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Two Analytical Methods for Detection and Elimination of the Static Hazard in Combinational Logic Circuits

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Circuits and Systems 2013年第7期4卷 466-471页

作者： Mihai Grigore Timis alexandru Valachi alexandru Barleanu andrei Stan Automatic Control and Computer Engineering Faculty Technical University Gh.Asachi Iasi Romania

In this paper, the authors continue the researches described in [1], that consists in a comparative study of two methods to eliminate the static hazard from logical functions, by using the form of Product of Sums (POS), static hazard “0”. In the first method, it used the consensus theorem to determine the cover term that is equal with the product of the two residual implicants, and in the second method it resolved a Boolean equation system. The authors observed that in the second method the digital hazard can be earlier detected. If the Boolean equation system is incompatible (doesn’t have solutions), the considered logical function doesn’t have the static 1 hazard regarding the coupled variable. Using the logical computations, this method permits to determine the needed transitions to eliminate the digital hazard.

关键词： Combinational Circuits Static Hazard Logic Design Boolean Functions

Logical Function Decomposition Method for Synthesis of Digital Logical System Implemented with Programmable Logic Devices (PLD)

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Circuits and Systems 2013年第7期4卷 472-477页

作者： Mihai Grigore Timis alexandru Valachi alexandru Barleanu andrei Stan Automatic Control and Computer Engineering Faculty Technical University Gh.Asachi Iasi Romania

The paper consists in the use of some logical functions decomposition algorithms with application in the implementation of classical circuits like SSI, MSI and PLD. The decomposition methods use the Boolean matrix calculation. It is calculated the implementation costs emphasizing the most economical solutions. One important aspect of serial decomposition is the task of selecting “best candidate” variables for the G function. Decomposition is essentially a process of substituting two or more input variables with a lesser number of new variables. This substitutes results in the reduction of the number of rows in the truth table. Hence, we look for variables which are most likely to reduce the number of rows in the truth table as a result of decomposition. Let us consider an input variable purposely avoiding all inter-relationships among the input variables. The only available parameter to evaluate its activity is the number of “l”s or “O”s that it has in the truth table. If the variable has only “1” s or “0” s, it is the “best candidate” for decomposition, as it is practically redundant.

关键词： Combinational Circuits Static Hazard Logic Design Boolean Functions Logical Decompositions

Validating cone-beam computed tomography for peri-implant bone morphometric analysis

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Bone Research 2014年第2期2卷 103-109页

作者： Yan Huang Jeroen Van Dessel Maarten Depypere Mostafa EzEldeen alexandru andrei Iliescu Emanuela Dos Santos Ivo Lambrichts Xin Liang Reinhilde Jacobs OMFS IMPATH Research Group Department of Imaging & Pathology Faculty of Medicine University of Leuven and Oral & Maxillofacial SurgeryUniversity Hospitals Leuven Leuven Belgium State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University ESAT/PSI Medical Image Computing KU Leuven Leuven Belgium Faculty of Dentistry UMF Craiova Romania School of Dentistry Pontifical Catholic University of Paraná Curitiba Brazil Biomedical Research Institute Hasselt University Diepenbeek Belgium School of Stomatology Dalian Medical University Dalian China

Cone-beam computed tomography （CBCT） has been recently used to analyse trabecular bone structure around dental implants. To validate the use of CBCT for three-dimensional （3D） peri-implant trabecular bone morphometry by comparing it to two-dimensional （2D） histology, 36 alveolar bone samples （with implants n=27 vs. without implants n=9） from six mongrel dogs, were scanned ex vivo using a high-resolution （80 ~m） CBCT. After scanning, all samples were decalcified and then sectioned into thin histological sections （-6 jim） to obtain high contrast 2D images. By using CTAn imaging software, bone morphometric parameters including trabecular number （Tb.N）, thickness （***）, separation （***） and bone volume fraction （BV/TV） were examined on both CBCT and corresponding histological images. Higher *** and ***, lower BV/TV and Tb.N were found on CBCT images （P〈0.001）. Both measurements on the peri-implant trabecular bone structure showed moderate to high correlation （r=0.65-0.85）. The Bland-Altman plots showed strongest agreement for *** followed by ***, Tb.N and BV/TV, regardless of the presence of implants. The current findings support the assumption that peri-implant trabecular bone structures based on high-resolution CBCT measurements are representative for the underlying histological bone characteristics, indicating a potential clinical diagnostic use of CBCT-based peri-implant bone morphometric characterisation.

关键词： bone CBCT

Molecular and cellular changes in the post-traumatic spinal cord remodeling after autoinfusion of a genetically-enriched leucoconcentrate in a mini-pig model

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Neural Regeneration Research 2023年第7期18卷 1505-1511页

作者： Maria Aleksandrovna Davleeva Ravil Rasimovich Garifulin Farid Vagizovich Bashirov andrei Aleksandrovich Izmailov Leniz Faritovich Nurullin Ilnur Ildusovich Salafutdinov Dilara Zilbarovna Gatina Dmitrij Nikolaevich Shcherbinin andrei Aleksandrovich Lysenko Irina Leonidovna Tutykhina Maksim Mikhailovich Shmarov Rustem Robertovich Islamov Department of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia Кazan Institute of Biochemistry and Biophysics Federal Research Center of Kazan Scientific Center of Russian Academy of SciencesKazanRussia Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia The National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation MoscowRussia

Post-traumatic spinal cord remodeling includes both degenerating and regenerating processes,which affect the potency of the functional recovery after spinal cord injury(SCI).Gene therapy for spinal cord injury is proposed as a promising therapeutic strategy to induce positive changes in remodeling of the affected neural *** our previous studies for delivering the therapeutic genes at the site of spinal cord injury,we developed a new approach using an autologous leucoconcentrate transduced ex vivo with chimeric adenoviruses(Ad5/35)carrying recombinant *** the present study,the efficacy of the intravenous infusion of an autologous genetically-enriched leucoconcentrate simultaneously producing recombinant vascular endothelial growth factor(VEGF),glial cell line-derived neurotrophic factor(GDNF),and neural cell adhesion molecule(NCAM)was evaluated with regard to the molecular and cellular changes in remodeling of the spinal cord tissue at the site of damage in a model of mini-pigs with moderate spinal cord *** animals were randomly divided into two groups of 4 pigs each:the therapeutic(infused with the leucoconcentrate simultaneously transduced with a combination of the three chimeric adenoviral vectors Ad5/35‐VEGF165,Ad5/35‐GDNF,and Ad5/35‐NCAM1)and control groups(infused with intact leucoconcentrate).The morphometric and immunofluorescence analysis of the spinal cord regeneration in the rostral and caudal segments according to the epicenter of the injury in the treated animals compared to the control mini-pigs showed:(1)higher sparing of the grey matter and increased survivability of the spinal cord cells(lower number of Caspase-3-positive cells and decreased expression of Hsp27);(2)recovery of synaptophysin expression;(3)prevention of astrogliosis(lower area of glial fibrillary acidic protein-positive astrocytes and ionized calcium binding adaptor molecule 1-positive microglial cells);(4)higher growth rates of regeneratingβIII-tubulin-positi

关键词： autologous genetically-enriched leucoconcentrate chimeric adenoviral vector gene therapy glial cell line-derived neurotrophic factor mini-pig neural cell adhesion molecule spinal cord contusion injury vascular endothelial growth factor

Assessment of health risk of the baikal region population associated with the wildfire air pollution:Approaches,modelling,digital environment

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Emerging Contaminants 2023年第1期9卷 33-40页

作者： Natalia Efimova Viacheslav Paramonov Viktor Rukavishnikov Roman Fedorov Gennadiy Ruzhnikov andrei Tsyrendorzhiyev East-Siberian Institute of Medical and Ecological Research 3“12a mikrorayon”Angarsk665827Irkutsk oblastRussia Matrosov Institute for System Dynamics and Control Theory of SB RAS 134 Lermontov St.Irkutsk664033Russia Rospotrebnadzor for the Republic of Buryatia 45Kluchevskaya St.Ulan-Ude670013Republic of BuryatiaRussia

The latest forecasts indicate wildfire activity in many parts of the *** smoke contains hazardous air pollutants such as carbon monoxide,nitrogen dioxide,ozone,particulate matter et ***,prediction of this impact and on time medical care are difficult due to the lack of digital decision-making *** aim of this study is to assess population health risks associated with the sub-daily exposure to wildfire smoke produced by massive foci of combustion near the populated areas and at a significant distance from *** consider reflex reactions as a response to a short-term *** maximum value of the 95th percentile from the series of observations at the monitoring point was used to assess the *** the mathematical description of the“concentration-effect”relationship,the model of individual thresholds is *** model describes a dependence as a straight line under the condition that the concentration is expressed in the form of a normalprobabilistic *** frequency of additional cases is determined by studying the number of requests for medical assistance(including calls for ambulance)with complaints of respiratory disorders,lacrimation,*** the territories affected by wildfires *** indicator is calculated per 1000 *** probability of negative biological effects in response to the impact of wildfire smoke is associated mainly with the content of CO and TPM in the conditions of the Baikal *** frequency of additional requests for medical care ranged from 0.137 to 0.933 per 1000 exposed population during the fire period in settlements where risk levels are>*** developed a digital environment that allows us to get information about harmful substances in the outdoor air from different sources and in different formats and data *** digital environment supports implementation of models for assessing hazards to human body organs.

关键词： Air pollution Wildfire Health risk Digital environment

Silica-Metal Spherules in Ignimbrites of Southern Primorye,Russia

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Journal of Earth Science 2011年第1期22卷 20-31页

作者： andrei V Grebennikov Far East Geological Institute Prospect Stoletia 159 690022 Vladivostok Russia

A comprehensive mineralogical-geochemical and petrological study of ignimbrites from the Yakut-Gora volcanic depression （Primorye, Far Eastern Russia） revealed a wide distribution of silica-metal spherules （＂globules＂） that are typical liquid immiscibility resultant. The metallic portion of a spherule （composition varies from low-carbon iron to cohenite） borders gas pores and is rimmed by symplectite that consists of quartz, magnetite, and silica-potassic glass. This allows us to consider that the whole formation formed through reduction of the enclosing silicate melt. Abundant evidence of high reduction states of ignimbrite melts and the presence of iron carbides suggest an H2-CH4 composition of the fluidal phase in ignimbrite magmas.

关键词： spherule native iron ignimbrite tektite Primorye Russia.

Hypopharyngeal cancer trends in a high-incidence region:A retrospective tertiary single center study

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世界临床病例杂志 2023年第24期11卷 5666-5677页

作者： Alina-Georgiana Vulcu Cordunianu Gabriel Ganea Mihai alexandru Cordunianu Daniel Cochior Cosmin Alec Moldovan Razvan Adam Doctoral School of Medicine Titu Maiorescu University of BucharestBucharest 040317Romania Department of Ear Nose Throat Head and Neck Surgery Carol Davila Central University Emergency Military HospitalBucharest 10825Romania Department of Pediatric Orthopedics Victor Gomoiu HospitalBucharest 022102Romania Department of Medical-Surgical and Prophylactic Disciplines Faculty of MedicineTitu Maiorescu UniversityBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania

BACKGROUND Hypopharyngeal cancer has the bleakest prognosis among head and neck cancers due to its extensive submucosal involvement,advanced tumor stage,and limited surgical reconstruction *** primary causes include alcohol consumption,tobacco use,genetic predisposition,1`diet,and socioeconomic *** squamous cell carcinoma(SCC)accounts for 95%of hypopharyngeal tumors,it remains a rare form,comprising only 3%-5%of all SCC cases in the head and neck ***,Central and Eastern Europe have the highest incidence rates for males(3.9 per 100000)and the third highest for females(2.26 per 100000),underscoring the significance of this seemingly uncommon *** Romania,hypopharyngeal cancer ranked 24th in incidence rate,with 634 new cases in *** To study the incidence,treatment and survival rates of hypopharyngeal tumor cases in a major ear,nose,throat(ENT)surgical *** A retrospective epidemiological clinical study was conducted on patients diagnosed and treated for hypopharyngeal cancer at the ENT department of"Carol Davila Central University Emergency Military Hospital"in Bucharest between January 2018 and August *** study included 53 patients and was authorized by the Ethics Committee of Titu Maiorescu Doctoral School(Bucharest,Romania)and the Ethics Committee of Carol Davila Central University Emergency Military Hospital(Bucharest,Romania).Inclusion criteria required a positive histopathological diagnosis of hypopharyngeal cancer,tumor localization in the hypopharyngeal region,and informed consent for data *** criteria involved major psychiatric pathologies and disagreement for data *** was based on ENT assessment,imaging reports,and laboratory *** methods were determined based on various *** tools,such as Adult Comorbidity Evaluation-27 and Karnofski Performance Status Scale,were used for risk assessment and functional capacity *** of life aspects were

关键词： Hypopharyngeal Cancer Organ conservation therapy Chemotherapy Radiotherapy Surgery

Fossil history of Mesozoic weevils （Coleoptera： Curculionoidea）

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Insect Science 2012年第6期19卷 683-698页

作者： andrei A. Legalov Laboratory of Phylogeny and Faunogenesis Institute of Systemafics and Ecology of Animals SB RAS Novosibirsk Russia

The first synopsis of Mesozoic weevils （Curculionoidea： Coleoptera） is pre- sented. Changes of family, genera and species abundance during the Mesozoic revealed three distributional patterns. The Jurassic （Karatau） fauna was dominated by the Nemony- chidae. During the Early Cretaceous （beginning at the Jurassic/Cretaceous border）, the Ithyceridae was the prevalent group with a significant role played by the Nemonychidae. In the Late Cretaceous （Cenomanian and Turonian）, the major groups were the Curculion- idae and Brentidae. Obviously, the change of weevil fauna during this period was due to the expansion of the angiosperms, which provided multiple niches in their vegetative and reproductive organs for weevil development.

关键词： Coleoptera Curculionoidea faunistic analysis fossil record Mesozoic,trophic levels

Nature Inspired Hay Fever Therapy

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Journal of Bionic Engineering 2008年第4期5卷 335-339页

作者： andrei P. Sommer Institute of Micro and Nanomaterials University of Ulm

The survival oriented adaptation of evolved biosystems to variations in their environment is a selective optimization process. Recognizing the optimised end product and its functionality is the classical arena of bionic engineering. In a primordial world, however, the molecular organization and functions of prebiotic systems were solely defined by formative processes in their physical and chemical environment, for instance, the interplay between interfacial water layers on surfaces and solar light. The formative potential of the interplay between light （laser light） and interfacial water layers on surfaces was recently exploited in the formation of supercubane carbon nanocrystals. In evolved biosystems the formative potential of interracial water layers can still be activated by light. Here we report a case of hay fever, which was successfully treated in the course of a facial rejuvenation program starting in November 2007. Targeting primarily interfacial water layers on elastin fibres in the wrinkled areas, we presumably also activated mast cells in the nasal mucosa, reported to progressively decrease in the nasal mucosa of the rabbit, when frequently irradiated. Hay fever is induced by the release of mediators, especially histamine, a process associated with the degranulation of mast cells. Decrease in mast cells numbers implies a decrease in the release of histamine. To the best of our knowledge this is the first report on the treatment of hay fever with visible light. This approach was inspired by bionic thinking, and could help ameliorating the condition of millions of people suffering from hay fever world wide.

关键词： allergic rhinitis biomimetic triangle crystalline interracial water layers light diamond elastin