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Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors

Light(Science & Applications) 2022年第3期11卷 22-34页

作者： Elena I.Shramova Stepan P.Chumakov victoria O.Shipunova Anastasiya v.Ryabova Georgij B.Telegin andrei v.kabashin Sergey M.Deyev Galina M.Proshkina Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences16/10 Miklukho-Maklaya StreetMoscow 117997Russia MEPhI(Moscow Engineering Physics Institute) Institute of Engineering Physics for Biomedicine(PhysBio)31 Kashirskoe shosseMoscow 115409Russia Prokhorov General Physics Institute Russian Academy of SciencesVavilova38Moscow 119991Russia Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesProspect Nauki 6Pushchino 142290Russia Aix Marseille University CNRSLP3163 Ave.De LuminyCase 91713288 MarseilleFrance

Photodynamic therapy(PDT)is one of the most appealing photonic modalities for cancer treatment based on anticancer activity of light-induced photosensitizer-mediated reactive oxygen species(ROS),but a limited depth of light penetration into tissues does not make possible the treatment of deep-seated neoplasms and thus complicates its widespread clinical ***,we introduce the concept of genetically encoded bioluminescence resonance energy transfer(BRET)-activated PDT,which combines an internal light source and a photosensitizer(PS)in a single-genetic construct,which can be delivered to tumors seated at virtually unlimited depth and then triggered by the injection of a substrate to initiate their *** illustrate the concept,we engineered genetic NanoLuc-miniSOG BRET pair,combining NanoLuc luciferase flashlight and phototoxic flavoprotein miniSOG,which generates ROS under luciferase-substrate *** prove the concept feasibility in mice bearing NanoLuc-miniSOG expressing tumor,followed by its elimination under the luciferase-substrate ***,we demonstrate a targeted delivery of NanoLuc-miniSOG gene,via tumor-specific lentiviral particles,into a tumor,followed by its successful elimination,with tumor-growth inhibition(TGI)coefficient exceeding 67%,which confirms a great therapeutic potential of the proposed *** conclusion,this study provides proof-of-concept for deep-tissue“photodynamic”therapy without external light source that can be considered as an alternative for traditional PDT.

关键词： neoplasms injection treatment

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Silica-Metal Spherules in Ignimbrites of Southern Primorye,Russia

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Journal of Earth Science 2011年第1期22卷 20-31页

作者： andrei v Grebennikov Far East Geological Institute Prospect Stoletia 159 690022 Vladivostok Russia

A comprehensive mineralogical-geochemical and petrological study of ignimbrites from the Yakut-Gora volcanic depression （Primorye, Far Eastern Russia） revealed a wide distribution of silica-metal spherules （＂globules＂） that are typical liquid immiscibility resultant. The metallic portion of a spherule （composition varies from low-carbon iron to cohenite） borders gas pores and is rimmed by symplectite that consists of quartz, magnetite, and silica-potassic glass. This allows us to consider that the whole formation formed through reduction of the enclosing silicate melt. Abundant evidence of high reduction states of ignimbrite melts and the presence of iron carbides suggest an H2-CH4 composition of the fluidal phase in ignimbrite magmas.

关键词： spherule native iron ignimbrite tektite Primorye Russia.

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Paleocene A-type igneous suites in the Sikhote-Alin(the East Asian continental margin):Petrological,geochronological,isotopic,and geodynamic constraints

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Geoscience Frontiers 2023年第6期14卷 386-413页

作者： andrei v.Grebennikov Sergei A.Kasatkin Far East Geological Institute Far Eastern Branch of the Russian Academy of Sciences159Prospekt 100-letiya VladivostokaVladivostok 690022Russian Federation

Global geodynamic reconstruction models of the Pacific margin of Asia refer to materials collected throughout Japan,Korea and northeastern China,but they lack data on southern ***,the Sikhote-Alin orogenic belt(NE Asia)constituted a single eastern margin of the paleo-Asian continent with the abovementioned territories in the *** isotopic,geochemical,and geochronological data show that Paleocene igneous activity(-61-55 Ma)is widely developed in south-ern *** rock compositions of the igneous rocks of this period yield ferroan,peraluminous,calc-alkaline to alkaline affinities,highly abundant LILE and HFSE(with pronounced Ba,Sr,Eu,and Ti neg-ative anomalies)and depleted *** initial melts,displaying Zr+Y+Ce+Nb>350 ppm and 10,000×Ga/Al>2.6,derived from an OIB-like mantle source crystallised under fairly reducing conditions(below FMQ buffer),and yield high temperature of zircon saturation(>850℃),indicating typical A-type granite and related volcanic rock *** is logical to associate variations in A-type rock geochemical composition with an enrichment of the upper part of the magma chamber with fluid-mobile components involving a reditribution of major and trace elements through fluid-magmatic *** depletion in Ca,Mg,Ba,Sr,Eu in the A-type rocks is caused by an outflow of these elements by an oxi-dizing,initially reduced,acidic fluid beyond the zone of magma ***-rock Sr-Nd isotope data argue for the generation of the A-type rocks by melting of dominantly a juvenile mantle component with a subordinate component of the ancient *** variations of igneous rocks of the reference area:^(87)Sr/^(86)Sr(t)(0.7024-0.7118),ε_(Nd)(t)(-0.9 to-5.1)and T_(DM2)(934-1277 Ma),result from the mixing of the OIB-like mantle source with selective melts or from the metapelite contamination of the Samarka terrane accretionary prism and of the Zhuravlevka-Amur turbidite basin,later followed by fluid-magma

关键词： Post-subduction magmatism Slab tear Sub-slab asthenosphere Strike-slip tectonic setting Lanthanide tetrad effect

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Paleocene–early Eocene post-subduction magmatism in Sikhote-Alin (Far East Russia): New constraints for the tectonic history of the Izanagi-Pacific ridge and the East Asian continental margin

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Geoscience Frontiers 2021年第4期12卷 71-85页

作者： andrei v.Grebennikov Igor v.Kemkin Alexander I.Khanchuk Far East Geological Institute Far Eastern BranchRussian Academy of Sciencespr.100-letiya Vladivostok 159Vladivostok 690022Russia Institute of Geology of Ore Deposits PetrographyMineralogy and Geochemistry(IGEM)Russian Academy of Sciences35 Staromonetny Per.Moscow 109017Russia

New isotopic,geochemical and geochronological data justify the widespread occurrence of middle Paleocene to early Eocene(60–53 Ma)post-subduction felsic magmatism across the entire Sikhote-Alin territory(southeastern Russia),conform with previous observations in Northeast China,the southern Korean Peninsula,and the Inner Zone of *** igneous activity in East Asia coincided with the reactivation(after tectonic quiescence between~93–60Ma)of left-lateral strike-slip displacements along the Tan-Lu and Central Sikhote-Alin faults and with the post-60 Ma cessation of subduction/accretion recorded in the Shimanto belt of SW *** Sikhote-Alin post-subduction igneous A-type rocks present diverse mineralogical and geochemical features that suggest interactions of the subducting plate with anhydrous mantle upwelling through slab tears in the continental *** middle Paleocene–early Eocene magmatismis not related to subduction but is synchronous with strikeslip tectonics and the termination of accretionary prism development,suggesting a shift in tectonic regime from oceanic plate subduction at a convergent margin to parallel sliding and initiation of a transformcontinental *** new observations are inconsistent with the current tectonic model of 60–50 Ma Izanagi-Pacific ridge subduction beneath East Asian continental margin.

关键词： Post-subduction magmatism Slab tear Sikhote-Alin Paleocene A-type rocks Izanagi-Pacific ridge

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Deep Forest as a framework for a new class of machine-learning models

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National Science Review 2019年第2期6卷 186-187页

作者： Lev v.Utkin Anna A.Meldo andrei v.Konstantinov Laboratory of Neural Network Technology and Artificial Intelligence Peter the Great St. Petersburg Polytechnic University

A new deep learning framework—the socalled Deep Forest (DF), proposed by Zhi-Hua Zhou and Ji Feng [1,2]—can be regarded as one of the important events of 2017 in machine learning, although it was unjustly unnoticed by a large number of researchers. The DF combines several ensemble-based methods, including Random Forests (RFs) and Stacking, into a structure that is similar to a multi-layer neural network, but each layer in the DF

关键词： Deep Forest as a framework for a new class of machine-learning models

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Hybrid Triboelectric-Electromagnetic Nanogenerators for Mechanical Energy Harvesting:A Review

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Nano-Micro Letters 2021年第12期13卷 163-220页

作者： Joao v.vidal vladislav Slabov andrei L.Kholkin Marco P.Soares dos Santos Department of Physics and CICECO-Aveiro Institute of Materials University of Aveiro3810-193 AveiroPortugal Department of Physics and I3N University of Aveiro3810-193 AveiroPortugal Laboratory of Functional Low-Dimensional Structures National University of Science and Technology MISISMoscowRussia Department of Mechanical Engineering Centre for Mechanical Technology and Automation(TEMA)University of Aveiro3810-193 AveiroPortugal

Motion-driven electromagnetictriboelectric energy generators(E-TENGs) hold a Hybrid triboelectric-electromagnetic generators C A Bgreat potential to provide higher voltages,higher currents and wider operating bandwidths than Cantilever generators1 μm both electromagnetic and triboelectric generators Rotating generatorsSliding generators standing alone. Therefore,they are promising solutions to autonomously supply a broad range of Flexible blade generators Magnetoelectric highly sophisticated devices. This paper provides generators a thorough review focused on major recent breakLinear generators Multidimensional generators throughs in the area of electromagnetic-triboelectric vibrational energy harvesting. A detailed Pendulum generators analysis was conducted on various architectures including rotational,pendulum,linear,sliding,cantilever,flexible blade,multidimensional and 1 cm magnetoelectric,and the following hybrid technologies. They enable highly e cient ways to harvest electric energy from many forms of vibrational,rotational,biomechanical,wave,wind and thermal sources,among others. Open-circuit voltages up to 75 v,short-circuit currents up to 60 mA and instantaneous power up to 144 mW were already achieved by these nanogenerators. Their transduction mechanisms,including proposed models to make intelligible the involved physical phenomena,are also overviewed here. A comprehensive analysis was performed to compare their respective construction designs,external excitations and electric outputs. The results highlight the potential of hybrid E-TENGs to convert unused mechanical motion into electric energy for both large-and small-scale ***,this paper proposes future research directions toward optimization of energy conversion e ciency,power management,durability and stability,packaging,energy storage,operation input,research of transduction mechanisms,quantitative standardization,system integration,miniaturization and multi-energy hybrid cells.

关键词： E-TENG Hybrid triboelectric-electromagnetic Nanogenerators Energy harvesting

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Compressively-strained GaSb nanowires with core-shell heterostructures

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Nano Research 2020年第9期13卷 2517-2524页

作者： Zhongyunshen Zhu Johannes Svensson Axel R.Persson Reine Wallenberg andrei v.Gromov Lars-Erik Wernersson Departm ent of Electrical and Information Technology Lund UniversityBox 11822100 LundSweden Centre for Analysis and Synthesis Lund UniversityBox 12422100 Lundt Sweden NanoLund Lund UniversityBox 11822100 LundSweden EaStCHEM School of ChemistryUniversity of EdinburghEdinburgh EH93FJUK

GaSb-based nanowires in a gate-all-around geometry are good candidates for binary p-type transistors,however they require the introduction of compressive strain to enhance the transport ***,we for the first time demonstrate epitaxial GaSb-GaASxSb1-x core-shell nanowires with a compressively strained *** axial and hydrostatic strain in GaSb core have been measured by X-ray diffraction(XRD)and Raman scattering,*** optimal sample,almost without plastic relaxation,has an axial strain of-0.88%and a hydrostatic strain of-1.46%,leading to a noticeable effect where the light hole band is calculated to be 33.4 mev above the heavy hole band at the *** valence band feature offers more light holes to contribute the transport process,and thus may provide enhanced hole mobility by reducing both the interband scattering and the hole effective *** results show that lattice-mismatched epitaxial core-shell heterostructures of high quality can also be realized in the promising yet demanding GaSb-based system.

关键词： compressive strain GaSb-GaAsxSbi-x core-shell nanowires heterostructure p-type transistors

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Modeling electronic and optical properties of Ⅲ–Ⅴ quantum dots-selected recent developments

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Light(Science & Applications) 2022年第1期11卷 13-26页

作者： Alexander Mittelstädt andrei Schliwa Petr Klenovský Institute for Solid State Physics Technical University of BerlinHardenbergstrasse 36D-10623 BerlinGermany Department of Condensed Matter Physics Faculty of ScienceMasaryk UniversityKotlářská267/261137 BrnoCzech Republic Czech Metrology Institute Okružní3163800 BrnoCzech Republic

Electronic properties of selected quantum dot(QD)systems are surveyed based on the multi-band k·p method,which we benchmark by direct comparison to the empirical tight-binding algorithm,and we also discuss the newly developed"linear combination of quantum dot orbitals"***,we focus on two major complexes:First,the role of antimony incorporation in InGaAs/GaAs submonolayer QDs and In1−xGax AsySb1−y/GaP QDs,and second,the theory of QD-based quantum cascade lasers and the related prospect of room temperature lasing.

关键词： quantum optical lasing

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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova andrei I.Fischer Natalia A.Nesterova Anatoliy v.Dobrodumov Anzhelika v.Garshinina Olga D.Shuvaeva Natalya v.Zakharova Evgenii F.Panarin Institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(N-vinylpyrrolidone(vP),N-methyl-N-vinylacetamide(MvAA),N-methacryloyl glucosamine(MAG))and anionic comononer sodium styrene sulfonate(NaSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-vinylamide units(vP,MvAA)is three times more intense than that observed for the complexes between Tb^(3+)and MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled by the values of binding constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

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Momentum considerations inside near-zero index materials

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Light(Science & Applications) 2022年第8期11卷 1782-1789页

作者： Michaël Lobet Iñigo Liberal Larissa vertchenko andrei vLavrinenko Nader Engheta Eric Mazur John A.Paulson School of Engineering and Applied Sciences Harvard University9 Oxford StreetCambridgeMA02138USA Department of Physics and Namur Institute of Structured Materials University of NamurRue de Bruxelles 515000NamurBelgium Electrical and Electronic Engineering Department Universidad Pública de NavarraCampus ArrosadíaPamplona31006Spain Department of Photonics Engineering Technical University of DenmarkØrsteds Plads 345ADK-2800 KgsLyngbyDenmark Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA

Near-zero index (NZI) materials, i.e., materials having a phase refractive index close to zero, are known to enhance or inhibit light-matter interactions. Most theoretical derivations of fundamental radiative processes rely on energetic considerations and detailed balance equations, but not on momentum considerations. Because momentum exchange should also be incorporated into theoretical models, we investigate momentum inside the three categories of NZI materials, i.e., inside epsilon-and-mu-near-zero (EMNZ), epsilon-near-zero (ENZ) and mu-near-zero (MNZ) materials. In the context of Abraham–Minkowski debate in dispersive materials, we show that Minkowski-canonical momentum of light is zero inside all categories of NZI materials while Abraham-kinetic momentum of light is zero in ENZ and MNZ materials but nonzero inside EMNZ materials. We theoretically demonstrate that momentum recoil, transfer momentum from the field to the atom and Doppler shift are inhibited in NZI materials. Fundamental radiative processes inhibition is also explained due to those momentum considerations inside three-dimensional NZI materials. Absence of diffraction pattern in slits experiments is seen as a consequence of zero Minkowski momentum. Lastly, consequence on Heisenberg inequality, microscopy applications and on the canonical momentum as generator of translations are discussed. Those findings are appealing for a better understanding of fundamental light-matter interactions at the nanoscale as well as for lasing applications.

关键词： materials. momentum Minkowski

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