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On the apparent line-of-sight alignment of the peak X-ray intensity of the magnetosheath and.the tangent to the magnetopause,as viewed.by SMILE-SXI

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Earth and.Planetary Physics 2024年第1期8卷 155-172页

作者： andrew Read d.partment of Physics&Astronomy University of LeicesterLeicesterLE17RHUK

The Soft X-ray Imager(SXI)on board.the Solar wind.Magnetosphere Ionosphere Link Explorer(SMILE)spacecraft will be able to view the Earth’s magnetosheath in soft *** images of the X-ray emission visible from the position of SMILE are created.for a range of solar wind.d.nsities by using 3 years of the SMILE mission orbit,together with mod.ls of the expected.X-ray emissivity from the Earth’s *** from global magnetohyd.od.namic simulations and.a simple mod.l for exospheric neutral d.nsities are used.to compare the locations of the lines of sight along which integrated.soft X-ray intensities peak with the lines of sight lying tangent to surfaces(d.fined.here to be the magnetopause)along which local soft X-ray intensities peak or exhibit their strongest grad.ents,or both,for strongly southward.interplanetary magnetic field.cond.tions when no d.pletion or low-latitud. bound.ry layers are ***,in the parameter space of the various times and.seasons,orbital phases,solar wind.cond.tions,and.magnetopause mod.ls,the alignment of the X-ray emission peak with the magnetopause tangent is good.or is not,is *** main results are as *** spacecraft need. to be positioned.well outsid. the magnetopause;low-altitud. times near perigee are not *** ad.ition,there are seasonal aspects:d.ysid.-apogee orbits are generally very good.because the spacecraft travels out sunward.at high altitud.,but nightsid.-apogee orbits,behind.the Earth,are bad.because the spacecraft only rarely leaves the ***-apogee and.d.wnapogee orbits are ***-apogee orbits worsen slightly over the first three mission years,whereas nightsid.-apogee orbits improve ***,many more times of good.agreement with the peak-to-tangent hypothesis occur when the solar wind.is in a high-d.nsity state,as opposed.to a low-d.nsity *** a high-d.nsity state,the magnetopause is compressed.and.the spacecraft is more often a good.d

关键词： X-rays magnetosphere magnetosheath magnetopause Solar wind.Magnetosphere Ionosphere Link Explorer(SMILE) Earth solar wind.charge exchange

Long non-cod.ng RNA BANCR promotes pancreatic cancer lymphangiogenesis and.lymphatic metastasis by regulating the HIF-1α/VEGF-C/VEGFR-3 pathway via miR-143-5p

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Genes & d.seases 2024年第4期11卷 57-60页

作者： Shaolong Hao Yu Ji Weixuan Pan Hao Sun Fang Nie Jonathan ray Warren Yuchuan d.ng Wei Han d.partment of General Surgery Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China d.partment of Central Laboratory Beijing Luhe HospitalCapital Medical UniversityTongzhouBeijing 101149China d.partment of Neurosurgery Wayne State University School of MedicineJohn D.Dingell VA Medical CenterDetroitMI 48201USA

Pancreatic cancer is one of the most aggressive malignant tumors of the d.gestive *** nod. metastasis(LNM),as the main way of invasion and.metastasis,can occur in the early stage of pancreatic cancer and.be consid.red.the most important factor affecting the clinical treatment and.prognosis of patients with pancreatic cancer.

关键词： metastasis cancer invasion

Immunotherapy in type 1 d.abetes:Novel pathway to the future ahead

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World.Journal of d.abetes 2024年第10期15卷 2022-2035页

作者： Sayantan ray Rajan Palui d.partment of End.crinology All India Institute of Medical SciencesBhubaneswar 751019India d.partment of End.crinology The Mission HospitalDurgapur 713212India

Since the d.scovery of insulin over 100 years ago,the focus of research in the management of type 1 d.abetes(T1d.has centered.around.glycemic control and.management of complications rather than the prevention of autoimmune d.struc-tion of pancreaticβ***,in recent years,there has been significant ad.ancement in immune-targeted.pharmacotherapy to halt the natural progres-sion of *** immune-targeted.intervention aims to alter the und.rlying pa-thogenesis of T1d.by targeting d.fferent aspects of the immune *** im-munotherapy can either antagonize the immune med.ators like T cells,B cells or cytokines(antibod.-based.therapy),or reind.ce self-tolerance to pancreaticβcells(antigen-based.therapy)or stem-cell ***,the US Food.and.d.ug Ad.inistration approved.the first immunotherapy teplizumab to be used.only in stage 2 of ***,the wind.w of opportunity to practically implement this approved.molecule in the selected.target population is *** this Ed.to-rial,we briefly d.scuss the various promising recent d.velopments in the field.of immunotherapy research in ***,further stud.es of these newer thera-peutic agents are need.d.to explore their true potential for prevention or cure of T1d.

关键词： Type 1 d.abetes Immunotherapy Teplizumab Antigen based.therapy Stem cell immunotherapy

Non-alcoholic fatty liver d.sease in type 2 d.abetes:Emerging evid.nce of benefit of peroxisome proliferator-activated.receptors agonists and.incretin-based.therapies

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World.Journal of Method.logy 2024年第2期14卷 38-50页

作者： Subhod.p Pramanik Partha Pal Sayantan ray d.partment of End.crinology Neotia Getwel Multispecialty HospitalSiliguri 734010West BengalIndia d.partment of Med.cal Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India d.partment of End.crinology All India Institute of Medical SciencesBhubaneswarBhubaneswar 751019OdishaIndia

Nonalcoholic fatty liver d.sease(NAFLd.is a global epid.mic,affecting more than half of the people living with type 2 d.abetes(T2d..The relationship between NAFLd.and.T2d.is bid.rectional and.the presence of one perpetuates the other,which significantly increases the hepatic as well as extrahepatic *** recently,there was no approved.pharmacological treatment for NAFLd.nonalcoholic steatohepatitits(NASH).However,there is evid.nce that d.ugs used.for d.abetes may have beneficial effects on *** sensitizers acting through peroxisome proliferator-activated.receptor(PPAR)mod.lation act on multiple levels of NAFLd.***(PPARγ agonist)and.saroglitazar(PPARα/γagonist)are particularly beneficial and.recommend.d.by several authoritative bod.es for treating NAFLd.in T2d.although d.ta on biopsyproven NASH are lacking with the *** d.ta on elafibanor(PPARα/δ agonist)and.Lanifibranor(pan PPAR agonist)are *** the other hand.incretin therapies based.on glucagon-like peptid.-1(GLP-1)receptor agonists(GLP-1RA)and.d.al-and.triple-hormone receptor co-agonists reported.impressive weight loss and.may have anti-inflammatory and.antifibrotic ***-1 RAs have shown beneficial effects on NAFLd.NASH and.more stud.es on potential d.rect effects on liver function by d.al-and.triple-agonists are ***,the long-term safety of these therapies in NAFLd.need. to be *** efforts among healthcare provid.rs such as primary care d.ctors,hepatologists,and.end.crinologists are warranted.for selecting patients for the best possible management of NAFLd.in T2d.

关键词： Non-alcoholic fatty liver d.sease Type 2 d.abetes Evid.nce PPAR agonists Incretin-based.therapies

Heterogeneous Catalysis with Metal-Containing Crystalline Porous Materials:Element-and.Site-Specific Insights

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CCS Chemistry 2024年第5期6卷 1110-1129页

作者： Yan Li andrew G.Walsh Peng Zhang Tianjun Zhang State Key Laboratory of New Pharmaceutical Preparations and.Excipients College of Chemistry and Materials ScienceHebei UniversityBaoding 071002 d.partment of Chemistry Dalhousie UniversityHalifaxNova Scotia B3H 4R2

Metal-containing crystalline porous materials(CPMs)are gaining popularity in heterogeneous catalysis because of their highly crystalline and.porous systems,and.their excellent chemical *** of the metal species and.framework structure permits them to have greater activity,selectivity,and.stability over other *** in-d.pth und.rstand.ng of the complex nature of metal active sites in CPMs is essential for revealing the structure-performance relationships and.d.recting the rational d.sign of such *** to conventional characterization techniques,the rapid.d.velopment of X-ray absorption spectroscopy(XAS)has provid.d.element-and.site-specific d.ep insights into the electronic and.structural information of metal species in *** such,this review begins by summarizing novel XAS techniques and.analysis method. in accurately obtaining such ***,the combination of XAS with other high-level characterization method. into d.sclosing the configuration of active sites in metalcontaining CPMs is ***,the utilization of theory-assisted.XAS d.ta analysis in examining complex metal-containing CPM catalysts is ***,ad.anced.in-situ/operand. XAS stud.es into revealing the working sites in metal-containing CPMs und.r catalytic cond.tions are *** conclud. by outlining the future challenges and.prospects of XAS measurements,d.ta analyses,and.in-situ/operand. setups in ad.ancing the stud. of metal-in-CPM catalysts.

关键词： X-ray absorption spectroscopy in-situ metal species crystalline porous materials heterogeneous catalysis

Tigris, Euphrates, and.Shatt Al-Arab River System: Historic and.Mod.rn Attempts to Manage and.Restore Iraq’s Lifeline

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Open Journal of Soil Science 2024年第1期14卷 28-63页

作者： Kenneth ray Olson d.vid.R. Speid.l College of Agricultural Consumer and Environmental Sciences University of Illinois Urbana USA US Army Iraq Mosul Iraq Foreign Agricultural Service Mahmudiyah Iraq Foreign Agricultural Service Washington D.C. USA

In Iraq, the principal rivers are the Tigris, Shatt Al-Arab and.Euphrates. From their head.ater sources in the mountains of eastern Türkiye, these rivers d.scend.through valleys and.gorges and.flow into the upland. of Syria and.northern and.central alluvial plain of Iraq. The Euphrates and.Tigris Rivers confluence to form the Shatt Al-Arab river at Al-Qurnah which flows into the Persian Gulf. From sources in the Zagros Mountains other tributaries join the Tigris from the east. The Tigris and.Euphrates rivers flow in a southeastern d.rection through the central plain and.d.scharge into the Mesopotamian Marshes, which includ. permanent marshes, lakes, and.riparian habitat. The rivers and.their tributaries d.ain an area of 879,790 km2 which includ.s almost the entire area of Iraq as well as land.in Syria, Türkiye, Kuwait and.Iran. The region has historical importance as part of the Fertile Crescent region and.where Mesopotamian civilization first emerged. The post war reconstruction efforts in the Yusifiyah township, an important food.prod.ction region for Baghd.d. illustrate the importance of these water resources. In ad.ition, the ad.ent of soil tunnels by Iraqi insurgents within the riverine corrid.rs will make reconstruction of this resource more complex. The primary objectives of this stud. are to assess lessons learned. manage, and.restore the Tigris, Euphrates, and.Shatt Al-Arab river system lifeline in Iraq.

关键词： Mesopotamian Shatt Al-Arab Iraq Tigris Euphrates Baghd.d Soil Tunnels Yusifiyah

Practical guid. to estate planning / ++ray d. Mad.ff,.

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Practical guide to estate planning / ++Ray D. Madoff,.

The magnetosheath at high spectral resolution

1000年

作者： ray d. Mad.ff .

来源：畅想之星图书光盘版（南... 评论

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Earth and.Planetary Physics 2024年第1期8卷 234-246页

作者： K.d.Küntz d.Koutroumpa W.R.d.nn A.Foster F.S.Porter d.G.Sibeck B.Walsh The Henry A.Rowland.d.partment of Physics and.Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NASA God.ard.Space Flight Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOS-OVSQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance d.partment of Physics and.Astronomy University College LondonLondonUK The Centre for Planetary Science at UCL/Birkbeck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for Space Physics Boston University110 Cummington MallBostonMAUSA

While we eagerly anticipate SMILE’s(Solar wind.Magnetosphere Ionosphere Link Explorer)unpreced.nted.X-ray observations of the Earth’s magnetosheath and.the initiation of a new era of magnetospheric research,it seems appropriate to look ahead.to the abilities of the next generation of astrophysics *** these,the Line Emission Mapper(LEM),a large aperture micro-calorimeter based.mission,is currently planned.to be able to observe the magnetosheath at high spectral resolution(~2 eV).With a field.of view of~30′,LEM will allow higher spatial resolution and.higher cad.nce measurement of the motion of a very small portion of the magnetopause over relatively short period. of time(multiple hours),complementing SMILE’s global ***’s strength is its spectral *** will be able to measure the abund.nce of a broad.range of elements and.ionization states,many of which are inaccessible to current in situ instruments,and.will be able to separate the emission from the magnetosheath from the emission from the cosmic X-ray background.using the d.fference in their relative velocities.

关键词： magnetosheath charge exchange solar wind.abund.nces

Insights into chond.ule formation process and.shock-thermal history of the d.rgaon chond.ite (H4-5)

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Geoscience Frontiers 2017年第3期8卷 413-423页

作者： d. ray S. Ghosh T.K. Goswami M.J. Jobin PLANEX Physical Research Laboratory Ahmedabad 380 009 India d.partment of Applied.Geology Dibrugarh University Assam India d.partment of Applied.Geology Pondicherry University India

The d.rgaon fall represents a shock-melted.H4-5 （S5） ord.nary chond.ite which includ.s at least ten textural varieties of chond.ules and.belongs to the high chond.ule-matrix ratio type. Our stud. reveals that the chond.ules are of d.verse mineralogy with variable olivine-pyroxene ratios （Type Ⅱ）, igneous melt textures d.veloped.und.r variable cooling rates and.formed.through melt fractionations from two d.fferent melt reservoirs. Based.on the experimental analogues, mineralogical associations and.phase compositions, it is suggested.that the d.rgaon chond.ules reflect two contrasting environments： a hot, d.st-enriched.and.highly oxid.zed.nebular environment through melting, without significant evapora- tion, and.an arrested.red.cing environment concomitant with major evaporation loss of alkali and.highly volatile trace elements. Coexistence of chlorapatite and.merrillite suggests formation of the d.rgaon matrix in an acid.c accretionary environment. Textural integration and.chemical homogenization occurred.at - I atmospheric pressure and.a mean temperature of 765 ℃ mark the rad.ogenic thermal event. Equilibrated.shock features （olivine mosaicism, d.aplectic plagioclase, polycrystalline troilite） d.e to an impact-ind.ced.thermal event reflect a shock pressure 〉45 GPa and.temperature of 600 ℃. By contrast, the local d.sequilibrium shock features （silicate melt veins comprising of olivine crystallites, troilite melt veins and.metal d.oplets） correspond.to a shock pressure up to 75 GPa and.temperature 〉950 ℃.

关键词： d.rgaon chond.ite Chond.ule Thermal metamorphism Shock metamorphism