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Neck dissection does not add to morbidity or mortality of laryngectomy

World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第4期5卷 215-221页

作者： Christopher C.Xiao Sarah A.Imam Shaun A.Nguyen Marc P.Camilon andrew b.baker Terry A.Day Eric J.Lentsch Department of Otolaryngology-Head and Neck Surgery Kaiser PermanenteNorthern CaliforniaOaklandCA94612USA Department of Health and Human Performance The CitadelCharlestonSC29409USA Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSC29425USA Oregon Health&Science University Ear Nose&ThroatPortlandOR97239USA

Objectives:To examine the national rates of complications,readmission,reoperation,death and length of hospital stay after *** explore the risks of neck dissection with laryngectomy using ***:The American College of Surgeons National Quality Improvement Program(ACS-NSQIP)database was reviewed *** database was analyzed for patients undergoing laryngectomy with and without neck ***,perioperative complication,reoperation,readmission,and death variables were ***:754 patients who underwent total laryngectomy during this time were *** analysis showed average age was 63 years old,566(75.1%)were white,and 598(79.3%)were *** these patients,520(69.0%)included a neck dissection while 234(31.0%)did *** comparing patients who received a neck dissection to those who did not,there were no significant differences in median length of hospital stay(12.5 days w/vs.13.3 days w/o,P=0.99),rates of complication(40%w/vs.35%w/o,P=0.23),reoperation(13.5%w/vs.14%w/o,P=0.81),readmission(14%w/vs.18%w/o,P=0.27),and death(1.3%w/vs.1.3%w/o,P>0.99).Furthermore,neck dissection did not increase the risk of complication(P=0.23),readmission(P=0.27),reoperation(P=0.81),death(P=0.94),or lengthened hospital stay(P=0.38).Conclusions:Concurrent neck dissection does not increase postoperative morbidity or mortality in patients undergoing total *** results may help physicians make decisions regarding concurrent neck dissection with total laryngectomy.

关键词： Laryngectomy Neck dissection Total laryngectomy Complication rates Outcomes

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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.beeren G.Dos Santos P.J.Dijkstra C.Mota J.bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.b.baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3b’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3b’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERbASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(bMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of bMP receptor II(bMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing blending Surface functionalization Surface density Click chemistry Human

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Thiol-ene conjugation of a VEGF peptide to electrospun scaffolds for potential applications in angiogenesis

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bioactive Materials 2023年第2期20卷 306-317页

作者： Tianyu Yao Honglin Chen Rong Wang Rebeca Rivero Fengyu Wang Lilian Kessels Stijn M.Agten Tilman M.Hackeng Tim G.A.M.Wolfs Daidi Fan Matthew b.baker Lorenzo Moroni Shaanxi Key Laboratory of Degradable biomedical Materials and Shaanxi R&D Center of biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityTaibai North Road 229Xi’anShaanxi710069China Complex Tissue Regeneration Department MERLN Institute for Technology Inspired Regenerative MedicineMaastricht UniversityMaastricht6229 ERthe Netherlands Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhou510080China Radboudumc Department of Dentistry-Regenerative BiomaterialsRadboud University Medical CenterPhilips van Leydenlaan 256525 EXNijmegenthe Netherlands School of Medicine South China University of TechnologyGuangzhou510006China Maastricht University Medical Center MUMC+ P.Debyelaan 256229 HXMaastrichtthe Netherlands Research School for Cardiovascular Diseases(CARIM) Maastricht UniversityUniversiteitssingel 506229ER Maastrichtthe Netherlands School for Oncology and Developmental biology(GROW) Maastricht UniversityUniversiteitssingel 406229ER Maastrichtthe Netherlands

Vascular endothelial growth factor(VEGF)plays a vital role in promoting attachment and proliferation of endothelial cells,and induces *** recent years,much research has been conducted on the functionalization of tissue engineering scaffolds with VEGF or a VEGF-mimetic peptide to promote ***,most chemical reactions are nonspecific and require organic solvents,which can compromise control over functionalization and alter peptide/protein *** attractive alternative is the fabrication of functionalizable electrospun fibers,which can overcome these *** this study,we used thiol-ene chemistry for the conjugation of a VEGF-mimetic peptide to the surface of poly(ε-caprolactone)(PCL)fibrous scaffolds with varying amounts of a functional PCL-diacrylate(PCL-DA)polymer.30%PCL-DA was selected due to homogeneous fiber morphology.A VEGF-mimetic peptide was then immobilized on PCL-DA fibrous scaffolds by a light-initiated thiol-ene reaction.7-Mercapto-4-methylcoumarin,RGD-FITC peptide and VEGF-TAMRA mimetic peptide were used to validate the thiol-ene reaction on the fibrous *** strength and elastic modulus of the 30%PCL-DA fibrous scaffolds were significantly increased after the *** of the 30%PCL-DA fibrous scaffolds with the VEGF peptide increased the surface water wettability of the *** structures could be obtained after using a photomask on the fibrous ***,in vitro studies indicated that scaffolds functionalized with the VEGF-mimetic peptide were able to induce phosphorylation of the VEGF receptor and enhanced HUVECs survival,proliferation and adhesion.A chick chorioallantoic membrane(CAM)assay further indicated that the VEGF peptide functionalized scaffolds were able to promote angiogenesis in *** results show that scaffold functionalization can be controlled via a simple polymer mixing approach,and that the functionalized VEGF peptide-scaffolds have potential for vascular

关键词： Electrospinning Fibrous scaffolds Thiol-ene reaction VEGF peptide

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Dairy cows inoculated with highly pathogenic avian influenza virus H5N1

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四川生理科学杂志 2024年第10期46卷 2275-2275页

作者： Amy L baker Virus and Prion Research Unit National Animal Disease Center Agricultural Research Service United States Department of Agriculture Ames Iowa USA National Veterinary Services Laboratories Animal and Plant Health Inspection Service United States Department of Agriculture Ames Iowa USA Veterinary Diagnostic and Production Animal Medicine Iowa State University Ames Iowa USA

Highly pathogenic avian influenza(HPAI)H5N1 hemagglutinin clade 2.***.4.4b was detected in the United States in *** HPAI viruses caused mortality events in poultry,wild birds,and wild *** March 25,2024,HPAI H5N1 clade 2.***.4.4b was confirmed in a dairy cow in Texas in response to a multi-state investigation into milk production losses.1 Over 200 positive herds were identified in 14 *** case description included reduced feed intake and rumen motility in lactating cows,decreased milk production,and thick yellow milk.2,3 The diagnostic investigation revealed viral RNA in milk and mammary tissue with alveolar epithelial degeneration and necrosis and positive immunoreactivity of glandular epithelium.A single transmission event,likely from birds,was followed by limited local transmission and onward horizontal transmission of H5N1 clade 2.***.4.4b genotype b3.13.4 We sought to experimentally reproduce infection with genotype b3.13 in Holstein yearling heifers and lactating *** were inoculated by aerosol respiratory route and cows by intramammary *** disease was mild in heifers,but infection was confirmed by virus detection,lesions,and *** disease in lactating cows included decreased rumen motility,changes to milk appearance,and production *** was confirmed by high levels of viral RNA detected in milk,virus isolation,lesions in mammary tissue,and *** study provides the foundation to investigate additional routes of infection,pathogenesis,transmission,and intervention strategies.

关键词： H5N1 cows fir

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Oxidative stress and male reproductive health

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Asian Journal of Andrology 2014年第1期16卷 31-38页

作者： Robert J Aitken Tegan b Smith Matthew S Jobling Mark A baker Geoffry N De Iuliis Priority Research Centre in Reproductive Science Discipline of Biological Sciences Faculty of Science and IT University of Newcastle Callaghan NSW 2308 Australia

One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to proteins and lipids in the sperm plasma membrane. The origins of such oxidative stress appear to involve the sperm mitochondria, which have a tendency to generate high leve｜s of superoxide anion as a prelude to entering the intrinsic apoptotic cascade. Unfortunately, these cells have very little capacity to respond to such an attack because they only possess the first enzyme in the base excision repair （bER） pathway, 8-oxoguanine glycosylase 1 （OGG1）. The latter successfully creates an abasic site, but the spermatozoa cannot process the oxidative lesion further because they lack the downstream proteins （APE1, XRCC1） needed to complete the repair process. It is the responsibility of the oocyte to continue the bER pathway prior to initiation of S-phase of the first mitotic division. If a mistake is made by the oocyte at this stage of development, a mutation will be created that will be represented in every cell in the body. Such mechanisms may explain the increase in childhood cancers and other diseases observed in the offspring of males who have suffered oxidative stress in their germ line as a consequence of age, environmental or lifestyle factors. The high prevalence of oxidative DNA damage in the spermatozoa of male infertility patients may have implications for the health of children conceived in vitro and serves as a driver for current research into the origins of free radical generation in the germ line.

关键词： DNA damage oxidative stress oxoguanine glycosylase 1 oocyte spermatozoa

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A comparative study on microstructure,nanomechanical and corrosion behaviors of AlCoCuFeNi high entropy alloys fabricated by selective laser melting and laser metal deposition

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Journal of Materials Science & Technology 2022年第36期131卷 221-230页

作者： Yaojia Ren Hong Wu bin Liu Yong Liu Sheng Guo ZbJiao Ian baker State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Department of Industrial and Materials Science Chalmers University of TechnologyGothenburg SE-41296Sweden Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Thayer School of Engineering Dartmouth CollegeHanover NH 03755-8000United States

The present study investigated the microstructure,nanomechanics,and corrosion behavior of AlCoCuFeNi high entropy alloys fabricated by selective laser melting(SLM)and laser metal deposition(LMD).The microstructure of SLM-processed specimens was mainly composed of columnar-grained bCC matrix(^90μm in width)and Cu-rich twinned FCC *** columnar grains grew epitaxially along the building direction and exhibited a strong{001}*** comparison,a coarse columnar-grained bCC matrix(^150μm in width)with a strongertexture,rod-like b2 precipitates,and large core-shell structured FCC phases were formed in the LMD-processed specimens due to the higher heat accumulation ***,the LMD-processed specimens showed a lower hardness,wear resistance,and corrosion resistance,but higher creep resistance and reduced Young's modulus than the SLM-processed *** cracks occurred in both types of specimens,which could not be completely suppressed due to Cu segregation.

关键词： Selective laser melting Laser metal deposition High entropy alloys Nanomechanics Corrosion

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Comparison of Phosphorus Sorption by Light-Weight Aggregates Produced in the United States

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Pedosphere 2014年第6期24卷 808-816页

作者： M.D.baker S.SIMKINS L.A.SPOKAS P.L.M.VENEMAN b.S.XING Stockbridge School of Agriculture University of MassachusettsAmherstMA 01003 (USA) U.S.Army Fort HoodTX 76544 (USA)

In this study, phosphorus(P) sorption of thirteen light-weight aggregates(LWAs) from USA was compared during batch equilibrium experiments in order to identify those materials which had the highest P sorption capacity for further study. Seven different levels of sorption activity were observed, which were broadly grouped into three categories—high performing, middle performing, and low performing aggregates. Chemical analysis of Ca, Al, Fe, and Mg was used to describe the differences between LWAs. There was a significant correlation between cation(especially Al, Ca, Fe, and Mg) content and P sorbed. Langmuir isotherms were used to describe P sorption maximum and binding affinity for four of the top five performing LWAs, Universal, Stalite "D", Stalite "Mix", and *** fifth aggregate, Lehigh, exhibited more complex sorption, and was better described by the Freundlich isotherm. Universal had a mean P sorption at the highest concentration of 824 mg kg-1, well above its calculated sorption maximum(702 mg kg-1), and also had the highest binding affinity(1.1 L mg-1). This experiment suggests that the top performing LWA(Universal) may perform poorly in column and field studies due to observed precipitates, which could degrade constructed wetland performance. Other LWAs may exhibit superior field performance due to their high calculated sorption maxima. In general, these results highlight the importance of batch experiments as a first step in identifying materials suitable for column and field experiments.

关键词： binding affinity constructed wetlands equilibrium P concentration media P sorption capacity

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Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

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biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： XIAO Tian Li YUAN Shu Qian GAO Jing Yu Julien Sbaker YANG Yi De WANG Xi Jie ZHENG Chan Juan DONG Yan Hui ZOU Zhi Yong Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

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Human Invasion by Lesser Known Medically Important Trematodes in the Proximity of Tshwane,Gauteng Province,South Africa

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地学前缘 2009年第S1期16卷 78-79页

作者： E.b.E.Moema P.H.King C.baker Department of biology University of Limpopo EM-Unit University of Limpopo

It is well-documented that digenetic trematodes exhibit complex life cycles where the definitive hosts are vertebrates—mostly birds,other mammals and *** is also known that digenetic trematodes are host specific,but changes in our feeding habits, agricultural and social practices,have led to human beings infected with parasites that were previously regarded to be of no or insignificant medical importance. The objective of this study was to identify the less known digenetic parasites in the water bodies around Tshwane that may result in possible

关键词： digenetic trematodes life cycles medical importance control measures

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Prognostic impact of the bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 157-162页

作者： Michael J Passeri Maria R baimas-George Jesse K Sulzer David A Iannitti John b Martinie Erin H baker Lee M Ocuin Dionisios Vrochides Division of HPb Surgery Department of SurgeryCarolinas Medical Center1025 Morehead Medical Dr.Suite 600CharlotteNC 28204USA

background:The bismuth-Corlette(bC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary *** the right hepatic artery crosses just behind the left bile duct,we hypothesized that bCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral ***:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September *** were assigned bC stages based on preoperative ***:Sixty-eight patients were included in the *** underwent staging laparoscopy after which 16 cases were aborted for metastatic *** the remaining 52 cases,14 cases were explored and aborted for locally advanced ***-eight underwent attempt at curative *** exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for bCⅢb staged lesions compared to 80.0%of bCⅢa lesions and to 82.4%for bCⅠ-Ⅲa staged lesions(Pbout 44.4%of bCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining bC ***:When hilar cholangiocarcinoma is preoperatively staged as bCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery.

关键词： bismuth-Corlette stage Cholangiocarcinoma biliary tract surgical procedures biliary tree Liver surgery

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