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Dynamic failure of dry and fully saturated limestone samples based on incubation time concept

Journal of Rock Mechanics and Geotechnical Engineering 2017年第1期9卷 125-134页

作者： Yuri v. Petrov Ivan v. Smirnov Grigory A. volkov andrei K. Abramian Anatoliy M. Bragov Stanislav N. verichev Saint Petersburg University Universitetskaya nab. 7-9 Saint Petersburg 199034 Russia Institute of Problems of Mechanical Engineering Russian Academy of Sciences Bolshoj pr. 61 V.O. Saint Petersburg 199178 Russia Lobachevsky State University of Nizhni Novgorod Prospekt Gagarina 23 Nizhny Novgorod 603950 Russia Allseas Engineering B.v. Poortweg 12 Delft 2612 PA The Netherlands

This paper outlines the results of experimental study of the dynamic rock failure based on the comparison of dry and saturated limestone samples obtained during the dynamic compression and split tests. The tests were performed using the Kolsky method and its modifications for dynamic splitting. The mechanical data(e.g. strength, time and energy characteristics) of this material at high strain rates are obtained. It is shown that these characteristics are sensitive to the strain rate. A unified interpretation of these rate effects, based on the structuraletemporal approach, is hereby presented. It is demonstrated that the temporal dependence of the dynamic compressive and split tensile strengths of dry and saturated limestone samples can be predicted by the incubation time criterion. Previously discovered possibilities to optimize(minimize) the energy input for the failure process is discussed in connection with industrial rock failure processes. It is shown that the optimal energy input value associated with critical load, which is required to initialize failure in the rock media, strongly depends on the incubation time and the impact duration. The optimal load shapes, which minimize the momentum for a single failure impact, are demonstrated. Through this investigation, a possible approach to reduce the specific energy required for rock cutting by means of high-frequency vibrations is also discussed.

关键词： Dynamic strength Incubation time criterion Split Hopkinson pressure bar(SHPB) test Tensile strength Compressive strength Water-saturated limestone vibration-assisted rock cutting

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Prazosin:a potential new management tool for iatrogenic autonomic dysreflexia in individuals with spinal cord injury?

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Neural Regeneration Research 2015年第4期10卷 557-558页

作者： Mei M.Z.Zheng Aaron A.Phillips Stacy L.Elliott andrei v.Krassioukov Experimental Medicine Program Faculty of MedicineUniversity of British ColumbiaVancouver V5Z 1M9Canada International Collaboration on Repair Discoveries (ICORD) University of British ColumbiaVancouver V5Z 1M9Canada Centre for Heart Lungand Vascular HealthFaculty of Health and Social DevelopmentUniversity of British ColumbiaKelowna V1V 1V7Canada Department of Psychiatry University of British Columbiaancouver V6T 2A1Canada Department of and Urologic Sciences University of British ColumbiaVancouver V5Z 1M9Canada vancouver Sperm Retrieval Clinic Vancouver Coastal Health AuthorityVancouver V5Z 1M9Canada G.F.Strong Rehabilitation Center Sexual Health Rehabilitation ServiceVancouver V5Z 2G9Canada Division of Physical Medicine and Rehabilitation Department of MedicineUniversity of British ColumbiaVancouver V5Z 2G9Canada

Spinal cord injury （SCI） is a devastating condition that not only results in a loss of motor functions but also severe autonomic dysfunctions （Krassioukov and Claydon, 2006）. Autonomic dysreflexia （AD） is a life threatening episode of tran- sient hypertension that occurs up to 30x/day （1 Ix/day on average） in those with cervical or high thoracic SCI （Hubli et al., 2015）. Most common triggers of AD are from stimuli such as a full bowel and/or bladder, or sexual arousal （Teasell et al., 2000）. Penile vibrostimulation （PvS） is a clinical pro- cedure for sperm retrieval used for the purpose of family planning or fertility assessment that unfortunately iatrogenically induces episodes of AD （Elliott, 2006）. Recently, we published a clinical trial highlighting that prazosin may be a viable option for treating AD secondary to PvS （Phillips et al., 2014）.

关键词： Prazosin SCI AD DBP

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Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors

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Light(Science & Applications) 2022年第3期11卷 22-34页

作者： Elena I.Shramova Stepan P.Chumakov victoria O.Shipunova Anastasiya v.Ryabova Georgij B.Telegin andrei v.Kabashin Sergey M.Deyev Galina M.Proshkina Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences16/10 Miklukho-Maklaya StreetMoscow 117997Russia MEPhI(Moscow Engineering Physics Institute) Institute of Engineering Physics for Biomedicine(PhysBio)31 Kashirskoe shosseMoscow 115409Russia Prokhorov General Physics Institute Russian Academy of SciencesVavilova38Moscow 119991Russia Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesProspect Nauki 6Pushchino 142290Russia Aix Marseille University CNRSLP3163 Ave.De LuminyCase 91713288 MarseilleFrance

Photodynamic therapy(PDT)is one of the most appealing photonic modalities for cancer treatment based on anticancer activity of light-induced photosensitizer-mediated reactive oxygen species(ROS),but a limited depth of light penetration into tissues does not make possible the treatment of deep-seated neoplasms and thus complicates its widespread clinical ***,we introduce the concept of genetically encoded bioluminescence resonance energy transfer(BRET)-activated PDT,which combines an internal light source and a photosensitizer(PS)in a single-genetic construct,which can be delivered to tumors seated at virtually unlimited depth and then triggered by the injection of a substrate to initiate their *** illustrate the concept,we engineered genetic NanoLuc-miniSOG BRET pair,combining NanoLuc luciferase flashlight and phototoxic flavoprotein miniSOG,which generates ROS under luciferase-substrate *** prove the concept feasibility in mice bearing NanoLuc-miniSOG expressing tumor,followed by its elimination under the luciferase-substrate ***,we demonstrate a targeted delivery of NanoLuc-miniSOG gene,via tumor-specific lentiviral particles,into a tumor,followed by its successful elimination,with tumor-growth inhibition(TGI)coefficient exceeding 67%,which confirms a great therapeutic potential of the proposed *** conclusion,this study provides proof-of-concept for deep-tissue“photodynamic”therapy without external light source that can be considered as an alternative for traditional PDT.

关键词： neoplasms injection treatment

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Structure-property relationships in ILs: A study of the alkyl chain length dependence in vaporisation enthalpies of pyridinium based ionic liquids

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Science China Chemistry 2012年第8期55卷 1525-1531,1-6页

作者： ZAITSAU Dzmitry H. YERMALAYEU andrei v. EMEL'YANENKO vladimir N. vEREvKIN Sergey P. WELZ-BIERMANN Urs SCHUBERT Thomas Department of Physical Chemistry University of Rostock Dr-Lorenz-Weg 1 D-18059 Rostock Germany Evonik Degussa Taiwan Ltd. 133 Minsheng East Road Section Taipei 10596 China 3IoLiTec Ionic Liquids Technologies GmbH Salzstrasse 184 74076 Heilbronn Germany

The enthalpies of vaporization for the series of pyridinium-based ionic liquids with bis(trifluoromethylsulfonyl)imide anion [CnPy][NTf2] (n = 2, 3, 4, 5, and 6) have been determined with the quartz crystal microbalance technique combined with the Langmuir evaporation. The linear dependence of vaporization enthalpies on the chain length has been revealed. New approach based on volumetric, surface tension, and speed of sound measurements has been developed for estimation of heat capacity differences between gas and liquid phase, which were required for adjustment of measured vaporization enthalpies to the ref- erence temperature 298 K.

关键词：离子液体蒸发焓吡啶类烷基链石英晶体微天平长度性能结构

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Design of broadband terahertz vector and vortex beams: I. Review of materials and components

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Light(Advanced Manufacturing) 2022年第4期3卷 126-144页

作者： Nikolay v.Petrov Bogdan Sokolenko Maksim S.Kulya andrei Gorodetsky Aleksey v.Chernykh Digital and Display Holography Laboratory ITMO UniversitySt.Petersburg 197101Russia v.I.vernadsky Crimean Federal University Simferopol 295007Russia School of Physics and Astronomy University of BirminghamBirmingham B152TTUK

In this paper,we review the existing approaches for vortex and vector beam shaping and generation in the terahertz frequency *** particular focus of this review is on the possibility of homogeneous topological charge formation in the ultra-wide spectral interval inherent to ultrashort terahertz *** review the available materials and components,analyse proposed and potentially possible solutions for broadband terahertz vortex and vector beam shaping,compare all developed approaches,and put forward a unified concept for constructing passive shapers of such beams from the existing component base.

关键词： Terahertz radiation vortex beams vector beams Achromatic wave plates Broadband terahertz radiation Digital holography Terahertz holography Total internal reflection Metasurface THz liquid crystals Geometric phase

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Design of broadband terahertz vector and vortex beams: II. Holographic assessment

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Light(Advanced Manufacturing) 2022年第4期3卷 14-26页

In this paper,we demonstrate the capabilities of the terahertz pulse time-domain holography in visualisation,simulation,and assessment of broadband THz vortex beam formation dynamics upon its shaping by elements of beam converter,and further propagation and *** adding Jones matrix formalism to describe broadband optical elements,we highlight the differences in the spatio-spectral and spatio-temporal structure of the formed vortex and vector beams dependence on the modulator used and visualise their modal *** influence of diffraction field structure from each element in the broadband vortex modulator is revealed in numerical simulation and the formed beams are analysed against the simplified Laguerre-Gaussian beam model.

关键词： Terahertz radiation vortex beams vector beams Achromatic wave plates Broadband terahertz radiation Digital holography Terahertz holography

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Resolution and contrast enhancement of laser-scanning multiphoton microscopy using thulium-doped upconversion nanoparticles

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Nano Research 2019年第12期12卷 2933-2940页

作者： Alexey B.Kostyuk Artem D.vorotnov Andrey v.Ivanov Arthur B.volovetskiy Aleksandr v.Kruglov Lyudmila M.Sencha Liuen Liang Evgenii L.Guryev vladimir A.vodeneev Sergey M.Deyev Yiqing Lu andrei v.Zvyagin Lobachevsky State University of Nizhny Novgorod Nizhny Novgorod 603950Russia Center of Biomedical Engineering Institute of Molecular MedicineSechenov UniversityMoscow 119991Russia ARC Centre of Excellence"Nanoscale BioPhotonics" Department of Physics and AstronomyMacquarie UniversitySydney 2109Australia Institute ofBioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia

High-contrast optical imagi ng is achievable using phosphoresce nt labels to suppress the short-lived background due to the optical backscatterand autofluoresce ***,the long-lived phosphorescence is generally incompatible with high-speed laser-scan ning imaging ***,we show that upc on versi on nan oparticles of structure NaYF4:Yb co-doped with 8%Tm(8T-UCNP)in combi nation with a commerciallaser-scanning multiphoton microscopy are uniquely suited for labeling biological systems to acquire high-resolution images with the enhancedcon *** comparison with many phosphoresce nt labels,the 8T-UCNP emission lifetime of-15μs affords rapid image ***-order optical nonlinearity of the 8T-UCNP(n=4,as confirmed experimentally and theoretically)afforded pushing the resolution limitattain able with UCNPs to the *** contrast enha nceme nt was achieved by suppressing the backgro und using(i)ban dpassspectral filtering of the narrow emission peak of 8T-UCNP at 455-nm,and(ii)time-gating implemented with a time-correlated single-photon counting system that demonstrated the contrast enhancement of>2.5-fold of polyethyle neimine-coated 8T-UCNPs take n up by huma nbreast adeno carcinoma cells *** a result,discrete 8T-UCNP nan oparticles became clearly observable in the freshly excised splee ntissue of laboratory mice 15-min post in trave nous injectio n of an 8T-UCNP *** dem on strated approach paves the way forhigh-contrast,high-resoluti on,and high-speed multiphot on microscopy in challe nging envir onments of i ntense autofluorescence,exogenous staining,and turbidity,as typically occur in intravital imaging.

关键词： upconversion nanoparticles autofluorescence time-gated imaging scanning microscopy time-correlated single photon counting

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The Basic Components of Software-Hardware System for Modeling and Control of the Toroidal Plasma by Epsilon-Nets on Heterogeneous Mini-Supercomputers

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Communications in Computational Physics 2018年第6期24卷 1-26页

作者： Fedor S.Zaitsev Alexei G.Shishkin andrei A.Lukianitsa Egor P.Suchkov Sergei v.Stepanov Fedor A.Anikeev Scientific Research Institute of System Development Russian Academy of SciencesNakhimovsky prosp.26 b.1117218MoscowRussia Moscow State University Department of Computational Mathematics and CyberneticsLenin’s Hills119991MoscowRussia.

A significant step towards the comprehensive solution of the important new fundamental control problems of high-temperature plasma of toroidal configuration is made by utilizing heterogeneous mini-supercomputers of NIISI RAS(Scientific Research Institute of System Development,Russian Academy of Science).The basic components of hardware and software modeling system and automatic real-time plasma feedback control are developed and *** system is named HASP CS(Hardware-Software Plasma Control System).It is based on a fundamentally new,more accurate and reliable control algorithm using a solution with a given accuracy of a number of inverse diagnostic problems by ∈-*** possibility of an application of the proposed technique during discharge time to provide feedback control of the boundary and internal plasma parameters is *** is shown that the complex allows investigating the processes in currently operated and designed fusion devices and solving problems of fusion application for energy *** recommendations to the engineering implementation of plasma control systems are *** directions for further research are formulated.

关键词： Control problem ∈-net plasma tokamak modeling

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Boron nitride nanotube growth via boron oxide assisted chemical vapor transport-deposition process using LiNO3 as a promoter

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Nano Research 2015年第6期8卷 2063-2072页

作者： andrei T. Matveev Konstantin L. Firestein Alexander E. Steinman Andrey M. Kovalskii Oleg I. Lebedev Dmitry v. Shtansky Dmitri Golberg National University of Science and Technology 'MISIS' Leninskiy prospect 4 Moscow 119049 Russia CRISMAT UMR 6508 CNRS-ENSICAEN 6BdMarechalJuin Caen 14050 France Institute for Materials Science (NIMS) Namiki 1 Ibaraki Tsukuba 3050044 Japan

高纯净的直、分离的 multiwalled 硼氮化物 nanotubes (BNNT ) 作为一个倡导者用浮雕 3 与氨经由硼氧化物蒸汽反应被种。硼氧化物的仅仅踪迹数量被精力散的 X 光检查(EDX ) 和拉曼光谱学在 BNNT 作为杂质检测。硼氧化物蒸汽从 B 的混合... 详细信息

高纯净的直、分离的 multiwalled 硼氮化物 nanotubes (BNNT ) 作为一个倡导者用浮雕 3 与氨经由硼氧化物蒸汽反应被种。硼氧化物的仅仅踪迹数量被精力散的 X 光检查(EDX ) 和拉曼光谱学在 BNNT 作为杂质检测。硼氧化物蒸汽从 B 的混合物被产生， FeO ，吗并且 MgO 粉末加热了到 1,150 爠灥潲畤楣汢?湡?楨桧祬愠瑣癩??卒攠晦'太B?獕湩?桴?牵档湩氭歩?杁??牡慲獹愠??卒猠'T瑳慲整?ㄠ????猯灵￣?楤畢祴?桰桴污瑡?愨洠浥敢?景瀠慬瑳捩穩牥?慦業祬?湡??‵殣?岣僫篤蔿藏????鐿???????脿???鯀魈鱋??︿????????????璣阿??鲣??觎????鑔鍽???????????恘? 恘？？

关键词：氮化硼纳米管生长机理化学气相传输氧化硼沉积过程硼氮纳米管温度范围卷曲纤维

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Cytotoxicity and non-specific cellular uptake of bare and surface-modified upconversion nanoparticles in human skin cells

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Nano Research 2015年第5期8卷 1546-1562页

作者： Anna E. Guller Alia N. Generalova Elena v. Petersen Andrey v. Nechaev Inna A. Trusova Nikolay N. Landyshev Annemarie Nadort Ekaterina A. Grebenik Sergey M. Deyev Anatoly B. Shekhter andrei v. Zvyagin Macquarie University Australia I.M. Sechenov First Moscow State Medical University Russia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences Russia Nizhny Novgorod State University Russia Moscow Institute of Physics and Technology Russia Moscow State University of Fine Chemical Technologies Russia University of Amsterdam the Netherlands

cytotoxicity 和 upconversion nanoparticle ( UCNP )的最流行的作文的非特定的细胞的举起， NaYF 4 :Yb3+ :Er3+,用正常人的皮肤房间被报导，包括真皮的成纤维细胞和使不朽的人表皮的线性 keratinocytes ( HaCaT )。同样综合的 UC... 详细信息

cytotoxicity 和 upconversion nanoparticle ( UCNP )的最流行的作文的非特定的细胞的举起， NaYF 4 :Yb3+ :Er3+,用正常人的皮肤房间被报导，包括真皮的成纤维细胞和使不朽的人表皮的线性 keratinocytes ( HaCaT )。同样综合的 UCNP 的新 hydrophilization 反应基于 tetramethylammonium 氢氧化物(TMAH ) 启用了赤裸的 UCNP 的内在的 cytotoxicity 的评估。UCNP 表面涂层和聚苯乙烯主人的 cytotoxicity 效果在集中范围上被调查有 24-h 孵化的 62.5125 g/mL，用 MTT 测试和光显微镜学。成纤维细胞生存能力没被 UCNP 损害，而 keratinocytes 的生存能力从 52% 变化了 ? 牧灡敨敮 ???? ?? 汣獡 ??  ???????? 愠瀭畬 ? 汰獵?? ㈠ ?? ?? ￣ ???? 控慬獳??? 汰獵瀭畬 ?? ￣″ ? ?? 〨??? 吗？？

关键词：皮肤细胞细胞毒性细胞摄取非特异性纳米粒子表面改性上转换皮肤成纤维细胞

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