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Gado.inium enhanced MRI in patients with left ventricular apical ballo.ning syndro.e implicates myo.arditis as an etio.o.y

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Wo.ld Jo.rnal o. Cardio.ascular Diseases 2013年第1期3卷 118-125页

作者： andrew o. maree Christian Witzke Go.tfred Ho.mvang Grego.y D. Lewis Hani Jneid Lindsay B. Reardo. Nadeem Afridi Marc J. Semigran G. William Dec Harry C. Lo.e Igo. F. Palacio. Cardio.o.y Sectio. Department of Medicine Waterford Regional Hospital Waterford Ireland.

Aims: Left ventricular apical ballo.ning syndro.e (LVABS) is a clinical co.ditio. o. unkno.n etio.o.y, characterized by acute o.set o. atypical apical wall mo.io. and absence o. co.o.ary artery disease. Gado.inium-enhanced cardiac magnetic reso.ance imaging (Gd-MRI) may be used to.identify patients with myo.arditis. Using cardiac MRI, we evaluated whether acute myo.arditis may be an etio.o.y that underlies LVABS. Metho.s and Results: Co.secutive patients who.presented with LVABS during a three-year perio. were included. Demo.raphic data was reco.ded and echo.ardio.raphy, co.o.ary angio.raphy, and hemo.ynamic assessment perfo.med. Gd-MRI was perfo.med in all patients. The study was deemed co.sistent with myo.arditis when glo.al myo.ardial to.skeletal muscle enhancement ratio.was ≥3.5. Regio.al Gd-MRI analysis was also.perfo.med. Patients (n = 11) were female (100%) and o. mean age 72 years (72 ± 11). Preceding febrile illness o.curred in 4 (36.3%) and leuko.yto.is in 6 (54.4%) patients. Initial mean left ventricular ejectio. fractio. (41% ± 12%) impro.ed (70.2% ± 8%) upo. fo.lo.-up (39 ± 43 days). Glo.al MRI analysis was po.itive in 5/11 (45.5%) (mean relative enhancement ratio.4.8 ± 1.4). Regio.al MRI analysis was po.itive in 4/6 further patients (o.erall: 9/11 (82%)). Co.clusio.s: Gado.inium enhanced MRI imaging in LVABS implicates myo.arditis as a po.sible etio.o.y. Regio.al MRI analysis adds sensitivity to.glo.al cardiac MRI evaluatio..

关键词： Left Ventricular Apical Ballo.ning Syndro.e Gado.inium-Enhanced Cardiac Magnetic Reso.ance Imaging Myo.arditis Catecho.amine

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So.uble epo.ide hydro.ase:a next-generatio. drug target fo. Alzheimer's disease and related dementias

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Neural Regeneratio. Research 2025年第9期20卷 2585-2586页

作者： andrew Grego.y Chengyun Tang Fan Fan Department o. Physio.o.y Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with pro.ectio.s indicating a substantial increase in affected individuals due to.the aging glo.al *** the Wo.ld Health o.ganizatio.,AD/ADRD has affected mo.e than 55 millio. individuals wo.ldwide,with an additio.al 10 millio. cases diagno.ed each year.

关键词： Alzheimer po.ulatio. drug

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Blo.d bio.arkers o. Alzheimer’s disease:impo.tant co.sideratio.s fo. use in clinical practice

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Neural Regeneratio. Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o.Do.d Anto.nette o.Co.no. Department o. Neuro.o.y Tallaght University HospitalDublinIreland Academic Unit o. Neuro.o.y Trinity College DublinIreland

Intro.uctio.:Fluid and po.itro. emissio. to.o.raphy(PET)bio.arkers that enable the detectio. o. the hallmark pro.eins o. Alzheimer’s disease(AD)(amylo.d and tau)have revo.utio.ized o.r appro.ch to.the diagno.is o. *** evo.utio. o. AD diagno.tic criteria to.include bio.o.ical characterizatio.(Alzheimer’s Asso.iatio. Wo.king Gro.p,2023)pro.ides an appro.riate framewo.k to.reduce levels o. clinico.patho.o.ic mismatch and impro.e in-vivo.diagno.tic *** the therapeutic landscape fo. neuro.egenerative disease evo.ves,it is increasingly incumbent o. clinicians to.pro.ide timely,and patho.o.ically precise diagno.es fo. ***,the expensive and invasive nature o. these tests limits their scalability.

关键词： Blo.d Alzheimer diagno.is

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Saturatio. in wavelength-divisio. multiplexing free-space o.tical co.municatio. systems

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Fro.tiers o. o.to.lectro.ics 2019年第2期12卷 197-207页

作者： Jeremiah o. BANDELE Malco.m Wo.LFSo. andrew J. PHILLIPS Department o. Electrical Electronics and Computer Engineering College of EngineeringAfe Babalola UniversityAdo-EkitiEkiti StateP.M.B 5454Nigeria Department o. Electrical and Electro.ic Engineering Faculty of EngineeringUniversity of Nottingham University ParkNottinghamNG7 2RDUK

The perfo.mance o. a wavelength-divisio. multiplexing (WDM) free-space o.tical (FSo. co.mu-nicatio. system in a turbulent atmo.phere emplo.ing o.tical amplifiers to.impro.e capacity is investigated, in the presence o. amplified spo.taneo.s emissio. no.se, scintillatio., beam spreading, atmo.pheric attenuatio. and interchannel cro.stalk. Using o.-o.f keying mo.ulatio., Mo.te Carlo.simulatio. techniques are used to.o.tain the average bit erro. rate and system capability due to.scintillatio. and the effect o. intro.ucing a po.er co.tro. algo.ithm (PCA) to.the system is investigated. The PCA ensures that at any receiving instant, the same turbulence- free po.ers are received by all the receiving lenses. The perfo.mance o. vario.s WDM FSo.co.municatio. system co.figuratio.s such as no.-amplified systems with an adaptive decisio. thresho.d (No.ADT), no.- amplified systems with a no.-adaptive decisio. thresho.d, fixed gain amplified systems with an adaptive decisio. thresho.d, fixed gain amplified systems with a no.- adaptive decisio. thresho.d and saturated gain amplified systems with a no.-adaptive decisio. thresho.d (So.- NADT) are investigated. Results o.tained sho. that the So.NADT is superio. to.the No.ADT and the PCA is o.ly beneficial in amplified systems.

关键词： wavelength-divisio. multiplexing (WDM) free-space o.tical (FSo. co.municatio. cro.stalk o.tical amplifier (o.) gain saturatio. decisio. thresho.d

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Human endo.eno.s retro.irus type-W and multiple sclero.is–related smo.dering neuro.nflammatio.

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Neural Regeneratio. Research 2025年第3期20卷 813-814页

作者： Jo.l Grucho. Laura Reiche andrew Chan Ro.ert Ho.pner Patrick Küry Department o. Neuro.o.y Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department o. Neuro.o.y InselspitalBern University Hospital and University of BernBernSwitzerland

Intro.uctio. to.human endo.eno.s retro.irus type-W(HERV-W): Geno.ic inheritance fro. the past includes retro.iral sequences that have been stably inco.po.ated into.o.r geno.es and acco.nt fo. up to.8% o. human DNA.

关键词： endo.eno.s inflammatio. Human

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Dynamic stress co.centratio. in an infinitely lo.g cylindrical cavity due to.a po.nt spherical so.rce embedded within a fluid-saturated po.o.lastic fo.matio. o. infinite extent

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Applied Mathematics and Mechanics(English Editio.) 2025年第1期46卷 139-156页

作者： H.Ho.SEINI o.BALILASHAKI Department o. Mechanical Engineering Faculty of EngineeringGolestan University

The effects o. a harmo.ically exciting mo.o.o.e so.rce o. an infinitely lo.g cylindrical cavity embedded entirely within a fluid-saturated po.o.lastic fo.matio. o. infinite extent are examined theo.etically. It is assumed that the so.rce is lo.ated o.tside the cavity at a specified distance fro. the bo.eho.e axis. The magnitudes o. the ho.p and radial stresses beside the po.e pressures exerted o. the interface and inside the po.o.s medium surro.nding the bo.eho.e are calculated and discussed. Bio.'s po.o.lastic mo.eling alo.g with three types o. bo.ndary co.ditio.s fo. the cylindrical interface including the ideal fluid, empty bo.eho.e, and rigid inclusio. with a hard bo.ndary is emplo.ed fo. the analysis. Utilizing a pro.er translatio.al additio. theo.em fo. expressing the incident spherical wave in terms o. cylindrical wave expansio.s, the pro.o.ed bo.ndary co.ditio.s at the interface are satisfied. Stresses are fo.mulated by means o. wave po.ential functio.s in a three-dimensio.al(3D) manner. The effects o. the frequency and the radial distance between the so.rce and bo.eho.e o. the induced stresses are examined fo. the first cylindrical mo.es o.er frequency spectra. Two.permeability co.ditio.s fo. the interface and three types o. so.ls fo. the po.o.s fo.matio. are co.sidered thro.gho.t the analysis. To.give an o.erall o.tline o. the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has co.siderable effects o. the induced stress values. In additio., the interface permeability co.ditio. and so.l characteristics play an impo.tant ro.e in determining the dynamic respo.se o. the bo.eho.e. Finally,the o.tained results are co.pared with the relevant analyses existing in the literature fo. so.e limit cases, and go.d agreement is achieved.

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Predictio. o. selected bio.iesel fuel pro.erties using artificial neural netwo.k

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Fro.tiers in Energy 2015年第4期9卷 433-445页

作者： So.o.o. o. GIWA Sunday o. ADEKo.AYA Kayo.e o. ADAMA Mo.uf o. MUKAILA Department o. Agricultural and Mechanical Engineering College of Engineering and Environmental Studies Olabisi Onabanjo University lbogun Campus Ifo Ogun State Nigeria

Bio.iesel is an alternative fuel to.replace fo.sil- based diesel fuel. It has fuel pro.erties similar to.diesel which are generally determined experimentally. The experimental determinatio. o. vario.s pro.erties o. bio.iesel is co.tly, time co.suming and a tedio.s pro.ess. To.so.ve these pro.lems, artificial neural netwo.k （ANN） has been co.sidered as a vital to.l fo. estimating the fuel pro.erties o. bio.iesel, especially fro. its fatty acid （FA） co.po.itio.. In this study, fo.r ANNs have been designed and trained to.predict the cetane number （CN）, flash po.nt （FP）, kinematic visco.ity （KV） and density o. bio.iesel using ANN with lo.sig and purelin transfer functio.s in the hidden layer o. all the netwo.ks. The five mo.t prevalent FAs fro. 55 feedsto.ks fo.nd in the literature utilized as the input parameters fo. the mo.el are palmitic, stearic, o.eic, lino.eic and lino.enie acids except fo. density netwo.k with a sixth parameter （temperature）. o.her FAs that are present in the bio.iesels have been co.sidered based o. the number o. carbo. ato. chains and the level o. saturatio.. Fro. this study, the predictio. accuracy and the average abso.ute deviatio. o. the netwo.ks are CN （96.69%; 1.637%）, KV （95.80%; 1.638%）, FP （99.07%; 0.997%） and density （99.40%; 0.101%）. These values are reaso.ably better co.pared to.previo.s studies o. empirical co.relatio.s and ANN predictio.s o. these fuel pro.erties fo.nd in literature. Hence, the present study demo.strates the ability o. ANN mo.el to.predict fuel pro.erties o. bio.iesel with high accuracy.

关键词： bio.iesel fuel pro.erties artificial neuralnetwo.k fatty acid predictio.

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Neuro.nflammatio. revisited thro.gh the micro.lial lens

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Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.B.Relvas Institute o. Research and Inno.atio. in Health(i3S)and Institute fo. Mo.ecular and Cell Bio.o.y(IBMC) University of PortoPortoPortugal Department o. Bio.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues between the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,beyo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship between neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elabo.ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(AD).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist but a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. brain diseases.

关键词： inflammatio. simplified activatio.

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Breakage o. dro.s and bubbles in a stirred tank： A review o.experimental studies

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Chinese Jo.rnal o. Chemical Engineering 2017年第6期25卷 698-711页

作者： Basim o. Hasan Department o. Chemical Engineering Technical University of Berlin 6ermany Department o. Chemical Engineering AI-Nahrain University lraq

The rate o. breakage o. dro.s and bubbles(fluid particles) in stirred systems is o. great co.sequence o. mass,heat, and mo.entum transpo.t pheno.ena. Therefo.e, o.er the years, the to.ic has gained a co.siderable attentio. fro. the researchers to.study and characterize this pheno.eno.. In present wo.k, the experimental studies o. breakage pheno.eno. in a stirred tank in the last fo.r decades were reviewed. The review highlighted the investigated experimental co.ditio.s and the majo. findings co.cerning the breakage mechanism and the effect o. o.erating co.ditio.s. The discrepancy and co.tradictio.s o. the o.tco.es o. tho.e studies were specified and discussed. Experimental o.servatio.s and co.clusio.s co.cerning the breakage characterizatio. parameters,such as defo.matio., breakage pro.ability, breakage time, and breakage lo.atio. were presented and co.mented o.. Po.sible future refinements and pro.pective were reco.mended. The review indicated that there are clear discrepancies and co.tradictio.s between previo.s studies regarding the effect o. so.e o.erating parameters and the values o. breakage time, breakage pro.ability, number o. daughter particles, and breakage lo.atio. relative to.the impeller. In additio., there are still many scientific gaps that need to.be studied and characterized in future by o.erco.ing specific experimental difficulties and uncertainties.

关键词： Dro. Bubble Breakage Stirred tank Review Breakage rate

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Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3D cellular mo.ility mechanisms

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

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