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Osteolytic effects of tumoral estrogen signaling in an estrogen receptor-positive breast cancer bone metastasis model

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 254-271页

作者： Julia N.Cheng Jennifer B.Frye Susan A.Whitman andrew G.Kunihiro Julia A.Brickey Janet L.funk Cancer Biology Graduate Interdisciplinary Program University of ArizonaTucsonAZ 85724USA Department of Medicine University of ArizonaTucsonAZ 85724USA Department of Nutritional Sciences University of ArizonaTucsonAZ 85724USA

Aim:Estrogen receptorα-positive(ER+)subtypes of breast cancer have the greatest predilection for forming osteolytic bone metastases(BMETs).Because tumor-derived factors mediate osteolysis,a possible role for tumoral ERαsignaling in driving ER+BMET osteolysis was queried using an estrogen(E2)-dependent ER+breast cancer BMET ***:Female athymic Foxn1nu mice were inoculated with human ER+MCF-7 breast cancer cells via the left cardiac ventricle post-E2 pellet placement,and age-and dose-dependent E2 effects on osteolytic ER+BMET progression,as well as direct bone effects of E2,were ***:Osteolytic BMETs,which did not form in the absence of E2 supplementation,occurred with the same frequency in young(5-week-old)*** mature(16-week-old)E2(0.72 mg)-treated mice,but were larger in young mice where anabolic bone effects of E2 were ***,in mice of a single age and across a range of E2 doses,anabolic E2 bone effects were constant,while osteolytic ER+BMET lesion incidence and size increased in an E2 dose-dependent *** in ER+tumor-bearing(but not tumor-naive)mice increased in an E2-dose dependent fashion at the bone-tumor interface,while histologic tumor size and proliferation did not vary with E2 dose.E2-inducible tumoral secretion of the osteolytic factor parathyroid hormone-related protein(PTHrP)was dose-dependent and mediated by ERα,with significantly greater levels of secretion from ER+BMET-derived tumor ***:These results suggest that tumoral ERαsignaling may contribute to ER+BMET-associated osteolysis,potentially explaining the greater predilection for ER+tumors to form clinically-evident osteolytic BMETs.

关键词： Breast cancer estrogen receptor bone metastasis estradiol osteolysis osteoclasts parathyroid hormone-related protein bone

THE RUMPSHAKER Fine Music for Your Nightlife Diet

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城市漫步（上海版、英文） 2015年第7期 86-87页

作者： andrew CHIN 不详

From funk legends to modern day Ibiza favorites,this month brings all sorts of groovy *** more,check ***/sha nghai every Thursday for our Weekly Party Planner.

关键词： favorite life Night

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NEW YEAR'S ROUNDUP Welcome 2015 with a bang

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城市漫步（上海版、英文） 2014年第12期 80-81页

作者： BETTY RICHARDSON andrew CHIN 不详

PARTIES DJ Santo Chino DADA isn't messing around for their New Year S Eve party,that's for *** Chino'been amassing quite the following over the past year with his monthly Same As It Ever Was *** takes t back to the basics with his all-vinyl sets that feature nothing but incredible music from disco to rock to funk.1 Dec 31 lpm-late,free *** 115 XingfuLu,by.

关键词： nothing party edible

A GRIMY SLICE OF GROOVE Soulspeak Turns to the Dark Side

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城市漫步（上海版、英文） 2016年第4期 44-44页

作者： andrew CHIN 不详

Forget everything you know about *** the Beijing-based producer may be best known for his funk-infused,soulful hip-hop beats,his debut release under the alias Kai Luen unveils a completely different side of his music... 详细信息

关键词： release everything musical