检索结果-南通市图书馆

Deep Geothermal: The ‘Moon Landing' Mission in the Unconventional Energy and Minerals Space

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2015年第1期26卷 2-10页

作者： Klaus Regenauer-Lieb andrew bunger Hui Tong Chua Arcady Dyskin Florian Fusseis Oliver Gaede Rob Jeffrey Ali Karrech Thomas Kohl Jie Liu Vladimir Lyakhovsky Elena Pasternak Robert Podgorney Thomas Poulet Sheik Rahman Christoph Schrank Mike Trefry Manolis Veveakis Bisheng Wu David A.Yuen Florian Wellmann Xi Zhang School of Petroleum Engineering University of New South WalesSydney NSW 2052Australia Earth Science and Resource Engineering CSIROKensington WA 6151Australia School of Earth and Environment The University of Western AustraliaPerth WA 6000Australia Department of Civil and Environmental Engineering & Department of Chemical and Petroleum Engineering University of PittsburghPittsburghPennsylvaniaUSA School of Geosciences University of EdinburghEdinburghUK Science and Engineering Faculty School of EarthEnvironmental and Biological SciencesEarth SystemsQueensland University of TechnologyBrisbaneAustralia Karlsruhe Institute of Technology KarlsruheGerman School of Earth Science and Geological Engineering Sun Yat-Sen University Geological Survey of Israel Jerusalem 95501Israel Idaho National Laboratory Idaho FallsUSA Land and Water CSIROFloreat Park WA 6014Australia School of Environmental Studies China University of Geosciences Department of Earth Sciences and Minnesota Supercomputing Institute University of MinnesotaMinneapolis MN 55455USA Aachen Institute for Advanced Study in Computational Engineering Science (AICES) RWTH Aachen University52062 AachenGermany

Deep geothermal from the hot crystalline basement has remained an unsolved frontier for the geothermal industry for the past 30 years. This poses the challenge for developing a new unconventional geomechanics approach to stimulate such reservoirs. While a number of new unconventional brittle techniques are still available to improve stimulation on short time scales, the astonishing richness of failure modes of longer time scales in hot rocks has so far been overlooked. These failure modes represent a series of microscopic processes： brittle microfracturing prevails at low temperatures and fairly high deviatoric stresses, while upon increasing temperature and decreasing applied stress or longer time scales, the failure modes switch to transgranular and intergranular creep fractures. Accordingly, fluids play an active role and create their own pathways through facilitating shear localization by a process of time-dependent dissolution and precipitation creep, rather than being a passive constituent by simply following brittle fractures that are generated inside a shear zone caused by other localization mechanisms. We lay out a new theoretical approach for the design of new strategies to utilize, enhance and maintain the natural permeability in the deeper and hotter domain of geothermal reservoirs. The advantage of the approach is that, rather than engineering an entirely new EGS reservoir, we acknowledge a suite of creep-assisted geological processes that are driven by the current tectonic stress field. Such processes are particularly supported by higher temperatures potentially allowing in the future to target commercially viable combinations of temperatures and flow rates.

关键词： geothermal energy enhanced geothermal systems fracture mechanics creep dissolution precipitation.

Mechanical Modeling of Dike Propagation: Methods, Recent Results and Links to Geophysics

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2016年第S1期90卷 151-页

作者： Eleonora RIVALTA Benoit TAISNE andrew bunger Richard KATZ Deutsches Geo Forschungs Zentrum GFZ Earth Observatory of Singapore Nanyang Technological University University of Pittsburgh University of Oxford

Magma is transported in brittle rock by *** plays a key role in tectonic phenomena such as continental rifting and plate divergence at mid-ocean *** spite of the importance of understanding how magma is

关键词： Mechanical Modeling of Dike Propagation rock Recent Results and Links to Geophysics Methods

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： andrew Gregory Chengyun Tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche andrew Chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

COHESIVE ZONE FINITE ELEMENT-BASED MODELING OF HYDRAULIC FRACTURES

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2009年第5期22卷 443-452页

作者： A.P.bunger Robert G.Jeffrey CSIRO Petroleum Resources Bayview AvenueClaytonVIC 3168Australia

Hydraulic fracturing is a powerful technology used to stimulate fluid production from reservoirs. The fully 3-D numerical simulation of the hydraulic fracturing process is of great importance to the efficient application of this technology, but is also a great challenge because of the strong nonlinear coupling between the viscous flow of fluid and fracture propagation. By taking advantage of a cohesive zone method to simulate the fracture process, a finite element model based on the existing pore pressure cohesive finite elements has been established to investigate the propagation of a penny-shaped hydraulic fracture in an infinite elastic medium. The effect of cohesive material parameters and fluid viscosity on the hydraulic fracture behaviour has been investigated. Excellent agreement between the finite element results and analytical solutions for the limiting case where the fracture process is dominated by rock fracture toughness demonstrates the ability of the cohesive zone finite element model in simulating the hydraulic fracture growth for this case.

关键词： hydraulic fracture cohesive zone model finite element method

STABLE BOUNDARY CONDITIONS AND DISCRETIZATION FOR P_(N) EQUATIONS

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2022年第6期40卷 977-1003页

作者： Jonas bunger Neeraj Sarna Manuel Torrilhon Applied and Computational Mathematics(ACoM) Department of MathematicsRWTH Aachen UniversitySchinkelstr 252062 AachenGermany

A solution to the linear Boltzmann equation satisfies an energy bound,which reflects a natural fact:The energy of particles in a finite volume is bounded in time by the energy of particles initially occupying the volume augmented by the energy transported into the volume by particles entering the volume over *** this paper,we present boundary conditions(BCs)for the spherical harmonic(P_(N))approximation,which ensure that this fundamental energy bound is satisfied by the P_(N) *** BCs are compatible with the characteristic waves of P_(N) equations and determine the incoming waves ***,energy bound and compatibility,are shown on abstract formulations of P_(N) equations and BCs to isolate the necessary structures and *** BCs are derived from a Marshak type formulation of BC and base on a non-classical even/odd-classification of spherical harmonic functions and a stabilization step,which is similar to the truncation of the series expansion in the P_(N) *** show that summation by parts(SBP)finite differences on staggered grids in space and the method of simultaneous approximation terms(SAT)allows to maintain the energy bound also on the semi-discrete level.

关键词： Boundary conditions Energy stability Spherical harmonic(P_(N))approximation Kinetic theory Moment method Boltzmann Linear transport

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

An overview on bone protein extract as the new generation of demineralized bone matrix

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2012年第12期55卷 1045-1056页

作者： ZHOU ZhiYu ZOU LiJin LI HaiSheng bunger Cody ZOU XueNong IOrthopadic Research lnstttute/Department of Orthpaedic Surgery First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 China Department of Burn Surgery First Affiliated Hospital of Nanchang University Nanchang 330031 China Orthopaedic Research Laboratory/ Department of Orthpaedlc Surgery Aarhus University Hospital Aarhus 8000 Denmark

Bone protein extract is regarded as the new generation of demineralized bone matrix. The aim of this paper is to describe and characterize the properties of demineralized bone matrix and its new generation product in addition to its application in animal and human studies. Bone protein extract has features of osteoconductivity, osteoinductivity and osteogenicity, which originate from its unique and precise processing. It has exhibited powerful bone formation capacity both in animal experiments and in clinical trials by providing an optimal microenvironment for osteogenesis. Furthermore, not only does it have excellent bio- compatibility, it also has good compatibility with other implant materials, helping it bridge the host and implanted materials. Bone protein extract could be a promising alternative for demineralized bone matrix as a bone graft substitute.

关键词： bone protein extract demineralized bone matrix autologous bone graft osteogenesis

同方期刊数据库

Structured matter creates toroidal structured light

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第9期11卷 1950-1951页

作者： andrew Forbes School of Physics University of the WitwatersrandJohannesburgSouth Africa

Nano-structured metasurfaces have to be tailored from artificial atoms that act as toroidal emitters,giving rise to a new form of light long predicted:"flying doughnuts"as propagating spatial-temporal electromagnetic ... 详细信息

关键词： visible matter artificial