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Additively manufactured Ti–Ta–Cu alloys for the next-generation load-bearing implants

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International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit Bandyopadhyay Indranath Mitra Sushant Ciliveri Jose D Avila William Dernell Stuart B goodman Susmita Bose W.M.Keck Biomedical Materials Research Laboratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America Department of Orthopedic Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

Bacterial colonization of orthopedic implants is one of the leading causes of failure and clinical complexities for load-bearing metallic implants. Topical or systemic administration of antibiotics may not offer the most efficient defense against colonization, especially in the case of secondary infection, leading to surgical removal of implants and in some cases even limbs. In this study, laser powder bed fusion was implemented to fabricate Ti3Al2V alloy by a 1:1 weight mixture of CpTi and Ti6Al4V powders. Ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed by the addition of Ta and Cu into the Ti3Al2V custom alloy. The biological,mechanical, and tribo-biocorrosion properties of Ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and 3 wt.% Cu(3Cu) were added to the Ti3Al2V alloy to enhance biocompatibility and impart inherent bacterial resistance. Additively manufactured implants were investigated for resistance against Pseudomonas aeruginosa and Staphylococcus aureus strains of bacteria for up to 48 h. A 3 wt.% Cu addition to Ti3Al2V displayed improved antibacterial efficacy, i.e.78%–86% with respect to CpTi. Mechanical properties for Ti3Al2V–10Ta–3Cu alloy were evaluated, demonstrating excellent fatigue resistance, exceptional shear strength, and improved tribological and tribo-biocorrosion characteristics when compared to Ti6Al4V. In vivo studies using a rat distal femur model revealed improved early-stage osseointegration for alloys with10 wt.% Ta addition compared to CpTi and Ti6Al4V. The 3 wt.% Cu-added compositions displayed biocompatibility and no adverse infammatory response in vivo. Our results establish the Ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving both in vivo biocompatibility and microbial resistance for the next generation of load-bearing metallic implants.

关键词： Ti6Al4V load-bearing implants additive manufacturing 3D printing antibacterial performance

Implementation of an international medical student pen-pal club:survey outcomes of perceptions in cultural competency and global health

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Global Health Journal 2024年第1期8卷 11-15页

作者： Max J.goodman Jennifer Livschitz Ji Won Kim Megan L.Schultz Medical College of Wisconsin MilwaukeeWI 53226USA Department of Pediatrics Division of Emergency MedicineMedical College of WisconsinMilwaukeeWI53226USA

Background:Pen-pal clubs(PPC)are used worldwide for students to learn about different cultures and other skillsets without the need for *** medical students are interested in global health opportunities abroad but costs,scheduling,and other barriers allow few to participate in such *** is important that medical students have nuanced global medical perspectives and can contribute to the global medical ***:The purpose of this study is to demonstrate that an international medical student PPC improves medical students'perspectives of cultural competency and global health ***:In 2021,a novel medical student PPC was established that began between an American and Japanese medical *** a shareholders meeting,it was decided that the number of medical schools involved globally be expanded through previous institutional affiliations and online *** total,the club connected 50 American medical students and 52 medical students from 17 high-and middle-income *** primary form of communication was online;pen-pals were encouraged to communicate monthly using provided topics,although frequency and way of communication was their *** February 2022,American PPC members were emailed a qualitative survey to assess the PPC's ***:The survey was completed by 42%of American PPC members,95%of which were 22-26 *** were preclinical medical students,60%whom were female and the majority either white(47%)or Asian(43%).Overall,the PPC positively influenced American medical students'perception of global medicine,medical education,and their cultural competency after joining the PPC compared to prior(P=0.004).Conclusion:PPCs encourage medical students to think from a global perspective and foster open-mindedness within varying social and cultural *** a global communication platform for students during medical school education may be an additional way to train aspiring global l

关键词： Pen-pals Medical student Global health Cultural competency

Mistreatment during Childbirth: Impact on Maternal Outcomes and Importance of Provider Perspectives

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Open Journal of Obstetrics and Gynecology 2024年第2期14卷 227-233页

作者： Samantha Truong Katherine Lindsey Doughty Mary Greenwald Annekathryn goodman Department of Obstetrics and Gynecology Massachusetts General Hospital Harvard Medical School Boston USA

Background: Dying in childbirth is one of the most common causes of death for women. While maternal mortality rates, defined as deaths per 100,000 live births, have been steadily dropping in most countries worldwide, maternal mortality rates have doubled in the United States in the last twenty years. This commentary examines the various contributing factors to this trend. Methods: A literature review was performed using the keywords: maternal mortality, United States, disrespectful maternity care, obstetric violence, provider perspectives, and disparities. Maternal mortality statistics were obtained from the World Health Organization website. Results: Medical factors associated with maternal mortality include increased maternal age and cardiovascular conditions. Social factors include barriers to healthcare access, delays in receiving medical care, reduction in reproductive health services in some states, and non-obstetrical deaths such as accidents, domestic violence, and suicide. Racial inequities and disparities of care are reflected in higher maternal mortality rates for minorities and people of color. Disrespectful maternity care or obstetric violence has been reported worldwide as a factor in delay of lifesaving obstetrical care and reluctance by a pregnant person to access the healthcare system. About one in five US women has reported experiencing mistreatment, varying from verbal abuse to lack of privacy, from coerced procedures to neglect during childbirth. Conclusion: This commentary highlights the importance of inclusion of providers in research on respectful maternity care. Provider burnout, moral distress, limited time, and burden of clinical responsibilities are known challenges to respectful and comprehensive medical care. The association of disrespectful care with poor maternal outcomes needs to be studied. Exploring root causes of disrespectful childbirth care can empower nurses, midwives, and physicians to improve their environment and find solutio

关键词： Maternal Mortality United States Disrespectful Maternity Care Obstetric Vi-olence Provider Perspectives Disparities

Maternal Mortality Rates among Im/Migrant Populations in the United States

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1161-1175页

作者： Tessa Peredy Mary Greenwald Katy Doughty Fachon Fiona Danaher Rashmi Jasrasaria Samantha Truong Annekathryn goodman University of New England College of Osteopathic Medicine Biddeford ME United States Department of Obstetrics and Gynecology Massachusetts General Hospital Boston Boston MA United States Center for Immigrant Health Massachusetts General Hospital Boston Boston MA United States

Introduction: Maternal mortality rates have more than doubled in the U.S over the last two decades, making it one of the few places in the world where maternal mortality is increasing. Differences in maternal mortality among certain races and ethnicities are known but few studies examine maternal mortality among immigrants. Since immigrants represent 13.7% of the U.S. population, it is essential to examine immigrant subsets to understand maternal mortality among this vulnerable population. Methods: A literature search identified 318 articles on maternal mortality and immigrants, with 12 articles from the U.S. The keywords included maternal mortality, United States, migrants, asylum seekers, immigrants, and disparities. Maternal mortality statistics were obtained from the World Health Organization and Center for Disease Control. Results: Studies analyzed in this review found an overall lower maternal mortality rate among immigrant women compared to U.S.-born women, except for Hispanic immigrant women. Black women had the highest maternal mortality rate, regardless of immigration status. Conclusion: Although the literature points to lower maternal mortality among immigrants, the data is still somewhat mixed, making it challenging to draw comprehensive conclusions. Additional research examining maternal mortality among Im/migrants in the U.S. is needed to guide future training among healthcare professionals and policymakers.

关键词： Maternal Mortality Im/Migrant Reproductive Health United States

Optimization and control of synchrotron emission in ultraintense laser–solid interactions using machine learning – CORRIGENDUM

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High Power Laser Science and Engineering 2024年第1期12卷 116-116页

作者： J.goodman M.King E.J.Dolier R.Wilson R.J.Gray P.McKenna 不详

Due to an isolated error in the 3D simulation parameters,the laser energy and intensity(calculated using the energy)values were incorrectly stated as 10.9 J and 3×10^(22) W cm^(−2),respectively,in Sections 3.3,7 and *** correct values are 39.8 J and 1.1×10^(23) W cm^(−2).Similarly,the values stated for the higher energy case,109 J and 3×10^(23) W cm^(−2) in Section 7,should be 398 J and 1.1×10^(24) W cm^(−2),respectively.

关键词： Bayesian optimization gamma rays laser-solid interactions machine learning radiation reaction

EBV conference establishes goals for defining disease-related EBV subtypes for vaccine development

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癌症 2009年第12期28卷 1233-1235页

作者： Laurie goodman The 2008 International Association for Research on Epstein-Barr virus and Associated Diseases (IARES) International Epstein-Barr Virus Genome Consortium (IEGC) GuangzhouChina Goodman Writing & Editiug14 Overbrook Terrace NaticMA 01760 USA

Epstein-Barr virus (EBV), a γ-herpesvirus, was identified more than four decades ago. It is a ubiquitous infectious agent that infects more than 90% of the world’s adult population. Primary EBV infection in most

关键词：疱疹病毒病毒感染单核细胞症状

Utilization of waste straw and husks from rice production:A review

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Journal of Bioresources and Bioproducts 2020年第3期5卷 143-162页

作者： Bernard A.goodman School of Physical Science and Technology Guangxi UniversityNanning 530004China School of Chemistry and Chemical Engineering Guangxi University for NationalitiesNanning 530008China

As a staple food for much of the world,rice production is ***,it also results in the generation of large quantities of non-food biomass,primarily in the form of straw and *** they have been little utilized and much rice straw is still simply burned,these ligno-cellulosic materials potentially have considerable *** review considers the composition of rice straw and husks,the various processes involved in the production of valuable products,and a range of uses to which they can be *** include agricultural amendments,energy production,environmental adsorbents,construction materials,and various speciality products.

关键词： Rice straw Rice husk Bioethanol Biogas Adsorbent Silica Cellulose Lignin

Clinical microdialysis in neuro-oncology: principles and applications

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Chinese Journal of Cancer 2011年第3期30卷 173-181页

作者： J. Clay goodman Department of Pathology & Immunology Baylor College of Medicine

Clinical microdialysis allows a discrete volume of the brain to be sampled for neurochemical analysis of neurotransmitters, metabolites, biomarkers, and drugs. The technique can be safely used in humans intraoperatively, in the intensive care unit, and in ambulatory settings. Microdialysis probes, micropumps, and analytical equipment are commercially available and have been used extensively for neurochemical monitoring in traumatic brain injury, stroke, and subarachnoid hemorrhage. There has been very limited use of microdialysis in neuro-oncology, but this technique has great promise in the study of the basic neurochemistry of brain tumors, alterations in neurochemistry in response to therapy, and the pharmacokinetics of chemotherapeutic agents. Microdialysis probes may also be used to deliver drugs while simultaneously permitting monitoring of neurochemical changes induced by this therapy.

关键词：微透析技术神经递质肿瘤学临床微透析探针应用原理化学监测

＂Not a Club for Ethical Culture＂： The Early Writings of Max Weber, Liang Qichao, and Kang Youwei on the Stock Exchange

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Frontiers of History in China 2015年第4期10卷 531-546页

作者： Bryna goodman Asian Studies Program and Department of History University of Oregon Eugene OR 97403 USA

This paper examines early discussions of stock exchanges by Max Weber, Liang Qichao, and Kang Youwei and considers their contemporaneity. Despite different contexts, the discussions shared a nineteenth-century preoccupation with global competition and Darwinian struggles for survival. All reveal the attendant anxieties of latecomer nations experiencing belated modernity. Weber, however, wrote from a position that embraced German colonialism, whereas Liang and Kang＇s advocacy of stock exchanges was marked by concerns for the Chinese nation that emerged as a result of the experience of colonialism and economic imperialism.

关键词： Max Weber Liang Qichao Kang Youwei stock exchanges finance