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Music alters heart rate and psychological responses but not muscle activation during light-intensity isometric exercise

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Sports Medicine and Health Science 2024年第4期6卷 394-401页

作者： andrew r.moore Jasmin C.Hutchinson Christa Winter Paul C.Dalton Lori A.Bolgla Vincent J.Paolone Department of Kinesiology Augusta University112015th St.AugustaGA30912USA Department of Exercise Science&Athletic Training Springfield College263 Alden St.SpringfieldMA01109USA Department of Psychology Springfield College263 Alden St.SpringfieldMA01109USA Heart&Vascular Institute Penn State College of MedicinePenn State University500 HMC Crescent RoadNorth Lobby HersheyPA17033USA Department of Physical Therapy Augusta University112015th St.AugustaGA30912USA

Listening to music manipulates attention to be more externally focused,which has the potential to improve muscular *** study aimed to determine the effect of listening to music on muscle activation during an isometric exercise task,and compare this effect to those of other attentional focus *** healthy subjects(n=35;16 men/19 women)completed an isometric elbow flexion task for 1 min in three randomized and counterbalanced conditions:internal focus(INT),external focus with a simple distraction task(EXT),or listening to music(MUS).Muscle activation of the biceps and triceps brachii and heart rate(Hr)were recorded throughout the exercise *** of perceived exertion(rPE),affective valence,and motivation were measured at the end of each *** was no difference in muscle activation measures among the three *** during MUS was lower than EXT at 15 s([89.4±11.8]beats/min vs.[93.1±12.9]beats/min;p=0.018)and 30 s([90.6±12.4]beats/min vs.[94.2±12.5]beats/min;p=0.026),and lower than INT at 60 s([93.3±13.3]beats/min vs.[96.7±12.0]beats/min;p=0.016).Overall rPE was higher for INT(13.4±2.2)than for MUS([12.6±2.0];p=0.020)and EXT([11.94±2.22];pr for MUS than for INT([2.7±1.4]vs.[2.1±1.5];p=0.011).Manipulating attentional focus did not alter muscle activation for a light-intensity isometric muscular endurance task,though MUS was reported as more positive and requiring less exertion to complete than *** music can therefore be recommended during light-intensity isometric exercise based on the psychological benefits observed.

关键词： Electromyography Attentional focus rating of perceived exertion Elbow flexion

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Pathophysiology and treatment of diabetic erectile dysfunction

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Asian Journal of Andrology 2006年第6期8卷 675-684页

作者： Charles r.moore Department of Urology University of Texas Health Science Center and MD Anderson Cancer CenterHoustonTexas 77030USA

The pathophysiology of diabetes is multifactorial and no single etiology is at the forefront. The proposed mechanisms of erectile dysfunction （ED） in diabetic patients includes elevated advanced glycation end-products （AGEs） and increased levels of oxygen free radicals, impaired nitric oxide （NO） synthesis, increased endothelin B receptor binding sites and ultrastructural changes, upregulated rhoA/rho-kinase pathway, NO-dependent selective nitrergic nerve degeneration and impaired cyclic guanosine monophosphate （cGMP）-dependent kinase-1 （PKG-1）. The treatment of diabetic ED is multimodal. Treatment of the underlying hyperglycemia and comorbidities is of utmost importance to prevent or halt the progression of the disease. The peripherally acting oral phosphodiesterase type 5 （PDE5） inhibitors are the mainstay of oral medical treatment of ED in diabetics. Vacuum erection devices are an additional treatment as a non-invasive treatment option. Local administration of vasoactive medication via urethral suppository or intracorpora! injection can be effective with minimal side-effects. Patients with irreversible damage of the erectile mechanism are candidates for penile implantation. Future strategies in the evolution of the treatment of ED are aimed at correcting or treating the underlying mechanisms of ED. With an appropriate vector, researchers have been able to transfect diabetic animals with agents such as neurotrophic factors and nitric oxide synthase （NOS）. Further studies in gene therapy are needed to fully ascertain its safety and utility in humans.

关键词： erectile dysfunction diabetes mechanism treatment

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Detection of the adulteration of extra virgin olive oil by near-infrared spectroscopy and chemometric techniques

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Food Quality and Safety 2018年第4期2卷 189-198页

作者： Nick Vanstone andrew moore Perry Martos Suresh Neethirajan BioNano Laboratory School of EngineeringUniversity of Guelph50 Stone Road EastGuelphOntario N1G 2W1Canada Agriculture&Food Laboratory Laboratory Services DivisionUniversity of Guelph95 Stone Road WestGuelphOntario N1G 2Z4Canada

Introduction and Objectives:Due to the value of extra virgin olive oil(EVOO),adulteration has become an important issue in the industry,which has created demand for quick and inexpensive fraud detection *** contrast to many current food fraud detection methods,near-infrared spectroscopy(NIrS)can be inexpensive and convenient by minimizing sample preparation and measurement *** this study,we developed a method using NIrS and chemometrics to detect adulteration of EVOO with other edible oil types that does not require sample preparation and can be completed in less than 10 ***,results,and Discussions:First,a single EVOO was adulterated with corn oil from 2.7%to 25%w/*** for the unadulterated sample and its adulterated counterparts were measured.A principal component analysis(PCA)scores plot showed separation between the adulterated mixtures and the unadulterated sample,which demonstrated that the developed method could detect as low as 2.7%w/w adulteration if an unadulterated sample of the oil in question is *** study adulteration detection without an unadulterated sample for reference,the spectra of unadulterated samples and samples adulterated with corn,sunflower,soybean,and canola oils were measured.A PCA with soft independent modelling of class analogy was used for adulteration *** limits of adulteration detection for corn,sunflower,soybean,and canola oils were found to be approximately 20%,20%,15%,and 10%,***:These results demonstrate that the developed method can be used to rapidly screen for adulterated olive oils.

关键词： olive oil adulteration spectroscopy chemometrics NIr principal component analysis

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Glacier geoengineering to address sea-level rise:A geotechnical approach

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Advances in Climate Change research 2020年第4期11卷 401-414页

作者： andrew LOCKLEY Michael WOLOVICK Bowie KEEFEr rupert GLADSTONE Li-Yun ZHAO John C.moore University College London(Bartlett School) LondonWC1H 0QBUK College of Global Change and Earth System Science Beijing Normal UniversityBeijing100875PR China Manastee road Galiano IslandBritish ColumbiaBC V0N 1P0Canada Arctic Centre University of LaplandRovaniemi96101Finland Southern Marine Science and Engineering Guangdong Laboratory Zhuhai519082China

It is remarkable that the high-end sea level rise threat over the next few hundred years comes almost entirely from only a handful of ice streams and large *** occupy a few percent of ice sheets’***,spatially limited interventions at source may provide globally-equitable mitigation from rising *** streams control draining of ice sheets;glacier retreat or acceleration serves to greatly increase potential sea level *** various climatic geoengineering approaches have been considered,serious consideration of geotechnical approaches has been limited e particularly regarding *** study summarises novel and extant geotechnical techniques for glacier restraint,identifying candidates for further *** include draining or freezing the bed;altering surface albedo;creating obstacles:retaining snow;stiffening shear margins with ice;blocking warm sea water entry;thickening ice shelves(increasing buttressing,and strengthening fractured shelves against disintegration);as well as using regional climate engineering or local cloud seeding to cool the glacier or add *** all of these ideas are judged reasonable or feasible,and even fewer are likely to be found to be advisable after further *** describing and evaluating the potential and risks of a large menu of responses e even apparently hopeless ones e we can increase the chances of finding one that works in times of need.

关键词： Climate intervention Targeted geoengineering Antarctica Greenland Glaciers Sea level rise

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灌溉作物生产函数的两种形式

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绵阳农专学报 1995年第1期12卷 82-101页

作者： Michael r.moore 曾国友肖光蓉

灌溉水的产出弹性对每一作物来说极无伸缩性，表明减少灌溉水的供应可能对作物产量只有相对较小的影响。本文报告了对美国17个西部州13种灌溉作物的柯布—道格拉斯和二次方程生产函数的预测。预测了每一作物的规模利益，灌溉水的产出弹... 详细信息

灌溉水的产出弹性对每一作物来说极无伸缩性，表明减少灌溉水的供应可能对作物产量只有相对较小的影响。本文报告了对美国17个西部州13种灌溉作物的柯布—道格拉斯和二次方程生产函数的预测。预测了每一作物的规模利益，灌溉水的产出弹性，水和土地之间的边际替代率。用统计测验的J—测验判断两种函数形式是否是正确的描述。结果表明：4种作物（大麦、高粱、甘薯和水稻）接受柯布—道格拉斯函数的描述，3种作物（棉花、蚕豆和甘薯）接受二次方程函数的描述。

关键词：生产函数灌溉产出弹性美国西部作物

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Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2031-2043页

作者： Sai Zhang Juan C.Marini Vengai Mavangira andrew Claude Julie moore Mahmoud A.Mohammad Nathalie L.Trottier Department of Animal Science Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USDA/ArS Children’s Nutrition research Center and Pediatric Critical Care Medicine Department of PediatricsBaylor College of MedicineHoustonTX 77030USA Department of Large Animal Clinical Sciences Michigan State UniversityEast LansingMI 48824USA Present address:Department of Animal Science Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Background The study objective was to test the hypothesis that low crude protein(CP)diet with crystalline amino acids(CAA)supplementation improves Lys utilization efficiency for milk production and reduces protein turnover and muscle protein *** lactating multiparous Yorkshire sows were allotted to 1 of 2 isocaloric diets(10.80 MJ/kg net energy):control(CON;19.24%CP)and reduced CP with“optimal”AA profile(OPT;14.00%CP).Sow body weight and backfat were recorded on d 1 and 21 of lactation and piglets were weighed on d 1,14,18,and 21 of *** d 14 and 18,a subset of 9 sows(CON=4,OPT=5)was infused with a mixed solution of 3-[methyl-2H3]histidine(bolus injection)and[13C]bicarbonate(priming dose)first,then a constant 2-h[13C]bicarbonate infusion followed by a 6-h primed constant[1-13C]lysine *** blood and milk sampling were performed to determine plasma and milk Lys enrichment,Lys oxidation rate,whole body protein turnover,and muscle protein *** Over the 21-d lactation period,compared to CON,sows fed OPT had greater litter growth rate(Pred to CON,sows fed OPT had greater efficiency of Lys(Pry flux(Protein turnover efficiency(Pred to CON,sows fed OPT tended to have lower whole body protein breakdown rate(P=0.069).Muscle protein breakdown rate did not differ between OPT and CON(P=0.197).Conclusion Feeding an improved AA balance diet increased efficiency of Lys and reduced whole-body protein turnover and protein *** results imply that the lower maternal N retention observed in lactating sows fed improved AA balance diets in previous studies may be a result of greater partitioning of AA towards milk rather than greater body protein breakdown.

关键词： Amino acid Efficiency Lactating sows Protein breakdown Protein turnover reduced protein diet

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倾斜转弯导弹的次优制导规律

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上海航天 1989年第1期6卷 16-23页

作者： romesh K.Aggarwal Charles r.moore 陈渊

倾斜转弯(BTT)导弹的非线性的俯仰和偏航动态耦合,是由导弹的侧向加速度和倾斜角引起的。由于这些非线性动态特性,最优加速度和倾斜速率指令的解只能通过两点边值问题求解的数值方法得到。具体实现时,必须有相应于现行系统状态其它部分... 详细信息

倾斜转弯(BTT)导弹的非线性的俯仰和偏航动态耦合,是由导弹的侧向加速度和倾斜角引起的。由于这些非线性动态特性,最优加速度和倾斜速率指令的解只能通过两点边值问题求解的数值方法得到。具体实现时,必须有相应于现行系统状态其它部分的动态过程,最优控制问题的解可以用扰动技术得到,这种技术根据能解的降阶问题的解,然后规定降阶解组合成全阶问题的近似解的方法,把系统分成慢速和快速状态。这种技术过去已被用于飞机和导弹弹道最优问题,可是这个问题的表述与其他问题不同。因为小扰动系数是滚动控制代价的加权因子。这样当这参数较小时,滚动控制代价也变得非常小,即这问题看成是"经济控制"问题。合成解由作为现行系统状态函数的滚动速率和加速度指令组合,"零阶慢速"解是侧滑转弯导弹的最优制导律。认为滚动速率无限快,忽略导弹倾斜角的动态情况可有效地获得这个解。"零阶快速"解提供滚动指令,这被认为是补偿倾斜角有限动态特性的校正项。慢速解需要一个"一阶"校正项,通常这一项用扰动理论来获得。但是对于这个问题,一个恰当"慢速"解能通过最优条件来得到,在仿真比较中,利用反向扫描方法可获得最优解,结果表明,BTT 导弹的"次优制导规律"是有效的。

关键词：导弹制导次优制导规律倾斜转弯

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Optical properties of Weyl semimetals

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National Science review 2019年第2期6卷 206-208页

作者： Joel E.moore Department of Physics University of California Materials Science Division Lawrence Berkeley National Laboratory

The behavior of electrons in ordinary metals is dominated by physics near the Fermi surface. Indeed, many of the first successes of the quantum theory of solids, such as understanding the large specific heat of metals, followed from applications of the Fermi surface concept. Great effort has been devoted in recent years to semimetals in which the Fermi surface shrinks to a set of Dirac or Weyl points, where four

关键词： As Ta Optical properties of Weyl semimetals

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Microbiological safety of spices and their interaction with antibiotics:implications for antimicrobial resistance and their role as potential antibiotic adjuncts

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Food Quality and Safety 2019年第2期3卷 93-97页

作者： rachel E.moore B.Cherie Millar Jayachandran r.Panickar John E.moore Department of Bacteriology Northern Ireland Public Health LaboratoryBelfast City HospitalLisburn RoadBelfastNorthern IrelandBT97ADUK School of Biomedical Sciences Ulster UniversityCromore RoadColeraineBT521SANorthern IrelandUK Centre for Experimental Medicine Queen’s University97 Lisburn RoadBelfast BT97BLNorthern IrelandUK Department of Paediatrics Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates

Objectives:A study was undertaken to:*** contaminating bacteria on a variety of spices purchased at retail market;*** if spice bacterial enrichments alter the phenotype of 13 bacterial foodborne and clinical pathogens and 1 probiotic organism;and *** if spices can alter antimicrobial activity of seven clinical antibiotics against 16 bacterial foodborne/clinical *** and Methods:Microbiological examination was undertaken employing 27 spice varieties with four antibiotics and 15 bacterial ***:Bacteriological contamination levels varied amongst spice varieties,ranging from Kasmin chilli powder(7.5×10^(6)cfu/g;log10^(6).88 cfu/g)to ginger(1.5×10^(4)cfu/g;log_(10)4.18 cfu/g);mean contamination was 1.38×10^(6)cfu/g(log_(10)6.14 cfu/g).Four species within the genus Bacillus were identified(Bacillus megaterium,Bacillus subtilis,Bacillus licheniformis,and Bacillus cereus).There was no phenotypic difference with the 14 bacteria,with bacterial colony growth/proliferation,pigment production,or with adhesin and mucoid *** of the spice cultures inhibited any of the 14 bacterial species *** the case of doxycycline,amoxicillin,colistin,erythromycin,and piperacillin/tazobactam,the zone of inhibition increased with the inclusion of the 26 spice varieties,suggesting that the spices were interacting synergistically with the antibiotic,thus making the antibiotic more potent against the bacteria ***:This study demonstrates a positive interaction between spices and conventional *** the burden of antimicrobial resistance(AMr)worldwide,but particularly in South Asian countries(India and Pakistan),any food-related innovation that can help maximize the potency of existing antibiotics is to be encouraged and *** specific mechanism as to how spices increase the potency of antibiotics needs to be elucidated,as well as novel food(spice)delivery modalities including novel medicinal foo

关键词： antibiotic resistance antimicrobial resistance Bacillus foodborne pathogen microbiology Pseudomonas aeruginosa spice

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