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Ischemic cholangiopathy after livertransplantation

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 495-501页

作者： andrew m. Cameron Ronald W. Busuttil Division of Liver and Pancreas Transplantation Department of SurgeryDavid Geffen School of Medicine at UCLALos AngelesCalifornia 90095-7054USA

Orthotopic liver transplantation ( OLT) has evolved over the last forty years from an experimental endeavor to standard of care therapy for many patients with end stage hepatic disease. many technical advances have contributed to the current success of OLT, but surgical complications, especially involving the biliary reconstruction, remain a morbid problem. Biliary complications after OLT include leaks and strictures. Strictures may be anastoinotic or intrahepatic and diffuse, as seen in cases of hepatic artery thrombosis. Current efforts to expand the limited donor pool include the use of non-heart beating donors. The organ procurement process in these donors entails an increased period of warm ischemia and results with non-heart beating donor grafts have been mixed. It is now appreciated that there is an increased incidence of subsequent diffuse biliary stricturing or ' ischemic cholangiopathy' in recipients of these organs. Animal models of this phenomenon and potential therapeutic strategies targeted at ischemic cholangiopathy are being developed with potential applicability to non-heart beating donation and will be the focus of this review.

关键词： orthotopic liver transplantation biliary strictures non-anastoinotic strictures ischemic cholangiopathy non-heart beating donor

The influence of metabolic disorders on adaptive immunity

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Cellular & molecular Immunology 2024年第10期21卷 1109-1119页

作者： Thomas j.C.Collins Pooranee K.morgan Kevin man Graeme I.Lancaster andrew j.murphy Division of Immunometabolism Baker Heart and Diabetes InstituteMelbourneVIC3004Australia Department of Immunology Monash UniversityMelbourneVIC3004Australia Peter Doherty Institute for Infection and Immunity MelbourneVIC3000Australia Department of microbiology and Immunology University of MelbourneParkvilleVIC3052Australia

The immune system plays a crucial role in protecting the body from invading pathogens and maintaining tissue *** homoeostatic lipid metabolism is an important aspect of efficient immune cell function and when disrupted immune cell function is *** are numerous metabolic diseases whereby systemic lipid metabolism and cellular function is *** the context of metabolic disorders,chronic inflammation is suggested to be a major contributor to disease progression.A major contributor to tissue dysfunction in metabolic disease is ectopic lipid deposition,which is generally caused by diet and genetic ***,we propose the idea,that similar to tissue and organ damage in metabolic disorders,excessive accumulation of lipid in immune cells promotes a dysfunctional immune system(beyond the classical foam cell)and contributes to disease ***,we review the evidence that lipid accumulation through diet can modulate the production and function of immune cells by altering cellular lipid *** can impact immune cell signalling,activation,migration,and death,ultimately affecting key aspects of the immune system such as neutralising pathogens,antigen presentation,effector cell activation and resolving inflammation.

关键词： Immunity metabolic Disorders Lipid metabolism Cell metabolism Immunometabolism Cancer

Assessing the microbiota of recycled bedding sand on a Wisconsin dairy farm

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journal of Animal Science and Biotechnology 2022年第2期13卷 601-612页

作者： Hannah E.Pilch andrew j.Steinberger Donald C.Sockett Nicole Aulik Garret Suen Charles j.Czuprynski Department of Pathobiological Sciences School of Veterinary MedicineUniversity of Wisconsin-MadisonMadison 53706USA Department of Bacteriology University of Wisconsin-MadisonMadison 53706USA microbiology Doctoral Training Program University of Wisconsin-MadisonMadison 53706USA Wisconsin Veterinary Diagnostic Laboratory School of Veterinary MedicineUniversity of Wisconsin-MadisonMadison 53706USA

Background:Sand is often considered the preferred bedding material for dairy cows as it is thought to have lower bacterial counts than organic bedding materials and cows bedded on sand experience fewer cases of lameness and *** can also be efficiently recycled and reused,making it ***,some studies have suggested that the residual organic material present in recycled sand can serve as a reservoir for commensal and pathogenic bacteria,although no studies have yet characterized the total bacterial community *** we sought to characterize the bacterial community composition of a Wisconsin dairy farm bedding sand recycling system and its dynamics across several stages of the recycling process during both summer and winter using 16S rRNA gene amplicon ***:Bacterial community compositions of the sand recycling system differed by both seasons and *** samples had higher richness and distinct community compositions,relative to winter *** both summer and winter samples,the diversity of recycled sand decreased with time drying in the recycling ***,summer sand 14 d post-recycling was enriched in operational taxonomic units(OTUs)belonging to the genera Acinetobacter and Pseudomonas,relative to freshly washed sand and sand from cow *** contrast,no OTUs were found to be enriched in winter *** sand recycling system contained an overall core microbiota of 141 OTUs representing 68.45%±10.33%SD of the total bacterial relative abundance at each sampled *** 4 most abundant genera in this core microbiota included Acinetobacter,Psychrobacter,Corynebacterium,and *** was present in greater abundance in summer samples,whereas Psychrobacter and Corynebacterium had higher relative abundances in winter *** had consistent relative abundances across both ***:These findings highlight the potential of recycled bedding sand as a bacterial reservo

关键词： Bovine Dairy farm microbiota Recycled bedding sand 16S rRNA sequencing

Large quantum alphabets with a tiny footprint

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Light(Science & Applications) 2024年第9期13卷 1701-1703页

作者： Fazilah Nothlawala andrew Forbes School of Physics University of the WitwatersrandJohannesburgSouth Africa

High-dimensional quantum states are known to offer advantages over their two-dimensional qubit counterparts,but their preparation and manipulation has been bulky and ***,quantum state control has been demonstrated on-chip with a~1μm2 footprint and nm-scale features,producing up to eight-dimensional quantum states and ushering in a new route to large quantum information encoding on a small footprint.

关键词： quantum states dimensional

Strong Laws of Large Numbers for Double Sums of Banach Space Valued Random Elements

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Acta mathematica Sinica,English Series 2019年第5期35卷 583-596页

作者： Robert PARKER andrew ROSALSKY Department of Biostatistics University of Florida Department of Statistics University of Florida

For a double array {V_(m,n), m ≥ 1, n ≥ 1} of independent, mean 0 random elements in a real separable Rademacher type p(1 ≤ p ≤ 2) Banach space and an increasing double array {b_(m,n), m ≥1, n ≥ 1} of positive constants, the limit law ■ and in L_p as m∨n→∞ is shown to hold if ■ This strong law of large numbers provides a complete characterization of Rademacher type p Banach spaces. Results of this form are also established when 0 mean 0 conditions are placed on the random elements and without any geometric conditions placed on the underlying Banach space.

关键词： Real separable Banach space double array of independent random elements strong law of large numbers almost sure convergence Rademacher type p Banach space convergence in Lp

Rehabilitation of erectile function following radical prostatectomy

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Asian journal of Andrology 2008年第1期10卷 61-74页

作者： andrew R. mcCullough Department of Urology New York University School of Medicine New York NY 10016 USA

The concept of muscle rehabilitation after nerve injury is not a novel idea and is practiced in many branches of medicine, including urology. Bladder rehabilitation after spinal cord injury is universally practiced. The erectile dysfunction （ED） experienced after radical prostatectomy （RP） is increasingly recognized as being primarily neurogenic followed by secondary penile smooth muscle （Sm） changes. There is unfortunately no standard approach to penile rehabilitation after RP because controlled prospective human studies are not available. This article reviews the epidemiology, experimental pathophysiological models, rationale for penile rehabilitation, and currently published rehabilitation strategies.

关键词： erectile dysfunction penile rehabilitation radical prostatectomy

GANana:Unsupervised Domain Adaptation for Volumetric Regression of Fruit

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Plant Phenomics 2021年第1期3卷 326-336页

作者： Zane K.j.Hartley Aaron S.jackson michael Pound andrew P.French School of Computer Science University of NottinghamNG71BBUK School of Biosciences University of NottinghamLE125RDUK

3D reconstruction of fruit is important as a key component of fruit grading and an important part of many size estimation *** many computer vision challenges,the 3D reconstruction task suffers from a lack of readily available training data in most domains,with methods typically depending on large datasets of high-quality image-model *** this paper,we propose an unsupervised domain-adaptation approach to 3D reconstruction where labelled images only exist in our source synthetic domain,and training is supplemented with different unlabelled datasets from the target real *** approach the problem of 3D reconstruction using volumetric regression and produce a training set of 25,000 pairs of images and volumes using hand-crafted 3D models of bananas rendered in a 3D modelling environment(Blender).Each image is then enhanced by a GAN to more closely match the domain of photographs of real images by introducing a volumetric consistency loss,improving performance of 3D reconstruction on real *** solution harnesses the cost benefits of synthetic data while still maintaining good performance on real world *** focus this work on the task of 3D banana reconstruction from a single image,representing a common task in plant phenotyping,but this approach is general and may be adapted to any 3D reconstruction task including other plant species and organs.

关键词： image render adapted

DeepRice: A deep learning and deep feature based classification of Rice leaf disease subtypes

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Artificial Intelligence in Agriculture 2024年第1期11卷 34-49页

作者： P.Isaac Ritharson Kumudha Raimond X.Anitha mary jennifer Eunice Robert andrew j Department of CSE Karunya Institute of Technology and Sciences CoimbatoreTamilnaduIndia Department of Robotics Engineering Karunya Institute of Technology and SciencesCoimbatoreIndia Department of mechatronics Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India Department of Computer Science and Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India

Rice stands as a crucial staple food globally,with its enduring sustainability hinging on the prompt detection of rice leaf ***,efficiently detecting diseases when they have already occurred holds paramount importance for solving the cost of manual visual identification and chemical *** the recent past,the identification of leaf pathologies in crops predominantly relies on manual methods using specialized equipment,which proves to be time-consuming and *** study offers a remedy by harnessing Deep Learning(DL)and transfer learning techniques to accurately identify and classify rice leaf diseases.A comprehensive dataset comprising 5932 self-generated images of rice leaves was assembled along with the benchmark datasets,categorized into 9 classes irrespective of the extent of disease spread across the *** classes encompass diverse states including healthy leaves,mild and severe blight,mild and severe tungro,mild and severe blast,as well as mild and severe brown *** meticulous manual labelling and dataset segmentation,which was validated by horticulture experts,data augmentation strategies were implemented to amplify the number of *** datasets were subjected to evaluation using the proposed tailored Convolutional Neural Networks *** performance are scrutinized in conjunction with alternative transfer learning approaches like VGG16,Xception,ResNet50,DenseNet121,Inception ResnetV2,and Inception *** effectiveness of the proposed custom VGG16 model was gauged by its capacity to generalize to unseen images,yielding an exceptional accuracy of 99.94%,surpassing the benchmarks set by existing state-of-the-art ***,the layer wise feature extraction is also visualized as the interpretable AI.

关键词： Rice leaf disease Deep learning CNN Crop yield Agriculture Food security

Thin Films of Ruthenium Phthalocyanine Complexes

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Nano Research 2009年第9期2卷 678-687页

作者： Tristan Rawling Christine E.Austin Dominic Hare Philip A.Doble Hadi m.Zareie andrew m.mcDonagh Institute for Nanoscale Technology University of Technology SydneySydneyNSW 2007Australia

Four new ruthenium phthalocyanine complexes bearing axial ligands with thioacetate groups that facilitate thin fi lm formation on gold surfaces are *** tunnelling microscopy(STm)images and surface coverage data obtained by solution inductively coupled plasma mass spectrometry(ICP-mS)experiments show that peripheral and axial ligand substituents on the complexes have a signifi cant effect on their surface coverage.A laser ablation ICP-mS technique that provides information about thin films across macro-sized areas is described here for the fi rst *** the technique,the maximum surface coverage of a ruthenium phthalocyanine complex was found to occur within one minute of gold substrate immersion in the complex-containing solution.

关键词： Ruthenium phthalocyanine gold surface laser ablation