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World Journal of Cardiology 2015年第11期7卷 817-821页

作者： Poay Huan loh Christos V Bourantas Pak Hei Chan Nikolaj Ihlemann Fin Gustafsson andrew l clark Susanna Price Carlo Di Mario Neil Moat Farqad Alamgir Rodrigo Estevez-loureiro lars SΦndergaard Olaf Franzen National University Heart Center Singapore University College london Cardiology Division Department of MedicineQueen Mary Hospitalthe University of Hong Kong Department of Cardiology Rigshospitalet University Hospital Hull and East Yorkshire Hospitals NHS Trust NIHR Cardiovascular BRU Royal Brompton Hospital and Imperial College King Abdulaziz Medical Center Complejo Asistencial Universitario de leon Klinik Im Park

Many patients with left ventricular systolic dysfunction have concomitant mitral regurgitation(MR). Their symptoms and prognosis worsen with increasing severity of MR. Percutaneous Mitra Clip® can be used safely to reduce the severity of MR even in patients with advanced heart failure and is associated with improved symptoms, quality of life and exercise tolerance. However, a few patients with very poor left ventricular systolic function may experience significant haemodynamic disturbance in the peri-procedural period. We present three such patients, highlighting some of the potential problems encountered and discuss their possible pathophysiological mechanisms and safety measures.

关键词： Mitral regurgitation Mitral valve left ventricular systolic dysfunction Chronic heart failure MitraClip Percutaneous

Electrically pumped quantum-dot lasersgrownon 300 mm patterned Si photonic wafers

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light(Science & Applications) 2022年第11期11卷 2698-2705页

作者： Chen Shang Kaiyin Feng Eamonn THughes andrew clark Mukul Debnath Rosalyn Koscica Gerald leake Joshua Herman David Harame Peter ludewig Yating Wan John E.Bowers Materials Department University of California Santa BarbaraSanta BarbaraCA 93106USA Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA OQE IncGreensboroNC 27409USA RF SUNY Polytechnic Institute AlbanyNY 12203USA NAsPIII/NV GmbH MarburgGermany

Monolithic integration of quantum dot(QD)gain materials onto Si photonic platforms via direct epitaxial growth is a promising solution for on-chip light sources.Recent developments have demonstrated superior device reliability in blanket hetero-epitaxy ofⅡ-Ⅴdevices on Si at elevated temperatures.Yet,thick,defect management epi designs prevent vertical light coupling from the gain region to the Si-on-lnsulator waveguides.Here,we demonstrate the frst electrically pumped QD lasers grown by molecular beam epitaxy on a 300 mm patterned(001)Si wafer with a buttcoupled configuration.Unique growth and fabrication challenges imposed by the template architecture have been resolved,contributing to continuous wave lasing to 60℃and a maximum double-side output power of 126.6 mW at 20℃with a double-side wall-plug efficiency of 8.6%.The potential for robust on-chip laser operation and effcient lowloss light coupling to Si photonic circuits makes this heteroepitaxial integration platform on Si promising for scalable and low-cost mass production.

关键词： pumped quantum coupling

Plasma Membrane-Associated SCAR Complex Subunits Promote Cortical F-Actin Accumulation and Normal Growth Characteristics in Arabidopsis Roots

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Molecular Plant 2008年第6期1卷 990-1006页

作者： Julia Dyachok Mon-Ray Shao Kevin Vaughn andrew Bowling Michelle Facette Stevan Djakovic lauren clark laurie Smith Section of Cell and Developmental Biology University of California San Diego 9500 Gilman Drive La Jolla CA 92093-0116 USA Southern Weed Science Research Unit USDA-ARS 141 Experiment Station Road Stoneville MS 38776 USA Carnegie Institution Department of Plant Biology 260 Panama Street Stanford CA 94305 USA Present address: Division of Plant Biology The Samuel Roberts Noble Foundation 2510 Sam Noble Pkwy Ardmore OK 73401 USA Present address: Section of Neurobiology University of California San Diego 9500 Gilman Drive La Jolla CA 92093-0116 USA

The ARP2/3 complex, a highly conserved nucleator of F-actin polymerization, and its activator, the SCAR complex, have been shown to play important roles in leaf epidermal cell morphogenesis in Arabidopsis. However, the intracellular site（s） and function（s） of SCAR and ARP2/3 complex-dependent actin polymerization in plant cells remain unclear. We demonstrate that putative SCAR complex subunits BRK1 and SCAR1 are localized to the plasma membrane at sites of cell growth and wall deposition in expanding cells of leaves and roots. BRK1 localization is SCAR-dependent, providing further evidence of an association between these proteins in vivo. Consistent with plasma membrane localization of SCAR complex subunits, cortical F-actin accumulation in root tip cells is reduced in brkl mutants. Moreover, mutations disrupting the SCAR or ARP2/3 complex reduce the growth rate of roots and their ability to penetrate semi-solid medium, suggesting reduced rigidity. Cell walls of mutant roots exhibit abnormal structure and composition at intercellular junctions where BRK1 and SCAR1 are enriched in the adjacent plasma membrane. Taken together, our results suggest that SCAR and ARP2/3 complex-dependent actin polymerization promotes processes at the plasma membrane that are important for normal growth and wall assembly.

关键词： cell expansion cell morphogenesis cytoskeleton root biology Arabidopsis.

Campaign-style U-Pb titanite petrochronology:Along-strike variations in timing of metamorphism in the Himalayan metamorphic core

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Geoscience Frontiers 2019年第3期10卷 827-847页

作者： Catherine M.Mottram John M.Cottle andrew R.C.Kylander-clark School of Earth and Environmental Sciences University of Portsmouth Department of Earth Science University of CaliforniaSanta Barbara

Present-day along-strike heterogeneities within the Himalayan orogen are seen at many scales, from variations within the deep architecture of the lithospheric mantle, to differences in geomorphologic surface processes. Here, we present an internally consistent petrochronologic dataset from the Himalayan metamorphic core(HMC), in order to document and investigate the causes of along-strike variations in its Oligocene-Miocene tectonic history. laser ablation split-stream analysis was used to date and characterise the geochemistry of titanite from 47 calc-silicate rocks across >2000 km along the Himalaya.This combined U-Pb-REE-Zr single mineral dataset circumvents uncertainties associated with interpretations based on data compilations from different studies, mineral systems and laboratories, and allows for direct along-strike comparisons in the timing of metamorphic processes. Titanite dates range from ～30 Ma to 12 Ma, recording(re-)crystallization between 625 ℃ and 815 ℃. Titanite T-t data overlap with previously published P-T-t paths from interleaved peltic rocks, demonstrating the usefulness of titanite petrochronology for recording the metamorphic history in lithologies not traditionally used for thermobarometry. Overall, the data indicate a broad eastward-younging trend along the orogen.Disparities in the duration and timing of metamorphism within the HMC are best explained by alongstrike variations in the position of ramps on the basal detachment controlling a two-stage process of preferential ductile accretion at depth followed by the formation of later upper-crust brittle duplexes.These processes, coupled with variable erosion, resulted in the asymmetric exhumation of a younger,thicker crystalline core in the eastern Himalaya.

关键词： Himalaya Petrochronology Titanite Metamorphic petrology

Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice

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Neural Regeneration Research 2020年第1期15卷 136-144页

作者： andrew Rclark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar Center for Orthopaedic Research and Translational Science Penn State Hershey College of MedicineMilton S.Hershey Medical CenterHersheyPAUSA Department of Orthopaedics The University of Rochester Medical CenterRochesterNYUSA Department of Medicine Aab Cardiovascular Research InstituteUniversity of Rochester School of Medicine and DentistryRochesterNYUSA Department of Biomedical Genetics The University of Rochester Medical CenterRochesterNYUSA

Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional recovery.We hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve injury.Mice with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP dose.While a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle controls.These findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal degeneration.The animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017.

关键词： 4-aminopyridine electron microscopy functional recovery nerve conduction velocity peripheral nerve injury pharmacokinetics transdermal administration

Calcite twinning strain variations across the Proterozoic Grenville orogen and Keweenaw-Kapuskasing inverted foreland,USA and Canada

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Geoscience Frontiers 2017年第6期8卷 1357-1384页

作者： John P.Craddock Suzanne D.Craddock Alex Konstantinou andrew R.C.Kylander-clark David H.Malone Geology Department Macalester CollegeSt.PaulMN 55105USA School of Earth Sciences and Environmental Sustainability Northern Arizona UniversityFlagstaffAZUSA Cyprus Hydrocarbons Company NicosiaCyprus Department of Earth Science University of CaliforniaSanta BarbaraCA 93106USA Department of Geography-Geology Illinois State UniversityNormalIL 61790-4400USA

We report the calcite twinning strain results of a traverse across the Grenville orogen from Parry Sound,Ontario(NW)to Ft.Ann,New York(SE),including the younger,adjacent Ordovician Taconic allochthon.Fifty four carbonates(marbles,calcite veins,Ordovician limestone)were collected resulting in 68 strain analyses on mechanically twinned calcite(n=2337 grains)across the Central Gneiss Belt(CGB;3 samples),the Central Metasedimentary Belt(CMB;27 samples),the Central Granulite Terrane(CGT;Adirondack's;13 samples)and the Ottawan Orogenic lid(OOl;11 samples).Twinning strains in the greenschist-grade OOl marbles preserve N-S shortening and U-Pb titanite ages(~1150 Ma;n=4)document these marbles formed during the Shawinigan(1190-1140 Ma)part of the Grenville orogen.From northwest to southeast,the Ottawan(1095-1020 Ma)twinning strain is dominantly a layerparallel shortening fabric oriented N-S(Parry Sound),then becomes parallel to the Grenville thrust direction(NW-SE)across the CMB to the Adirondack Highlands where the sub-horizontal shortening strain becomes margin-parallel(SW-NE).Within the regional sample suite there are two areas studied in detail,the Bancroft shear zone(n=11)and a roadcut on the southeast side of the Adirondack Mountains(Ft.Ann,NY;n=8).Marbles from the Bancroft shear zone contain calcite grains with 2 sets of twin lamellae(e_1 and e_2).The better-developed e_1 sets(n=406)record a horizontal fabric oriented NW-SE whereas the younger e_2 lamellae(n=146)preserve a margin-parallel(SW-NE)horizontal fabric.Both the e_1 and e_2 strains record an overprint vertical shortening strain(NEV),perhaps related to extensional orogenic collapse.We also report an Ottawan orogen-aged granoblastic mylonite(1093 Ma,U-Pb zircon;1102 Ma Ar-Ar biotite)in the Keweenaw thrust hanging wall 500 km inboard of the Grenville front and interpret the relations of Grenville-Keweenaw far-field dynamics.

关键词： Orogenic belts Strain Proterozoic

石榴石lu-Hf、原位独居石U-Pb定年对多期变形的时代制约--以北祁连托勒牧场为例

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岩石学报 2015年第12期31卷 3755-3768页

作者：曹汇丛源李广旭许翠萍 Jeff VERVOORT andrew KYlANDER-clark 大陆构造与动力学国家重点实验室、中国地质科学院地质研究所北京100037 中国地质科学院矿产资源研究所北京100037 美国华盛顿州立大学普尔曼WA99163 美国加州大学圣巴巴拉分校圣巴巴拉CA93106

多期变质变形事件的精确年代限定是造山构造年代学研究的热点问题之一。本文尝试运用面理弯切轴测量技术,结合石榴石lu-Hf和原位独居石U-Pb定年,厘定北祁连托勒牧场地区石榴石和斜长石斑晶记录的两期构造变形事件:石榴石斑晶生长记录的... 详细信息

多期变质变形事件的精确年代限定是造山构造年代学研究的热点问题之一。本文尝试运用面理弯切轴测量技术,结合石榴石lu-Hf和原位独居石U-Pb定年,厘定北祁连托勒牧场地区石榴石和斜长石斑晶记录的两期构造变形事件:石榴石斑晶生长记录的早期构造变形事件年代为512.3±2.7Ma;斜长石斑晶生长记录的晚期构造变形事件年代不早于481.0±2.3Ma,并推断该期构造变形水平挤压主应力方向为北东-南西。斜长石斑晶内未发现独居石,用于年代学测试的独居石颗粒均位于斜长石斑晶外基质中。显微构造分析认为,独居石生长不早于斜长石斑晶。481.0±2.3Ma的独居石U-Pb年龄,应为斜长石斑晶所记录构造变形的时代下限。结合前人锆石U-Pb定年和Hf同位素研究结果分析认为,获得的512.3±2.7Ma石榴石-全岩lu-Hf等时线年龄,代表了祁连洋俯冲过程中石榴石的生长时间,后期变质变形作用未对石榴石的lu-Hf同位素体系产生明显影响。结合显微构造分析,石榴石lu-Hf定年可为早期构造变形提供有效年代学制约。

关键词：多期变形石榴石lu-Hf 独居石U-Pb定年北祁连托勒牧场

Trans-Gulf of Mexico loop migration of tree swallows revealed by solar geolocation

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Current Zoology 2014年第5期60卷 653-659页

作者： David W. BRADlEY Robert G. clark Peter O. DUNN andrew J. lAUGHlIN Caz M. TAYlOR Carol VlECK linda A. WHITTINGHAM David W. WINKlER D. Ryan NORRIS Department of Integrative Biology University of Guelph Guelph Ontario N1G 2W 1 Canada Bird Studies Canada Port Rowan Ontario N0E 1M0 Canada Environment Canada. Saskatoon. Saskatchewan S7N 0X4. Canada Behavioral and Molecular Ecology Group Department of Biological Sciences University of Wisconsin Milwaukee Wisconsin 53201 USA Department of Ecology and Evolutionary Biology Tulane University New Orleans Louisiana 70118 USA Department of Ecology Evolution and Organismal Biology Iowa State University Ames IA 50011-1020 USA Department of Ecology and Evolutionary Biology Museum of Vertebrates and Lab of Ornithology Comell University Ithaca New York 14853 USA

Between 2011-2013,Zoological Research has released 3 special issues on Primates and Animal Models of Human Diseases.Now,after a year of preparation,we are pleased to release this fourth special issue.In this issue,we compiled12 review,research articles and letters to the editor,each examining different aspects of scientific and medical research using non-primates as an animal model,with a special emphasis on recent developments in genetic,virological,behavioristic and methodological studies.

关键词：墨西哥湾迁移过程太阳能地理位置循环路易斯安那州鸟类迁徙燕子

A hybrid organic-inorganic polariton lED

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light(Science & Applications) 2019年第1期8卷 475-485页

作者： Rahul Jayaprakash Kyriacos Georgiou Harriet Coulthard Alexis Askitopoulos Sai K.Rajendran David M.Coles andrew J.Musser Jenny clark Ifor D.W.Samuel Graham A.Turnbull Pavlos G.lagoudakis David G.lidzey Department of Physics and Astronomy The University of SheffieldHicks BuildingHounsfield RoadSheffield S37RHUK Department of Physics and Astronomy University of SouthamptonSouthampton SO171BJUK Skolkovo Institute of Science and Technology MoskvaRussia Organic Semiconductor Centre SUPASchool of Physics and AstronomyUniversity of St AndrewsSt.AndrewsFife KY169SSUK Baker laboratory Cornell University259 East AvenueIthacaNY 14850USA

Polaritons are quasi-particles composed of a superposition of excitons and photons that can be created within a strongly coupled optical microcavity.Here,we describe a structure in which a strongly coupled microcavity containing an organic semiconductor is coupled to a second microcavity containing a series of weakly coupled inorganic quantum wells.We show that optical hybridisation occurs between the optical modes of the two cavities,creating a delocalised polaritonic state.By electrically injecting electron–hole pairs into the inorganic quantum-well system,we are able to transfer energy between the cavities and populate organic-exciton polaritons.Our approach represents a new strategy to create highly efficient devices for emerging‘polaritonic’technologies.

关键词： state. inorganic polar

T-DNA-Induced Chromosomal Translocations in feronia and anxur2 Mutants Reveal Implications for the Mechanism of Collapsed Pollen Due to Chromosomal Rearrangements

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Molecular Plant 2014年第10期7卷 1591-1594页

作者： Colin Ruprecht[a],, andrew Carroll[b] Staffan Persson[a],[c], a Max-Planck-Institute for Molecular Plant Physiology Am Muehlenberg 1 14476 Potsdam Germanyb Department of Biology Stanford University Stanford CA 94305 USAc ARC Centre of Excellence in Plant Cell Walls School of Botany University of Melbourne Parkville 3010 Victoria Australia

Dear Editor, Approximately every fifth Arabidopsis T-DNA inser- tion line contains chromosomal translocations caused by the inserted T-DNA （clark and Krysan, 2010）. Albeit broad use of T-DNA lines for mutant analysis, little is known about the consequences of these chromosomal rearrangements and only a few studies describe chromosomal aberrations in the mutant lines. While plant growth in general is not affected by such chromosomal translocations, defects in gametophyte development have been observed in lines that are heterozygous for the T-DNA insertion （Ray et al., 1997; Curtis et al., 2009）.

关键词： T-DNA插入染色体易位染色体重排突变系体显示苹果属机制花粉