检索结果-南通市图书馆

CD8+t.cell met.bolic flexibilit. elicit.d by CD28-ARS2 axisdriven alt.rnat.ve splicing of PKM support. ant.t.mor immunit.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Cait.in M.James Shivana M.Light.an Jason H.t.ng Guanxi Qiao t.ffany R.Emmons t.ejaswini Giridharan Shengqi Hou andrew M.Int.ekofer Richard M.Higashi t.resa W.M.Fan andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabet. A.Repasky Kelvin P.Lee Scot. H.Olejniczak Depart.ent.of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Depart.ent.of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pat.ogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Cent.r for Environment.l Syst.ms Biochemist.y Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Depart.ent.of Cancer Genet.cs and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present.address:Universit. of Colorado Boulder BoulderCO 80309USA Present.address:Dana Farber Cancer Inst.t.t. BostonMA 02215USA Present.address:Massachuset.s Inst.t.t. of t.chnology BostonMA 02139USA Present.address:Melvin and Bren Simon Comprehensive Cancer Cent.r Indiana University School of MedicineIndianapolisIN 46202USA

Met.bolic flexibilit. has emerged as a crit.cal det.rminant.of CD8+t.cell ant.t.mor act.vit.,yet.t.e mechanisms driving t.e met.bolic flexibilit. of t.cells have not.been *** t.is st.dy,we invest.gat.d t.e influence of t.e nuclear cap-binding complex(CBC)adapt.r prot.in ARS2 on mat.re t.*** doing so,we discovered a novel signaling axis t.at.endows act.vat.d CD8+t.cells wit. flexibilit. of glucose ***2 upregulat.on driven by CD28 signaling reinforced splicing fact.r recruit.ent.t. pre-mRNAs and affect.d approximat.ly one-t.ird of t.cell act.vat.on-induced alt.rnat.ve splicing *** t.ese effect.,t.e CD28-ARS2 axis suppressed t.e expression of t.e M1 isoform of pyruvat. kinase in favor of PKM2,a key det.rminant.of CD8+t.cell glucose ut.lizat.on,int.rferon gamma product.on,and ant.t.mor effect.r ***,PKM alt.rnat.ve splicing occurred independent.y of CD28-driven PI3K pat.way act.vat.on,revealing a novel means by which cost.mulat.on reprograms glucose met.bolism in CD8+t.cells.

关键词： Immunomet.bolism mRNA splicing CD8 t.cells ARS2 PKM2

Dynamics of self-hybridized excit.n–polarit.ns in 2D halide perovskit.s

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light.Science & Applicat.ons) 2024年第1期13卷 13-22页

作者： Surendra B.Anant.araman Jason Lynch Christ.pher E.St.vens Christ.pher Munley Chent.o Li Jin Hou Hao Zhang andrew t.rma t.omas Darlingt.n Francis Coen Kevin Li Arka Majumdar PJames Schuck Adit.a Mohit. Hayk Harut.unyan Joshua R.Hendrickson Deep Jariwala Depart.ent.of Elect.ical and Syst.ms Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laborat.ry Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Depart.ent.of Physics University of WashingtonSeattleWA98195USA Depart.ent.of Physics Emory UniversityAtlantaGA30322USA Depart.ent.of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Depart.ent.of Mat.rials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Depart.ent.of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Depart.ent.of Elect.ical and Comput.r Engineering University of WashingtonSeattleWA98195USA

Excit.ns,bound elect.on–hole pairs,in t.o-dimensional hybrid organic inorganic perovskit.s(2D HOIPs)are capable of forming hybrid light.mat.er st.t.s known as excit.n-polarit.ns(E–Ps)when t.e excit.nic medium is confined in an opt.cal *** t.e case of 2D HOIPs,t.ey can self-hybridize int. E–Ps at.specific t.icknesses of t.e HOIP cryst.ls t.at.form a resonant.opt.cal cavit. wit. t.e ***,t.e fundament.l propert.es of t.ese self-hybridized E–Ps in 2D HOIPs,including t.eir role in ult.afast.energy and/or charge t.ansfer at.int.rfaces,remain ***,we demonst.at. t.at.0.5µm t.ick 2D HOIP cryst.ls on Au subst.at.s are capable of support.ng mult.ple-orders of self-hybridized E–P *** E–Ps have high Q fact.rs(>100)and modulat. t.e opt.cal dispersion for t.e cryst.l t. enhance sub-gap absorpt.on and *** varying excit.t.on energy and ult.afast.measurement.,we also confirm energy t.ansfer from higher energy E–Ps t. lower energy E–***,we also demonst.at. t.at.E–Ps are capable of charge t.ansport.and t.ansfer at.*** findings provide new insight. int. charge and energy t.ansfer in E–Ps opening new opport.nit.es t.wards t.eir manipulat.on for polarit.nic devices.

关键词： charge polar excit.t.on

Evaluat.on of nat.ral goet.it. on t.e removal of arsenat. and selenit. from wat.r

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environment.l Sciences 2019年第2期31卷 133-141页

作者： andrew t.Jacobson Maohong Fan Depart.ent.of Chemical Engineering University of Wyoming

Elevat.d arsenic and selenium concent.at.ons in wat.r cause healt. problems t. bot. humans and wildlife. Nat.ral and ant.ropogenic act.vit.es have caused cont.minat.on of t.ese element. in wat.rs worldwide, making t.e development.of efficient.cost.effect.ve met.ods in t.eir removal essent.al. In t.is work, removal of arsenat. and selenit. from wat.r by adsorpt.on ont. a nat.ral goet.it.(α-FeO OH) sample was st.died at.varying condit.ons. t.e dat. was t.en compared wit. ot.er arsenat., selenit./goet.it. adsorpt.on syst.ms as much of lit.rat.re shows discrepancies due t. varying adsorpt.on condit.ons. Charact.rizat.on of t.e goet.it. was complet.d using induct.vely coupled plasma mass spect.omet.y, X-ray diffract.on, Fouriert.ansform infrared spect.oscopy, scanning elect.on microscopy, and Brunauer–Emmet.–t.ller surface area analysis. Pseudo-first.order(PFO) and pseudo-second order(PSO) kinet.c models were applied; including comparisons of different.regression met.ods. Various adsorpt.on isot.erm models were applied t. det.rmine t.e best.fit.ing model and t. compare adsorpt.on capacit.t.s wit. ot.er works. Desorpt.on/leaching of arsenat. and selenit. was st.died t.ough t.e addit.on of phosphat. and hydroxyl ions. Langmuir isot.erm modeling result.d in maximum adsorpt.on capacit.es of 6.204 and 7.740 mg/g for arsenat. and selenit. adsorpt.on,respect.vely. t.e PSO model applied wit. a non-linear regression result.d in t.e best.kinet.c fit. for bot. adsorpt.on and desorpt.on of arsenat. and selenit.. Adsorpt.on decreased wit. increasing pH. Phosphat. induced desorpt.on result.d in t.e highest.percent.ge of arsenat. and selenit. desorbed, while hydroxide induced result.d in t.e fast.st.desorpt.on kinet.cs.

关键词： Arsenic Selenium Adsorpt.on Desorpt.on FeOOH Wat.r t.eat.ent

Synt.esis, propert.es, and applicat.ons of graphene oxide/reduced graphene oxide and t.eir nanocomposit.s

在线全文

学校读者我要写书评

暂无评论

Nano Mat.rials Science 2019年第1期1卷 31-47页

作者： andrew t. Smit. Anna Marie LaChance Songshan Zeng Bin Liu Luyi Sun Polymer Program Institute of Materials Science University of Connecticut Storrs Connecticut 06269 United States Depart.ent.of Chemical and Biomolecular Engineering University of Connecticut Storrs Connecticut 06269 United States of Mat.rials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Depart.ent.of Biomedical Engineering University of Connecticut Storrs Connecticut 06269 United States

t.anks t. t.eir remarkable mechanical, elect.ical, t.ermal, and barrier propert.es, graphene-based nanocomposit.s have been a hot.area of research in t.e past.decade. Because of t.eir simple t.p-down synt.esis, graphene oxide (GO) and reduced graphene oxide (rGO) have opened new possibilit.es for gas barrier, membrane separat.on, and st.muli-response charact.rist.cs in nanocomposit.s. Herein, we review t.e synt.esis t.chniques most.commonly used t. produce t.ese graphene derivat.ves, discuss how synt.esis affect. t.eir key mat.rial propert.es, and highlight.some examples of nanocomposit.s wit. unique and impressive propert.es. We specifically highlight.t.eir performances in separat.on applicat.ons, st.muli-responsive mat.rials, ant.-corrosion coat.ngs, and energy st.rage. Finally, we discuss t.e out.ook and remaining challenges in t.e field of pract.cal indust.ial-scale product.on and use of graphene-derivat.ve-based polymer nanocomposit.s.

关键词： Graphene oxide Reduced graphene oxide Graphene quant.m dot. polymer Nanocomposit.s Synt.esis Propert.es of graphene and graphene oxide Applicat.ons

Primary parasit.ids of red scale （Aonidiella aurant.i） in Aust.alia and a review of t.eir int.oduct.ons from Asia

在线全文

学校读者我要写书评

暂无评论

Insect.Science 2017年第1期24卷 150-168页

作者： Hang t. Dao G. andrew C. Beat.ie Robert.Spooner-Hart.Markus Riegler Paul Holford Universit. of West.rn Sydney Penrith NSW 2751 Australia Plant.Prot.ct.on Research Inst.t.t. Chem Tu Liem Hanoi Vietnam

We used morphological and molecular differences t. confirm t.e ident.t.es of red scale （Aonidiella aurant.i） and yellow scale （A. cit.ina）, and t.eir primary parasit.ids, in Aust.alia. An ext.nsion t. t.e dist.ibut.on of yellow scale was confirmed. Six primary parasit.ids of red scale were ident.fied： Aphyt.s chrysomphali, A. lingnanensis, A. melinus, Comperiella bifasciat., Encarsia cit.ina, and E. perniciosi. Wit. t.e except.on of A. lingnanensis, t.ese parasit.ids, and a species of Aphelinus, were det.ct.d in associat.on wit. red scale during st.dies in cit.us orchards in coast.l New Sout. Wales bet.een 2009 and 2012. t.o races ofA. melinus were recorded： one from t.e Indian Subcont.nent. t.e ot.er previously only recorded in China. t.e st.dies, and reviews of hist.rical records, led us t. conclude t.at.4 parasit.ids, A. lingnanensis, C. bifasciat., and bot. species of Encarsia, were present.in Aust.alia before successful or unsuccessful formal int.oduct.ons bet.een 1902 and 1970. t.e A. melinus race previously recorded in China may also have been present.before t.e Indian Subcont.nent.race was formally int.oduced in 1961. We suggest.t.e possibilit. t.at.t.e nat.ral dist.ibut.on of some of t.e parasit.ids may include East.and Sout.east.Asia, and part. of Aust.alasia. We found no report. of nat.ve armored scales being recorded on species and hybrids of Cit.us int.oduced t. Aust.alia, and no report. of int.oduced armored scales being recorded on nat.ve Rut.ceae, including 6 species of Cit.us. However, we subsequent.y recorded yellow scale on Geijera parviflora, a nat.ve rut.ceous t.ee.

关键词： Aonidiella Aphyt.s cit.us Comperiella Encarsia red scale

Comparison of Ext.apolat.on and Int.rpolat.on Met.ods for Est.mat.ng Daily Phot.synt.et.cally Act.ve Radiat.on(PAR)——A Case St.dy of t.e Poyang Lake Nat.onal Nat.re Reserve,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geo-Spat.al Informat.on Science 2010年第4期13卷 235-242页

作者： WU Guofeng Jan de Leeuw andrew K. Skidmore LIU Yaolin Herbert.H. t. Prins School of Resource and Environment.l Science Wuhan University 129 Luoyu Road Wuhan 430079 China Key Laborat.ry of Geographic Informat.on Syst.m of t.e Minist.y of Educat.on Wuhan University 129 Luoyu Road Wuhan 430079 China Int.rnat.onal Livest.ck Research Inst.t.t. (ILRI) P. O. Box 30709 Nairobi 00100 Kenya Depart.ent.of Nat.ral Resources International Institute for Geo-Information Science and Earth Observation P. O. Box 6 Hengelosestraat 99 7500 AA Enschede the Netherlands Resource Ecology Group Department of Environmental Sciences Wageningen University Droevendaalsesteeg 3A 6708 PB Wageningen the Netherlands

Measurement. of phot.synt.et.cally act.ve radiat.on （PAR）, which are indispensable for simulat.ng plant.growt. and product.vit., are generally very scarce. t.is st.dy aimed t. compare t.o ext.apolat.on and one int.rpolat.on met.ods for est.mat.ng daily PAR reaching t.e eart. surface wit.in t.e Poyang Lake nat.onal nat.re reserve, China. t.e daily global solar radiat.on records at.Nanchang met.orological st.t.on and daily sunshine durat.on measurement. at.nine met.orological st.t.ons around Poyang Lake were obt.ined t. achieve t.e object.ve. t.o ext.apolat.on met.ods of PARs using recorded and est.mat.d global solar radiat.on at.Nanchang st.t.on and t.ree st.t.ons （Yongxiu, Xingzi and Duchang） near t.e nat.re reserve were carried out. respect.vely, and a spat.al int.rpolat.on met.od combining t.iangulat.d irregular net.ork （t.N） and inverse dist.nce weight.ng （IDW） was imple- ment.d t. est.mat. daily PAR. t.e performance evaluat.on of t.e t.ree met.ods using t.e PARs measured at.Dahuchi Conservat.on St.t.on （day number of measurement.= 105 days） revealed t.at. （1） t.e spat.al int.rpolat.on met.od achieved t.e best.PAR est.ma- t.on （R2 - 0.89, s.c. = 0.99, F= 830.02, P 〈 0.001 ）; （2） t.e ext.apolat.on met.od from Nanchang st.t.on obt.ined an unbiased result.（R2 = 0.88, s.c. = 0.99, F = 745.29, P 〈 0.001）; however, （3） t.e ext.apolat.on met.ods from Yongxiu, Xingzi and Duchang st.t.ons were not.suit.ble for t.is specific sit. for t.eir biased est.mat.ons. Considering t.e assumpt.ons and principles support.ng t.e ext.apolat.on and int.rpolat.on met.ods, t.e aut.ors conclude t.at.t.e spat.al int.rpolat.on met.od produces more reliable result. t.an t.e ext.apolat.on met.ods and holds t.e great.st.pot.nt.al in all t.st.d met.ods, and more PAR measurement. should be recorded t. evaluat. t.e seasonal, yearly and spat.al st.bilit.es of t.ese models for t.eir applicat.on t. t.e whole nat.re reserve of Poyang Lake.

关键词： phot.synt.et.cally act.ve radiat.on (PAR) ext.apolat.on int.rpolat.on t.iangulat.d irregular net.ork (t.N) inverse dist.nce weight.ng (IDW)

Novel ecosyst.ms creat.d by coal mines in cent.al Queensland’s Bowen Basin

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2013年第1期2卷 368-379页

作者： Pet.r D Erskine andrew t.Flet.her Cent.e for Mined Land Rehabilit.t.on The University of QueenslandBrisbane QLD 4072Australia

Int.oduct.on:Open-cut.coal mining began in cent.al Queensland’s Bowen Basin approximat.ly 50 years *** t.is period of t.me,mine rehabilit.t.rs have used a variet. of t.ee,shrub,and groundcover species t. creat.‘novel ecosyst.ms’t. st.bilise soils and provide veget.t.ve cover for pre-supposed final end-land *** examine post.mining rehabilit.t.on from mult.ple soil and veget.t.on monit.ring act.vit.es in t.e Bowen Basin t. assess t.e similarit. of landforms,plant.composit.on,and t.ends in plant.diversit. compared t. unmined reference ***:Rehabilit.t.d spoil dumps and reference sit.s were assessed using soil and veget.t.on dat. cont.ined in compliance monit.ring report. from Goonyella Riverside,Moura,Oaky Creek,Rollest.n,and Blackwat.r ***,soil chemist.y,and plant.species mixes of rehabilit.t.on aged from 2 t. 22 years were compared t. select.d reference ***:Mines in t.is region have generally proposed one of t.o post.rehabilit.t.on end-land uses:eit.er past.re for cat.le grazing or reconst.uct.d nat.ve communit.es which pot.nt.ally provide nat.ve fauna *** dat. from a select.on of t.ese mine sit.s suggest.t.at.when t.eir rehabilit.t.on was compared t. nearby reference sit.s median slope values were bet.een 2.5 and 7 t.mes st.eper and soil pH,elect.ical conduct.vit.,and phosphorus levels were significant.y *** st.eply sloped landforms,poor soil charact.rist.cs,depauperat. nat.ve species pool,and uniform presence of exot.c past.re grasses in t.e rehabilit.t.on indicat. t.at.most.of t.ese newly creat.d ecosyst.ms should not.be used for cat.le grazing and also have few nat.ral ***:Legislat.ve and communit. expect.t.ons have changed progressively over t.me and,alt.ough much of t.e rehabilit.t.on is current.y dominat.d by an assemblage of exot.c buffel grass(Cenchrus ciliaris)and Acacia spp.,recent.environment.l aut.orit.es suggest.t.ese‘novel ecosyst.ms’will be judged against.nat.ve refere

关键词： Coal mining Complet.on crit.ria Environment.l condit.ons Novel ecosyst.ms

Pseudouridines in spliceosomal snRNAs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prot.in & Cell 2011年第9期2卷 712-725页

作者： andrew t.Yu Junhui Ge Yi-t.o Yu Depart.ent.of Biochemist.y and Biophysics Center for RNA BiologyUniversity of Rochester Medical Center601 Elmwood AvenueRochesterNY 14642USA Depart.ent.of Pat.ology Changzheng HospitalSecond Military Medical UniversityShanghai 200003China

Spliceosomal RNAs are a family of small nuclear RNAs(snRNAs)t.at.are essent.al for pre-mRNA *** vert.brat. spliceosomal snRNAs are ext.nsively pseudouridylat.d aft.r *** in spliceosomal snRNAs are generally clust.red in regions t.at.are funct.onally import.nt.during *** of t.ese modified nucleot.des are conserved across species *** st.dies have demonst.at.d t.at.spliceosomal snRNA pseudouridylat.on is cat.lyzed by t.o different.mechanisms:an RNA-dependent.mechanism and an RNA-independent.*** funct.ons of t.e pseudouridines in spliceosomal snRNAs(U2 snRNA in part.cular)have also been ext.nsively *** dat. indicat. t.at.virt.ally all pseudouridines in U2 snRNA are funct.onally *** t.e current.y known pseudouridines(const.t.t.ve modificat.ons),recent.work has also indicat.d t.at.pseudouridylat.on can be induced at.novel posit.ons under st.ess condit.ons,t.us st.ongly suggest.ng t.at.pseudouridylat.on is also a regulat.ry modificat.on.

关键词： small nuclear RNAs(snRNAs) pseudouridine spliceosome small nuclear ribonucleoprot.ins(snRNPs)

在线全文

学校读者我要写书评

暂无评论

Ride t.e Indian

考试与评价（英语高一专刊） 2018年第9期 43-44,38页

作者： andrew t. Pellet.er