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Genome-Wide Survey and Evolutionary Analysis of Trypsin Proteases in Apicomplexan Parasites

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Genomics, Proteomics & Bioinformatics 2010年第2期8卷 103-112页

作者： Aylan Farid Arenas Juan Felipe Osorio-Méndez andres julian gutierrez Jorge E. Gomez-Marin Grupo de Parasitología Molecular (GEPAMOL) Centro de Investigaciones BiomédicasUniversidad del QuindíoArmeniaColombia

Apicomplexa are an extremely diverse group of unicellular organisms that infect humans and other animals. Despite the great advances in combating infectious diseases over the past century, these parasites still have a tremendous social and economic burden on human societies, particularly in tropical and subtropical regions of the world. Proteases from apicomplexa have been characterized at the molecular and cellular levels, and central roles have been proposed for proteases in diverse processes. In this work, 16 new genes encoding for trypsin proteases are identified in 8 apicomplexan genomes by a genome-wide survey. Phylogenetic analysis suggests that these genes were gained through both intracellutar gene transfer and vertical gene transfer. Identification, characterization and understanding of the evolutionary origin of protease-mediated processes are crucial to increase the knowledge and improve the strategies for the development of novel chemotherapeutic agents and vaccines.

关键词： Apicomplexa trypsin endosymbiotic gene transfer

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Origami-inspired perovskite X-ray detector by printing and folding

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npj Flexible Electronics 2023年第1期7卷 471-478页

作者： Henning Mescher Fabian Schackmar Robert Huber Helge Eggers Marcus Zuber Elias Hamann Georg Gramlich julian Dangelmaier Qiaoshuang Zhang andres Georg Rösch Thomas Zwick Gerardo Hernandez-Sosa Ulrich W.Paetzold Uli Lemmer Light Technology Institute(LTI) Karlsruhe Institute of Technology(KIT)Karlsruhe 76131Germany Institute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen 76344Germany InnovationLab(IL) Heidelberg 69115Germany Institute for Photon Science and Synchrotron Radiation(IPS) Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen 76344Germany Laboratory for Applications of Synchrotron Radiation(LAS) Karlsruhe Institute of Technology(KIT)Karlsruhe 76131Germany Institute of Radio Frequency Engineering and Electronics(IHE) Karlsruhe Institute of Technology(KIT)Karlsruhe 76131Germany

X-ray detectors are of pivotal importance for the scientific and technological progress in a wide range of medical,industrial,and scientific ***,we take advantage of the printability of perovskite-based semiconductors and achieve a high X-ray sensitivity combined with the potential of an exceptional high spatial resolution by our origami-inspired folded perovskite X-ray *** high performance of our device is reached solely by the folded detector architecture and does not require any *** design and fabrication of a foldable perovskite sensor array is presented and the detector is characterized as a planar and as a folded *** to 50 kVp−150 kVp X-ray radiation,the planar detector reaches X-ray sensitivities of 25−35μC/(Gyaircm^(2)),whereas the folded detector achieves remarkably increased X-ray sensitivities of several hundredμC/(Gyaircm^(2))and a record value of 1409μC/(Gyaircm^(2))at 150 kVp without photoconductive ***,the potential of an exceptional high spatial resolution of the folded detector of more than 20 lp/mm under 150 kVp X-ray radiation is demonstrated.

关键词： perovskite exceptional planar

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史密森南广场园区规划

城市环境设计 2019年第2期118卷 160-169页

作者： Aaron Hales Alana Goldweit Alexandre Hamlyn Andriani Atmadja Annette Miller Benjamin DiNapoli Benjamin Novacinski Cadence Bayley Choonghyo Lee Chris Falla Daisy Zhong Daniele Pronesti Doug Stechschulte Emily Chen Gabriel Hernandez Solano Janice Rim Jennifer Shen Jeremy Alain Siegel Jihoon Hyun julian andres Ocampo Salazar Kalina Pilat Katarzyna Starczewska Lina Bondarenko Mahsa Malek Manon Otto Martin Voelkle Ola Hariri Otilia Pupezeanu Saecheol Oh Sara Ibrahim Stephen Kwok Stephen Steckel Suemin Jeon Tammy Teng Taylor Fulton Tianqi Zhang Vincent Fulia Wells barber Wesley Chiang Zhifei Xu 陈子钰

通过与史密森学会、当地居民以及决策者的密切合作,我们为南广场园区制定了总体规划,作为对旧与新的重新诠释——方案利用园区内的现有元素,在严格监管与历史保护的限制中寻求自由。该提案旨在提升并扩大游客服务和教育空间,在博物馆与... 详细信息

通过与史密森学会、当地居民以及决策者的密切合作,我们为南广场园区制定了总体规划,作为对旧与新的重新诠释——方案利用园区内的现有元素,在严格监管与历史保护的限制中寻求自由。该提案旨在提升并扩大游客服务和教育空间,在博物馆与花园之间建立清晰的入口和联系,并取代已达到使用寿命的老化建筑机械系统。与此同时,团队致力于保留豪普

关键词：园区规划总体规划 Avenue 史密森史密森学会基础隔震弗里尔交通流线

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79&PARK住宅区

城市环境设计 2019年第2期118卷 198-209页

作者： H?gni Laksáfoss Agata Wozniczka Agne Tamasauskaite Alberto Herzog Borko Nikolic Christin Svensson Claudio Moretti Dominic Black Eva Seo-Andersen Frederik Wegener Gabrielle Nadeau Jacob Lykkefold Aaen Jaime Peiro Suso Jan Magasanik Jesper Boye Andersen Jonas Aars? Larsen julian andres Ocampo Salazar Karl Johan Nyqvist Karol Bogdan Borkowski Katarina Mácková Katrine Juul Kristoffer Negendahl Lucian Racovitan Maria Teresa Fernandez Rojo Max Gabriel Pinto Min Ter Lim Narisara Ladawal Schr?der Romea Muryn Ryohei Koike Sergiu Calacean Song He Taylor McNally-Anderson Terrence Chew Thomas Sebastian Krall Tiago Sá Tobias Vall? S?rensen Tore Banke Laurian Ghinitoiu 朱翰林

位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥... 详细信息

位于G?rdet国家公园边缘,Kullen有意识地塑造了一个尊重且适应环境的形式,并展现出与众不同的社区和壮丽的景色。为直接回应周围环境,建筑的西北和东南角高起至临近周边的高度;而距离公园最远、且本是视野最不好的东北角被拉高以使其拥有公园和港口最壮阔的景色。建筑西南角延伸至最远处的G?rdet国家公园;为了在建筑和自然之间创造一个人性化的柔和边缘,西南角被尽可能地压低,变成

关键词：住宅区