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Trochanteric bursitis information on the internet;can we trust the information presented?

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World Journal of Orthopedics 2020年第10期11卷 473-474页

作者： richard Tyrrell Martin Kelly Cian kennedy Department of Trauma and Orthopaedics University Hospital LimerickLimerick V94 F858Ireland

Trochanteric bursitis is one of the most common causes of lateral hip pain in *** prevalence of unilateral trochanteric bursitis is 15.0%in women and 8.5%in *** to internet based information has increased dramatically and health related information is now one of the most popular searches in online activity,despite this the quality of information can *** objective of this paper is to examine the quality and readability of internet based information of trochanteric ***,we have found a high variability among not only the quality but also the readability of information *** that appeared first on each search engine for trochanteric bursitis did not necessarily score better,demonstrating the importance of providing patients with high quality *** articles should use more critical appraisal tools in order to provide the reader with more high quality and readable information.

关键词： Internet Quality Readability DISCERN Journal of American Medical Association Flesh Reading Ease

A Cilia-inspired Closed-loop Sensor-actuator Array

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Journal of Bionic Engineering 2018年第3期15卷 526-532页

作者： James G. H. Whiting richard Mayne Chris Melhuish andrew Adamatzky Unconventional Computing Centre and Bristol Robotics Laboratory University of the West of England Bristol UK

Cilia are finger-like cell-surface organelles that are used by certain varieties of aquatic unicellular organisms for motility, sensing and obj ect manipulation. Initiated by internal generators and external mechanical and chemical stimuli, coordinated undulations of cilia lead to the motion of a fluid surrounding the organism. This motion transports micro-particles towards an oral cavity and provides motile force. Inspired by the emergent properties of cilia possessed by the pond organism P. caudatum, we propose a novel smart surface with closed-loop control using sensor-actuators pairings that can manipulate objects. Each vibrating motor actuator is controlled by a localised microcontroller which utilises proximity sensor information to initiate actuation. The circuit boards are designed to be plug-and-play and are infinitely up-scalable and reconfigurable. The smart surface is capable of moving objects at a speed of 7.2 millimetres per second in forward or reverse direction. Further development of this platform will include more anatomically similar biomimetic cilia and control.

关键词： bioinspiration artificial cilia object manipulation sorting platforms

Knowledge,attitude and recommendations for practice regarding dengue among the resident population of Queensland,Australia

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 360-366页

作者： Narayan Gyawali richard Stewart Bradbury andrew William Taylor-Robinson School of Medical and Applied Sciences Central Queensland University

Objective:To investigate levels of awareness of dengue among the inhabitants of Queensland(QLD),a dengue-prevalent state in the north east of ***:A computer-assisted telephone interviewing survey was conducted in mid2014.A total of 1 223 randomly selected respondents( 18 years) across QLD completed a structured questionnaire covering all aspects of ***:97.55% had heard of dengue and participated *** them,54.70% had travelled overseas(48.11% to dengue-risk countries) in the last five years.A total of94.47% said transmission is by mosquito *** addition,84.83% knew of current transmission of dengue in QLD,while 80.97% knew the focus is Far North and North ***,2.35% and 8.97% had experienced an infection in their life or that of their immediate family/partner,respectively.85.03% identified correctly at least one means of prevention.A total of 69.72% advised to use insect repellent,wear covered clothing and avoid visiting mosquito-prone areas while 20.93% advised fumigation and clearing water containers around *** was a significant difference(P 0.05).Conclusions:Although many people throughout QLD have heard of dengue,about 15%appear unaware of local transmission,its symptoms and of methods to reduce risk of infection.A lack of knowledge regarding prevention of mosquito breeding is evident in South East QLD,where dengue is not currently *** study suggests that future dengue awareness campaigns should target communities in both endemic and potentially endemic areas throughout Queensland.

关键词： Dengue Awareness Survey Transmission Prevention Queensland

Use of exclusive enteral nutrition in adults with Crohn's disease: A review

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World Journal of Gastroenterology 2013年第43期19卷 7652-7660页

作者： Catherine L Wall andrew S Day richard B Gearry Department of Paediatrics University of OtagoChristchurch 8140New Zealand Department of Medicine University of OtagoChristchurch 8140New Zealand

Exclusive enteral nutrition(EEN)is well-established as a first line therapy instead of corticosteroid(CS)therapy to treat active Crohn’s disease(CD)in *** also has been shown to have benefits over and above induction of disease remission in paediatric ***,other than in Japanese populations,this intervention is not routinely utilised in *** investigate potential reasons for variation in response between adult studies of EEN and CS *** Ovid database was searched over a 6-mo *** directly comparing EEN and CS therapy in adults were *** articles were *** therapy remission rates varied *** compliance with EEN therapy due to unpalatable formula was an issue in half of the *** rates of studies that only included patients with previously untreated/new CD were higher than studies including patients with both existing and new *** was limited evidence to determine if disease location,duration of disease or age of diagnosis affected EEN therapy *** is some evidence to support the use of EEN as a treatment option for a select group of adults,namely those motivated to adhere to an EEN regimen and possibly those newly diagnosed with *** addition,the use of more palatable formulas could improve treatment compliance.

关键词： Exclusive enteral nutrition Crohn’s disease Adults

Assessment of the usefulness of integrated disease surveillance and response on suspected ebola cases in the Brong Ahafo Region, Ghana

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Infectious Diseases of Poverty 2015年第1期4卷 168-175页

作者： Kofi Issah kennedy Nartey richard Amoah Emmanuel George Bachan Jacob Aleeba Enuamah Yeetey Timothy Letsa Ghana Health Service Regional Health DirectorateP.O.Box 145SunyaniBrong Ahafo RegionGhana Kintampo Health Centre Ghana Health ServiceKintampoBrong Ahafo RegionGhana

Background:This study assessed the quality,core and support functions of the integrated disease surveillance and response(IDSR)system relating to 18 suspected cases of Ebola virus disease(EVD)in the Brong Ahafo Region,***:Data was collected on selected indicators of the surveillance system relating to 18 suspected cases of EVD,from epidemiological week 19 to 45 of *** conducted in-depth interviews with seven medical directors and two district directors of health services,and also reviewed documentation on the implementation of the core,support and quality functions of the IDSR *** also monitored news in the media and rumours about EVD within the community as well as in health facility surveillance ***:The study identified gaps in the implementation of IDSR relating to 18 suspected cases of *** staff heavily relied on haemorrhage as the only symptom for detection of suspected EVD *** blood samples and a swab of secretions from the mouth of the thirteenth patient(who died)tested negative for EVD using PCR assay in laboratory *** blood samples of three patients were discarded,as they did not fit the case definition for suspected cases,whilst two refused for their blood samples to be *** community-based surveillance(CBS)system has not been given a prominent role in EVD surveillance and response,as demonstrated by CBS volunteers and health staff not receiving any training in these *** was intense public interest in EVD in August and September *** interest has since waned for reasons that have to be formally *** fear of and anxiety about EVD still remain challenges due to a lack of in-depth knowledge about the disease in ***:Ghana has been one of the pioneers in the implementation of IDSR in *** this,gaps have been identified in the implementation of IDSR relating to EVD in the Brong Ahafo *** address these gaps,the CBS system has to activ

关键词： Ebola Disease surveillance Brong Ahafo Ghana

Scaffolds based therapy for osteochondral lesions of the talus:A systematic review

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World Journal of Orthopedics 2017年第10期8卷 798-808页

作者： Yoshiharu Shimozono Youichi Yasui andrew W Ross Wataru Miyamoto John G kennedy Hospital for Special Surgery New York Department of Orthopaedic Surgery Teikyo University School of Medicine Department of Orthopaedic Surgery Kyoto University Graduate School of Medicine

AIM To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus(OLT). METHODS A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence(LOE) and quality of evidence(QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated. RESULTS Twenty-eight studies for a total of 897 ankles were included; 96% were either LOE Ⅲ or Ⅳ. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation(MACT), nine bone marrow derived cell transplantation(BMDCT), four autologous matrixinduced chondrogeneis(AMIC), and four studies of other techniques. The categories of general demographics(93%) and patient-reported outcome data(85%) were well reported. Study design(73%), imaging data(73%), clinical variables(49%), and patient history(30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society(AOFAS) score at final follow-up was: 86.7 in MACT, 88.2 in BMDCT, and 82.3 in AMIC. Eight studies reported that a weighted mean of 68.3% ofpatients returned to a previous level of sport activity. CONCLUSION Scaffold-based therapy for OLT may produce favorable clinical outcomes, but low LOE, poor QOE, and variability of the data have confounded the effectiveness of this treatment.

关键词： Scaffold Ankle Talar osteochondral lesion Systematic review Cartilage

Genomic analysis uncovers functional variation in the C-terminus of anthocyanin-activating MYB transcription factors

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Horticulture Research 2021年第1期8卷 885-898页

作者： Jessica A.Rodrigues richard V.Espley andrew C.Allan The New Zealand Institute for Plant and Food Research Limited 120 Mount Albert RoadSandringhamAuckland 1025New Zealand School of Biological Sciences University of Auckland3A Symonds StAuckland 1010New Zealand

MYB transcription factors regulate diverse aspects of plant development and secondary metabolism,often by partnering in transcriptional regulatory ***,we harness genomic resources to identify novel MYBs,thereby producing an updated eudicot MYB phylogeny with revised relationships among subgroups as well as new information on sequence variation in the disordered C-terminus of anthocyanin-activating ***®and hidden Markov model scans of gene annotations identified a total of 714 MYB transcription factors across the genomes of four crops that span the eudicots:apple,grape,kiwifruit and *** model-based phylogenetic inference identified novel members of previously defined subgroups,and the function of specific anthocyanin-activating subgroup 6 members was assayed transiently in tobacco *** conservation within subgroup 6 highlighted one previously described and two novel short linear motifs in the disordered C-terminal *** novel motifs have a mix of hydrophobic and acidic residues and are predicted to be relatively ordered compared with flanking protein *** of motifs with the Eukaryotic Linear Motif database suggests roles in protein–protein *** of motifs and their flanking regions from strong anthocyanin activators into weak activators,and vice versa,affected *** conclude that,although the MYB C-terminal sequence diverges greatly even within MYB clades,variation within the C-terminus at and near relatively ordered regions offers opportunities for exploring MYB function and developing superior alleles for plant breeding.

关键词： phylogeny metabolism thereby

Growth and chemical responses of trembling aspen to simulated browsing and ungulate saliva

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Journal of Plant Ecology 2016年第4期9卷 474-484页

作者： Ken Keefover-Ring kennedy F.Rubert-Nason Alison E.Bennett richard L.Lindroth Department of Entomology University of Wisconsin-Madison1630 Linden Dr.MadisonWI 53706USA The James Hutton Institute InvergowrieDundee DD25DAScotlandUK

Aims Woody plant-browser systems represent an understudied facet of *** subjected four genotypes of trembling aspen to artificial browsing,similar to that of a large mammalian herbivore,and applied deer saliva to clipped and unclipped trees to assess:(i)the effects of artificial browsing on aspen growth and phytochemistry of leaves and stems,(ii)genotypic variation in responses and(iii)potential alterations of responses by mammalian *** Potted aspen trees were grown outdoors on the University of Wisconsin-Madison *** experiment consisted of a fullycrossed,2×2×4 randomized complete block design,with two levels of artificial browsing(unclipped and clipped),two levels of saliva application(no saliva and saliva)and four aspen *** simulate ungulate browsing damage,we removed the upper 50%of the stem of half of the trees by pinching the stem with needle-nosed pliers and then separating it by *** half of the damaged trees,we immediately swabbed the wound with deer *** in the unclipped plus saliva treatment were swabbed with saliva at the 50%height *** assess the effects of clipping and saliva application,we harvested all trees after 2 months and measured various growth and chemical *** measurements included height,vertical growth,mass of leaves,stems and roots,leaf number and area and bud *** parameters included defensive,nutritional and structural components of both foliage and *** Findings Clipping affected most of the growth parameters measured,decreasing tree height,leaf,stem,root and total tree mass and leaf *** trees had greater vertical growth,more leaves and higher specific leaf area(SLA)than unclipped *** saliva had little to no effect on plant growth response to the clipping *** budset was delayed by clipping and varied among genotypes but not in response to saliva *** also affected most of the phytochemical variables measure

关键词： ungulate browsing deer saliva defensive chemistry genetic variation Populus tremuloides tolerance

Can palliative radiotherapy influence prostate-specific antigen response in patients with castrate-resistant prostate cancer treated with systemic therapy(chemotherapy or abiraterone)?——a report of three cases

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Cancer Biology & Medicine 2015年第1期12卷 60-63页

作者： Mohan Hingorani Sanjay Dixit Pattu Pugazhenthi Simon Hawkyard andrew Robertson richard Khafagy Department of Clinical Oncology Castle Hill HospitalHull and East YorkshireNHS TrustCottinghamEast Riding of YorkshireHU16 5JQUK Department of Urology Scarborough District General Hospital

Palliative radiotherapy(pRT) is primarily employed for palliation of bone pain in patients with castrate-resistant prostate cancer(CRPC). However, evidence that p RT influences prostate-specific antigen response in patients with CRPC on systemic therapy is lacking. We describe three cases of CRPC progressing after treatment with docetaxel(n=2) and abiraterone(n=1), who responded unusually after p RT for bone pain with the development of a significant biochemical response and restoration of response to systemic therapy. The possibility of p RT influencing metastatic disease in CRPC has not been previously reported, and raises the possibility of radiation-induced modulation of anti-tumor immune response mechanisms that may play a role in the restoration of response to systemic treatment.

关键词： Prostate cancer palliative radiotherapy chemotherapy