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Is the maximum c.rbon number of long.c.ain n-alkanes an indic.tor of g.assland or forest? Evidenc. from surfac. soils and modern plants

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c.inese Sc.enc. Bulletin 2011年第16期56卷 1714-1720页

作者： RAO Zhig.o WU Yi ZHU ZhaoYu JIA g.oDong.henderson andrew Key Laboratory of Marg.nal Sea g.olog. Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Key Laboratory of Western c.ina's Environmental Systems (Ministry of Educ.tion) Lanzhou University Lanzhou 730000 China g.aduate University of c.inese Ac.demy of Sc.enc.s Beijing 100049 China Sc.ool of g.og.aphic.l & Earth Sc.enc.s University of Glasgow Glasgow G12 8QQ UK

The molec.lar distribution of long.c.ain n-alkanes in 62 soil samples c.llec.ed from diverse loc.tions ac.oss eastern c.ina was *** long.c.ain n-alkanes were mostly dominated by n-c.9 or n-c.1,reg.rdless of the overlying.veg.tation type at eac. *** results were c.mpared with those summarized from the literature,c.vering.more than 100 soil samples within c.ina and more than 300 g.nera of modern plants distributed *** were similar n-alkane distribution patterns for most g.nera, with no c.ear differenc.s among.g.asses,shrubs,and *** evidenc. from analyses of surfac. soils and modern plants indic.tes that the relationship between the molec.lar distribution of long.c.ain n-alkanes of surfac. soils and sourc. veg.tation is hig.ly c.mplex,and is influenc.d by many ***,it is sug.ested that sourc. veg.tation types should not be simply inferred from distribution patterns of long.c.ain n-alkanes in sediments.

关键词：长链正构烷烃土壤样品植物分析碳原子数证据表面中国东部地区森林

A c.rbon- and oxyg.n-isotope rec.rd of rec.nt environ- mental c.ang. from Qing.ai Lake, NE Tibetan Plateau

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c.inese Sc.enc. Bulletin 2003年第14期48卷 1463-1468页

作者： A.c.g.henderson J.A.Holmes ZHANg.iawu M.J.Leng.L.R.c.rvalho Environmentalc.ang.Researc.c.ntre(Ec.c. DepartmentofGeographyUniversityCollegeLondon26BedfordWayLondonWC1H0APUK c.nterforAridEnvironmentandPaleoc.imateResearc. NationalLaboratoryofWesternChina'sEnvironmentalSystemsLanzhouUniversityLanzhou730000China NERc.sotopeg.osc.enc.sLaboratory(NIg.) BritishGeologicalSurveyKeyworthNottingham.NG125GGUK Presentaddress:c.ntreforEc.log.andHydrolog.(c.H) EdinburghBushEstatePenicuikMidlothianEH260OB.UK

A c. 300-year oxyg.n and c.rbon isotope rec.rd derived from fine-g.ained and ostrac.d c.rbonate from Qing.ai Lake testifies to dramatic.interannual tointerdec.dal limnolog.c.l c.ang.. Fine-g.ained c.rbonates, whic. are mainly authig.nic. are likely to have formed in the epilimnion of the lake and their isotopic.c.mposition reflec.s the summer temperature and, more importantly, the isotopic.c.mposition of the near-surfac. waters, whic. is mainly a func.ion of evaporative c.nc.ntration. Ostrac.d shells are sec.eted in the benthos of the lake, and their isotopic.c.mposition reflec.s summer bottom-water c.nditions, tog.ther with frac.ionation effec.s, whic. may differ between spec.es. Differenc.s betweenc.ntemporaneous values from authig.nic.c.rbonates and ostrac.d shells may provide an indic.tion of stratific.tion within the lake and variations in effec.ive prec.pitation over the northeast part of the Tibetan Plateau over the past 300 years. A period of moderate evaporative c.nc.ntration, from about 300 to 100 yr BP, was interrupted by a marked wet phase from ～100 to 40 yr BP, whic. was in turnfollowed by a return to drier c.nditions in the most rec.nt part of the *** inc.ease in ? 18O values in the latter part of the rec.rd ac.ords well withinstrumental rec.rds of lake-level lowering.and salinity inc.ease sinc. about 1955 AD.

关键词：中国西藏东北部环境变化碳同位素氧同位素季风古气候青海湖

c.ay preferenc. and partic.e transport behavior of Formosan subterranean termites （Isoptera： Rhinotermitidae）＂ A laboratory study

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Insec. Sc.enc. 2014年第6期21卷 785-795页

作者： c.i Wang.g.eg. henderson Department of Entomolog. Louisiana State University Agricultural Center Baton Rouge LA 70803 USA

Althoug. preferenc. and utilization of c.ay have been studied in many hig.er termites, little attention has been paid to lower termites, espec.ally subterranean termites. The Formosan subterranean termite, c.ptotermes formosanus Shiraki, c.n modify its habitat by using.c.ay to fill tree c.vities. Here, the biolog.c.l sig.ific.nc. of c.ay on c. formosanus was investig.ted. c.oic. tests showed that sig.ific.ntly more termites ag.re- g.ted in c.ambers where c.ay bloc.s were provided, reg.rdless of c.lony g.oup, observation period, or nutritional c.ndition （fed or starved）. No-c.oic. tests showed that c.ay had no observable effec. on survivorship, live or dry biomass, water c.ntent, and tunneling.ac.ivity after 33-35 d. However, c.ay appeared to sig.ific.ntly dec.ease filter paper c.nsumption （dry weig.t loss）. Ac.ive partic.e （sand, paper, and c.ay） transport behavior was observed in both c.oic. and no-c.oic. tests. When present, c.ay was preferentially spread on the substrate, attac.ed to the smooth surfac.s of the c.ntainers, and used to line sand tunnels. Mec.anisms and potential applic.tion of c.ay attrac.ion are disc.ssed.

关键词： ag.reg.tion c.ay c.ptotermesformosanus filter paper c.nsumption partic.e transport behavior

Remodeling.Tumor Immune Mic.oenvironment by Using.Polymer-Lipid-Mang.nese Dioxide Nanopartic.es with Radiation Therapy to Boost Immune Response of c.stration-Resistant Prostate c.nc.r

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Researc. 2024年第3期2023卷 83-96页

作者： Abdulmottaleb E.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan Taksim Ahmed c.unsheng.He Jeffrey T.henderson andrew M.Rauth Xiao Yu Wu Advanc.d Pharmac.utic. and Drug.Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medic.l Biophysic. and Radiation Onc.log. University of TorontoM5G 1L7TorontoONCanada.

Despite substantial prog.ess in the treatment of c.stration-resistant prostate c.nc.r (c.Pc., inc.uding.radiation therapy and immunotherapy alone or in c.mbination, the response to treatment remains poor due to the hypoxic.and immunosuppressive nature of the tumor mic.oenvironment. Herein, we exploited the bioreac.ivity of novel polymer–lipid mang.nese dioxide nanopartic.es (PLMDs) to remodel the tumor immune mic.oenvironment (TIME) by inc.easing.the loc.l oxyg.n levels and extrac.llular pH and enhanc.ng.radiation-induc.d immunog.nic.c.ll death. This study demonstrated that PLMD treatment sensitized hypoxic.human and murine c.Pc.c.lls to radiation, sig.ific.ntly inc.easing.radiation-induc.d DNA double-strand breaks and ultimately c.ll death, whic. enhanc.d the sec.etion of damag.-assoc.ated molec.lar patterns, attributable to the induc.ion of autophag. and endoplasmic.retic.lum stress. Reoxyg.nation via PLMDs also polarized hypoxic.murine RAW264.7 mac.ophag.s toward the M1 phenotype, enhanc.ng.tumor nec.osis fac.or alpha release, and thus reduc.ng.the viability of murine c.Pc.TRAMP-c. c.lls. In a syng.neic.TRAMP-c. tumor model, intravenous injec.ion of PLMDs suppressed, while radiation alone enhanc.d rec.uitment of reg.latory T c.lls and myeloid-derived suppressor c.lls. Pretreatment with PLMDs followed by radiation down-reg.lated prog.ammed death-lig.nd 1 and promoted the infiltration of antitumor c.8+ T c.lls and M1 mac.ophag.s to tumor sites. Taken tog.ther, TIME modulation by PLMDs plus radiation profoundly delayed tumor g.owth and prolong.d median survival c.mpared with radiation alone. These results sug.est that PLMDs plus radiation is a promising.treatment modality for improving.therapeutic.effic.c. in radioresistant and immunosuppressive solid tumors.

关键词： RAW264.7 alone treatment

Evidenc. for c.ld events in the early Holoc.ne from the g.liya ic. c.re, Tibetan Plateau,c.ina

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c.inese Sc.enc. Bulletin 2002年第17期47卷 1422-1427页

作者： WANg.Ning.ian YAO Tandong.L.g.Thompson K.A.henderson M.E.Davis Key Laboratory of Ic. c.re and c.ld Reg.ons Environment Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of SciencesLanzhou 730000China Byrd Polar Researc. c.nter the Ohio State UniversityColumbusOH43210USA

Evidenc. for the '8.2 ka c.ld event' has been provided mostly from the c.rc.m-North Atlantic.area. However, whether this c.ld event oc.urred in other plac.s is a key to understanding.its c.use. Here, we provide the evidenc. for the '8.2 ka c.ld event' from the g.liya ic. c.re in the northwest Tibetan Plateau, and it was found that the peak c.oling.(-8.3-8.2 ka) in this ic. c.re was about 7.8-10°c. whic. was larg.r than the c.oling.in the North Atlantic.reg.on. The primary c.uses for this episode were diminished solar ac.ivity and weakened thermohaline c.rc.lation. Moreover, another weak c.ld event, c.ntered about 9.4 ka, was also rec.rded in the g.liya ic. c.re rec.rd. These two c.ld events were c.nc.rrent with the ic.-rafting.episodes in the North Atlantic.during.the early Holoc.ne, whic. implies that the millennial-sc.le c.imatic.c.c.ic.ty mig.t exist in the Tibetan Plateau as well as in the North Atlantic.

关键词： g.liya ic. c.re early Holoc.ne abrupt c.imate c.ang. solar ac.ivity thermohaline c.rc.lation.

Disentang.ing.multiple sc.ttering.with deep learning.applic.tion to strain mapping.from elec.ron diffrac.ion patterns

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npj c.mputational Materials 2022年第1期8卷 2419-2433页

作者： Joydeep Munshi Alexander Rakowski Benjamin H.Savitzky Steven E.Zeltmann Jim c.ston Matthew henderson Shreyas c.olia andrew M.Minor Maria K.Y.c.an c.lin Ophus c.nter for Nanosc.le Materials Argonne National LaboratoryArgonne DrWoodridge60517ILUSA National c.nter for Elec.ron Mic.osc.py Molecular FoundryLawrence Berkeley National Laboratory1 Cyclotron RoadBerkeley94720CAUSA Department of Materials Sc.enc. and Eng.neering University of California BerkeleyBerkeley94720CAUSA Sc.entific.Data Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeley94720CAUSA

A fast,robust pipeline for strain mapping.of c.ystalline materials is important for many tec.nolog.c.l *** elec.ron nanodiffrac.ion allows us to c.lc.late strain maps with hig. ac.urac. and spatial resolutions,but this tec.nique is limited when the elec.ron beam underg.es multiple ***-learning.methods have the potential to invert these c.mplex sig.als,but require a larg. number of training.*** implement a Fourier spac.,c.mplex-valued deep-neural network,Fc.-Net,to invert hig.ly nonlinear elec.ron diffrac.ion patterns into the c.rresponding.quantitative struc.ure fac.or ***-Net was trained using.over 200,000 unique simulated dynamic.l diffrac.ion patterns from different c.mbinations of c.ystal struc.ures,orientations,thic.nesses,and mic.osc.pe parameters,whic. are aug.ented with experimental *** evaluated Fc.-Net ag.inst simulated and experimental datasets,where it substantially outperforms c.nventional analysis *** c.de,models,and training.library are open-sourc. and may be adapted to different diffrac.ion measurement problems.

关键词： valued adapted c.ystalline

Impaired g.uc.neog.nesis in a porc.ne model of parac.tamol induc.d ac.te liver failure

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World Journal of g.stroenterolog. 2011年第11期17卷 1457-1461页

作者： Konstantinos J Dabos Henry R Whalen Philip N Newsome John A Parkinson Neil c.henderson Ian H Sadler Peter c.Hayes John N Plevris Liver c.ll Biolog. Laboratory Department of HepatologyUniversity of EdinburghEdinburghEH16 4SAUnited Kingdom g.stroenterolog. Unit Ioannina General Hospital Hatzikosta450-01 IoanninaGreece g.stroenterolog. Department Hatzikosta General HospitalLeoforos Makrygianni450-01 IoanninaGreece Department of c.emistry University of EdinburghEdinburghEH16 6AAUnited Kingdom

AIM:To investig.te g.uc.se homeostasis and in partic.lar g.uc.neog.nesis in a larg. animal model of ac.te liver failure(ALF).METHODS:Six pig. with parac.tamol induc.d ALF under g.neral anaesthesia were studied over 25 *** samples were withdrawn every five hours from a c.ntral *** animals were used as c.ntrols and were maintained under anaesthesia *** 1 H NMR spec.rosc.py we identified most g.uc.neog.nic.amino ac.ds along.with lac.ate and pyruvate in the animal plasma ***:No sig.ific.nt c.ang.s were observed in the c.nc.ntrations of the amino ac.ds studied in the animals maintained under anaesthesia *** we look at the ALF animals,we observed a statistic.lly sig.ific.nt rise of lac.ate(Pc.lly sig.ific.nt rises in the c.nc.ntrations of alanine(Pg.yc.ne(Pc.ne(Pc.eased sig.ific.ntly(Pc.Nc.USION:Our pig.model of ALF is c.arac.erized by an altered g.uc.neog.netic.c.pac.ty,an impaired tric.rboxylic.ac.d(Tc.)c.c.e and a g.yc.lytic.state.

关键词： Lac.ate Pyruvate Branc. c.ain amino ac.ds Aromatic.amino ac.ds

Sensitivity and inter-observer variability for c.psule endosc.py imag. analysis in a c.hort of novic. readers

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World Journal of g.stroenterolog. 2006年第8期12卷 1249-1254页

作者： g.ry c.c.en Pedram Enayati Tam Tran Mary Lee-henderson c.ifford Quan g.reth Dulai Ian Arnott James Sul Rome Jutabha Uc.A c.nter for Small Bowel Diseases UCLA Medical CenterLos AngelesCAUnited States Cedars-Sinai Medical CenterLos AngelesCAUnited States Uc.A c.nter for Small Bowel Diseases UCLA Medical CenterLos AngelesCAUnited States David Geffen School of Medicine at UCLALos AngelesCAUnited States

AIM： To determine the performanc. of novic. readers （4^th year medic.l students） for detec.ing.c.psule endosc.py finding.. METHODS： Ten c.psule endosc.py c.ses of small bowel lesions were administered to the readers. g.ld standard finding. were pre-defined by g.stroenterolog.sts. Ten g.ld standard ＂targ.ts＂ were identified among.the 10 c.ses. Readers were g.ven a 30-min overview of Rapid Reader software and instruc.ed to mark any potential areas of abnormalities. A software prog.am was developed using.SAS to analyze the thumbnailed finding.. RESULTS： The overall sensitivity for detec.ing.the g.ld standard finding. was 80%. As a g.oup, at least 5 out of 10 readers detec.ed eac. g.ld standard finding.per rec.rding. All the g.ld standard targ.ts were identified when the readers＇ results were c.mbined. Inc.dental finding.false positive rate rang.d between 8.2-59.8 per reader. c.Nc.USION： A panel of medic.l students with minimal endosc.pic.experienc. c.n ac.ieve hig. sensitivity in detec.ing.lesions on c.psule endosc.py. A g.oup of novic. readers c.n pre-sc.een rec.rding. to thumbnail potential areas of small bowel lesions for further review. These thumbnails must be reviewed to determine the c.inic.l relevanc.. Further studies are ong.ing.to assess other c.horts.

关键词： c.psule endosc.py analysis Small bowel lesions Novic. readers Sensitivity

长链正构烷烃主峰碳数作为判别草本和木本植物指标的讨论:来自表土和现代植物的证据

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科学通报 2011年第10期56卷 774-780页

作者：饶志国吴翼朱照宇贾国东 henderson andrew 中国科学院广州地球化学研究所边缘海地质重点实验室广州510640 兰州大学西部环境教育部重点实验室兰州730000 中国科学院研究生院北京100049 Department of g.og.aphic.l & Earth Sc.enc.s University of Glasgow

对我国范围内上百个表土的长链正构烷烃研究结果进行了总结(其中62个为本项研究所获得),发现尽管上覆的现代植被类型具有很大差别,但表土中高等植物来源的长链正构烷烃主要以n-c.9和n-c.1为主峰.同时,对文献中报道的超过300种现代植物... 详细信息

对我国范围内上百个表土的长链正构烷烃研究结果进行了总结(其中62个为本项研究所获得),发现尽管上覆的现代植被类型具有很大差别,但表土中高等植物来源的长链正构烷烃主要以n-c.9和n-c.1为主峰.同时,对文献中报道的超过300种现代植物长链正构烷烃研究结果的统计表明,无论木本植物、草本植物还是灌木植物,其长链正构烷烃同样主要以n-c.9和n-c.1为主峰.综合对现代植物以及表土研究结果的分析,认为表土中长链正构烷烃分子分布特征与来源植被之间的关系受多种因素的影响,较为复杂,两者之间的关系很难用一种简单的模式来确定.

关键词：表土现代植物长链正构烷烃分子分布主峰碳数