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Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease

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Neural Regeneration Research 2017年第6期12卷 916-917页

作者： Willian O.castillo andres Felipe Aristizabal-Pachon Department of Biology University of Cauca Department of Genetics Ribeirao Preto Medical SchoolUniversity of Sao Paulo–USP

Alzheimer’s disease（AD）is the most common type of dementia in elderly *** a growing aging population not only in the United States but also in the worldwide,AD constitutes an emergent public health problem.

关键词： DNA Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer’s disease AChE

Human papillomavirus in upper digestive tract tumors from three countries

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World Journal of Gastroenterology 2011年第48期17卷 5295-5304页

作者： andres castillo Chihaya Koriyama Michiyo Higashi Muhammad Anwar Mulazim Hussain Bukhari Edwin Carrascal Lida Mancilla Hiroshi Okumura Masataka Matsumoto Kazumasa Sugihara Shoji Natsugoe Yoshito Eizuru Suminori Akiba Department of Epidemiology and Preventive Medicine Kagoshima University Graduate School of Medicaland Dental Sciences Department of Human Pathology Kagoshima University Graduate School of Medical and Dental Sciences King Edward Medical University Department of Pathology Universidad del Valle Universidad Santiago de Cali Department of Surgical Oncology and Digestive Surgery Ka-goshima University Graduate School of Medical and Dental Sci-ences Department of Maxillofacial Diagnostic and Surgical Science Kagoshima University Graduate School of Medical and Dental Sciences Department of Surgical Oncology and Digestive Surgery Ka-goshima University Graduate School of Medical and Dental Sciences Division of Oncogenic and Persistent Viruses Kagoshima University Graduate School of Medical and Dental Sciences

AIM: To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses. METHODS: The present study examined the presence of HPV in squamous cell carcinomas of the oral cavity (n = 71), and esophagus (n = 166) collected from Japan, Pakistan and Colombia, with different HPV exposure risk and genetic backgrounds. The viral load and physical status of HPV16 and HPV16-E6 variants were examined. Comparison of p53 and p16INK4a expression in HPV-positive and HPV-negative cases was also made. RESULTS: HPV16 was found in 39 (55%) oral carcinomas (OCs) and 24 (14%) esophageal carcinomas (ECs). This site-specific difference in HPV detection between OCs and ECs was statistically significant (P < 0.001). There was a significant difference in the geographical distribution of HPV16-E6 variants. Multiple infections of different HPV types were found in 13 ECs, but multiple infections were not found in OCs. This difference was statistically significant (P = 0.001). The geometric means (95% confidence interval) of HPV16 viral load in OCs and ECs were 0.06 (0.02-0.18) and 0.12 (0.05-0.27) copies per cell, respectively. The expression of p16INK4a proteins was increased by the presence of HPV in ECs (53% and 33% in HPV-positive and-negative ECs, respectively; P = 0.036), and the high-risk type of the HPV genome was not detected in surrounding normal esophageal mucosa of HPV-positive ECs. CONCLUSION: Based on our results, we cannot deny the possibility of HPV16 involvement in the carcinogenesis of the esophagus.

关键词： Human papillomavirus Viral load Physical sta-tus E6 p53 p16^INK4a

The Acute and Chronic Effects of Co-Administration of Turmeric and Black Pepper Extracts in Genetic Hypertension

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Journal of Biosciences and Medicines 2023年第8期11卷 114-128页

作者： Ma. Guadalupe Calderón-gallardo Lilia castillo-Martínez Samuel Estrada-Soto Itzell A. gallardo-Ortíz Rafael Villalobos-Molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Programa de Maestría y Doctorado en Ciencias Médicas Odontológicas y de la Salud Doctorado en Investigación Clínica Experimental en Salud Universidad Nacional Autónoma de México Ciudad de México México Instituto Nacional de Nutrición Salvador Zubirán Ciudad de México México Facultad de Farmacia Universidad Autónoma del Estado de Morelos Cuernavaca México

High blood pressure is the main risk factor for cardiovascular diseases, it affects many people worldwide and is a public health problem. This study explored the acute and chronic actions of a mixture of turmeric (95% curcumin) plus black pepper (95% piperine) extracts, in the blood pressure pattern in spontaneously hypertensive rats (SHR) along they age. For the acute study male adult (4 - 7 months old) SHR and their control Wistar Kyoto rats (WKY) were used. A single oral dose of the mixture of turmeric/black pepper extracts (200 mg/2mg, respectively) suspension was administered. Tail-cuff was used to determine blood pressure during 180 min. For the chronic study, young (1-month-old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In a second chronic assay adult (5 months old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In all three studies, a decrease in systolic, diastolic and mean blood pressure was observed, being higher in SHR and negligible in WKY rats. The mixture of turmeric/black pepper extracts showed antihypertensive actions in SHR rats with no effect on WKY rats. The mixture delayed the onset of hypertension in young SHR rats.

关键词： Curcuma longa L. Peper nigrum L. Hypertension Polyphenol SHR

Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile

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World Journal of Gastroenterology 2006年第38期12卷 6188-6192页

作者： andres castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba Department of Epidemiology and Preventive Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Division of Persistent and Oncogenic Viruses Center for Chronic Viral Diseases Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Department of Pathology University of Valle Faculty of Health Sciences Sede San Fernando Cali Colombia Department of Pathology P. Catholic University Santiago Chile Gastroenterology and Pathologic Unit Hospital San Camilo San Felipe Chile Institute for Digestive Diseases Chileno-Japones at San Borja- Arriaran Hospital Santiago Chile Geriatric Health Services Facility Kagoshima Japan

AIM： To examine the presence of human papillomavirus （HPV） in esophageal squamous cell carcinoma （ESCC） specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively.METHODS： We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5＋/GP6＋ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16^INK4A protein immunostaining of all the specimens was conducted.RESULTS： HPV was detected in 21 ESCC specimens （29%）. Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases （13%） and in 5 Chilean cases （19%）. HPV-18 was detected in i0 cases （21%） in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 （without statistical significance）, but a significantly lower prevalence of HPV-18 than in Colombian cases （P = 0.011） even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country.CONCLUSION： HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC.

关键词： Human papillomavirus Esophageal squamous cell cancer Colombia Chile

Prevalence of Primary Open Angle Glaucoma among Patients with Diagnosis of Systemic Hypertension and Diabetes Mellitus: The Colombian Glaucoma Study

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Open Journal of Ophthalmology 2020年第2期10卷 99-114页

作者： Carlos E. Rivera Erika Cantor andres castillo Alexander Martinez Lyle Newball Juan C. Rueda Alejandro Valencia Sandra Belalcazar Tulio Cabal Oscar Albis-Donado Fabian Mendez Fundación Oftalmológica del Valle Cali Colombia Institute of Statistics Universidad de Valparaiso Valparaiso Chile Department of Biology Faculty of Natural & Exact Sciences Universidad del Valle Cali Colombia Ophthalmology Residency Program Universidad del Valle Centro Médico Imbanaco Cali Colombia Clínica Lynd Newball San Andrés Islas Colombia FOSCAL Internacional Bucaramanga Colombia Glaucoma Unit Medellin Colombia Fundación Oftalmológica Nacional Bogotá Colombia Clínica Visión Cabal Buga Colombia Visual Sense Private Practice Mexico City Mexico School of Public Health GESP Group Universidad del Valle Cali Colombia

Objective: To establish the prevalence and risk factors of Primary Open Angle Glaucoma (POAG) among patients with Systemic Hypertension (SH) and Diabetes Mellitus (DM) in six cities of Colombia. Methods: A cross-sectional study among hypertensive and diabetic patients was conducted in Colombia. This study included 2067 subjects older than 50 years of age diagnosed with SH and/or DM. Participants underwent a complete ophthalmic examination including intraocular pressure (IOP) measurement by Goldmann tonometry and blood pressure measurement. The glaucoma diagnosis was confirmed by structural and functional evidence. Interviews and standardized questionnaires were used to evaluate participants’ lifestyle and other health conditions. Results: Among participants with DM/SH, 142 cases of POAG were confirmed for a prevalence of 5.6% [95% CI: 4.6 - 6.6], while 9.1% were glaucoma suspects [95% CI: 7.8% - 10.4%]. The majority of confirmed cases (77.5%) were undiagnosed. The prevalence of POAG was significantly higher with male gender, greater age, and diastolic blood pressure > 90 mmHg as risk factors. Conclusion: We found a high prevalence of POAG in patients with adequate SH and DM care in a novel Latino population. We also found great unawareness of the disease in this population. Our results have potentially enormous public health implications for Colombia and other Latino populations.

关键词： Open Angle-Glaucoma Glaucoma Systemic Hypertension Diabetes Mellitus

Magnetism of Cr Impurities Embedded in Cu fcc Matrix： Density Functional Calculations

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材料科学与工程（中英文B版） 2014年第8期4卷 262-267页

作者： Juan Ulisses gallardo Zazueta Raul Enrique Felix Medina Manuel andres Leyva Lucero Ricardo Alberto Guirado Lopez Salvador Meza Aguilar Instituto de Fisica Manuel Sandoval Vallarta Universidad Aut6noma de San Luis PotosL San Luis Potos~ San Luis Potosi 78290MOxico Facultad de Ciencias Fisico-Matematicas Universidad A utonoma de Sinaloa Culiaean Sinaloa 80010 Mexico

We present extensive first principles density functional theory (DFT) calculations dedicated to analyze the magnetic properties of Crn (n = 2 and 3) impurities embedded in a Cu fcc matrix. We consider several dimers and trimers having different interatomic distances. In all cases the Cr atoms have been embedded as substitutional impurities in the metallic network. For the case of the dimers we have considered two magnetic configurations: Ferromagnetic (Antiferromagnetic) when the atomic magnetic moments are parallel (antiparallel) each other, for this case we have found that the lowest-energy state corresponds to the antiferromagnetic coupling between Cr atoms whose interatomic distance is a√2. In the case of the Cr trimers we have considered three or four magnetic configurations, depending on the Cr impurity geometry, for this case we have found that the lowest-energy state corresponds to the antiferromagnetic Cr trimer AF (↑,↓,↓) forming an isosceles right angle triangle whose hypotenuse and legs length are a√2 and a, respectively, with magnetic moments c (2) = 3.45/-3.32/3.45 μB.

关键词：密度泛函理论磁性杂质嵌入式 FCC 反铁磁耦合等腰直角三角形铬矩阵