检索结果-南通市图书馆

Effect of photo-biodegradation and biodegradation on the biogeochemical cycling of dissolved organic matter across diverse surface water bodies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2019年第3期31卷 130-147页

作者： m.S.Sankar Padmanava Dash Shatrughan Singh YueHan Lu andrew E.mercer Shuo Chen Department of Geosciences Mississippi State University Department of Geological Sciences University of Alabama Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology

The objective of this research was to quantify the temporal variation of dissolved organic matter(DOm) in five distinct waterbodies in watersheds with diverse types of land use and land cover in the presence and absence of sunlight. The water bodies were an agricultural pond, a lake in a forested watershed, a man-made reservoir, an estuary, and a bay. Two sets of samples were prepared by dispensing unfiltered samples into filtered samples in 1:10 ratio(V/V). The first set was exposed to sunlight(10 hr per day for 30 days) for examining the combined effect of photo-biodegradation, while the second set was stored in dark for examining biodegradation alone. Spectroscopic measurements in tandem with multivariate statistics were used to interpret DOm lability and composition. The results suggest that the agricultural pond behaved differently compared to other study locations during degradation experiments due to the presence of higher amount of microbial humic-like and protein-like components derived from microbial/anthropogenic sources. For all samples, a larger decrease in dissolved organic carbon(DOC) concentration(10.12% ±9.81% for photo-biodegradation and 6.65% ± 2.83% for biodegradation) and rapid transformation of DOm components(i.e., terrestrial humic-like components into microbial humic and protein-like components) were observed during photo-biodegradation *** suggest that sunlight facilitated DOm biodegradation, resulting in simpler recalcitrant molecules regardless of original composition. Overall, it was found that combined effects of light and bacteria are more efficient than bacterial effects alone in remineralizing and altering DOm, which highlights the crucial importance of sunlight in transforming aquatic DOm.

关键词： Photo-biodegradation Biodegradation Dissolved organic matter Land use and land cover Half-life EEm-PARAFAC

Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第9期13卷 1378-1383页

作者： Leo K Cheng Rie Komuro Travis m Austin martin L Buist andrew J Pullan Bioengineering Institute The University of Auckland Private Bag 92019 Auckland 1142 New Zealand Division of Bioengineering National University of SingaporeSingapore Bioengineering Institute The University of Auckland Private Bag 92019 Auckland 1142 New ZealandDepartment of Engineering Science The University of Auckland

One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.

关键词： model Bidomain Simulation Interstitial cells of Cajal Physiome GIOIE

microbiome and colorectal carcinogenesis:Linked mechanisms and racial differences

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第2期14卷 375-395页

作者： Sofia C Tortora Vimal m Bodiwala andrew Quinn Laura A martello Shivakumar Vignesh Department of medicine and Division of Gastroenterology&Hepatology SUNY Downstate Health Sciences UniversityBrooklynNY 11203United States

Various studies have shown the interplay between the intestinal microbiome,environmental factors,and genetic changes in colorectal cancer(CRC)*** this review,we highlight the various gut and oral microbiota associated with CRC and colorectal adenomas,and their proposed molecular mechanisms in relation to the processes of“the hallmarks of cancer”,and differences in microbial diversity and abundance between race/*** with CRC showed increased levels of Bacteroides,Prevotella,Escherichia coli,enterotoxigenic Bacteroides fragilis,Streptococcus gallolyticus,Enterococcus faecalis,Fusobacterium nucleatum(***)and Clostridium *** levels of Bacteroides have been found in African American(AA)compared to Caucasian American(CA)***-inflammatory bacteria such as *** and Enterobacter species were significantly higher in ***,AA patients have been shown to have decreased microbial diversity compared to CA *** studies have shown that using microbiome profiles in conjunction with certain risk factors such as age,race and body mass index may help predict healthy colon vs one with adenomas or *** is one of the most common bacterial infections in humans and is more prevalent in Non-Hispanic-Blacks as compared to Non-Hispanic *** condition causes increased systemic inflammation,immune dysregulation,gut microbiota dysbiosis and thereby possibly influencing colorectal ***-associated bacteria such as Fusobacterium,Prevotella,Bacteroides and Porphyromonas have been found in CRC tissues and in feces of CRC ***,a deeper understanding of the association between oral and gastrointestinal bacterial profile,in addition to identifying prevalent bacteria in patients with CRC and the differences observed in ethnicity/race,may play a pivotal role in predicting incidence,prognosis,and lead to the development of new treatments.

关键词： Colorectal cancer Oral microbiome Gut microbiome Hallmarks of cancer Racial/ethnic microbial diversity

Pancreaticopleuralfistula:etiology,treatmentandlong-termfollow-up

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 215-219页

作者： Keith J Roberts maria Sheridan Gareth morris-Stiff andrew m Smith Department of Pancreatic Surgery St James University HospitalLeedsUK

BACKGROUND:Pancreaticopleural fistula(PPF) are *** multidisciplinary treatment is required due to nutritional compromise and *** is the first description of long-term follow-up of patients with ***:Eleven patients with PPF treated at a specialist unit were ***,investigation,treatment and outcomes were ***:Pancreatitis was the etiology of the PPF in 9 patients,and in the remaining 2 the PPF developed following distal ***-sectional imaging demonstrated the site of duct disruption in 10 cases,with endoscopic retrograde cholangiopancreatography identifying the final *** of pancreatic exocrine secretion and percutaneous drainage formed the mainstay of *** cases resolved following pancreatic duct stent insertion and three patients required surgical treatment for established *** were no *** all cases that resolved there has been no recurrence of PPF over a median follow-up of 50 months(range 15-62).CONCLUSIONS:PPF is an uncommon event complicating pancreatitis or pancreatectomy;pancreatic duct disruption is the common link.A step-up approach consisting of minimally invasive techniques treats the majority with surgery needed for refractory sepsis.

关键词： pancreatic disease pancreatitis pancreatic pseudocyst

Strong Laws of Large Numbers for Double Sums of Banach Space Valued Random Elements

在线全文

学校读者我要写书评

暂无评论

Acta mathematica Sinica,English Series 2019年第5期35卷 583-596页

作者： Robert PARKER andrew ROSALSKY Department of Biostatistics University of Florida Department of Statistics University of Florida

For a double array {V_(m,n), m ≥ 1, n ≥ 1} of independent, mean 0 random elements in a real separable Rademacher type p(1 ≤ p ≤ 2) Banach space and an increasing double array {b_(m,n), m ≥1, n ≥ 1} of positive constants, the limit law ■ and in L_p as m∨n→∞ is shown to hold if ■ This strong law of large numbers provides a complete characterization of Rademacher type p Banach spaces. Results of this form are also established when 0 mean 0 conditions are placed on the random elements and without any geometric conditions placed on the underlying Banach space.

关键词： Real separable Banach space double array of independent random elements strong law of large numbers almost sure convergence Rademacher type p Banach space convergence in Lp

Ischemic cholangiopathy after livertransplantation

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 495-501页

作者： andrew m. Cameron Ronald W. Busuttil Division of Liver and Pancreas Transplantation Department of SurgeryDavid Geffen School of Medicine at UCLALos AngelesCalifornia 90095-7054USA

Orthotopic liver transplantation ( OLT) has evolved over the last forty years from an experimental endeavor to standard of care therapy for many patients with end stage hepatic disease. many technical advances have contributed to the current success of OLT, but surgical complications, especially involving the biliary reconstruction, remain a morbid problem. Biliary complications after OLT include leaks and strictures. Strictures may be anastoinotic or intrahepatic and diffuse, as seen in cases of hepatic artery thrombosis. Current efforts to expand the limited donor pool include the use of non-heart beating donors. The organ procurement process in these donors entails an increased period of warm ischemia and results with non-heart beating donor grafts have been mixed. It is now appreciated that there is an increased incidence of subsequent diffuse biliary stricturing or ' ischemic cholangiopathy' in recipients of these organs. Animal models of this phenomenon and potential therapeutic strategies targeted at ischemic cholangiopathy are being developed with potential applicability to non-heart beating donation and will be the focus of this review.

关键词： orthotopic liver transplantation biliary strictures non-anastoinotic strictures ischemic cholangiopathy non-heart beating donor

management of borderline and locally advanced pancreatic cancer:Where do we stand?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第9期20卷 2255-2266页

作者： Jin He andrew J Page matthew Weiss Christopher L Wolfgang Joseph m Herman Timothy m Pawlik Department of Surgery Johns Hopkins Hospital Baltimore MD 21287 United States Department of Radiation Oncology Johns Hopkins Hospital Baltimore MD 21287 United States

many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic *** definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of *** the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal *** feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 *** initially unresectable LAPC,neoadjuvant should be strongly ***,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual *** efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with *** review focuses on patients with LAPC and addresses recent advances and controversies in the field.

关键词： Pancreas Locally advanced Chemotherapy Radiation Irreversible electroporation Pancreatic cancer

Loss of Hox5 function results in myofibroblast mislocalization and distal lung matrix defects during postnatal development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2018年第9期61卷 1030-1038页

作者： Steven m.Hrycaj Leilani marty-Santos andrew J.Rasky Nicholas W.Lukacs Deneen m.Wellik Department of Internal medicine Division of Molecular Medicine and Genetics University of Michigan Department of Pathology University of Michigan Department of Cell and Developmental Biology University of Michigan

Alveologenesis is the final stage of lung development and is responsible for the formation of the principle gas exchange units called alveoli. The lung mesenchyme, in particular the alveolar myofibroblasts, are drivers of alveolar development, however,few key regulators that govern the proper distribution and behavior of these cells in the distal lung during alveologenesis have been identified. While Hox5 triple mutants(Hox5 aabbcc) exhibit neonatal lethality, four-allele, compound mutant mice(Hox5 AabbCc) are born in mendelian ratios and are phenotypically normal at birth. However, they exhibit defects in alveologenesis characterized by a BPD-like phenotype by early postnatal stages that becomes more pronounced at adult stages. Invasive pulmonary functional analyses demonstrate significant increases in total lung volume and compliance and a decrease in elastance in Hox5 compound mutants. SmA+ myofibroblasts in the distal lung are distributed abnormally during peak stages of alveologenesis and aggregate, resulting in the formation of a disrupted elastin network. Examination of other key components of the distal lung ECm, as well as other epithelial cells and lipofibroblasts reveal no differences in distribution. Collectively, these data indicate that Hox5 genes play a critical role in alveolar development by governing the proper cellular behavior of myofibroblasts during alveologenesis.

关键词： Hox5 alveologenesis alveolar myofibroblasts lung ECm postnatal lung development

Thin Films of Ruthenium Phthalocyanine Complexes

在线全文

学校读者我要写书评

暂无评论

Nano Research 2009年第9期2卷 678-687页

作者： Tristan Rawling Christine E.Austin Dominic Hare Philip A.Doble Hadi m.Zareie andrew m.mcDonagh Institute for Nanoscale Technology University of Technology SydneySydneyNSW 2007Australia

Four new ruthenium phthalocyanine complexes bearing axial ligands with thioacetate groups that facilitate thin fi lm formation on gold surfaces are *** tunnelling microscopy(STm)images and surface coverage data obtained by solution inductively coupled plasma mass spectrometry(ICP-mS)experiments show that peripheral and axial ligand substituents on the complexes have a signifi cant effect on their surface coverage.A laser ablation ICP-mS technique that provides information about thin films across macro-sized areas is described here for the fi rst *** the technique,the maximum surface coverage of a ruthenium phthalocyanine complex was found to occur within one minute of gold substrate immersion in the complex-containing solution.

关键词： Ruthenium phthalocyanine gold surface laser ablation