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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica d.Eisner Li Xie Minhu Chen department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CIdoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

Magnetically controlled growing instrumentation for early onset scoliosis: Caution needed when interpreting the literature

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World Journal of Orthopedics 2019年第11期10卷 394-403页

作者： Kenneth Aaron shaw Justin M Hire Scott Kim dennis P devito Michael L Schmitz Joshua S Murphy department of Orthopaedic Surgery Dwight D.Eisenhower Army Medical CenterFort GordonGA 30905United States department of Orthopaedic Surgery General Leonard Wood Army Community HospitalFort Leonard WoodMO 65473United States University of Tennessee Health Science Center MemphisTN 38163United States department of Pediatric Orthopaedic Surgery Children’s Healthcare of AtlantaScottish Rite CampusAtlantaGA 30342United States

BACKGROUNd Magnetically controlled growing rods(MCGR) are a novel treatment option for early onset scoliosis(EOS). Although the complication profile with MCGR use has been reviewed, these reviews do not take into account important implants modifications, termed iterations, that were made due to early on postoperative complications is not well reported or *** To assess the effect of MCGR implant iterations on post-operative complications in *** A systematic review was performed to identify studies investigating MCGR specifically for the treatment of EOS, refined to those reporting the implant iteration, specifically the incorporation of the keeper plate to the implant *** with mixed implant iteration usage were excluded. Complications following surgery were recorded as well as potential risk factors and compared between implant *** Although 20 articles were identified for inclusion, 5 included mixed implant iteration leaving a total of 271 patients identified through 15 clinical studies thatmet inclusion criteria. The average follow-up was 25.4-mo. Pre-keeper plate implants were utilized in 3 studies with a total of 49 patients. Overall, 115(42.4%)post-operative complications were identified, with 87% defined as major. The addition of the keeper plate significantly decreased the rate of post-operative complications per study(35.7% vs 80.6%, P = 0.036), and the rate of distraction failure(8.1% vs 40.8%, P = 0.02). Unplanned reoperation occurred in 69(26.7%)patients but was not different between implant iteration cohorts(25.5% without keeper plate vs 27.1% with keeper plate, P = 0.92).CONCLUSION MCGR for EOS has a cumulative complication rate of 42.4% but this is significantly reduced to 35.7% when reviewing only keeper-plate enabled implants. However, 25% of published articles included mixed implant *** studies should discern between implants iterations when reporting on the usage of MCGR for EOS.

关键词： Complications Early onset scoliosis Magnetically controlled growing instrumentations Keeper plate Reoperation Systematic review

Risk stratification for coronary artery disease in multi-ethnic populations:Are there broader considerations for cost efficiency?

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World Journal of Methodology 2019年第1期9卷 1-19页

作者： Pupalan Iyngkaran William Chan danny Liew Jalal Zamani John d Horowitz Michael Jelinek david L Hare James A shaw department of Cardiology Flinders UniversityNT Medical School department of Cardiology Alfred and Western Health University of Melbourne Clinical Outcomes Research School of Public Health and Preventive MedicineMonash University department of Interventional Cardiology Feris Shiraz UniversityShiraz University of Medical Sciences department of Cardiology and Clinical Pharmacology the Queen Elizabeth HospitalUniversity of Adelaide department of Cardiology Vincent’s Hospital Cardiovascular Research University of Melbourne department of Cardiology The Alfred HospitalBaker IDI Heart and Diabetes Institute

Coronary artery disease(CAd) screening and diagnosis are core cardiac specialty *** symptoms,autopsy correlations supported reductions in coronary blood flow and dynamic epicardial and microcirculatory coronaries artery disease as *** angina remains a clinical diagnosis,most cases require correlation with a diagnostic *** the onset of the evidence building process much research,now factored into guidelines were conducted among population and demographics that were homogenous and often prior to newer technologies being *** we see a more diverse multi-ethnic population whose characteristics and risks may not consistently match the populations from which guideline evidence is *** it would seem veryunlikely that for the majority,scientific arguments against guidelines would differ,however from a translational perspective,there will be populations who differ and importantly there are cost-efficacy questions,e.g.,the most suitable first-line tests or what parameters equate to an adequate *** article reviews non-invasive diagnosis of CAd within the context of multi-ethnic patient populations.

关键词： Cost efficacy Coronary artery disease Coronary heart disease Ethnicity Outcomes Risk stratification

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一种使废胶再生的新技术问世

轮胎研究与开发 1996年第1期22卷 23-24页

作者： shaw,d 邓海燕

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立构复合结构增韧左旋聚乳酸的结构与性能

高分子材料科学与工程 2013年第2期29卷 54-57页

作者：孙志丹徐阳陈晓浪 shaw Ling Hsu 张志斌材料先进技术教育部重点实验室西南交通大学材料科学与工程学院四川成都610031 西南交通大学生命科学与工程学院四川成都610031 Polymer Science and Engineering department and Materials Research Science and Engineering Center University of Massachusetts Amherst Massachusetts 01003 USA

以左旋聚乳酸(PLLA)为基体聚合物材料、右旋聚乳酸-聚乙二醇-右旋聚乳酸(PdLA-PEG-PdLA)三嵌段共聚物作为增韧改性剂,通过熔融共混方法制备了PLLA/PdLA-PEG-PdLA共混物。通过红外光谱(FT-IR)、差示扫描量热仪(dSC)、X射线衍射(XRd)和拉... 详细信息

以左旋聚乳酸(PLLA)为基体聚合物材料、右旋聚乳酸-聚乙二醇-右旋聚乳酸(PdLA-PEG-PdLA)三嵌段共聚物作为增韧改性剂,通过熔融共混方法制备了PLLA/PdLA-PEG-PdLA共混物。通过红外光谱(FT-IR)、差示扫描量热仪(dSC)、X射线衍射(XRd)和拉伸行为测试对PLLA和PLLA/PdLA-PEG-PdLA共混物的结构、晶型和力学性能进行了研究。结果表明,PdLA-PEG-PdLA三嵌段共聚物的加入,共混体系生成了PLA立构复合结构。与纯PLLA相比,PLLA共混物的玻璃化转变温度显著下降,热稳定性能明显改善,而且PLLA基体的韧性得到了较大程度的提高。

关键词：左旋聚乳酸立构复合结构共混物增韧

An external quantum efficiency of>20%from solutionprocessed poly(dendrimer)organic light-emitting diodes

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npj Flexible Electronics 2018年第1期2卷 213-218页

作者： Fatemeh Maasoumi Ross d.Jansen-van Vuuren Paul E.shaw Emma V.Puttock Ravi Chandra Raju Nagiri Jake A.McEwan Mark Bown Jenny L.O’Connell Christopher J.dunn Paul L.Burn Ebinazar B.Namdas Centre for Organic Photonics&Electronics(COPE) School of Chemistry&Molecular Biosciences and School of Mathematics&PhysicsUniversity of QueenslandSt.LuciaQLD 4072Australia CSIRO Manufacturing Research WayClaytonVIC 3168Australia

Controlling the orientation of the emissive dipole has led to a renaissance of organic light-emitting diode(OLEd)research,with external quantum efficiencies(EQEs)of>30%being reported for phosphorescent *** highly efficient OLEds are generally manufactured using evaporative methods and are comprised of small-molecule heteroleptic phosphorescent iridium(III)complexes blended with a host and additional layers to balance charge injection and *** area OLEds for lighting and display applications would benefit from low-cost solution processing,provided that high EQEs could be ***,we show that poly(dendrimer)s consisting of a non-conjugated polymer backbone with iridium(III)complexes forming the cores of firstgeneration dendrimer side chains can be co-deposited with a host by solution processing to give highly efficient *** bilayer devices comprising the emissive layer and an electron transport layer gave an EQE of>20%at luminances of up to≈300 cd/m^(2),showing that polymer engineering can enable alignment of the emissive dipole of solution-processed phosphorescent materials.

关键词： quantum dipole light

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医疗评估的准则

国外医学（医院管理分册） 1990年第3期7卷 108-110页

作者： C d.shaw 富绍祯

无论全英的政府机构、医院院长或医院各个科室均认为医疗评估必须予以贯彻,然而对全国或地区来说,对评估的定义和含意未必有统一见解。本文旨在寻找衡量医院评估的设计和有效性.有七项准则可资利用,它述及医务人员和管理人员职责,医疗组... 详细信息

无论全英的政府机构、医院院长或医院各个科室均认为医疗评估必须予以贯彻,然而对全国或地区来说,对评估的定义和含意未必有统一见解。本文旨在寻找衡量医院评估的设计和有效性.有七项准则可资利用,它述及医务人员和管理人员职责,医疗组织,评估范围,主要特征,所需资源,记录保存和评价。

关键词：医疗质量准则