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Hyperhomocysteinemia and Associated Biological Markers in a Congolese Population of Type 2 Diabetes Mellitus in Brazzaville

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Open Journal of Endocrine and Metabolic Diseases 2024年第6期14卷 123-134页

作者： V. R. Ikia Monde A. L. M. Boumba E. Mokondjimobe H. Poaty G. Loubano-Voumbi W. F. Ondongo A. G. Mayindou Kimbangu K. Onanga F. Elilie Mawa Ongoth E. Bouenizabila C. andres H. G. Monabeka Biochemistry Laboratory Service University Hospital Center Brazzaville Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Congo Research Area of Pointe-Noire National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Congo Microbiology and Molecular Biology Department Loandjili General Hospital Pointe-Noire Congo LOMO Research University Kinshasa DRC Department of Statistics Health Information and Epidemiology Surveillance Departmental Directorate of Health Care and Services Brazzaville Congo Department of Endocrinology University Hospital Center Brazzaville Congo Department of Biochemistry and Molecular Biology Bretonneau Regional University Hospital Tours France

The search for new biomarkers predictive of type 2 diabetes currently constitutes a research avenue in Bioclinical. Total homocysteine remains a preferred target due to its involvement in the occurrence of degenerative complications in type 2 diabetics. The aim of this work was to study hyperhomocysteinemia and other biochemical markers associated with T2D in the Congolese population. This was an analytical case-control study carried out between October 2022 and October 2023. The study population consisted of 150 subjects including 100 T2D patients and 50 control subjects. The main clinical data were collected on a pre-established form. Homocysteine determination was carried out by the sandwich ELISA method. The other biochemical markers were measured by colorimetric enzymatic methods. Hyperhomocysteinemia was present in 27.3% (41/150) of the entire study population. Type 2 diabetics had a frequency of hyperhomocysteinemia of 36% (36/100) and control 10% (5/50) (p = 0.001). The mean hyperhomocysteinemia concentration was 31.9 μmol/l with extremes ranging from 18 to 103 μmol/l. Means of biological markers between diabetics and controls showed a statistically significant difference (p = 0.01). The risk factors associated with this HHcy were: sex (OR = 3.5), age (OR = 9.4), sedentary lifestyle (OR = 3.4) and glycosylated hemoglobin (OR = 12) with a p-value <0.05 respectively. Our results suggest that hyperhomocysteinemia can be considered as a predictive biomarker in the bioclinic of Congolese type 2 diabetic patients.

关键词： Hyperhomocysteinemia Biological Markers T2DM Brazzaville

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Rupture area analysis of the Ecuador (Musine) Mw = 7.8 thrust earthquake on April 16, 2016, using GOCE derived gradients

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Geodesy and Geodynamics 2017年第1期8卷 49-58页

作者： Orlando Alvarez andres Folguera Mario Gimenez lnstituto Geofisico y Sismologico lng Volponi Universidad Nacional de San Juan Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Argentina indean-instituto de Estudios Andinos "Don Pablo Groeber" Departamento de Cs. Geologicas FCEN Universidad de Buenos Aires Argentina

The Ecuador Mw - 7.8 earthquake on April 16, 2016, ruptured a nearly 200 km long zone along the plate interface between Nazca and South American plates which is coincident with a seismic gap since 1942, when a Mw - 7.8 earthquake happened. This earthquake occurred at a margin characterized by moderately big to giant earthquakes such as the 1906 （Mw 8.8）. A heavily sedimented trench explains the abnormal lengths of the rupture zones in this system as inhibits the role of natural barriers on the propagation of rupture zones. High amount of sediment thickness is associated with tropical climates, high erosion rates and eastward Pacific dominant winds that provoke orographic rainfalls over the Pacific slope of the Ecuatorian Andes. Offshore sediment dispersion off the oceanic trench is controlled by a close arrangement of two aseismic ridges that hit the Costa Rico and South Ecuador margin respectively and a mid ocean ridge that separates the Cocos and Nazca plate trapping sediments. Gravity field and Ocean Circulation Explorer （GOCE） satellite data are used in this work to test the possible relationship between gravity signal and earthquake rupture structure as well as registered aftershock seismic activity. Reduced vertical gravity gradient shows a good correlation with rupture structure for certain degrees of the harmonic expansion and related depth of the causative mass; indicating, such as in other analyzed cases along the subduction margin, that fore-arc structure derived from density heterogeneities explains at a certain extent propagation of the rupture zones. In this analysis the rupture zone of the April 2016 Ecuador earthquake developed through a relatively low density zone of the fore-arc sliver. Finally, aftershock sequence nucleated around the area of maximum slips in the rupture zone, suggesting that heterogeneous density structure of the fore-arc determined from gravity data could be used in forecasting potential damaged zones associated with big rupture

关键词： Gravity field and Ocean Circulation Explorer(GOCE)Vertical gravity gradientEcuador earthquakeTrench sedimentsRupture zone

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All-optical switching in silicon photonic waveguides with an epsilon-near-zero resonant cavity [Invited]

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Photonics Research 2018年第5期6卷 I0026-I0030页

作者： andres D.NEIRA GREGORY A.WURTZ ANATOLY V.ZAYATS Department of Physics King's College London

Strong nonlinearity of plasmonic metamaterials can be designed near their effective plasma frequency in the epsilon-near-zero(ENZ) regime. We explore the realization of an all-optical modulator based on the Au nonlinearity using an ENZ cavity formed by a few Au nanorods inside a Si photonic waveguide. The resulting modulator has robust performance with a modulation depth of about 30 dB/μm and loss less than 0.8 dB for switching energies below 600 fJ. The modulator provides a double advantage of high mode transmission and strong nonlinearity enhancement in the few-nanorod-based design.

关键词： All-optical switching silicon photonic waveguides an epsilon-near-zero resonant cavity

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Hyponatraemia and cirrhosis

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Gastroenterology Report 2014年第1期2卷 21-26页

作者： Robert J.Gianotti andres Cardenas Department of Gastroenterology Beth Israel Deaconess Medical CenterBoston MA GI Unit Institut Clinic de Malalties Digestives i MetaboliquesHospital ClinicUniversity of Barcelona

Hyponatraemia is a common complication of advanced cirrhosis related to an impairment in the renal capacity for eliminating solute-free water,causing a retention of water that is disproportionate to the retention of sodium,thus leading to a reduction in serum sodium concentration and *** main pathogenic factor responsible for hyponatraemia is a non-osmotic hypersecretion of arginine vasopressin(AVP)or antidiuretic hormone from the neurohypophysis,related to circulatory *** in cirrhosis is associated with increased morbidity and *** is also associated with increased morbidity and impaired short-term survival after *** current standard of care based on restricting fluids to 1-1.5 L/day is rarely *** approaches,such as albumin infusion and the use of vaptans—which act by specifically antagonizing the effects of AVP on the V2 receptors located in the kidney tubules—have been evaluated for their role in the management of *** short-term treatment with vaptans is associated with a marked increase in renal solute-free water excretion and improvement of hyponatraemia;however their use in patients with end-stage liver disease is limited by hepatotoxic effects of some of these *** administration of vaptans seems to be effective in maintaining the improvement of serum sodium concentration,but the available information is still limited.

关键词： hyponatraemia cirrhosis end-stage liver disease vaptans

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Platelet rich plasma(PRP)induces autophagy in osteoblast precursor 3T3-L1

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BIOCELL 2018年第1期42卷 13-16页

作者： SERGIO andres CARMINATI MARÍA CAROLINA BARBOSA CLAUDIO MARCELO FADER Universidad Nacional de Cuyo Facultad de OdontologíaMendozaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET).Instituto de Histología y Embriología(IHEM) Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendozaArgentina

Autophagy is an essential cellular homeostatic mechanism by which intracellular components are delivered into the lysosomes for degradation and *** has been related with a diversity of pathological or physiological dentary processes such as bone remodeling,skeletal aging,osteoclastogenesis,osteoblastogenesis and different types of oral ***-rich plasma(PRP),isolated from autologous blood,is a plasma preparation containing a higher concentration of platelets which contains numerous different growth factors and cytokines that activate several cellular signaling *** purpose of this study is to investigate the effect of PRP on autophagy stimulation in both osteoblast precursor 3T3-L1 and non-related osteoblastic *** results showed that PRP can increase the number of autophagic structures in 3T3-L1 and HeLa(cervical cancer cells)***,we have determined by Western blot a rise in the lipidated form of the autophagic protein LC3(***3-II)upon PRP *** together,our results suggest that PRP is able to induce a strongly autophagy response in osteoblast precursor and,to a lesser extent,in non-related osteoblastic cells,suggesting that PRP could be a potential therapeutic tool for some autophagy-related diseases associated with bone homeostasis.

关键词： Autophagy 3T3-L1 Platelet rich plasma Odontology

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Coxsackievirus B infection presenting as a hemorrhagic pericardial effusion causing tamponade

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Journal of Geriatric Cardiology 2020年第10期17卷 642-644页

作者： Fadi Kandah Pooja Dhruva Jose Ruiz andres Martinez William Kogler Internal Medicine University of Florida Health JacksonvilleJacksonvilleUSA

The coxsackievirus is well known for its vastly differing clinical *** with coxsackievirus usually present with a viral prodrome which can then progress to the cardiac symptoms of chest pain and/or *** patients improv... 详细信息

关键词： Cardiac tamponade Coxsackievirus Pericarditis

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Different maternal investment strategies for male and female calves in a polygynous mammal

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Current Zoology 2019年第3期65卷 269-277页

作者： Francisco CEACERO Martina KOMARKOVA andres J.GARCIA Laureano GALLEGO Department of Animal Science and Food Processing Faculty of Tropical AgriSciencesCzech University of Life Sciences Kamycka 12916500 Praha 6-Suchdol Czech Republic Department of Ethology Institute of Animal Science Pratelstvi 815 10401 Praha - Uhnneves Czech Republic Instituto de Investigacion en Recursos Cinegeticos (IREC) Consejo Superior de Investigaciones Cientificas-Universidad de Castilla-La Mancha-Junta de Comunidades de Castilla-La Mancha (CSIC-UCLM-JCCM) Ronda de Toledo s/n 13071 Ciudad RealSpain Seccion de Recursos Cinegeticos y Ganaderos Instituto de Desarrollo Regional (IDR)02071 AlbaceteSpain Departamento de Ciencia y Tecnologia Agroforestal y Genetica ETSIAM Universidad de Castilla-La Mancha(UCLM)02071 AlbaceteSpain

Mater nal effects occur whe n the phe no type of the mother in flue nces that of the young to the detriment of her survival, growth or fitn ess. The in vestment of the mother can be affected by mater nal body condition and/or experience. Trivers-Willard Hypothesis (TWH) and Local Resource Competition Hypothesis (LRCH) are the main hypotheses used to explain bias in birth sex-ratios in mammals, as well as for sex-biased maternal investment. Both hypotheses suggest that a different amount of investment must be expected according to the sex of the young. However, recent studies suggest that these differences are not in quantity but in the strategies: mechanisms and objectives may differ for each sex. We studied how maternal characteristics (age, body mass, body condition, and domi nance status) influence re leva nt aspects of the birth and early growth of the calf (birth date, birth body mass, body mass at weaning, and body condition at weaning) separately for each sex;and how that investment is mediated by milk production and composition (lactose, fat, and protein). One hundred eighty-eight newborns from 75 captive red deer hinds aged from 2 to 19 years were analyzed. The main differential investment observed was related to birth date: when producing a female, hinds give birth earlier in the season only if they have a good body condition;however, when gestating a male it is the older hinds those which deliver earlier. Subsequently, milk production and composition are correlated with birth body mass in female calves, but to weaning body mass in males. Thus, only hind body mass affects the weaning body mass of female calves, compared with age and hind body mass in males. These results suggest that while TWH fits the maternal investment strategy found for male calves, it is LRCH which correlates with the maternal investment patterns observed for females.

关键词： birth date body condition local resources competition hypothesis milk production sex-ratio Trivers-Willard hypothesis

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Left ventricular non-compaction presenting as cardio-embolic stroke

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Journal of Geriatric Cardiology 2020年第10期17卷 645-646页

作者： andres Martinez Michael Omar Fadi Kandah Jose Ruiz Ahsan Niazi Department of Internal Medicine University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Cardiology University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Neurology University of Florida College of Medicine-JacksonvilleFloridaUSA

A 39-year-old male with no known comorbidities presented with sudden onset right-sided *** examination,blood pressure was 128/79 mmHg,National Institutes of Health Stroke Scale score was 4 and there were no signs of heart *** computerized tomography demonstrated an ischemic infarct of the left middle cerebral artery distribution and brain magnetic resonance imaging later confirmed it(Figure 1).

关键词： Cardio-embolic Cardiomyopathy Non-compaction Trabeculae

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Fast preparation route to high-performances textured Sr-doped Ca_3Co_4O_9 thermoelectric materials through precursor powder modification

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Science China Materials 2019年第3期62卷 399-406页

作者： Miguel Angel Torres Gustavo Garcia Idoia Urrutibeascoa Maria Antonieta Madre Juan Carlos Diez andres Sotelo ICMA (CSIC-Universidad de Zaragoza) Centro Stirling S. Coop. Mondragon Unibertsitatea

This work presents a short and very efficient method to produce high performance textured Ca_3Co_4O_9 thermoelectric materials through initial powders modification. Microstructure has shown good grain orientation, and low porosity while slightly lower grain sizes were obtained in samples prepared from attrition milled powders. All samples show the high density of around 96% of the theoretical *** similar characteristics are reflected in, approximately,the same electrical resistivity and Seebeck coefficient values for both types of samples. However, in spite of similar power factor(PF) at low temperatures, it is slightly higher at high temperature for the attrition milled samples. On the other hand, the processing time reduction(from 38 to 2 h) when using attrition milled precursors, leads to lower mechanical properties in these samples. All these data clearly point out to the similar characteristics of both kinds of samples, with a drastic processing time decrease when using attrition milled precursors, which is of the main economic importance when considering their industrial production.

关键词： ceramics oxides hot-pressing electrical properties power factor

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Research on Transitional Justice,International Humanitarian Law and Internal Conflicts——The Case of Colombia and El Salvador

Research on Transitional Justice,International Humanitarian ...

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作者： Fabio andres Piraquive Puerto 华中师范大学

学位级别：硕士

本文以萨尔瓦多(中美洲)和哥伦比亚(南美洲)的国内冲突为例,探讨了国际人道主义法在萨尔瓦多和哥伦比亚的国内冲突中,通过国际规范进行的强有力的干预以及人道主义法在结束两国国内冲突中的作用。研究表明,过渡司法和国际人道主义法虽... 详细信息

本文以萨尔瓦多(中美洲)和哥伦比亚(南美洲)的国内冲突为例,探讨了国际人道主义法在萨尔瓦多和哥伦比亚的国内冲突中,通过国际规范进行的强有力的干预以及人道主义法在结束两国国内冲突中的作用。研究表明,过渡司法和国际人道主义法虽然在结束非国际性武装冲突中具有较强的适用性,但仍然存在不足之处,需要不断改进和完善。需要强调的是,本研究将国际人道主义法分为两部分:一是国际冲突规则,二是非国际冲突规则。而本文主要研究第二部分的“非国际冲突规则”,它们主要来源于日内瓦公约的第三条和公约第二《附加议定书》中的过渡司法和武装冲突法。

关键词：非国际武装冲突国际人道主义法过渡司法哥伦比亚萨尔瓦多

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