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Combination antiretroviral studies for patients with primary biliary cirrhosis

World Journal of Gastroenterology 2016年第1期22卷 349-360页

作者： Ellina lytvyak Aldo J Montano-loza andrew l mason Division of Gastroenterology and Hepatology University of Alberta

Following the characterization of a human betaretrovirus in patients with primary biliary cirrhosis(PBC),pilot studies using antiretroviral therapy have been conducted as proof of principal to establish a link of virus with disease and with the eventual aim to find better adjunct therapies for patients unresponsive to ursodeoxycholic *** the first open label pilot study,the reverse transcriptase inhibitor lamivudine had little demonstrable biochemical or histological effect after 1 ***,lamivudine in combination with zidovudine was associated with a significant reduction in alkaline phosphatase as well as improvement in necroinflammatory score,cholangitis and ductopenia over a 12 mo period.A double blind,multi-center randomized controlled trial using lamivudine with zidovudine for 6 mo confirmed a significant reduction in alkaline phosphatase,AlT and AST in patients on antiviral ***,none of the patients achieved the stringent endpoint criteria for normalization of alkaline ***,some patients developed biochemical rebound consistent with drug resistance.A major fault of these studies has been the inability to measure the viral load in peripheral blood and therefore,provide a direct correlation between improvement of hepatic biochemistry and reduction in viral ***,viral mutants to lamivudine with zidovudine were later characterized in the NOD.c3c4 mouse model of PBC that has been used to test other antiretroviral regimens to *** combination of tenofovir and emtricitabine reverse transcriptase inhibitors and the HIV protease inhibitor,lopinavir were found to abrogate cholangitis in the NOD.c3c4 mouse model and the same regimen normalized the liver tests in a PBC patient with HIV and human betaretrovirus *** combination antiretroviral therapy has now been used in a double blind randomized controlled crossover study for patients with PBC followed by an open label extension *** a thi

关键词： Primary biliary cirrhosis Antiretroviraltherapy Human betaretrovirus Randomized controlledtrial Endpoints for trials

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Clinical Efficacy and Adverse Reactions of Photodynamic Therapy in the Treatment of Malignant Skin Tumors and Precancerous Skin Diseases

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Advances in Modern Oncology Research 2019年第5期5卷 6-8页

作者： andrew l.mason Chadia Chourabi Department of Genetics University of North CarolinaChapel HillNC Alliance Protocol Operations Office University of ChicagoChicagoIL

The purpose of the study was to investigate the efficacy and safety of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin *** of all,100 patients with malignant skin tumor and pre-cancer skin disease admitted to our hospital from January 20,2018 to September 18,2018 were selected,and all of them adopted photodynamic *** 100 patients included 40 cases of basal cell carcinoma,14 cases of squamous cell carcinoma,7 cases of proliferative erythema,9 cases of Bowen’s disease and 39 cases of solar *** the 100 patients,77 cases had excellent curative effect,18 cases had good effect and 5 cases had poor effect,and the overall effective rate was 95%(95/100).After 6 months of follow-up,5 cases of basal cell carcinoma,2 cases of squamous cell carcinoma,0 cases of proliferative erythra,1 case of Bowen’s disease and 3 cases of solar keratosis recurred,with an overall recurrence rate of 14%(14/100).The adverse reactions of pruritus were 90%(90/100),81%(81/100),90%(90/100)and 3%(3/100).Therefore,the application of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases is not only effective,but also safe and not easy to relapse.

关键词： Malignant skin tumor Precancerous skin disease Photodynamic therapy Adverse reactions

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A signal-substrate match in the substrate-borne component of a multimodal courtship display

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Current Zoology 2010年第3期56卷 370-378页

作者： Damian O.ElIAS andrew C.mason Eileen A.HEBETS Department of Environmental Science Policy and ManagementUniversity of California Integrative Behaviour and Neuroscience Group University of Toronto Scarborough School of Biological Sciences University of Nebraska

The environment can impose strong limitations on the efficacy of signal transmission. In particular, for vibratory communication, the signaling environment is often extremely heterogeneous at small scales. Nevertheless, natural selection is expected to select for signals well-suited for effective transmission. Here, we test for substrate-dependent signal efficacy in the wolf spider Schizocosa stridulans Strattou 1991. We first explore the transmission characteristics of this important signaling mo- dality by playing recorded substrate-bome signals through three different substrates （leaf litter, pine litter, and red clay） and measuring the propagated signal. We found that the substrate-bome signal of S. stridulans attenuates the least on leaf litter, the substrate upon which the species is naturally found. Next, by assessing mating success with artificially muted and non-muted males across different signaling substrates （leaf litter, pine litter, and sand）, we explored the relationship between substrate-bome signaling and signaling substrate for mating success. We found that muted males were unsuccessful in obtaining copulations re- gardless of substrate, while mating success was dependent on the signaling substrate for non-muted males. For non-muted males, more males copulated on leaf litter than any other substrate. Taken together, these results conflrm the importance of sub- strate-bome signaling in S. stridulans and suggest a match between signal properties and signal efficacy - leaf litter transmits the signal most effectively and males are most successful in obtaining copulations on leaf litter [Current Zoology 56 （3）： 370-378, 2010].

关键词： Environmental heterogeneity Sensory drive Mate choice Communication

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Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第1期 314-316页

作者： Miguel A.liuzzi-Vaamonde Jackson B.lancaster Samantha A.mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. Before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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Mice with a heterozygous lrp6 deletion have impaired fracture healing

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Bone Research 2016年第2期4卷 101-109页

作者： Travis A Burgers Juan F Vivanco Juraj zahatnansky andrew J Vander Moren James J mason Bart O Williams Center for Cancer and Cell Biology Program for Skeletal Disease and Tumor Microenvironment Van Andel Research Institute Grand Rapids MhUSA Faculfad de Ingenieria y Ciencias Adolfo Ib6fiez University Vifia del Mar Chile padnos College of Engineering and Computing Grand Valley State University Grand Rapids MI USA

Bone fracture non-unions, the failure of a fracture to heal, occur in 10%-20% of fractures and are a costly and debilitating clinical problem. The Wnt/fl-catenin pathway is critical in bone development and fracture healing. Polymorphisms of linking low-density lipoprotein receptor-related protein 6 （lRP6）, a Wnt-binding receptor, have been associated with decreased bone mineral density and fragility fractures, although this remains controversial. Mice with a homozygous deletion of lrp6 have severe skeletal abnormalities and are not viable, whereas mice with a heterozygous deletion have a combinatory effect with lrp5 to decrease bone mineral density. As fracture healing closely models embryonic skeletal development, we investigated the process of fracture healing in mice heterozygous for lrp6 （lrp6~/-） and hypothesized that the heterozygous deletion of lrp6 would impair fracture healing. Mid-diaphyseal femur fractures were induced in lrp6~^- mice and wild-type controls （lrp6~/~）. Fractures were analyzed using micro-computed tomography （~CT） scans, biomechanical testing, and histological analysis. lrp6~/- mice had significantly decreased stiffness and strength at 28 days post fracture （PF） and significantly decreased BV/TV, total density, immature bone density, and mature area within the callus on day-14 and -21 PF; they had significantly increased empty callus area at days 14 and 21 PF. Our results demonstrate that the heterozygous deletion of lrp6 impairs fracture healing, which suggests that lrp6 has a role in fracture healing.

关键词： bone Mice with a heterozygous lrp6 deletion have impaired fracture healing

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Standardizing and Centralizing Datasets for Efficient Training of Agricultural Deep learning Models

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Plant Phenomics 2023年第4期5卷 689-702页

作者： Amogh Joshi Dario Guevara mason Earles Department of Viticulture and Enology University of CaliforniaDavisDavisCAUSA Department of Biological and Agricultural Engineering University of CaliforniaDavisDavisCAUSA AI Institute for Next-Generation Food Systems(AIFS) University of CaliforniaDavisDavisCAUSA

In recent years,deep learning models have become the standard for agricultural computer *** models are typically fine-tuned to agricultural tasks using model weights that were originally fit to more general,non-agricultural *** lack of agriculture-specific fine-tuning potentially increases training time and resource use,and decreases model performance,leading to an overall decrease in data *** overcome this limitation,we collect a wide range of existing public datasets for 3 distinct tasks,standardize them,and construct standard training and evaluation pipelines,providing us with a set of benchmarks and pretrained *** then conduct a number of experiments using methods that are commonly used in deep learning tasks but unexplored in their domain-specific applications for *** experiments guide us in developing a number of approaches to improve data efficiency when training agricultural deep learning models,without large-scale modifications to existing *** results demonstrate that even slight training modifications,such as using agricultural pretrained model weights,or adopting specific spatial augmentations into data processing pipelines,can considerably boost model performance and result in shorter convergence time,saving training ***,we find that even models trained on low-quality annotations can produce comparable levels of performance to their high-quality equivalents,suggesting that datasets with poor annotations can still be used for training,expanding the pool of currently available *** methods are broadly applicable throughout agricultural deep learning and present high potential for substantial data efficiency improvements.

关键词： weights overcome shorter

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The Origin of Spots in Contact Aureoles and Over-Heating of Country Rock Next to a Dyke

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Journal of Earth Science 2018年第5期29卷 1005-1009页

作者： Roger mason Rong liu School of Earth Sciences China University of Geosciences

Petrographic comparison of andalusite in the contact aureole of the Fangshan pluton, Zhoukoudian, Beijing, China, and hornfels in the aureole of the Markfield diorite, leicestershire, Eng- land, shows that spots characteristic of the outer zones of contact metamorphic aureoles did not form during the progressive stage of contact metamorphism, but are pseudomorphs after earlier andalusite with characteristic chiastolite microstructure. The baked margin produced by contact metamorphism of syenite against a dyke in the Houshihushan ring complex, Shanhaiguan, Hebei Province, China, is an unusual feature caused by the dyke＇s role as a feeder to a family of cone-sheets.

关键词： contact metamorphism contact aureole retrogression hornfels spots Zhoukoudian Houshihushan.

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Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study

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World Journal of Gastroenterology 2015年第16期21卷 4925-4932页

作者： Tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard andrew mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener Department of Interventional and Diagnostic Radiology University Hospital Ulm Department of Internal Medicine I University Hospital Ulm louis Stokes Cleveland Department of Veterans Affairs Medical Center Section of Infectious Diseases and Clinical Immunology Comprehensive Infectious Diseases Center Ulm

AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional ***:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of *** underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and ***' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were *** order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and ***:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of *** average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 *** most common symptoms were jaundice, abdominal pains, and weight *** of interventions per patient ranged from one to *** retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone interven

关键词： Alveolar echinococcosis Endoscopic retrograde cholangiopancreatography Hepatobiliary complication Magnetic resonance cholangiopancreatography Percutaneous transhepatic cholangiodrainage Stent placement Treatment

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Diaphragmatic hernia after right donor and hepatectomy: a rare donor complication of partial hepatectomy for transplantation

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 459-461页

作者： Alan M.Hawxby David P.mason andrew S.Klein Division of Transplant and Thoracic Surgery Department of Surgery The Johns Hopkins HospitalBaltimoreMDUSA

BACKGROUND: Because of the critical worldwide shortage of cadaveric organ donors, transplant professionals have increasingly turned to living donors. Partial hepatectomy for adult living donor liver transplantation has been performed since the late 1990s. Most often,the complications of living donor hepatectomy have been related to the biliary tract, specifically biliary leaks. METHODS: A 54-year-old man underwent donor right hepatectomy for living donor liver transplantation. Three years after liver donation he presented with upper abdominal pain and fullness. Radiographic workup revealed a diaphragmatic hernia of the right hemithorax. RESUlTS: After thoracoscopic evaluation of the right hemithorax, diaphragmatic hernia was repaired. Currently the patient remains well several months after the repair with complete resolution of abdominal pain, normal chest X-ray examination demonstrating no recurrence of diaphragmatic hernia, and normal liver functions tests. CONClUSIONS: Multiple complications of living donor liver transplantation have been described the transplant literature. Diaphragmatic hernia is a formerly-undescribed complication of right donor hepatectomy for transplantation.

关键词： living donor liver transplantation donor complications diaphragmatic hernia

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Poetry Translation Depends on the Translator’s Purpose:An Interview with Ian mason about Poetry Translation and Translation Studies

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Comparative literature:East & West 2011年第1期 146-154页

作者： Ian mason Heriot-Watt University

本文针对诗歌翻译及中西翻译研究的一些问题,对英国翻译研究学者伊恩·梅森进行了访谈。梅森教授据自己的研究角度,指出诗歌翻译取决于译者目的,同时对于诗歌翻译的未来表示了深切的担忧;对于西方翻译研究的成就与现状做了中肯而客观的... 详细信息

本文针对诗歌翻译及中西翻译研究的一些问题,对英国翻译研究学者伊恩·梅森进行了访谈。梅森教授据自己的研究角度,指出诗歌翻译取决于译者目的,同时对于诗歌翻译的未来表示了深切的担忧;对于西方翻译研究的成就与现状做了中肯而客观的评述。这次访谈既讨论了不同视角导致的对诗歌翻译的不同理解,也显示出西方学者对待学术问题的严谨与坦率。

关键词：诗歌翻译翻译研究访谈梅森研究角度不同视角西方学者学术问题译者英国

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