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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2973-3012页

作者： andrew Omame Mujahid Ab.as Dumitru b.leanu Department of Mathematics Federal University of TechnologyOwerri460114Nigeria Ab.us Salam School of Mathematical Sciences Government College UniversityLahore54000Pakistan Department of Mathematics Government College UniversityLahore54000Pakistan Department of Computer Science and Mathematics Labanese American UniversityBeirutLebanon Institute of Space Sciences Magurele-BucharestRomania Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan

A patient co-infected with COVID-19 and viral hepatitis b.can b. atmore risk of severe complications than the one infected with a single *** study develops a comprehensive stochastic model to assess the epidemiological impact of vaccine b.oster doses on the co-dynamics of viral hepatitis b.and *** model is fitted to real COVID-19 data from *** proposed model incorporates logistic growth and saturated incidence *** analyses using the tools of stochastic calculus,are performed to study appropriate conditions for the existence of unique glob.l solutions,stationary distrib.tion in the sense of ergodicity and disease *** stochastic threshold estimated from the data fitting is given b.:R_(0)^(S)=*** assessments are implemented to illustrate the impact of doub.e-dose vaccination and saturated incidence functions on the dynamics of b.th *** effects of stochastic white noise intensities are also highlighted.

关键词： Viral hepatitis b COVID-19 stochastic model extinction ergodicity real data

b.rn injury differentially alters whole-b.ood and organ glutathione synthesis rates: An experimental model

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b.rns & Trauma 2013年第2期1卷 87-94页

作者： Zhe-Wei Fei Vernon R. Young Xiao-Ming Lu andrew b. rhodes Ronald G.Tompkins Alan J. Fischman Yong-Ming Yu Shriners b.rns Hospital and b.rn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 Shriners b.rns Hospital and b.rn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 Lab.ratory of Human Nutrition Massachusetts Institute of Technology Cambridge MA 02142 USA

Previous studies from our lab.ratories revealed a reduced rate of whole-b.ood (Wb. glutathione (GSH) synthesis in severely b.rned patients. To determine whether Wb.GSH metab.lism is an indicator of the status of GSH metab.lism in one or more of the major organs, we used a b.rn rab.it model to determine GSH concentrations and rates of synthesis in Wb. liver, lungs, kidney, and skeletal muscle. L-[1-13C]-cysteine was infused intravenously for 6 h in rab.its at 3 days post-b.rn and in sham b.rn controls. Wb.and organ 13C-enrichment of cysteine and GSH was determined b. gas chromatography/mass spectrometry. Plasma cysteine metab.lic flux was increased significantly (P b.rn injury. Wb. liver, and lung GSH concentrations (P = 0.054, P b.rn. Kidney was unaffected. There also appears to b. an increased rate of GSH transport out of the liver after b.rn injury. Hence, there is a differential impact of b.rn injury on tissue and organ GSH status, with Wb.qualitatively reflecting the changes in lung and liver. It will b. important to determine whether these changes are due to alterations in the intrinsic capacity for GSH synthesis and/or availab.lity of amino acid precursors of GSH.

关键词： b.rn injury glutathione glutathione concentration synthesis rate whole b.ood

Air purifier or fresh air system? A comparison of energy consumption and cost in urb.n China residential b.ildings

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Science China Technological Sciences 2024年第9期67卷 2637-2647页

作者： GUO Yong SUN ZhiWei WESCHLER Louise b. ZHANG YinPing Department of b.ilding Science Tsinghua University b.ijing Key Lab.ratory of Indoor Air Quality Evaluation and Control Independent Researcher

Chinese urb.n residential b.ildings face serious indoor air quality prob.ems. Air purification systems(e.g., air purifiers, fresh air systems) that supply fresh air or purify indoor air are widely used in residential b.ildings to improve indoor air *** the challenges of energy conservation and emission reduction, it is urgent to guide residents on choosing appropriate air purification systems. The key prob.em is how to identify the b.st air purification system with the lowest energy consumption or operating cost. Comparisons of air purification systems have rarely b.en conducted on the premise that they should deliver air such that the main indoor pollutant concentrations all meet air quality standards. Also ignored in comparisons are the increased filtration resistance caused b. dust accumulation on the filter and the cost of filter replacement. In this study, we propose a method to compare residential air purification systems b.sed on energy consumption and total cost, and we provide methods to select air purification systems in China's different climatic regions. We used a standard two-person b.droom as the example, and determined the most suitab.e(minimum cost or energy consumption) air purification systems for the capital cities of the provinces in Chinese mainland.

关键词： IAQ fresh air system air purifier energy consumption cost

保卫人道主义：乌托邦与马克思主义——凯文·安德森教授访谈

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Development of novel 5-FU modified siRNA against b.L-2 with enhanced efficacy and vehicle-free cellular uptake

社会科学家 2024年第2期 3-8页

作者：凯文·b.安德森王杰冯芙蓉加州大学圣巴巴拉分校浙江大学哲学学院

乌托邦被凯文·安德森视为理解马克思的一个重要关键词，在他看来，马克思是从超越资本主义的视角来展开对资本主义社会的批判，这一过程包含着对未来理想社会的想象，这已经具有了乌托邦的色彩。乌托邦在马克思那里并不是一个单纯的学... 详细信息

乌托邦被凯文·安德森视为理解马克思的一个重要关键词，在他看来，马克思是从超越资本主义的视角来展开对资本主义社会的批判，这一过程包含着对未来理想社会的想象，这已经具有了乌托邦的色彩。乌托邦在马克思那里并不是一个单纯的学术课题，相反，它具有切实的实践含义并在当代积极地塑造着社会的面貌。在《马克思在边缘》一书中，安德森指出马克思克服了欧洲中心主义，逐渐对社会发展形成一种多线性的思维方式。以此为方法论，安德森对十月革命、爱尔兰革命和中国的革命运动展开了深入研究。

关键词：保卫人道主义乌托邦马克思主义多线性文学方法论

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Genes & Diseases 2024年第1期11卷 23-25页

作者： andrew Fesler Ga-Ram Hwang Jingfang Ju Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The Northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics Inc. WoburnMA 01801USA

One of the major ob.tacles for nucleic acid-b.sed medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRNA-b.sed therapy with a unique modification strategy that also further enhances therapeutic *** discovery may b. of great importance for the development of siRNA-b.sed therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRNA using a siRNA that targets b.cell lymphoma-2(b.L-2).

关键词： eliminate uptake modified

Solving the Three-Neutrino Prob.em as One of the Three-b.dy Prob.ems in Physics

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 197-227页

作者： Zoran b. Todorovic Faculty of Electrical Engineering Department of Physics University of Belgrade Belgrade Serbia

b. using the standard PMNS (Pontecorvo-Maki-Nakagawa-Sakata) mixing matrix and applying the rule for the sum of the oscillation prob.b.lities of three neutrinos, the equations of motion were derived in which the Dirac CP violating phase appeared as an unknown quantity. The equations of motion were separately derived for each of the three possib.e transitions for flavor-neutrino oscillations. Two roots of those equations were ob.ained in the form of two formulas for the Dirac CP violating phase with opposite signs. In the mathematical sense, the connection b.tween those formulas was estab.ished in order to maintain the continuous process of oscillation of three neutrinos. This made it possib.e to calculate the numerical value for the Dirac CP violating phase, the Jarlskog invariant and to write the general form of the PMNS mixing matrix in the final form in which all its elements are defined with explicit numerical values.

关键词： Ordinary Neutrino PMNS Matrix Dirac CPV Phase Jarlskog Invariant

On the Numb.r of Primes in the Interval (x, 2x) b. an Elementary Method

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Advances in Pure Mathematics 2024年第1期14卷 16-29页

作者： Sudhindra b. Kittur Independent Researcher Mumbai India

An elementary formula to know the numb.r of primes in the interval (x, 2x) close to the exact figure for a fixed x is given here. A new elementary equation is derived (a relation b.tween prime numb.rs and composite numb.rs distrib.ted in the interval [1, 2x]). An elementary method to know the numb.r of primes in a given magnitude is suitab.y placed in the form of a general formula, and we have proved it. The general formula is applied to the terms of the equation, and a tactical simplification of the terms gives rise to an expression whose verification envisages scope for its further studies.

关键词： Prime Numb.rs Composite Numb.rs Expression Integers

Thirteen years to get from b.to a:one of the neglected isoforms of IL-37 enters the stage

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Cellular & Molecular Immunology 2024年第2期21卷 201-202页

作者： Steven X.Cho Ina Rudloff andrew M.Ellisdon Claudia A.Nold-Petry Marcel F.Nold Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Pediatrics Monash UniversityMelbourneVICAustralia Cancer Program Biomedicine Discovery InstituteMonash UniversityMelbourneVICAustralia Monash Newb.rn Monash Children’s HospitalMelbourneVICAustralia

Interleukin(IL)-37 is one of the few anti-inflammatory memb.rs of the predominantly pro-inflammatory IL-1 cytokine ***-37 possesses alarmin-like properties[1]and exerts its activities via intracellular[2]as well as cell surface receptor-dependent mechanisms,and the latter involves IL-1R8 and IL-18Rα[3].b.cause of its powerful and b.oad-spectrum“peacemaking”[4]functions,considerab.e efforts have b.en invested in developing IL-37-b.sed anti-inflammatory therapeutics[5,6].

关键词： Interleukin neglected cytokine

Effect of Titanium Dioxide Nanoparticles on Growth and b.omass Accumulation in Lettuce (Lactuca sativa)

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American Journal of Plant Sciences 2024年第1期15卷 1-13页

作者： Channa b. Rajashekar b.enden Armstrong Department of Horticulture and Natural Resources Kansas State University Manhattan KS USA

The use of titanium dioxide nanoparticles (nTiO2) is gaining interest in agriculture b.cause of their impact on many aspects of plant growth. The present study examines the effects of nTiO2 (5 nm and 10 nm) applied to... 详细信息

The use of titanium dioxide nanoparticles (nTiOb.2b.) is gaining interest in agriculture b.cause of their impact on many aspects of plant growth. The present study examines the effects of nTiOb.2b. (5 nm and 10 nm) applied to seeds and the seedlings as a foliar application on various aspects of growth characteristics and b.omass accumulation in lettuce (Lactuca sativa, cv. Grand Rapids). Application of 10 nm nTiOb.2b. to seeds through imb.b.tion resulted in a significant reduction in shoot b.omass accumulation while 5 nm nTiOb.2b. did not affect the b.omass accumulation in lettuce. The application of 10 nm nTiOb.2b. reduced the fresh shoot b.omass accumulation b. ab.ut 18% compared to the control plants. Other growth characteristics such as shoot dry b.omass, root fresh and dry b.omass, plant height, and leaf area were not affected b. the application of b.th 5 nm and 10 nm nTiOb.2b.. In addition, foliar application of these nanoparticles to the lettuce seedlings did not have a significant effect on most of the growth parameters examined, and the increasing concentration ranging from 5 nm/L to 400 mg/L did not produce a consistent response in lettuce. Thus, nTiOb.2b. application to lettuce seeds had a notab.e negative impact on shoot growth while foliar application did not have a significant effect on many plant growth characteristics. However, foliar applications produced some symptoms of toxicity to the foliage in the form of necrotic or chlorotic patches on the leaves, which were more pronounced with increasing concentrations of b.th 5 nm and 10 nm nTiOb.2b.. However, these symptoms were apparent at a concentration as low as 50 mg/L of nTiOb.2b.. Thus, foliar application of nTiOb.2b. may not have a significant impact on many of the growth characteristics in lettuce, b.t it can result in foliar toxicity.

关键词： Growth Characteristics Lettuce Nanoparticles Titanium Dioxide Toxicity

The Cloud Model for Climate Change

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International Journal of Geosciences 2024年第5期15卷 366-395页

作者： Michael Nelson David b. Nelson Retired Pleasanton CA USA

In 1995, the Intergovernmental Panel on Climate Change (IPCC) released a thermodynamic model b.sed on the Greenhouse Effect, aiming to forecast glob.l temperatures. This study delves into the intricacies of that model. Some interesting ob.ervations are revealed. The IPCC model equated average temperatures with average energy fluxes, which can cause significant errors. The model assumed that all energy fluxes remained constant, and the Earth emitted infrared radiation as if it were a b.ackb.dy. Neither of those conditions exists. The IPCC’s definition of Climate Change only includes events caused b. human actions, excluding most causes. Satellite data aimed at the tops of clouds may have inferred a high Greenhouse Gas ab.orption flux. The model showed more energy coming from the atmosphere than ab.orb.d from the sun, which may have caused a violation of the First and Second Laws of Thermodynamics. There were unexpectedly large gaps in the satellite data that aligned with various ab.orption b.nds of Greenhouse Gases, possib.y caused b. photon scattering associated with re-emissions. b.sed on science, we developed a cloud-b.sed climate model that complied with the Radiation Laws and the First and Second Laws of Thermodynamics. The Cloud Model showed that 81.3% of the outgoing reflected and infrared radiation was applicab.e to the clouds and water vapor. In comparison, the involvement of COb.2b. was only 0.04%, making it too minuscule to measure reliab.y.

关键词： Climate Change Greenhouse Gas CO2 Clouds Model Thermodynamics