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Readmission after TIPS:an up-to-date landscape

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Gastroenterology Report 2020年第2期8卷 83-84,I0001页

作者： Octavi Basssegoda andres Cardenas GI/Liver Unit Institut de Malalties Digestives i MetaboliquesHospital ClinicUniversity of BarcelonaBarcelonaSpain Institut Dinvestigacions Biomediques August Pi I Sunyer(IDIBAPS) Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBEReHD)BarcelonaSpain

Portal hypertension in patients with cirrhosis is common and can lead to severe complications that are associated with decreased *** these complications,portal hypertensive bleeding and refractory ascites in many cases can be managed with the placement of a transjugular intrahepatic portosystemic shunt(TIPS).Current indications of TIPS placement include variceal hemorrhage refractory or recurrent to standard therapy with vasoactive drugs and endoscopic variceal ligation[1].Also,in carefully selected patients(***-Pugh class C cirrhosis with score 10-13 and Child Turcotte Pugh(CTP)class B with active bleeding on endoscopy),early TIPS(placed within 72 hours of admission)after vasoactive drugs and endoscopic band ligation improves *** intervention reduces the risk of rebleeding among this group of high-risk patients and is associated with increased survival[2].TIPS is also a treatment of choice in patients bleeding from cardiofundal varices(GOV2 and IGV1)and ectopic varices[1].Refractory ascites is also an indication for TIPS ***,its efficacy is controversial in this *** is clear that TIPS is associated with a better control of ascites than large-volume *** said,TIPS is followed by a greater incidence of hepatic *** results regarding the survival benefits of TIPS have emerged and are still a matter of intense debate[3].In summary,a careful selection of candidates for TIPS placement is necessary if refractory ascites is the indication for ***,TIPS can be detrimental in older patients with cardiopulmonary disease as well as in patients in CTP class C and higher Model for End Stage Liver Disease(MELD)*** has to be noted that most of the randomized trials evaluating survival of TIPS have been performed using bare stents[4].

关键词： refractory indication admission

Light Induced Inhibition of Protein Phosphatase Calcineurin

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Chinese Journal of Chemistry 2014年第10期32卷 1011-1014页

作者： andres Quintero Weilin Lin Sophia Hermann Yixin Zhang BCUBE Center for Molecular Bioengineering Technische Universität DresdenArnoldstrasse 1801307 DresdenGermany

Light-induced switching of drug activity can be used to realize spatio-temporal control of biological activity in cells and in *** our study of light-switchable derivatives of immunosuppressive drug cyclosporin A(CsA)in their inhibition of protein phosphatase calcineurin(CaN),we have discovered that 7-methyl-6-thioguanosine(MESG)inhibits CaN under light irradiation through a photo-crosslinking *** inhibition has shown selectivity over other enzymes such as phosphatase PP2A,protease chymotrypsin,and cyclophilin 18,the receptor protein for *** discovery could pave the way to discover new covalent inhibitors for protein phosphtase,to design immunophilin-independent CaN inhibitors,and to design new light controlled inhibitors to modulate signal transduction.

关键词： inhibitor photo-switching immunosuppression calcineurin phosphatase

Optimal thermoelectric figure of merit of Si/Ge core-shell nanowires

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Nano Research 2015年第8期8卷 2611-2619页

作者： Kaike Yang andres Cantarero Angel Rubio Roberto D'Agosta Nano-Bio Spectroscopy Group and ETSF Scientific Development Center Departamento de Fisica de Materiales Universidad del Pais Vasco UPV/EHU San Sebastian 20018 Spain Instituto de Ciencia de Materiales Universidad de Valencia Valencia 46071 Spain Ikerbasque Basque foundation for Science Bilbao 48013 Spain

We investigate the thermoelectric energy conversion efficiency of Si and Ge nanowires, and in particular, that of Si/Ge core-shell nanowires. We show how the presence of a thin Ge shell on a Si core nanowire increases the overall figure of merit. We find the optimal thickness of the Ge shell to provide the largest figure of merit for the devices. We also consider Ge core/Si shell nanowires, and show that an optimal thickness of the Si shell does not exist, since the figure of merit is a monotonically decreasing function of the radius of the nanowire. Finally, we verify the empirical law relating the electron energy gap to the optimal working temperature that maximizes the efficiency of the device.

关键词： thermoelectric properties Seebeck coefficient silicon and germanium core-shell nanowires

Adipose tissue lipolysis and remodeling during the transition period of dairy cows

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Journal of Animal Science and Biotechnology 2017年第4期8卷 787-798页

作者： G.andres Contreras Clarissa Strieder-Barboza William Raphael Department of Large Animal Clinical Sciences College of Veterinary MedicineMichigan State UniversityEast LansingMI 48824USA

Elevated concentrations of plasma fatty acids in transition dairy cows are significantly associated with increased disease susceptibility and poor lactation performance. The main source of plasma fatty acids throughout the transition period is lipolysis from adipose tissue depots. During this time, plasma fatty acids serve as a source of calories mitigating the negative energy balance prompted by copious milk synthesis and limited dry matter *** research has demonstrated that lipolysis in the adipose organ is a complex process that includes not only the activation of lipolytic pathways in response to neural, hormonal, or paracrine stimuli, but also important changes in the structure and cellular distribution of the tissue in a process known as adipose tissue remodeling. This process involves an inflammatory response with immune cell migration, proliferation of the cellular components of the stromal vascular fraction, and changes in the extracellular matrix. This review summarizes current knowledge on lipolysis in dairy cattle, expands on the new field of adipose tissue remodeling, and discusses how these biological processes affect transition cow health and productivity.

关键词： Adipose tissue macrophages Adipose tissue remodeling Lipolysis Transition dairy cows

Cenozoic basin evolution of the Central Patagonian Andes:Evidence from geochronology, stratigraphy, and geochemistry

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Geoscience Frontiers 2019年第3期10卷 1139-1165页

作者： A.Encinas A.folguera R.Riffo P.Molina L.Fernández Paz V.D.Litvak D.A.Colwyn V.A.Valencia M.Carrasco Departamento de Ciencias de la Tierra Facultad de Ciencias Químicas Universidad de Concepción Instituto de Estudios Andinos Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Departamento de Ciencias Geológicas CONICET-Universidad de Buenos Aires Instituto de Estudios Andinos Don Pablo Groeber (IDEAN) Department of Geology & Geophysics Yale University School of the Environment Washington State University

The Central Patagonian Andes is a particular segment of the Andean Cordillera that has been subjected to the subduction of two spreading ridges during Eocene and Neogene times. In order to understand the Cenozoic geologic evolution of the Central Patagonian Andes, we carried out geochronologic(U-Pb and^(40)Ar/^(39)Ar), provenance, stratigraphic, sedimentologic, and geochemical studies on the sedimentary and volcanic Cenozoic deposits that crop out in the Meseta Guadal and Chile Chico areas(～47°S). Our data indicate the presence of a nearly complete Cenozoic record, which refutes previous interpretations of a hiatus during the middle Eocene-late Oligocene in the Central Patagonian Andes. Our study suggests that the fluvial strata of the Ligorio Marquez Formation and the flood basalts of the Basaltos Inferiores de la Meseta Chile Chico Formation were deposited in an extensional setting related to the subduction of the Aluk-Farallon spreading ridge during the late Paleocene-Eocene. Geochemical data on volcanic rocks interbedded with fluvial strata of the San Jose Formation suggest that this unit was deposited in an extensional setting during the middle Eocene to late Oligocene. Progressive crustal thinning allowed the transgression of marine waters of Atlantic origin and deposition of the upper Oligocene-lower Miocene Guadal Formation. The fluvial synorogenic strata of the Santa Cruz Formation were deposited as a consequence of an important phase of compressive deformation and Andean uplift during the early-middle Miocene. Finally, alkali flood basalts of the late middle to late Miocene Basaltos Superiores de la Meseta Chile Chico Formation were extruded in the area in response to the suduction of the Chile Ridge under an extensional regime. Our studies indicate that the tectonic evolution of the Central Patagonian Andes is similar to that of the North Patagonian Andes and appears to differ from that of the Southern Patagonian Andes, which is thought to have been the s

关键词： Central Patagonian Andes U-Pb geochronology Ar-Ar geochronology Geochemistry Stratigraphy Sedimentology

Deep Learning Based Intelligent Industrial Fault Diagnosis Model

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Computers, Materials & Continua 2022年第3期70卷 6323-6338页

作者： R.Surendran Osamah Ibrahim Khalaf Carlos andres Tavera Romero Center for Artificial Intelligence&Research(CAIR) Chennai Institute of TechnologyChennai600069India Al-Nahrain Nanorenewable Energy Research Center Al-Nahrain UniversityBaghdad64074Iraq COMBA I+D Research Group of Universidad Santiago de Cali Santiago de CaliColombia

In the present industrial revolution era,the industrial mechanical system becomes incessantly highly intelligent and ***,it is necessary to develop data-driven and monitoring approaches for achieving quick,trustable,and high-quality analysis in an automated *** diagnosis is an essential process to verify the safety and reliability operations of rotating *** advent of deep learning(DL)methods employed to diagnose faults in rotating machinery by extracting a set of feature vectors from the vibration *** paper presents an Intelligent Industrial Fault Diagnosis using Sailfish Optimized Inception with Residual Network(IIFD-SOIR)*** proposed model operates on three major processes namely signal representation,feature extraction,and *** proposed model uses a Continuous Wavelet Transform(CWT)is for preprocessed representation of the original vibration *** addition,Inception with ResNet v2 based feature extraction model is applied to generate high-level ***,the parameter tuning of Inception with the ResNet v2 model is carried out using a sailfish ***,a multilayer perceptron(MLP)is applied as a classification technique to diagnose the faults *** experimentation takes place to ensure the outcome of the presented model on the gearbox dataset and a motor bearing *** experimental outcome indicated that the IIFD-SOIR model has reached a higher average accuracy of 99.6%and 99.64%on the applied gearbox dataset and bearing *** simulation outcome ensured that the proposed model has attained maximum performance over the compared methods.

关键词： Intelligent models fault diagnosis industrial control deep learning feature extraction

Advanced interatrial block as a key marker for atrial fibrillation recurrence： Bayes＇ syndrome

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Journal of Geriatric Cardiology 2017年第3期14卷 169-173页

作者： Adrian Baranchuk andres Enriquez Pavel Antiperovitch Bryce Alexander Goksel Cinier Department of Medicine Kingston General Hospital Queen's University Kingston Ontario Canada Section of Cardiac Electrophysiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center Istanbul Turkey

It was not until 1979 that Bayes de Ltma described atrial conduction blocks and classified them as interatrial and intra- *** blocks refer to conduction disorders lo- cated between the atria, while intraalxial blocks occur within the same atrium. This work motivated several authors, in- cluding Bayes himself, to further investigate atrial conduc- tion and interatrial block （IAB）.

关键词： Atrial fibrillation Bayes syndrome Bachmann's bundle Interatrial block

Impacts of fire severity and cattle grazing on early plant dynamics in old-growth Araucaria-Nothofagus forests

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Forest Ecosystems 2019年第4期6卷 298-311页

作者： Paola Arroyo-Vargas andres Fuentes-Ramírez Bart Muys Aníbal Pauchard Laboratorio de Biometría Departamento de Ciencias ForestalesUniversidad de La FronteraCasilla 54-DTemucoChile Programa de Magíster en Manejo de Recursos Naturales Facultad de Ciencias Agropecuarias y ForestalesUniversidad de La FronteraCasilla 54-DTemucoChile Butamallin Research Center for Global Change Universidad de La FronteraTemucoChile Instituto de Ecología y Biodiversidad(IEB) SantiagoChile Department of Earth and Environmental Sciences University of LeuvenCelestijnenlaan 200EBox 24113001 LeuvenBelgium Laboratorio de Invasiones Biológicas(LIB) Facultad de Ciencias ForestalesUniversidad de ConcepciónCasilla 160-CConcepciónChile.

Background: Fire has historically shaped the dynamics of Araucaria araucana-Nothofagus pumilio forests in the Andean region of South America. Nevertheless, human disturbances and stronger drought events have resulted in increased occurrence and severity of wildfires. Regardless of their conservation relevance, the initial response to fire of Araucaria-Nothofagus forests has not been well documented. Through this research we tested the hypothesis that plant composition of Araucaria-Nothofagus forest after fire will initially differ in its recovery depending on fire severity, but over time, plant similarity will increase among areas with different levels of fire severity. The study was carried out in old-growth Araucaria-Nothofagus forests in south-central Chile(38°S) that were burned in 2015. We studied vegetation response to three levels of fire severity(low(LS), moderate(MS) and high(HS) severity), also including an adjacent unburned forest(UN), which were assessed one, two and three years after fire. We also evaluated the impact of cattle on plant recovery after fire. We measured species richness, abundance, plant diversity and origin of all vascular plant ***: Species richness and plant abundance responded differently to fire severity. Time-since-fire had a significant effect on plant richness and abundance. Plant composition within LS areas was similar to UN areas, but MS and HS areas were significantly less diverse compared to UN and LS. In absence of other major disturbances, similarity in plant composition tended to increase over time across the different levels of fire severity, becoming more similar to UN. We also found a synergetic effect of cattle and fire on species richness. This interaction promotes the establishment of nonnative species and limits the recovery of native species following ***: Fire severity had a significant impact on the plant community of old-growth Araucaria-Nothofagus forests,especially in areas of high fir

关键词： Fire severity gradient Wildfire Post-fire plant recovery Cattle exclusion Synergistic effects of disturbances Araucaria araucana Nothofagus pumilio

Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer's disease

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Neural Regeneration Research 2017年第6期12卷 916-917页

作者： Willian O.Castillo andres Felipe Aristizabal-Pachon Department of Biology University of Cauca Department of Genetics Ribeirao Preto Medical SchoolUniversity of Sao Paulo–USP

Alzheimer’s disease（AD）is the most common type of dementia in elderly *** a growing aging population not only in the United States but also in the worldwide,AD constitutes an emergent public health problem.

关键词： DNA Galantamine protects against beta amyloid peptide-induced DNA damage in a model for Alzheimer’s disease AChE