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Journal of Integrative Plant Biology 2016年第3期58卷 266-279页

作者： Weibin Song Baobao Wang andrew L hauck Xiaomei Dong Jieping Li Jinsheng Lai State Key Laboratory of Agrobiotechnology and National Maize Improvement Center of China Department of Plant Genetics and BreedingChina Agricultural University

Maize（Zea mays） root system architecture（RSA）mediates the key functions of plant anchorage and acquisition of nutrients and water. In this study,a set of 204 recombinant inbred lines（RILs） was derived from the widely adapted Chinese hybrid ZD958（Zheng58 Chang7-2）,genotyped by sequencing（GBS） and evaluated as seedlings for 24 RSA related traits divided into primary,seminal and total root classes. Signi ficant differences between the means of the parental phenotypes were detected for 18 traits,and extensive transgressive segregation in the RIL population was observed for all traits. Moderate to strong relationships among the traits were discovered. A total of 62 quantitative trait loci（QTL） were identi fied that individually explained from1.6% to 11.6%（total root dry weight/total seedling shoot dry weight） of the phenotypic variation. Eighteen,24 and 20 QTL were identi fied for primary,seminal and total root classes of traits,respectively. We found hotspots of 5,3,4 and 12 QTL in maize chromosome bins 2.06,3.02-03,9.02-04,and 9.05-06,respectively,implicating the presence of root gene clusters or pleiotropic effects. These results characterized the phenotypic variation and genetic architecture of seedling RSA in a population derived from a successful maize hybrid.

关键词： Maize root system architecture QTL bin map genotyping by sequencing(GBS)

Population genomic analysis and Genome wide association studies through the re-sequencing of 778 maize inbred lines

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Population genomic analysis and Genome wide association stud...

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

第一届全国玉米生物学学术研讨会

作者：史俊鹏 Zhipeng Liu Baobao Wang Xin Wang andrew hauck Shaojun Xie Hainan Zhao Mei Zhang Silong Sun Haiming Zhao Weibin Song Jinsheng Lai State Key Laboratory of Agrobiotechnology and National Maize Improvement Center China Agricultural University

Modern maize breeding process have generated enormous amount of genetic variants which may contribute to the phenotype *** top of re-sequencing data of 278 maize inbred lines,we expanded the population to 778 lines with.5x depth on average and identified 56 million *** 30%of the SNPs are novel and enriched in rare *** non-syn/syn ratio is 1.09 which is comparable with

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： andrew Gregory Chengyun Tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche andrew Chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Equations for estimating the above-ground biomass of Larix sibirica in the forest-steppe of Mongolia

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Journal of Forestry Research 2013年第3期24卷 431-437页

作者： Purevragchaa Battulga Jamsran Tsogtbaatar Choimaa Dulamsuren Markus hauck Institute of Geoecology Mongolian Academy of Sciences Chingeltei District Department of Plant Ecology Albrecht von Haller Institute of Plant Sciences Georg August University of Gttingen

Biomass functions were established to estimate above-ground biomass of Siberian larch （Larix sibirica） in the Altai Mountains of Mon- golia. The functions are based on biomass sampling of trees from 18 different sites, which represent the driest locations within the natural range ofL. sibirica. The best performing regression model was found for the equations y = （D2 H）/（a＋bD） for stem biomass, y = aDb for branch biomass, and y=aDb Hc for needle biomass, where D is the stem diameter at breast height and H is the tree height. The robustness of the biomass functions is assessed by comparison with equations which had been previously published from a plantation in Iceland. There, y=aDb Hc was found to be the most significant model for stem and total above-ground biomasses. Applying the equations from Iceland for estimating the above-ground biomass of trees from Mongolia resulted in the underesti- mation of the biomass in large-diameter trees and the overestimation of the biomass in thin trees. The underestimation of thick-stemmed trees is probably attributable to the higher wood density, which has to be ex- pected under the ultracontinental climate of Mongolia compared to the euoceanic climate of Iceland. The overestimation of the biomass in trees with low stem diameter is probably due to the high density of young growth in the not systematically managed forests of the Mongolian Altai Mountains, which inhibits branching, whereas the plantations in Iceland are likely to have been planted in lower densities.

关键词： allometry biomass functions Central Asia forest-steppe Siberian larch

Response of tree-ring width to climate warming and selective logging in larch forests of the Mongolian Altai

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Journal of Plant Ecology 2014年第1期7卷 24-38页

作者： Choimaa Dulamsuren Mookhor Khishigjargal Christoph Leuschner Markus hauck Department of Plant Ecology Albrecht von Haller Institute of Plant SciencesGeorg August University of GöttingenUntere Karspüle 237073 GöttingenGermany

Aims The Mongolian Altai is an old settlement area,which is populated by pastoral nomads since 2000–3000 *** in this region(at ca.2300 m a.s.l.)are highly fragmented and border on steppe and alpine grasslands,which are used for mobile livestock *** climate in Central Asia is warming to levels clearly above the global average,which affects the ***,the transition from planned to market economy and the decollectivization of livestock 20 years ago has strongly changed land use practices in Mongolia,especially resulting in an increase in recent logging *** were interested in the question how climate warming and selective logging influence the annual stem growth and the stand *** The impact of climate and land use by the pastoral nomads on the annual stem increment of more than 1800 trees of Siberian larch(Larix sibirica)was *** groups of trees with divergent growth trends depending on the social position and stand history were identified by non-metric multidimensional scaling and analysis of ***-term trends in the annual stem increment were analyzed by establishing separate regional growth curves for trees of different age *** Findings Instrumental climate data substantiate an increase of temperature by 2.1°C since 1940 at constant *** benefit from the increased ***–response analysis revealed that radial stem increment was promoted by the temperature in early summer,but also high precipitation in spring and in the year before tree-ring *** dynamics is also strongly influenced by anthropogenic *** addition to the natural forest dynamics,logging resulted in divergent growth trends within given age classes and habitats(forest interior and forest edge);overall,22 groups of trees with different characteristics in the annual radial stem increment were identified.A tree-ring series-based reconstruction of logging inten

关键词： climate change forest management forest-steppe ecotones Central Asia Larix sibirica

Forest edge–interior differentiation in the epiphytic lichen diversity of the forest steppe in the Khangai Mountains, Mongolia

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Journal of Plant Ecology 2014年第3期7卷 287-297页

作者： Markus hauck Uwe de Bruyn Samjaa Javkhlan Dorjburgedaa Lkhagvadorj Department of Plant Ecology Albrecht von Haller Institute of Plant SciencesGeorg August University of GöttingenUntere Karspüle 237073 GöttingenGermany Von-Müller-Straße 30 26123 OldenburgGermany Institute of Botany Mongolian Academy of SciencesZhukov Street 7Ulan Bator 51Mongolia School of Economics and Business Mongolian State University of AgricultureUlan BatorMongolia

Aims The effects of traditional land use by mobile livestock keepers on biodiversity in forest steppe ecotones are insufficiently *** are an important part of forest plant *** we analyze differences in the diversity and composition of the epiphytic lichen vegetation between the edge and the interior of Siberian larch forests in the Khangai Mountains,western Mongolia,which are highly subdivided into *** asked whether the epiphytic lichen vegetation at the forest edge differs significantly from that in the interior,whether the edge is inhabited by more nitrophilous species than the interior and whether the density of nomad camps around the forest affects epiphytic lichen *** Cover percentages of epiphytic lichen species were recorded from 20 trees per plot on 6 plots in the interior and 6 plots at the edge of Larix sibirica *** position of nomad summer camps was surveyed using Global Positioning *** were analyzed with pairwise significance tests,analysis of similarities,nonmetric multidimensional scaling and canonical correspondence *** Findings The composition of the epiphytic lichen vegetation clearly differed between the two habitats,with more species being more frequent at the edge than in the ***,there was no difference in species richness(α-diversity).The epiphyte vegetation at the edge was more uniform and characterized by lower variation of tree-levelα-diversity and lowerβ-diversity than in the *** the edge,only nitrophytic lichens were dominant,whereas in the interior,nitrophytes and acidophytes were among the dominant *** pattern is probably attributable to the spatial heterogeneity of the intensity of forest grazing and was shown to be influenced by the density of nomad summer camps in the vicinity of the ***-levelα-diversity increased with stem diameter,but high-diameter trees were *** results suggest that the present level of forest pat

关键词： alpha-diversity beta-diversity edge effect nitrophytes pastoral nomadism

Dynamic multimedia stream adaptation and rate control for heterogeneous networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第Z1期7卷 63-69页

作者： SZWABE Andrzej SCHORR Andreas hauck Franz J. KASSLER Andreas J. Poznan University of Technology Poznan 60-965 Poland University of Ulm Ulm 89069 Germany University of Karlstad Karlstad SE-65188 Sweden

Dynamic adaptation of multimedia content is seen as an important feature of next generation networks and pervasive systems enabling terminals and applications to adapt to changes in e.g. context, access network, and available Quality-of-Service(QoS) due to mobility of users, devices or sessions. We present the architecture of a multimedia stream adaptation service which enables communication between terminals having heterogeneous hardware and software capabilities and served by heterogeneous networks. The service runs on special content adaptation nodes which can be placed at any location within the network. The flexible structure of our architecture allows using a variety of different adaptation engines. A generic transcoding engine is used to change the codec of streams. An MPEG-21 Digital Item Adaptation (DIA) based transformation engine allows adjusting the data rate of scalable media streams. An intelligent decision-taking engine implements adaptive flow control which takes into account current network QoS parameters and congestion information. Measurements demonstrate the quality gains achieved through adaptive congestion control mechanisms under conditions typical for a heterogeneous network.

关键词： Stream adaptation, Quality-of-Service (QoS), Heterogeneous networks, Rate control, MPEG-21 DIA

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Geoecological parameters indicate discrepancies between potential and actual forest area in the forest-steppe of Central Mongolia

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Forest Ecosystems 2021年第4期8卷 735-754页

作者： Michael Klinge Choimaa Dulamsuren Florian Schneider Stefan Erasmi Uudus Bayarsaikhan Daniela Sauer Markus hauck Department of Physical Geography Institute of GeographyUniversity of GöttingenGoldschmidtstraBe 537077 GöttingenGermany Applied Vegetation Ecology Faculty of Environment and Natural ResourcesUniversity of FreiburgTennenbacher Str.479106 FreiburgGermany Institute of Farm Economics Thünen InstituteBundesallee 6338116 BraunschweigGermany Department of Biology School of Arts and SciencesNational University of MongoliaBaga toiruu 47Sukhbaatar duuregUlaanbaatarMongolia

Background:Forest distribution in the forest-steppe of Mongolia depends on relief,permafrost,and climate,and is highly sensitive to climate change and anthropogenic *** fires and logging decreased the forest area in the forest-steppe of *** intention of this study was to identify the geoecological parameters that control forest distribution and living-tree biomass in this semi-arid *** on these parameters,we aimed to delineate the area that forest might potentially occupy and to analyse the spatial patterns of actual and potential tree ***:We used a combination of various geographic methods in conjunction with statistical analyses to identify the key parameters controlling forest *** several field campaigns,we mapped tree biomass and ecological parameters in a study area within the Tarvagatai Nuruu National Park(central Mongolia).Forest areas,topographic parameters and vegetation indices were obtained from remote sensing *** correlations between forest distribution and living-tree biomass on one hand,and topographic parameters,climate data,and environmental conditions on the other hand,were used to delineate the area of potential forest distribution and to estimate total living-tree biomass for this ***:Presence of forest on slopes was controlled by the factors elevation,aspect,slope,mean annual precipitation,and mean growing-season *** these factors allowed for estimation of potential forest area but was less suitable for tree-biomass *** significant differences in mean living-tree biomass existed between sites exposed to different local conditions with respect to forest fire,exploitation,and soil *** biomass was reduced at forest edges(defined as 30m wide belt),in small fragmented and in large forest *** biomass in the study area was 20×10^(9) g(1,086 km^(2) forest area),whereas the potential tree biomass would reach up to 65×10^(9)

关键词： Biomass Fire Forest-steppe Geoecological factors Mongolia Permafrost