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Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model

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World Journal of Stem Cells 2019年第2期11卷 84-99页

作者： Mariana Lizeth Orozco Morales Nagi M Marsit Owen D McIntosh andrew hopkinson Laura E Sidney Academic Ophthalmology Division of Clinical Neuroscience University of Nottingham

BACKGROUND An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells(hCEC).AIM To investigate whether corneal-stroma derived stem cells(CSSC) seeded on an amniotic membrane(AM) construct manifests an anti-inflammatory, healing *** Treatment of hCEC with ethanol and pro-inflammatory cytokines were compared in terms of viability loss, cytotoxicity, and pro-inflammatory cytokine release, in order to generate the in vitro injury. This resulted in an optimal injury of 20%(v/v) ethanol for 30 s with 1 ng/mL interleukin-1(IL-1) beta. Co-culture experiments were performed with CSSC alone and with CSSC-AM *** effect of injury and co-culture on viability, cytotoxicity, IL-6 and IL-8 production, and IL1 B, TNF, IL6, and CXCL8 mRNA expression were *** Co-culture with CSSC inhibited loss of hCEC viability caused by injury. Enzyme linked immunosorbent assay and polymerase chain reaction showed a significant reduction in the production of IL-6 and IL-8 pro-inflammatory cytokines, and reduction in pro-inflammatory cytokine mRNA expression during co-culture with CSSC alone and with the AM construct. These results confirmed the therapeutic potential of the CSSC and the possible use of AM as a cell carrier for application to the ocular *** CSSC were shown to have a potentially therapeutic anti-inflammatory effectwhen treating injured hCEC, demonstrating an important role in corneal regeneration and wound healing, leading to an improved knowledge of their potential use for research and therapeutic purposes.

关键词： Cornea Corneal injuries Injury model Corneal epithelium Corneal stroma-derived stem cells Amnion Anti-inflammatory Cell therapy

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Perceptual and Sensory-Functional Consequences of Skin Care Products

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第1期3卷 66-78页

作者： Steve Guest Francis McGlone andrew hopkinson Zachary A. Schendel Kevin Blot Greg Essick Regional Center for Neurosensory Disorders School of Dentistry University of North Carolina at Chapel Hill Chapel Hill USA School of Natural Sciences and Psychology Liverpool John Moores University Liverpool UK Unilever R & D Port Sunlight UK 4Unilever R & D Trumbull USA. Unilever R & D Trumbull USA.

Skin care products are often designed to provide tangible, physical benefits to skin health. Alleviation of dry skin and minimization of the signs of aging and post-injury scarring are important benefits targeted by many products on the market. Equally important to these benefits are favorable, desirable sensory attributes, without which products are unlikely to be used and repurchased. Other products are designed primarily to deliver sensory—or sensual—benefits (e.g., many cosmetic creams). This review considers the tactile sensory experience delivered by skin care products by examining: 1) their instrumentally-measured rheology and tribology;2) their influence on the skin’s mechanics (e.g., compliance);3) their implications for changing sensory function (e.g., tactile sensitivity);and 4) the possibility that skin care products alter their own perception. Products that contain chemosensates (e.g., capsaicin, menthol) or pharmaceutical actives are not considered here. Although numerous perceptual-physical links have been reported, formulation rules by which products can be designed for optimal skinfeels are currently unavailable from the existing literature. This is because of inconsistencies among studies in the perceptual attributes investigated, the physical characterizations chosen to describe the products, and analysis methods employed. To provide a robust method for designing products with beneficial and desirable skinfeels, we propose the use of 1) a consistent lexicon that fully describes the perceptual experience of any product investigated, 2) a means of recording the mechanical events at the fingertip skin that occur when a skin care product is manually applied to the body. This approach contrasts with previous instrumental (in vitro) methods that may not generalize well to product-treated human skin (in vivo). Ongoing studies that record mechanical events at the skin surface show promise in identifying realistic models of the perception of skin care prod

关键词： Review Rheology Tribology Perception Sensory Function Tactile

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NICE指南更新概要:慢性阻塞性肺疾病的诊断和管理

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英国医学杂志中文版 2020年第6期23卷 346-352页

作者： Nicholas S hopkinson andrew Molyneux Joshua Pink Marie C Harrisingh 颜佳扬(译者) 林辉煌(译者) 姜红妮(审校者) 瞿介明(审校者) National Heart and Lung Institute Imperial CollegeLondonUK Sherwood Forest Hospitals NHS Foundation Trust NottinghamshireUK National Institute for Health and Care Excellence LondonUK 上海交通大学医学院附属瑞金医院

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)具有高发病率和高病死率,在英国被确诊为COPD的共有130万人。COPD也是常见的住院原因之一。虽然英国国家医疗服务体系(National Health Service,NHS)已将呼吸系统疾病纳... 详细信息

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)具有高发病率和高病死率,在英国被确诊为COPD的共有130万人。COPD也是常见的住院原因之一。虽然英国国家医疗服务体系(National Health Service,NHS)已将呼吸系统疾病纳入其长期计划的优先范畴,但是英国皇家内科医师学会COPD审查项目却显示整个医疗体系仍存在大量缺陷,包括肺康复治疗、戒烟治疗和流感疫苗等方面均未落实到位。

关键词：慢性阻塞性肺疾病呼吸系统疾病流感疫苗肺康复治疗英国国家医疗服务体系医疗体系住院原因 pulmonary

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