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Prevalence of Potential Drug-Drug Interactions in Hospitalized Surgical Patients

Journal of Pharmacy and Pharmacology 2016年第12期4卷 658-666页

作者： Virginia Aleyda Sanchez-Lopez Lorena Michele Brennan-Bourdon Ana Rosa Rincon-Sanchez Maria CristinaIslas-Carbajal andres navarro-ruiz Selene Guadalupe Huerta-Olvera Departamento de Fisiologia Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara 44340Jalisco Mdxico Comisi6n para la Protecci6n contra Riesgos Sanitarios del Estado de Jalisco (COPRISJAL) Guadalajara 44500 Jalisco Mdxico Departamento de Biologia Molecular y Genomica Centro Universitario de Ciencias de la Salud Universidad de GuadalajaraGuadalajara 44340 Jalisco Mexico Servicio de Farmacia Hospital General Universitario de Elche Elche (Alicante) 03203 Spain Departamento de Ciencias Medicas y de la Vida Centro Universitario de la Cienega Universidad de Guadalajara Ocotlan47820 Jalisco. Mexico

The objective of this study is to estimate the prevalence and describe the characteristics of pDDIs （potential drug-drug interactions） in medical prescriptions of hospitalized surgical patients. In this cross-sectional study, we analyzed 370 medical prescriptions from the surgery unit of a Mexican public teaching hospital. The identification and classification of potential drug-drug interactions were performed with the Micromedex 2.0 electronic drug information database. Results were analyzed with descriptive statistics and we estimated OR （odds ratio） to determine associated risk factors. From the study, it was found that the prevalence of potential drug-drug interactions was 45.9%. A total of 385 interactions were identified. Of these, 54.3% were classified as major and 60.5% as pharmacodynamic. Prescriptions for more than seven drugs （OR =7.33, CI （confidence interval） = 4.59-11.71） and advanced age 〉 60 years, （OR = 1.79, CI = 1.06-2.74） were positively associated with the presence of potential drug-drug interactions. We found a high prevalence of clinically relevant pDDIs in the surgery unit. In view of this outcome, the safety of drug combinations in hospitalized surgical patients should be evaluated during the prescription process in order to prevent adverse events.

关键词： Potential drug-drug interactions medical prescriptions concomitant drugs surgery.

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Carbon stock estimation in halophytic wooded savannas of Uruguay:An ecosystem approach

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Forest Ecosystems 2024年第4期11卷 580-589页

作者： andres Baietto andres Hirigoyen Carolina Toranza Franco Schinato Maximiliano Gonzalez Rafael navarro Cerrillo Forest Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay National Research Program of Forest Production National Agriculture Research InstituteTacuaremboPO 97000Uruguay Soil and Water Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay Department of Forestry Engineering University of CordobaCordobaPO 14014Spain

Savannas constitute a mixture of trees and shrub patches with a more continuous herbaceous *** contribution of this biome to the soil organic carbon(SOC)and above-ground biomass(AGB)carbon(C)stock globally is ***,they are frequently subjected to land use changes,promoting increases in CO_(2) *** Uruguay,subtropical wooded savannas cover around 100,000 ha,of which approximately 28%is circumscribed to sodic soils(i.e.,subtropical halophytic wooded savannas).Nevertheless,there is little background about the contribution of each ecosystem component to the C stock as well as site-specific allometric *** study was conducted in 5 ha of subtropical halophytic wooded savannas of the national protected area Esteros y Algarrobales del Rio *** work aimed to estimate the contribution of the main ecosystem components(e.g.,soil,trees,shrubs,and herbaceous plants)to the C ***-specific allometric equations for the most frequent tree species and shrub genus were fitted based on basal diameter(BD)and total height(H).The fitted equations accounted for between 77%and 98%of the aerial biomass variance of Netuma affinis and Vachellia *** shrubs(Baccharis sp.),the adjusted equation accounted for 86%of total aerial biomass.C stock for the entire system was 116.71±11.07 Mg·ha^(-1),of which 90.7%was allocated in the soil,8.3%in the trees,0.8%in the herbaceous plants,and 0.2%in the *** results highlight the importance of subtropical halophytic wooded savannas as C sinks and their relevance in the mitigation of global warming under a climate change scenario.

关键词： Carbon stock Climate change Biomass modeling Sodic soils

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Coxsackievirus B infection presenting as a hemorrhagic pericardial effusion causing tamponade

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Journal of Geriatric Cardiology 2020年第10期17卷 642-644页

作者： Fadi Kandah Pooja Dhruva Jose ruiz andres Martinez William Kogler Internal Medicine University of Florida Health JacksonvilleJacksonvilleUSA

The coxsackievirus is well known for its vastly differing clinical *** with coxsackievirus usually present with a viral prodrome which can then progress to the cardiac symptoms of chest pain and/or *** patients improv... 详细信息

关键词： Cardiac tamponade Coxsackievirus Pericarditis

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Left ventricular non-compaction presenting as cardio-embolic stroke

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Journal of Geriatric Cardiology 2020年第10期17卷 645-646页

作者： andres Martinez Michael Omar Fadi Kandah Jose ruiz Ahsan Niazi Department of Internal Medicine University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Cardiology University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Neurology University of Florida College of Medicine-JacksonvilleFloridaUSA

A 39-year-old male with no known comorbidities presented with sudden onset right-sided *** examination,blood pressure was 128/79 mmHg,National Institutes of Health Stroke Scale score was 4 and there were no signs of heart *** computerized tomography demonstrated an ischemic infarct of the left middle cerebral artery distribution and brain magnetic resonance imaging later confirmed it(Figure 1).

关键词： Cardio-embolic Cardiomyopathy Non-compaction Trabeculae

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Queens remate despite traumatic mating in stingless bees

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Current Zoology 2022年第1期68卷 81-92页

作者： Jamille Costa VEIGA Gustavo Rodrigo Sanches ruiz Gislene Almeida CARVALHO-ZILSE Cristiano MENEZES Felipe andres Leon CONTRERA Bee Biology and Ecology Lab Instituto de Ciencias BiologicasUniversidade Federal do ParaBelem66075-110 ParaBrazil Biodiversity and Ecosystem Services Research Group Instituto Tecnologico Vale-Desenvolvimento SustentavelBelem66055-090 ParaBrazil Ecology and Zoology of Invertebrates Lab Instituto de Ciencias BiologicasUniversidade Federal do ParaBelem66075-110 ParaBrazil Bee Research Group Instituto Nacional de Pesquisas da AmazoniaManaus69067-375 AmazonasBrazil Research and Development Embrapa Meio AmbienteJaguariuna13820-000 Sao PauloBrazil

Males can control female reproduction using genital plugs to impede access by *** social bees,ants,and wasps,plugging may involve traumatic mating,with females being *** stingless bees,chances are that plugs may promote ovarian activan,and are thought to ensure single mating—a general tendency among the social ***,understanding on relationships between mating plugs,traumatic mating,and mating systems in stingless bees remains *** address this,we(1)compared mated queens of 7 Neotropical species to understand the patterns of copulatory marks in females and(2)compared pre-and post-mating genitalia of males and females in Melipona fasciculata to depict plug functional *** revealed an unprecedented consequence of mating in stingless bees:the characteristic marks left by mating plugs on female abdomens and the inferences that can be made from *** our surprise,in 1 species *** we found that queens retain the plug long after mating,and may carry it for the rest of their *** the other 6 species retained the plug for only a short *** queens were only found in ***,whose multiple copulatory marks match previous findings of polyandry in this *** study shows that queens can remate,and suggests that male genital morphology may determine in part the time persistence of *** conclude that traumatic mating plugs do not fully prevent remating in stingless bees and that mating systems are not uniform in this ***,exceptional cases of facultative polyandry in social insects—for example,when mating plugs fail—may confirm a general tendency for single mating in close link with efficient mating plugs.

关键词： copulatory marks facultative polyandry genital morphology male harm sexual conflict

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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of Clinical Cases 2025年第3期13卷 35-41页

作者： andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia Cisneros Maria Jose Garcia Larrosa Maria del Mar Callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management

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The Early Evolutionary History and Adaptive Radiation of the Pterosauria

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Acta Geologica Sinica(English Edition) 2012年第6期86卷 1356-1365页

作者： Brian andres Department of Geology University of South Florida

Phylogenetic analyses of early pterosaur species are relatively new and contradictory. However, they imply a similar evolutionary history for early pterosaurs： a large divergence of all major early groups of pterosaurs before the first named pterosaur species appeared in the fossil record. This large, unsampled divergence may be a record of the initial adaptive radiation of the pterosaurs, but a recent comprehensive phylogenetic analysis reconstructs named Triassic pterosaur species grouped together in a monophyletic clade with all other major groups diverging later. Ten patterns that characterize adaptive radiations put forward by Gavrilets and Losos （2009） are assessed for congruence with the comprehensive phylogeny and two previous phylogenies to determine which are consistent with our notions of an adaptive radiation. Of the eight patterns that can be applied to pterosaurs, only six vary between pterosaur phylogenies. Of these six patterns, all apply to the three phylogenies with varying amounts of support. For many patterns, however, the comprehensive phylogeny has a greater magnitude, shorter time span, or is the only topology within which they can be assessed. Pterosaurs are characterized by an adaptive radiation no matter which phylogeny is considered, but congruence with the fossil record increases the support and information content of a phylogeny by reducing the time and area within which to reconstruct evolutionary history.

关键词： Pterosauria adaptive radiation phylogeny Triassic

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Phylogenetic framework for coevolutionary studies： a compass for exploring jungles of tangled trees

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Current Zoology 2016年第4期62卷 393-403页

作者： andres MARTiNEZ-AQUINO Division Zoologfa Invertebrados Museo de La Plata FCNyM UNLP Paseo del Bosque s/n 1900 La Plata Argentina

Phylogenetics is used to detect past evolutionary events, from how species originated to how their ecological interactions with other species arose, which can mirror cophylogenetic patterns. Cophylogenetic reconstructions uncover past ecological relationships between taxa through inferred coevolutionary events on trees, for example, codivergence, duplication, host-switching, and loss. These events can be detected by cophylogenetic analyses based on nodes and the length and branching pattern of the phylogenetic trees of symbiotic associations, for example, host-parasite. In the past 2 decades, algorithms have been developed for cophylogetenic analyses and implemented in different software, for ex ample, statistical congruence index and event-based methods. Based on the combination of these approaches, it is possible to integrate temporal information into cophylogenetical inference, such as es- timates of lineage divergence times between 2 taxa, for example, hosts and parasites. Additionally, the advances in phylogenetic biogeography applying methods based on parametric process models and combined Bayesian approaches, can be useful for interpreting coevolutionary histories in a scenario of biogeographical area connectivity through time. This article briefly reviews the basics of parasitology and provides an overview of software packages in cophylogenetic methods. Thus, the objective here is to present a phylogenetic framework for coevolutionary studies, with special emphasis on groups of parasitic organisms. Researchers wishing to undertake phylogeny-based coevolutionary studies can use this review as a ＂compass＂ when ＂walking＂ through jungles of tangled phylogenetic trees.

关键词： coevolution cophylogenetic analyses host-parasite molecular systematics parametric biogeography symbiosis.

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Fetkin-hydro,a new thermo-hydrological algorithm for low-temperature thermochronological modeling

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Geoscience Frontiers 2021年第3期12卷 186-200页

作者： Francisco Sánchez andres Barrea Federico M.Dávila andres Mora Centro de Investigaciones en Ciencias de la Tierra(CICTERRA) CONICET-UNCFCEFyNCiudad UniversitariaAv.Vélez Sarsfield 16115000 CórdobaArgentina Facultad de Matemática AstronomíaFísica y Computación(FAMAF)Ciudad UniversitariaAv.Medida Allende 21445000 CórdobaArgentina Ecopetrol BotafogoRio de JaneiroBrazil

Despite two decades of major advances in the field of thermochronological modeling,state-of-the-art numerical implementations still rely mostly on burial and exhumation processes to explain radiometric *** though such an approach has proved valuable,failing to account for other first-order geological variables has led to misinterpretations and therefore,calls for a *** this study a new version of the Fetkin(finite element temperature kinematics,Ecopetrol)program is *** new algorithm couples time-dependent hydrological and thermal calculations,thus rendering thermochronological ages that,instead of being solely dependent on the kinematical evolution of a system,conditioning by the fluid flow is also *** contrast with previous thermochronological models,this work considers the influence of effective stress on rock properties(porosity and permeability)and therefore,in thermal *** analyses addressing relevant geological questions show not only the versatility of the code but also,new perspectives on forward low-temperature thermochronological *** circulation through pure-sandstone settings produce colder thermal architectures than those obtained in impermeable *** in cooling ages from models with and without fluid circulation are up to 5 Myr.A 4-fold variation in thrusting rates(0.5 km/Myr to 2 km/Myr)produces a 15-Myr difference in cooling ages in models with fluid flow,which contrasts to much lower differences,only 2 Myr,in domains without(or minimal)fluid circulation.2D thermal solutions in fold-bend-fold thrust belts composed of sandstones remain static despite substantial relief development by kinematic folding.A case-study from Western Argentina,in the Andean Precordillera,confirms the plausibility of the numerical algorithm here posed and raises new questions on the first-order thermal controls in settings under deformation.

关键词： Thermochronology Hydrogeology Fluid flow Numerical modeling

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Ascites, refractory ascites and hyponatremia in cirrhosis

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Gastroenterology Report 2017年第2期5卷 104-112,I0001页

作者： Brett Fortune andres Cardenas Department of Gastroenterology and Hepatology Weill Cornell Medical CollegeNYUSA Institut de Malalties Digestivesi Metabolique Hospital ClinicUniversity of BarcelonaBarcelonaSpain

Ascites is the most common complication related to cirrhosis and is associated with increased morbidity and *** is a consequence of the loss of compensatory mechanisms to maintain the overall effective arterial blood volume due to worsening splanchnic arterial vasodilation as a result of clinically significant portal *** order to maintain effective arterial blood volume,vasoconstrictor and antinatriuretic pathways are activated,which increase overall sodiumand fluid *** a result of progressive splanchnic arterial vasodilation,intestinal capillary pressure increases and results in the formation of protein-poor fluid within the abdominal cavity due to increased capillary permeability from the hepatic sinusoidal *** some patients,the fluid can translocate across diaphragmatic fenestrations into the pleural space,leading to hepatic *** addition,infectious complications such as spontaneous bacterial peritonitis can ***,as the liver disease progresses related to higher portal pressures,loss of a compensatory cardiac output and further splanchnic vasodilation,kidney function becomes compromised fromworsening renal vasoconstriction as well as the development of impaired solute-free water excretion and severe sodium *** then translate into significant clinical complications,such as refractory ascites,hepatorenal syndrome and hyponatremia,and all are linked to increased ***,liver transplantation is the only curative option for this spectrumof clinical manifestations but ongoing research has led to further insight on alternative *** review will further explore the current understanding on the pathophysiology andmanagement of ascites as well as expand on two advanced clinical consequences of advanced liver disease,refractory ascites and hyponatremia.

关键词： ascites portal hypertension cirrhosis hyponatremia

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