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Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: Current evidence

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World Journal of Diabetes 2019年第5期10卷 291-303页

作者： Leonardo Pozo Fatimah Bello andres Suarez Francisco E Ochoa-Martinez Yamely Mendez Chelsea H Chang Salim Surani University of Texas Rio Grande Valley-Doctors Hospital at Renaissance Internal Medicine Residency Program Faculty of Medicine Universidad Autonoma de Nuevo LeonUniversity Hospital "Dr. José Eleuterio González" Faculty of Medicine "Dr. Alberto Romo Caballero" Universidad Autonoma de Tamaulipas Medical Critical Care Services Christus Spohn Hospitals-Corpus Christi

Cardiovascular diseases(CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus(T2DM)suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration(FDA) established new expectations for the evaluation of new antidiabetic agents, advising for pre and,in some cases, post-marketing data on major cardiovascular events. As a direct consequence, there has been a paradigm shift in new antidiabetic agents that has given birth to the recently published American Diabetes Association/European Association for the Study of Diabetes consensus statement recommending sodium-glucose cotransporter-2 inhibitors(SGLT2i) and glucagon like peptide-1 receptor agonists(GLP-1RA) in patients with T2DM and established CVD. As a result of over a decade of randomized placebo controlled cardiovascular outcome trials, the aforementioned drugs have received FDA approval for risk reduction of cardiovascular(CV) events in patients with T2DM and established CV ***2i have been shown to have a stronger benefit in patients with congestiveheart failure and diabetic kidney disease when compared to their GLP-1RA counterparts. These benefits are not withstanding additional considerations such as cost and the multiple FDA Black Box warnings. This topic is currently an emerging research area and this mini-review paper examines the role of these two novel classes of drugs in patients with T2DM with both confirmed, and at risk for, CVD.

关键词： Type 2 diabetes mellitus Glucagon-like-peptide 1 agonists Sodium-glucose cotransporter-2 inhibitor Cardiovascular disease Major adverse cardiovascular event

Agronomic assessment of two populations of intermediate wheatgrass—Kernza^(®)(Thinopyrum intermedium)in temperate South America

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Grassland Research 2022年第4期1卷 262-278页

作者： andres Locatelli Lucia Gutierrez Olivier Duchene Pablo R.Speranza Valentin D.Picasso Risso Polo agro-alimentario Centro Universitario Litoral NorteEstacion Experimental Mario Antonio CassinoniUniversidad de la RepúblicaPaysanduUruguay Departamento de Producción Vegetal Facultad de AgronomiaUniversidad de la RepúblicaPaysanduUruguay Departamento de Biometría Estadística y ComputaciónFacultad de AgronomíaUniversidad de la RepúblicaMontevideoUruguay Department of Agronomy University of Wisconsin–MadisonMadisonWisconsinUSA Agroecology and Environment Research Unit ISARALyonFrance Departamento de Biología Vegetal Facultad de AgronomiaUniversidad de la RepúblicaMontevideoUruguay Departamento de Producción Animal y Pasturas Facultad de AgronomiaUniversidad de la RepúblicaMontevideoUruguay

Background Kernza®intermediate wheatgrass is a perennial grain and forage crop that can provide several ecosystem *** research efforts focused on Kernza have taken place in high *** goal of this study was to evaluate,for the first time,the agronomic performance of Kernza in a low-latitude region with mild *** A KS-cycle 4 Kernza population(A)was planted in spring in Wisconsin,USA,and selected in one cycle for lower vernalization requirements,obtaining a new population(B).These two populations,at three nitrogen(N)fertilization rates,were evaluated in a full factorial,completely randomized field experiment in Uruguay over 2 *** The populations were similar in grain yields and flowering time in the 1st year,but population B had 63%lower grain yield in the 2nd year and 20%lower forage yield throughout the *** the N rate to 160 kg ha−1 led to a 63%increase in grain yield and 28%increase in forage yield across *** yields and nutritive values were similar to those reported in the northern ***,grain yields for both the 1st(316 kg ha−1)and 2nd year(41 kg ha−1)were lower due to reduced flowering and weed *** Expansion of Kernza to lower-latitude regions will require further breeding to improve reproductive performance.

关键词： low-latitude regions nitrogen fertilization rates perennial grains Thinopyrum intermedium vernalization requirements

Importance of ROS1 gene fusions in non-small cell lung cancer

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Cancer Drug Resistance 2023年第2期6卷 332-344页

作者： Meri Muminovic Carlos Rodrigo Carracedo Uribe andres Alvarez-Pinzon Khine Shan Luis E.Raez Department of Hematology-Oncology Memorial Cancer Institute/Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Department of Internal Medicine Memorial Health Care SystemFlorida International UniversityPembroke PinesFL 33028USA Office of Human Research Memorial Healthcare SystemPembroke PinesFL 33028USA

Targeted therapy has become one of the standards of care for advanced lung *** than 10 genetic aberrations have been discovered that are actionable and several tyrosine kinase inhibitors(TKIs)have been approved to target each of *** several genetic aberrations that are actionable in non-small cell lung cancer(NSCLC),ROS1 translocations also known as gene fusion proteins,are found in only 1%-2%of the patient ***1 mutations can usually be detected using a combination of techniques such as immunohistochemistry(IHC),Fluorescence in-situ testing(FISH),polymerase chain reaction(PCR),and nextgeneration sequencing(NGS).However,RNA NGS and ctDNA NGS(liquid biopsies)also contribute to the *** are currently numerous FDA-approved agents for these tumors,including crizotinib and entrectinib;however,there is in-vitro sensitivity data and clinical data documenting responses to ceritinib and *** responses and survival rates with these agents are frequently among the best compared to other TKIs with genetic aberrations;however,intrinsic or extrinsic mechanisms of resistance may develop,necessitating research for alternative treatment *** combat the mechanisms of resistance,novel agents such as repotrectenib,cabozantinib,talotrectinib,and others are being *** this article,we examine the literature pertaining to patients with ROS1 tumors,including epidemiology,clinical outcomes,resistance mechanisms,and treatment options.

关键词： ROS1 targeted therapy non-small cell lung cancer

The Effect of Brain Gym on Global Cognitive Function of Institutionalized Older People

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International Journal of Mental Health Promotion 2022年第3期24卷 375-383页

作者： Araceli Cano-Estrada Araceli Jimenez-Mendoza Denny Contreras-Guerrero Mario Hernandes-Alejandro andres Salas-Casas Escuela Superior de Tlahuelilpan Universidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico Escuela Nacional de Enfermería y Obstetricia.Universidad Nacional Autónoma de México Mexico CityMéxico Departomento de Bioingenieria Unidad Profesional Interdisciplinaria de Biotecnología del Instituto Politecnico Nacional(UPIBIIPN)Mexico CityMexico Instituto de Ciencias de la Salud.Universidad Autónoma del Estado de Hidalgo.Pachuca Hidalgo.México.Scuela Superior de TlahuelilpanUniversidad Autónoma del Estado de HidalgoTlahuelilpanHidalgoMéxico

Cognitive function of older adults is influenced by several factors such as age,sex,education,and physical activity so that it can impact the decrease in progressive cognitive *** is necessary to implement cognitive training in old people’s care to prevent or delay the onset of age-related cognitive *** gym is a series of simple motion exercises and is an alternative therapy that stimulates the *** study aims to evaluate the effect of brain gym as a cognitive training intervention on global cognitive functioning of institutionalized older *** study is a non-randomized quasi-experimental one using pre-and post-test control group *** participants of the study were 65 years old or older who had been part of gerontological centers from a local *** were divided into two groups:control and intervention,each one with 15 ***-Mental State Examination was applied to the sample before and after the cognitive *** brain gym training consists of bi-weekly group meeting for 12 weeks,lasting 50 min *** treated group had a significantly better global cognitive ***(memory),orientation and language skills were the domains with the most significant changes(p<0.05).On the other hand,no significant changes were found in the participants of control groups during post *** results suggest that cognitive training based in brain gym improves global cognitive function of institutionalized older people lease type your abstract *** of a research paper is typically 200 to 400 words in length,and 150 to 300 words for a review *** shall be running continuously(not structured)and shall not include reference *** that appear only once in the abstract should be defined in *** abbreviations appear more than once,the full definitions should be provided first before they can be used elsewhere.

关键词： Cognitive function brain gymnastic older people gerontological center physical activity

Analysis of the Estonian Forest Conservation Area Network

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Journal of Environmental Science and Engineering(B) 2012年第6期1卷 779-788页

作者： Henn Korjus Diana Laarmann andres Kiviste Institute of Forestry and Rural Engineering Estonian University of Life Sciences Tartu 51014 Estonia

Estonian Forestry Development Programme set in 2003 ambitious goal that area of strictly protected forests should increase at least to 10% from total forest area in Estonia before 2010 by expanding the area of old-growth under protection, improving the representativeness of conservation areas and establishment of large conservation sites. Inventory of forests was carried out on existing and possible new conservation areas within the Estonian Forest Conservation Area Network project （EFCAN） in 1999-2001. EFCAN project had remarkable results. The share of strictly protected forests has increased to 7.8% of total forest area by 2009 and the network of conservation areas is quite well covering all forest ecosystems in Estonia. Several selected areas are still not protected for different reasons. These areas should still be considered for protection as the areas may lose their conservation value. Several forest types （meso-eutrophic, eutrophic boreo-nemoral and eutrophic paludifying forests） should have larger area for conservation and large disturbance areas （wind damage, forest fire） should be also included into the network.

关键词： Forest conservation biological diversity ecological network

The parallel-plate resonator:An RF probe for MR and MRI studies over a wide frequency range

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Magnetic Resonance Letters 2023年第4期3卷 306-318页

作者： andres Ramírez Aguilera Kevin J.Sanders Gillian R.Goward Bruce *** UNB MRI Centre Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Department of Chemistry McMaster UniversityHamiltonOntarioL8S 4L8Canada

We explore the use of the parallel-plate resonator for the study of thin cuboid samples over a wide range of magnetic resonance *** parallel-plate resonator functions at frequencies from tens to hundreds of *** parallel-plate resonators are presented and discussed in a frequency range from 8 to 500 *** resonance experiments were performed on both horizontal and vertical bore magnet systems with lithium and hydrogen ***-plate radiofrequency(RF)probes are easy to build and easy to *** and simulations showed good sensitivity of the parallel-plate RF probe geometry with a small decrease in sensitivity at higher frequencies.

关键词： Parallel-plate resonator Optimization Magnetic resonance/magnetic resonance imaging(MR/MRI) Batteries

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中国家族企业代际传承对企业创新的影响

中国家族企业代际传承对企业创新的影响

作者： andres QIU 郑州大学

学位级别：硕士

在中国的市场经济体制中,家族企业拥有着举足轻重的能量,在推动经济高质量发展起着至关重要的作用。对于家族企业而言,代际传承是维持家族企业根基稳固和追求基业长青的重要阶段,正是因为家族成员在企业管理中具有较高的话语权,因此家... 详细信息

在中国的市场经济体制中,家族企业拥有着举足轻重的能量,在推动经济高质量发展起着至关重要的作用。对于家族企业而言,代际传承是维持家族企业根基稳固和追求基业长青的重要阶段,正是因为家族成员在企业管理中具有较高的话语权,因此家族核心成员在代际传承顺利进行的过程中起着决定性作用。在当前形势下,相当一部分家族企业即将或已经进入代际传承阶段。然而,中国家族企业仍面临“富不过三代”的困境和挑战。代际传承由于涉及两代家族管理者之间控制权、领导权威等交接,将对家族企业创新产生影响,是推动家族企业可持续发展的关键因素。因此,研究家族成员在代际传承过程中对企业创新的作用有着重大的理论价值与实践意义。本文以代际传承的动态过程为研究情境,为了深入研究影响企业创新的因素,以2010-2018年中国A股上市家族企业为研究样本,考察了代际传承对企业创新高质量发展的影响。结果发现:代际传承对企业创新具有显著的抑制作用。此外,本研究还发现家庭教育背景下的冲突程度越高,代际传承对企业创新的负面影响越大;假若二代继承人是独生子女,可以在一定程度上缓解代际传承对企业创新的负面影响;男性继承人比女性继承人更能削弱家族企业代际传承对企业创新所带来的负面作用;较高的机构持股可以缓解代际传承对创新强度的负面影响。相较于已有文献,本文的可能贡献在于:(1)丰富了家族企业的创新理论。目前关于中国家族企业的研究大多关注财务绩效,但很少研究中国家族企业的代际传承和创新的质量。(2)本文从家族企业代际传承这一动态过程的角度,回答了代际传承为什么会影响企业创新的问题,加深了人们对家族企业代际传承和企业创新之间关系的印象和理解。本文的研究成果对于推动家族企业顺利完成代际传承具有重要现实意义,有助于引导企业在代际传承时期加强内部和外部的监督反馈和约束机制,从而对继承计划、股权转让等方面作出科学合理的配置,并促使家族人员更清楚自身在企业中的定位,对如何保持家族企业高质量创新提供了经验证据。

关键词：家族企业企业创新代际传承

An SPM stage driven by three stepper motors

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Journal of Measurement Science and Instrumentation 2017年第3期8卷 271-276页

作者： BAI Jiang-hua Physics Departm ent Portland State University Oregon 97201 USA

A scanning probe microscope(SPM)stage controlled by three stepper motors is designed,which has more flexibilitiesthan that of one motor controlled stage,while the control whom is more *** this project,we build the stageactions in an Arduino microcontroller,and finite state machine(FSM)is also built in the Arduino micro controller to communicatewith a computer and a radio frequency(RF)controller.A special displaying scheme with five states is employed to indicatethe operation of the ***,the stage is fully tested and has a700nm resolution in Z motion of the SPM.

关键词： scanning probe microscope (SPM) stepper motors radio frequency (RF) control Lab VIEW

Thickness determination of MoS2,MoSe2,WS2 and WSe2 on transparent stamps used for deterministic transfer of 2D materials

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Nano Research 2019年第7期12卷 1691-1695页

作者： Najme S. Taghavi Patricia Gant Peng Huang Iris Niehues Robert Schmidt Steffen Michaelis de Vasconcellos Rudolf Bratschitsch Mar Garcia-Hernandez Riccardo Frisenda andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid (ICMM)Consejo Superior de Investigaciones Cientificas (CSIC)Sor Juana Ines de la Cruz 328049 MadridSpain Faculty of Physics Khaje Nasir Toosi University of Technology (KNTU)Tehran 19697 64499Iran State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Institute of Physics and Center for Nanotechnology University of Munster48149 MunsterGermany

Here,we propose a method to determine the thickness of the most common transition metal dichalcogenides (TMDCs) placed on the surface of transparent stamps,used for the deterministic placement of two-dimensional materials,by analyzing the red,green and blue channels of transmission-mode optical microscopy images of the *** particular,the blue channel transmittance shows a large and monotonic thickness dependence,making it a very convenient probe of the flake *** method proves to be robust given the small flake-to-flake variation and the insensitivity to doping changes of *** also tested the method for MoSe2,WS2 and *** results provide a reference guide to identify the number of layers of this family of materials on transparent substrates only using optical microscopy.

关键词： transition metal dichalcogenides optical identification transparent substrate trasmittance