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2011年ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS颅外颈动脉和椎动脉疾病患者处理指南(续前) 美国心脏病学会基金会/美国心脏协会实践指南顾问委员会、美国卒中协会、美国神经科学护理协会、美国神经外科医师协会、美国放射学学会、美国神经放射学学会?

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国际脑血管病杂志 2013年第10期 721-758页

作者： Thomas G.Brott jonathan L.Halperin Suhny Abbara j.Michael Bacharach john D.Barr Ruth L.Bush Christopher U.Cates Mark A.Creager Susan B.Fowler Gary Friday Robert H.Rosenwasser Allen j.taylor 曲东锋陈兴洲南京脑血管疾病分册杂志社

7血运重建术7.1关于颈动脉血运重建术患者选择的推荐意见Ⅰ级推荐1对于在6个月内有过非致残性缺血性卒中或TIA症状（包括半球事件或一过性黑矇）且手术风险中等或较低的患者,如果无创性成像显示同侧颈内动脉内径减少>70%[20,83]（A级证...

7血运重建术7.1关于颈动脉血运重建术患者选择的推荐意见Ⅰ级推荐1对于在6个月内有过非致残性缺血性卒中或TIA症状（包括半球事件或一过性黑矇）且手术风险中等或较低的患者,如果无创性成像显示同侧颈内动脉内径减少>70%[20,83]（A级证据）或经导管血管造影显示同侧颈内动脉内径减少>50%[20,70,83,359]（B级证据）且预期围手术期卒中或死亡发生率低于6%,应行CEA。2对于血管内介入治疗风险中等或较低的有症状患者,当无创性成像显示同侧颈内动脉内径

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The 13th and 14th Workshops on Antarctic Meteorology and Climate

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Advances in Atmospheric Sciences 2020年第5期37卷 423-430页

作者： Matthew A.LAZZARA Sophie A.ORENDORF taylor P.NORTON jordan G.POWERS David H.BROMWICH Scott CARPENTIER john j.CASSANO Steven R.COLWELL Arthur M.CAYETTE Kirstin WERNER Antarctic Meteorological Research Center Space Science and Engineering CenterUniversity of Wisconsin-MadisonMadisonWI 53706USA Department of Physical Sciences School of Arts and SciencesMadison Area Technical CollegeMadison WI 53704USA Department of Atmospheric Sciences University of Wisconsin-MadisonMadisonWI 53706USA National Center for Atmospheric Research Boulder CO 53706USA Polar Meteorology Group Byrd Polar&Climate Research CenterThe Ohio State UniversityColumbus OH 43210USA Bureau of Meteorology HobartTasmania 7001Australia Cooperative Institute for Research in Environmental Sciences and Department of Atmospheric and Oceanic Sciences University of ColoradoBoulderCO 80309USA British Antarctic Survey Cambridge CB30ETUnited Kingdom Naval Information Warfare Center CharlestonSC 29406USA Year of Polar Prediction(YOPP)International Coordination Office Alfred Wegener InstituteHelmholtz Centre for Polar and Marine ResearchBremerhaven 27570Germany

*** In july 2018,the Antarctic community came together to meet at the 13th Workshop on Antarctic Meteorology and Climate(WAMC)in Madison,Wisconsin,USA(Fig.1);and in the following year in june 2019,the 14th WAMC was held in Charleston,South Carolina,USA(Fig.2).With a growing history,the WAMC addresses the topics of Antarctic meteorology and climate(Kameda et al.,2008;Colwell et al.,2016;Lazzara et al.,2018)as well as weather-related issues of scientific and operational *** workshops bring together researchers,operational forecasters,numerical modelers,observational specialists,and *** themes of both workshops included Antarctic meteorological observations,Antarctic atmospheric numerical modeling,Antarctic meteorological and climate research,and Antarctic weather forecasting and operational *** 2018 and 2019 WAMC were both followed by a one-day focus on the Year of Polar Prediction-Southern Hemisphere(YOPP-SH),when preparations and follow-up discussions were made with regard to the YOPP Special Observing Period from 16 November 2018 to 15 February 2019.

关键词： Antarctic weather meteorological

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Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits

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Molecular Plant 2012年第2期5卷 366-375页

作者： Andrej Kochevenko Wagner L. Araujo Gregory S. Maloney Denise M. Tieman Phuc Thi Do Mark G. taylor Harry j. Klee Alisdair R. Fernie Max Planck Institute of Molecular Plant Physiology 14476 Potsdam-Golm Germany Departamento de Biologia Vegetal Universidade Federal de Vicosa 36570-000 Vicosa Minas Gerais Brazil Horticultural Sciences Department and the Plant Molecular ＆ Cellular Biology Program University of Florida Gainesville FL 32611 USA

The branched-chain amino acid transaminases （BCATs） have a crucial role in metabolism of the branched-chain amino acids leucine, isoleucine, and valine. These enzymes catalyze the last step of synthesis and the initial step of degradation of these amino acids. Although the biosynthetic pathways of branched chain amino acids in plants have been extensively investigated and a number of genes have been characterized, their catabolism in plants is not yet completely understood. We previously characterized the branched chain amino acid transaminase gene family in tomato, revealing both the subcellular localization and kinetic properties of the enzymes encoded by six genes. Here, we examined possible functions of the enzymes during fruit development. We further characterized transgenic plants differing in the expression of branched chain amino acid transaminases I and 3, evaluating the rates of respiration in fruits deficient in BCAT1 and the levels of volatiles in lines overexpressing either BCAT1 or BCAT3. We quantitatively tested, via precursor and isotope feeding experiments, the importance of the branched chain amino acids and their corresponding keto acids in the formation of fruit volatiles. Our results not only demonstrate for the first time the importance of branched chain amino acids in fruit respiration, but also reveal that keto acids, rather than amino acids, are the likely precursors for the branched chain flavor volatiles.

关键词： alternative electron transport metabolic regulation molecular physiology nitrogen metabolism volatiles tomato.

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油菜与诸葛菜的几种分子标记比较研究

中国油料作物学报 2002年第2期24卷 22-25页

作者：吴沿友王宝利 Paul W.j.taylor 中国科学院地球化学研究所环境化学国家重点实验室贵州贵阳550002 DepartmentofCropProduction JointCentreforCropImprovementTheUniversityofMelbourne

利用分子标记 (随机引物、简单重复序列、微卫星DNA重复序列、rDNA -ITS)比较研究了白菜型油菜与诸葛菜的亲缘关系。RAPD分析表明 ,诸葛菜与白菜型油菜PCR产物相似性只有 10 %左右 ;简单重复序列 (SSRs)标记中引物B .n .12A的PCR产物表... 详细信息

利用分子标记 (随机引物、简单重复序列、微卫星DNA重复序列、rDNA -ITS)比较研究了白菜型油菜与诸葛菜的亲缘关系。RAPD分析表明 ,诸葛菜与白菜型油菜PCR产物相似性只有 10 %左右 ;简单重复序列 (SSRs)标记中引物B .n .12A的PCR产物表明诸葛菜与白菜型油菜有明显差异 ,诸葛菜没有扩增产物 ,白菜型油菜具有明显的扩增产物 ;引物ITS4-IT5的PCR产物也有明显的差异。这些结果说明白菜型油菜与诸葛菜的亲缘关系不是很近。结合其他学者的工作 ,讨论了甘蓝型油菜。

关键词：白菜油菜诸葛菜分子标记细胞融合-染色体组分割亲缘关系比较研究

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H2 production and performance of nickel based catalysts synthesized using supercritical fluids for the gasification of biomass

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H2 production and performance of nickel based catalysts synt...

Effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis

第九届全国氢能学术会议

作者： G.j.DiLeo A.D.taylor University of Michigan

＜正＞We have devised a method for synthesizing 1-D carbon supported Ni metal-based catalysts（Ni/C） using supercritical fluids as a reaction *** single walled carbon nanotubes or carbon fibers（CF） as a support;we circumvent the challenges typically associated with controllably loading metal particles onto these hydrophobic ***

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Modern Research in Inflammation 2012年第2期1卷 26-32页

作者： N. Mikirova A. Rogers j. Casciari P. taylor Riordan Clinic Wichita USA

Rheumatoid arthritis (RA) is a major inflammatory joint disease that causes cartilage destruction, bone erosions, and joint destruction. Oxidative stress is elevated in RA patients implying reactive oxygen species (ROS) are possible mediators of tissue damage. ROS trigger a cascade of events through nuclear factors’ activation (NF-kappa B), which up-regulates gene expression of pro-inflammatory cytokines that mediate the immune responses causing inflammation. As ascorbic acid can reduce oxidative stress, decrease production of pro-inflammatory cytokines, and suppress the activation of NF-kappa B, we suggest that millimolar concentration of ascorbic acid may be useful in RA treatment. In our study we analyzed the effect of intravenous vitamin C (IVC) treatment on eleven subjects with RA. Our data suggest that IVC therapy with dosages of 7.5 g - 50 g can reduce inflammation. The level of inflammation as measured by C-reactive protein levels was decreased on average by 44%. Based on our pilot study, we hypothesize that IVC therapy can be a useful strategy in treating RA.

关键词： Rheumatoid Arthritis Inflammation C-Reactive Protein Intravenous Vitamin C

BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

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journal of Molecular Cell Biology 2020年第5期12卷 397-399页

作者： jisha Antony Gregory Gimenez Terry taylor Umaima Khatoon Robert Day Ian MMorison julia AHorsfield Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9016New Zealand Maurice Wilkins Centre for Molecular Biodiscovery The University of AucklandPrivate Bag 92019AucklandNew Zealand Southern Community Laboratories Dunedin 9016New Zealand Department of Biochemistry University of OtagoDunedin 9054New Zealand

Cohesin is a multiprotein complex that not only is essential for cell division but also has key roles in genome organization that underpin its gene regulatory *** mutations of genes encoding cohesin subunits occur in myeloid malignancies at 10%–12%(Kon et al.,2013),and the frequency of cohesin mutation in Down syndrome-associated megakaryoblastic leukaemia is even higher(~50%)(Yoshida et al.,2013).Cohesin insufficiency reinforces stem cell programmes and impairs differentiation in haematopoietic stem cells(Mazumdar et al.,2015;Mullenders et al.,2015;Viny et al.,2015).The STAG2 subunit of cohesin is the most frequently mutated in myeloid malignancies(Kon et al.,2013).In contrast to other cohesin subunits,complete loss of STAG2 is tolerated due to partial compensation by ***2 and STAG1 have redundant roles in cell division(Benedetti et al.,2017;van der Lelij et al.,2017).However,cohesin-STAG1 and cohesin-STAG2 have non-redundant roles in facilitating 3D genome organization to delineate tissue-specific gene expression(Kojic et al.,2018).

关键词： function. redundant

Diversity in global gene expression and morphology across a watercress (Nasturtium officinale R. Br.) germplasm collection: first steps to breeding

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Horticulture Research 2015年第1期2卷 175-182页

作者： Adrienne C.Payne Graham j.j.Clarkson Steve Rothwell Gail taylor Centre for Biological Sciences Institute for Life SciencesUniversity of SouthamptonSouthamptonSO171BJUK Vitacress Salads Ltd Lower Link FarmSt Mary BourneAndoverHampshireSP116DBUK

Watercress(Nasturtium officinale ***.)is a nutrient intense,leafy crop that is consumed raw or in soups across the globe,but for which,currently no genomic resources or breeding programme *** morphological,biochemical and functional genomic variation was identified for the first time in a newly established watercress germplasm collection,consisting of 48 watercress accessions sourced from contrasting global *** length,stem diameter and anti-oxidant(AO)potential varied across the *** variation was used to identify three extreme contrasting accessions for further *** in global gene expression was investigated using an Affymetrix Arabidopsis ATH1 microarray gene chip,using the commercial control(C),an accession selected for dwarf phenotype with a high AO potential(dwarfAO,called‘Boldrewood’)and one with high AO potential alone.A set of transcripts significantly differentially expressed between these three accessions,were identified,including transcripts involved in the regulation of growth and development and those involved in secondary *** particular,when differential gene expression was compared between C and dwarfAO,the dwarfAO was characterised by increased expression of genes encoding glucosinolates,which are known precursors of phenethyl isothiocyanate,linked to the anti-carcinogenic effects well-documented in *** study provides the first analysis of natural variation across the watercress genome and has identified important underpinning information for future breeding for enhanced anti-carcinogenic properties and morphology traits in this nutrient-intense crop.

关键词： breeding dwarf germplasm

Conjugate strike-slip faulting along the Bangong-Nujiang suture zone accommodates coeval east-west extension and north-south shortening in the interior of the Tibetan Plateau

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Conjugate strike-slip faulting along the Bangong-Nujiang sut...