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Type XIX collagen: a promising biomarker from the basement membranes

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Neural Regeneration Research 2020年第6期15卷 988-995页

作者： Ana C.Calvo Laura moreno Leticia moreno Janne m.Toivonen Raquel manzano Nora molina miriam de la Torre Tresa López Francisco J.miana-mena maría J.munoz Pilar Zaragoza Pilar Larrodé Alberto García-Redondo Rosario Osta Laboratory of Genetics and Biochemistry(LAGENBIO) University of ZaragozaFaculty of Veterinary SciencesInstituto de Investigación Sanitaria de Aragón(IIS)IA2CIBERNEDZaragozaSpain Hospital Clínico Universitario lozano Blesa ZaragozaSpain Neurology Department ALS UnitCIBERER U-723Health Research InstituteMadridSpain

Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological *** XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this *** collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different *** molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to *** most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of *** physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in ***,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic *** XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis *** novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.

关键词： anti-tumor and anti-angiogenic properties C1 domain COL19A1 gene and protein levels compensatory effect FACIT collagens hippocampal interneurons matricryptins multiplexins NC1 domain regenerative response skeletal muscle type XIX collagen

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英格兰东南部蕈样肉芽肿病患者的存活率

世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 49-50页

作者： morales m.m. Putcha V. Evans H.S. 冯义国 Public Health and Environmental Care Department of Preventive Medicine University of Valencia Avda. Vicente Andres Estelles s/n ES- 46100 Burjasot Valencia Spain

Background: mycosis fungoides (mF) is the most common skin lymphoma. The aetiology of mF remains unknown, and no therapy has to date significantly altered patient survival. Objective: The present study examines trends in survival of mF patients in a well- defined population- based disease group, namely patients registered over a 40- year period at the Thames Cancer Registry, Southeast England. methods: The Thames Cancer Registry is a population- based registry, covering a population of approximately 14 million people. Data were taken from the Surveillance, Epidemiology and End Results cancer registry programme and the National Centre for Health Statistics. The database was used to identify cases of mF diagnosed between 1961 and 2000. A total of 985 records were identified, 821 (83% ) of which had complete information on age, sex, year of diagnosis and area of residence. The observed and relative survivals of patients diagnosed during the periods 1971- 1975, 1981- 1985 and 1991- 1995 were examined over a 5- year period of follow- up, using the relsurv Stata program to perform Cox proportional hazard analysis. Results: A total of 821 mF eligible patients were available with a median followup of 4.3 years and a maximum follow- up of 30 years. The overall 5- year relative survival rate was 80% , and there was marked improvement between 1971 and 1981. The prognostic factors leading to a significantly poorer survival were high age, male sex, the presence of the Sé zary syndrome, the use of hormone treatment and radiotherapy. Conclusions: A statistically significantly better survival over the last 20 years was found. The prognosis is generally good for most patients but not all. The best survival was seen for the female patients under 45 years of age without the presence of the Sé zary syndrome. This difference in survival may be partly due to a difference in the disease stage or different treatment, or to both.

关键词：蕈样肉芽肿病皮肤淋巴瘤肿瘤登记中位随访期放射治疗注册系统病因学并非全部

Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of Geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel manuel méndez-Bailón JoséPérez-Silvestre Josémaría Fernández-Rodríguez Beatriz Cuesta García Adrián Argüelles-Curto Álvaro González-Franco Alicia Conde-martel Sara Carrascosa-García marta Sánchez-marteles Josémanuel Cerqueiro-González Noel Lorenzo-Villalba manuel montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKGROUND Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** PIONEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced NT-proBNP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and November 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).CONCLUSION Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

得克萨斯二迭纪含水层/半隔水层系统中深井注射处置酸性废水的地球化学模拟

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华东地质学院学报 1993年第2期16卷 163-166页

作者： m.A.Gardiner J.myers 全仁和

地球化学程序 EQ3NR/EQ6用来模拟西得克萨斯州某化工厂的酸性废物流体与 San andres(常用的白云岩注入带)和 Grayburg 组(上覆硬石膏半隔水层)主体岩石之间的相互作用。该模拟使用了三种流体:混合废物、未稀释的酸性度物和天然 Grayburg... 详细信息

地球化学程序 EQ3NR/EQ6用来模拟西得克萨斯州某化工厂的酸性废物流体与 San andres(常用的白云岩注入带)和 Grayburg 组(上覆硬石膏半隔水层)主体岩石之间的相互作用。该模拟使用了三种流体:混合废物、未稀释的酸性度物和天然 Grayburg 地下水。注入带内的白云岩迅速与废酸性反应,导致度物的全部或部分中和,及大量岩石的溶解。这种溶解作用增加了主体岩石的孔隙度和透水性,并使变质和未变质的任一种废物流体进入 Grayburg 组地层中与之接触。溶解硬石膏的能力是溶液中硫和钙的富集程度以及 pH 值、温度和离子强度的函数。废液不断地直接与白云岩、硬石膏反应模拟、化学演化过程提供了评价硬石膏的化学稳定性和半隔水层阻滞垂直流动能力的手段。

关键词：废水地球化学含水层深井处理

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79&PARK住宅区

城市环境设计 2019年第2期118卷 198-209页

作者： H?gni Laksáfoss Agata Wozniczka Agne Tamasauskaite Alberto Herzog Borko Nikolic Christin Svensson Claudio moretti Dominic Black Eva Seo-Andersen Frederik Wegener Gabrielle Nadeau Jacob Lykkefold Aaen Jaime Peiro Suso Jan magasanik Jesper Boye Andersen Jonas Aars? Larsen Julian andres Ocampo Salazar Karl Johan Nyqvist Karol Bogdan Borkowski Katarina mácková Katrine Juul Kristoffer Negendahl Lucian Racovitan maria Teresa Fernandez Rojo max Gabriel Pinto min Ter Lim Narisara Ladawal Schr?der Romea muryn Ryohei Koike Sergiu Calacean Song He Taylor mcNally-Anderson Terrence Chew Thomas Sebastian Krall Tiago Sá Tobias Vall? S?rensen Tore Banke Laurian Ghinitoiu 朱翰林

位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥... 详细信息

位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥有公园和港口最壮阔的景色。建筑西南角延伸至最远处的G?rdet国家公园;为了在建筑和自然之间创造一个人性化的柔和边缘,西南角被尽可能地压低,变成

关键词：住宅区

First Trimester Uterine Rupture: A Case Report on a Patient with Unsuspected müllerian Duct Anomaly

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Open Journal of Obstetrics and Gynecology 2021年第7期11卷 917-921页

作者： Rosales H. Diego García B. Julián Valdes R. Enrique Cartallier Otone Rojas L. Daniel Valdes m. Enrique montero S. Juan Eliash D. Hector Universidad andres Bello Santiago Chile Hospital El Pino San Bernardo Chile Universidad de Chile Santiago Chile

Introduction: mullerian malformations are a group of malformations that result from an alteration of embryonic development. most cases are asymptomatic, however, in pregnant patients it has been associated with recurr... 详细信息

Introduction: Mullerian malformations are a group of malformations that result from an alteration of embryonic development. Most cases are asymptomatic, however, in pregnant patients it has been associated with recurrent abortion or premature delivery. Case presentation: 12 + 2 weeks pregnant woman consulted for abdominal pain, vomiting and fever. During the study, a transvaginal ultrasound was performed, where two endometric cavities and a pregnancy in the right horn were observed. The evolution of the patient was torpid, reaching hypovolemic shock, resolved by an emergency laparotomy where the rupture of the right horn was found. Discussion: The bicornuate uterus is the consequence of a partial fusion of the paramesonephric ducts during the fetal development, resulting in two functional uterine horns. Patients with bicornuate uterus may be asymptomatic,mi

关键词： Uterine Rupture müllerian Duct Anomalies Pregnancy Complications

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阿基坦创意经济与文化中心

城市环境设计 2019年第2期118卷 74-83页

作者： Alexander Codda Alicia marie Sarah Borhardt Annette Birthe Jensen ?smund Skeie Aya Fibert Bartosz Kobylakiewicz Bernhard Touzet Brigitta Gulyás David Tao Edouard Champelle Espen Vik Greta Krenciute Greta Tafel Hyojin Lee Ivan Genov Jan magasanik Jeffrey mark mikolajewski Karol Bogdan Borkowski Katarzyna Swiderska Kekoa Charlot Lorenzo Boddi maria Teresa Fernandez Rojo melissa andres michael Sch?nemann Jensen Nicolas millot Ola Hariri Ole Dau mortensen Pascale Julien Paul-Antoine Lucas Raphael Ciriani Santiago Palacio Villa Se Hyeon Kim Sebastian Liszka Seunghan Yeum Snorre Emanuel Nash J?rgensen Teresa Fernández Thiago De Almeida Thomas Jakobsen Randb?ll Yang Du Zoltan David Kalaszi Ivan mata Laurent de Carniere 朱翰林

这栋建筑将三个文化机构融入其中:FRAC(阿基坦区当代艺术基金会)、ECLA(写作、音乐、电影和广播文化机构)和OARA(阿基坦区行为艺术家工作室)。现在它们被共同整合为阿基坦创意经济与文化中心,即méCA文化中心。我们希望设计一栋可以将... 详细信息

这栋建筑将三个文化机构融入其中:FRAC(阿基坦区当代艺术基金会)、ECLA(写作、音乐、电影和广播文化机构)和OARA(阿基坦区行为艺术家工作室)。现在它们被共同整合为阿基坦创意经济与文化中心,即méCA文化中心。我们希望设计一栋可以将波尔多滨水步道整合其中的建筑,允许公众生活路线从中穿过。

关键词：阿基坦波尔多城市客厅经济与文化

神经性厌食症青少年患者诊断时和体重恢复后的心脏情况

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 43-43页

作者： Olivares J.L. Vázquez m. Fleta J. 贺莉 Department of Paediatrics Lozano Blesa Hospital University of Zaragoza School of Medicine C/ Domingo Miral s/n 50009 Zaragoza Spain

The aim of this study was to compare heart abnormalities in a group of young women with anorexia nervosa at diagnosis and after weight restoration. A total of 40 young women with anorexia nervosa were evaluated, at baseline, (diagnosis) and follow-up (9 to 18 months later) and matched with 40 healthy women of the same age and of normal weight. QT interval was measured from surface electrocardiograms. QT dispersion was defined as the difference between maximum QT and minimum QT occurring in any of the 12 leads. Left ventricular enddiastolic diameter, left ventricular end-systolic diameter, left ventricular mass, left ventricular mass index, cardiac output, fractional shortening and fractional ejection, were measured by echocardiography. In anorexia nervosa patients, corrected QT interval and QT dispersion, significantly decreased from base-line to follow-up. Left ventricular end-diastolic dimension, left ventricular mass index, and cardiac output, in anorexia nervosa were significantly lower at diagnosis than at follow-up after weight restoration. Conclusion: Adolescents with anorexia nervosa have significant functional and structural cardiac abnormalities; weight gain was associated with improvement. Appropriate attention should be paid to cardiac involvement.

关键词：神经性厌食症左室容积指数左心室收缩末舒张末期心输出量射血分数体表心电图超声心动图离散度指数和