 3750-3756页

作者： andrew J Gawron Ikuo Hirano Division of Gastroenterology Department of MedicineNorthwestern University Feinberg School of MedicineChicagoIL 60611-2951United States

Gastroesophageal reflux disease (GERD) contributes substantially to morbidity and to costs in the United States health care system. The burden of this disease has resulted in attempts at improving diagnosis and characterizing patients. Numerous research and technical advances have enhanced our understanding of both the utility and limitations of a variety of diagnostic modalities. The purpose of this review is to highlight recent advances in GERD diagnostic testing and to discuss their implications for use in clinical practice. Topics addressed include esophageal pH monitoring, impedance testing, symptom association analyses, narrow-band imaging, and histopathology.

关键词： Gastroesophageal reflux disease pH impedance pH monitoring Symptom association

Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第8期13卷 1332-1337页

作者： Eoin O'Neill andrew Harkin Neuropsychopharmacology Research Group School of Pharmacy and Pharmaceutical Sciences & Trinity College Institute of Neuroscience Trinity College

Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson＇s disease （PD）, whereas pharmacological approaches to increase noradrenaline bioavailability may provide neuroprotection. Noradrenaline inhibits microglial activation and suppresses pro-inflamma- tory mediator production （e.g., tumor necrosis factor-a, interleukin-1β ＆ inducible nitric oxide synthase activity）, thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflamma- tory stimulus. Neighbouring astrocyte populations promote a neurotrophic environment in response to β2-adrenoceptor （β2-AR） stimulation via the production of growth factors （e.g., brain derived neurotrophic factor, cerebral dopamine neurotrophic factor ＆ glial cell derived neurotrophic factor which have shown promising neuroprotective and neuro-restorative effects in the nigrostriatal dopaminergic system. More recent findings have demonstrated a role for the β2-AR in down-regulating expression levels of the human a-synuclein gene SNCA and relative a-synuclein protein abundance. Given that a-synuclein is a major protein constituent of Lewy body pathology, a hallmark neuropathological feature in Parkinson＇s disease, these findings could open up new avenues for pharmacological intervention strategies aimed at alleviating the burden of a-synucleinopathies in the Parkinsonian brain. In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via （1） inhibiting nigral microglial activation ＆ pro-inflammatory mediator production, （2） promoting the synthesis of neurotrophic factors from midbrain astrocytes and （3） downregulating a-synuclein gene expression and protein abundance in a β2-AR-dependent manner. Thus, taken together, either pharmacologically enhancing extra-synaptic noradrenaline bioavailability or targeting glial β2-ARs direct

关键词： noradrenaline microglia astrocytes inflammation Parkinson's disease neuroprotection animalmodel dopamie

Born from a Flood: The Salton Sea and Its Story of Survival

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2016年第1期27卷 89-97页

作者： andrew F.B.Tompson Atmospheric Earth and Energy Division Lawrence Livermore National Laboratory Livermore

The Salton Sea is a terminal lake located in the deepest point of the topographically closed Salton Trough in southeastern California. It is currently the largest lake in area in the state. It was created by a flooding event along the Colorado River in 1905-1907, similar to the way historical floods over past centuries created ephemeral incarnations of ancient Lake Cahuilla in the same location. Its position at the center of today＇s Imperial Valley, a hot and arid locale home to some of the most productive irrigated agricultural lands in the United States, has ensured its ongoing survival through a delicate balance between agricultural runoff, its principal form of input, and vast evaporation losses. Nevertheless, its parallel role as a recreational resource and important wildlife habitat, established over its first century of existence, is threatened by increasing salinity decreasing water quality, and reduced water allocations from the Colorado River that feeds the valley＇s agriculture. The Salton Sea faces an increasingly uncertain future that will be influenced by reduced water imports from the Colorado River, demands for additional water sources to support farming and energy industries in the valley, and needs to stabilize the lake salinity, maintain recreational resources, and preserve what have become important ecosystems and wildlife habitats.

关键词： Salton Sea flood terminal lake water agriculture salinity wildlife habitat.

Rational Schur Superalgebras

在线全文

学校读者我要写书评

暂无评论

Algebra Colloquium 2024年第2期31卷 209-220页

作者： andrew Riesen Shun-Jen Cheng Department of Mathematical and Statistical Sciences University of Alberta 1132489 Ave NWEdmontonAlbertaCanada 不详

We develop and study the generalization of rational Schur algebras to the super *** to the classical case,this provides a new method for studying rational supermodules of the general linear supergroup GL(m|n).Furthermore,we establish a Schur-Weyl duality result for rational Schur superalgebras and conclude that under certain conditions these objects will be semisimple.

关键词： Schur algebra supermathematics general linear supergroup

Some Strong Laws of Large Numbers for Blockwise Martingale Difference Sequences in Martingale Type p Banach Spaces

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2012年第7期28卷 1385-1400页

作者： andrew ROSALSKY Le Van THANH Department of Statistics University of Florida Department of Mathematics Vinh University

For a blockwise martingale difference sequence of random elements {Vn, n ≥ 1} taking values in a real separable martingale type p （1 ≤ p ≤ 2） Banach space, conditions are provided for strong laws of large numbers of the form limn→∞ Vi/gn = 0 almost surely to hold where the constants gn ↑∞. A result of Hall and Heyde [Martingale Limit Theory and Its Application, Academic Press, New York, 1980, p. 36] which was obtained for sequences of random variables is extended to a martingale type p （1〈 p ≤2） Banach space setting and to hold with a Marcinkiewicz-Zygmund type normalization. Illustrative examples and counterexamples are provided.

关键词： Sequence of Banach space valued random elements blockwise martingale difference sequence strong law of large numbers almost sure convergence martingale type p Banach space

Brains, bacteria and behaviors: the role of interferon-gamma in the pathogenesis of pneumococcal meningitis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第1期16卷 125-126页

作者： Lay Khoon Too andrew Mitchell Molecular Immunopathology Unit Bosch Institute and School of Medical SciencesSave Sight InstituteFaculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Materials Characterisation and Fabrication Platform Department of Chemical EngineeringThe University of MelbourneMelbourneVictoriaAustralia

of bacterial meningitis that occurs following brain infection by the Gram-positive cocci Streptococcus *** only does it cause acute mortality,but pneumococcal meningitis also accounts for the highest proportion of survivors living with neurological sequelae,including behavioral disorders,cognitive deficits,hearing loss,motor impairment and *** than 90 distinct pneumococcal serotypes have been identified worldwide based on their capsular compositions and serological *** replacement continually poses great challenge to costly vaccination programs in developed countries(Koelman et al.,2020),this has therefore emphasized the need to develop new treatment strategies in addition to improving vaccine coverage.

关键词： meningitis epilepsy mortality

Palladium-catalyzed S_(N)2 glycosylation of phenols

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第4期67卷 1037-1038页

作者： Yu Zhu P.andrew Evans Department of Chemistry Queen’s University90 Bader LaneKingstonK7L 3N6Canada Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China

Glycosides are essential structural motifs present in an array of important medicines,materials,and natural products[1].Nevertheless,the chemo-and stereoselective construction of the glycosidic linkage is a long-standing challenge because relatively minor variations in the glycosyl donor or acceptor’s structure can impact stereoselectivity,thus influencing the product's functional properties.

关键词： properties Palladium catalyzed

On Some Cycles in Wenger Graphs

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2020年第2期36卷 492-502页

作者： Ye WANG Felix LAZEBNIK andrew THOMASON College of Mathematical Sciences Harbin Engineering UniversityHarbin 150001China Department of Mathematical Sciences University of DelawareNewark.DE 19716U.S.A. DPMMS Centre for Mathematical SciencesWilberforce RoadCambridgeUK

Let p be a prime,q be a power of p,and let Fq be the field of q *** any positive integer n,the Wenger graph Wn(q)is defined as follows:it is a bipartite graph with the vertex partitions being two copies of the(n+1)-dimensional vector space Fq^n+1,and two vertices p=(p(1),…,p(n+1))and l=[l(1),…,l(n+1)]being adjacent if p(i)+l(i)=p(1)l(1)i-1,for all i=2,3,…,n+*** 2008,Shao,He and Shan showed that for n≥2,Wn(q)contains a cycle of length 2 k where 4≤k≤2 p and k≠*** this paper we extend their results by showing that(i)for n≥2 and p≥3,Wn(q)contains cycles of length 2k,where 4≤k≤4 p+1 and k≠5;(ii)for q≥5,0

关键词： cycle pancyclic finite field Wenger graph graph embeddings

Teleseismic waves reveal anisotropic poroelastic response of wastewater disposal reservoir

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2021年第6期5卷 547-558页

作者： andrew J Barbour Nicholas M Beeler u.s.geological survey earthquake science centerusa

Connecting earthquake nucleation in basement rock to fluid injection in basal,sedimentary reservoirs,depends heavily on choices related to the poroelastic properties of the fluid-rock system,thermo-chemical effects *** constraints on these parameters outside of laboratory settings are rare,and it is commonly assumed that the rock layers are *** the Arbuckle wastewater disposal reservoir in Osage County,Oklahoma,high-frequency formation pressure changes and collocated broadband ground velocities measured during the passing of large teleseismic waves show a poroelastic response of the reservoir that is both azimuthally variable and anisotropic;this includes evidence of static shifts in pressure that presumably relate to changes in local *** azimuthal dependence in both the static response and shear coupling appears related to tectonic stress and strain indicators such as the orientations of the maximum horizontal stress and faults and *** dynamic strains from a nearby borehole strainmeter,we show that the ratio of shear to volumetric strain coupling is~0.41 which implies a mean Skempton's coefficient of A=0.24 over the plausible range of the undrained Poisson's *** these observations are made at relatively low confining pressure and differential stress,we suggest that the hydraulically conductive fracture network is a primary control on the coupling between pore pressure diffusion and elastic stresses in response to natural or anthropogenic sources.

关键词： poroelasticity dynamic strain anisotropy wastewater disposal Oklahoma induced seismicity