检索结果-南通市图书馆

Treatment of intermediate-risk prostate cancer with active surveillance in the routine care—Long-term outcomes of a prospective noninterventional study(HAROW)

在线全文

学校读者我要写书评

暂无评论

Current Urology 2024年第2期18卷 115-121页

作者： Lothar Weissbach andreas schwarte Edith A.Boedefeld Jan Herden Health Research for Men GmbH BerlinGermany Urological practice Borken BorkenGermany Department of Urology Uro-OncologyRobot-Assisted and Reconstructive UrologyFaculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany PAN Clinic Urological practiceCologneGermany

Background:We report here the long-term outcomes of patients with intermediate-risk prostate cancer(PCa)treated with active surveillance(As)in a daily routine *** andmethods:HAROW(2008–2013)was a noninterventional,health service research study investigating themanagement of localized PCa in a community setting.A substantial proportion of the study centers were office-based urologists.A follow-up examination of all intermediate-risk patients with As was ***,cancer-specific,metastasis-free,and treatment-free survival rates,as well as reasons for discontinuation,were determined and ***:Of the 2957 patients enrolled,52 with intermediate-risk PCa were managed with As and were available for *** median follow-up was 6.8 years(interquartile range,3.4–8.6 years).seven patients(13.5%)died of causes unrelated to PCa,of whom 4 were under As or under watchful *** patients(3.8%)developed *** estimated 8-year overall,cancer-specific,metastasis-free,and treatment-free survival rates were 85%(95%confidence interval[CI],72%–96%),100%,93%(95%CI,82%–100%),and 31%(95%CI,17%–45%),*** analysis,prostate-specific antigen density of≥0.2 ng/mL2 was significantly predictive of receiving invasive treatment(hazard ratio,3.29;p=0.006).Reasons for discontinuation were more often due to patient's or physician's concerns(36%)than due to observed clinical ***:Although survival outcome data for intermediate-risk patients managed with As in real-life health care conditions were promising,rates of discontinuation were high,and discontinuation was often a patient's decision,even when the signs of disease progression were *** might be an indication of higher levels of mental burden and anxiety in this specific subgroup of patients,which should be considered when making treatment *** a psychological perspective,not all intermediate-risk patients are optimal candidates for A

关键词： Active surveillance Intermediate-risk prostate cancer HAROW study Conservative management Outcomes research

An illustrated guide to:Parsimonious multi-scale full-waveform inversion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake science 2024年第6期37卷 574-583页

作者： andreas Fichtner solvi Thrastarson Dirk-Philip van Herwaarden sebastian Noe Department of Earth sciences ETH ZürichZürich 8049Switzerland

Having been a seemingly unreachable ideal for decades,3-D full-waveform inversion applied to massive seismic datasets has become reality in recent *** achieving unprecedented resolution,it has provided new insight into the structure of the Earth,from the upper few metres of soil to the entire *** by these successes,the technology is now being translated to medical ultrasound and non-destructive *** remarkable progress,the computational cost of fullwaveform inversion continues to be a major *** limits the amount of data that can be exploited,and it largely inhibits quantitative and comprehensive uncertainty *** notes complement a presentation on recent developments in full-waveform inversion that are intended to reduce computational cost and assimilate more data,thereby improving tomographic *** suite of strategies includes flexible and user-friendly spectral-element simulations,the design of wavefieldadapted meshes that harness prior information on wavefield geometry,dynamic mini-batch optimisation that naturally takes advantage of data redundancies,and collaborative multi-scale updating to jointly constrain crustal and mantle structure.

关键词： Earth model seismology full-waveform inversion

Zeno and the Wrong Understanding of Motion—A Philosophical-Mathematical Inquiry into the Concept of Finitude as a Peculiarity of Infinity

在线全文

学校读者我要写书评

暂无评论

Journal of Applied Mathematics and Physics 2024年第3期12卷 912-929页

作者： andreas Herberg-Rothe Faculty of social and Cultural studies University of Applied Sciences Fulda Hesse Germany

In contrast to the solutions of applied mathematics to Zeno’s paradoxes, I focus on the concept of motion and show that, by distinguishing two different forms of motion, Zeno’s apparent paradoxes are not paradoxical at all. Zeno’s paradoxes indirectly prove that distances are not composed of extensionless points and, in general, that a higher dimension cannot be completely composed of lower ones. Conversely, lower dimensions can be understood as special cases of higher dimensions. To illustrate this approach, I consider Cantor’s only apparent proof that the real numbers are uncountable. However, his widely accepted indirect proof has the disadvantage that it depends on whether there is another way to make the real numbers countable. Cantor rightly assumes that there can be no smallest number between 0 and 1, and therefore no beginning of counting. For this reason he arbitrarily lists the real numbers in order to show with his diagonal method that this list can never be complete. The situation is different if we start with the largest number between 0 and 1 (0.999…) and use the method of an inverted triangle, which can be understood as a special fractal form. Here we can construct a vertical and a horizontal stratification with which it is actually possible to construct all real numbers between 0 and 1 without exception. Each column is infinite, and each number in that column is the starting point of a new triangle, while each row is finite. Even in a simple sine curve, we experience finiteness with respect to the y-axis and infinity with respect to the x-axis. The first parts of this article show that Zeno’s assumptions contradict the concept of motion as such, so it is not surprising that this misconstruction leads to contradictions. In the last part, I discuss Cantor’s diagonal method and explain the method of an inverted triangle that is internally structured like a fractal by repeating this inverted triangle at each column. The consequence is that we encounter t

关键词： Zeno False Assumptions about Motion Finitude Infinity Cantor’s Diagonal Method Inverted Triangle as a Different Method Vertical and Horizontal Dimensions Quantum Theory Relativity of space and Time Depending on Velocity

退火热处理对增材制造Alsi10Mg合金宏观和微观变形行为的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

金属学报 2024年第8期60卷 1091-1099页

作者：张星星 LUTZ andreas 甘为民 MAAWAD Emad KRIELE Armin 中国科学院高能物理研究所多学科研究中心北京100049 Mercedes Benz AG Research and Development DepartmentLeibnizstr.271032 BöblingenGermany Institute of Materials Physics Helmholtz-Zentrum HereonMax-lanck-Str.121502 GeesthachtGermany German Engineering Materials science Centre(GEMs)at Heinz Maier-Leibnitz Zentrum(MLZ) Helmholtz-Zentrum Hereon85748 GarchingGermany

增材制造Alsi10Mg合金存在显著的残余应力,对零件的形状尺寸精度、服役安全性和抗腐蚀性能等产生不利影响。在实际应用中,对残余应力敏感的应用需采用去应力退火以消除残余应力。然而,目前对增材制造Alsi10Mg合金退火后力学特性的理解... 详细信息

增材制造Alsi10Mg合金存在显著的残余应力,对零件的形状尺寸精度、服役安全性和抗腐蚀性能等产生不利影响。在实际应用中,对残余应力敏感的应用需采用去应力退火以消除残余应力。然而,目前对增材制造Alsi10Mg合金退火后力学特性的理解还停留在宏观层面。为了更深入地揭示其微观力学行为与内在机制,本工作利用同步辐射X射线衍射技术,对合金进行原位变形研究,分析Al和si相的晶格应变应力演化,明确各物相对合金加工硬化率的具体贡献,并对位错密度的演变进行了量化分析,从而阐明了退火热处理对增材制造Alsi10Mg合金载荷传递行为与位错行为的影响。

关键词：同步辐射X射线衍射原位变形增材制造 Alsi10Mg合金热处理

Endoscopic submucosal dissection and endoscopic mucosal resection for esophageal and gastric lesions:A comparison of procedures

在线全文

学校读者我要写书评

暂无评论

Laparoscopic, Endoscopic and Robotic surgery 2024年第2期7卷 66-71页

作者： Gustav Holm schæbel andreas Weise Mucha Charlotte Egeland Michael Patrick Achiam Department of surgery and Transplantation Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esophageal and gastric lesions are effectively managed with minimally invasive upper endoscopic procedures such as endoscopic mucosa resection(EMR)and endoscopic submucosal dissection(EsD),offering patients alternatives to invasive *** EsD is well established in Eastern Asia,its adoption in Denmark for superficial esophageal cancer is *** study presents real-world data on the feasibility,safety,and hospitalization duration associated with EsD and EMR for esophageal and gastric *** A retrospective analysis was conducted on patients who underwent EsD or EMR at a specialized center in Denmark from October 2016 to June *** on treatment,indication,lesion location,hospitalization duration,procedure duration,specimen size,complications,recurrence,and one-year overall survival were *** comparisons utilized the Mann-Whitney U test,independent sample median test,and chi-squared *** The study included 130 patients(144 procedures):72 underwent EsD and 58 underwent *** with EMR,EsD resulted in greater percentages of en bloc and R0 resections(98.8%vs.64.1%,ps.23.8%,ps(28.7%vs.3.1%,ps(119.5 min vs.37.0 min,psD procedure time significantly decreased over time(p=0.01).The local recurrence rates were 14.5%for EsD and 23.8%for EMR(p=0.767).The one-year overall survival rates were similar between the groups(95.8%vs.94.8%,p=0.553).Conclusion Both EsD and EMR are safe and viable for treating esophageal and gastric *** offers advantages but requires more time and *** findings support the literature,emphasizing the importance of considering patient-specific factors and surgeon proficiency in selecting the appropriate procedure.

关键词： Endoscopic submucosal dissection Endoscopic mucosa resection Gastroesophageal cancer Real-world data

Chronic effects of stretching on range of motion with consideration of potential moderating variables:A systematic review with meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of sport and Health science 2024年第2期13卷 186-194页

作者： andreas Konrad shahab Alizadeh Abdolhamid Daneshjoo saman Hadjizadeh Anvar Andrew Graham Ali Zahiri Reza Goudini Chris Edwards Carina scharf David George Behm Institute of Human Movement science Sport and HealthGraz UniversityGraz A-8010Austria school of Human Kinetics and Recreation Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of sport Injuries and Corrective Exercises Faculty of Sport SciencesShahid Bahonar University of KermanKerman 76169-13439Iran

Background:It is well known that stretch training can induce prolonged increases in joint range of motion(ROM).However,to date more information is needed regarding which training variables might have greater influence on improvements in ***,the purpose of this metaanalysis was to investigate the effects of stretch training on ROM in healthy participants by considering potential moderating variables,such as stretching technique,intensity,duration,frequency,and muscles stretched,as well as sex-specific,age-specific,and/or trained state-specific adaptations to stretch ***:We searched through PubMed,scopus,Web of science,and sportDiscus to find eligible studies and,finally,assessed the results from 77 studies and 186 effect sizes by applying a random-effect ***,by applying a mixed-effect model,we performed the respective subgroup *** find potential relationships between stretch duration or age and effect sizes,we performed a ***:We found a significant overall effect,indicating that stretch training can increase ROM with a moderate effect compared to the controls(effect size=-1.002;Z=-12.074;95%confidence interval:-1.165 to-0.840;psubgroup analysis showed a significant difference between the stretching techniques(p=0.01)indicating that proprioceptive neuromuscular facilitation and static stretching produced greater ROM than did ballistic/dynamic ***,there was a significant effect between the sexes(p=0.04),indicating that females showed higher gains in ROM compared to ***,further moderating analysis showed no significant relation or ***:When the goal is to maximize ROM in the long term,proprioceptive neuromuscular facilitation or static stretching,rather than ballistic/dynamic stretching,should be *** to consider in future research as well as sports practice is that neither volume,intensity,nor frequency of stretching were

关键词： Flexibility Long-term stretching stretch training

Laser material processing optimization using bayesian optimization: a generic tool

在线全文

学校读者我要写书评

暂无评论

Light(Advanced Manufacturing) 2024年第3期5卷 75-85页

作者： Tobias Menold Volkher Onuseit Matthias Buser Michael Haas Nico Bär andreas Michalowski Institut fuer strahlwerkzeuge(IFsW) University of Stuttgart70569 StuttgartGermany Graduate school of Excellence advanced Manufacturing Engineering(GsaME) University of Stuttgart70569 StuttgartGermany

Optimizing laser processes is historically challenging,requiring extensive and costly *** solve this issue,we apply Bayesian optimization for process parameter optimization to laser cutting,welding,and *** demonstrate how readily available Bayesian optimization frameworks enable efficient optimization of laser processes with only modest expert *** studies on laser cutting,welding,and polishing highlight its adaptability to real-world manufacturing ***,the examples emphasize that with suitable cost functions and boundaries an acceptable optimization result can be achieved after a reasonable number of experiments.

关键词： Bayesian optimization Design of experiments Laser cutting Laser welding Laser polishing

Fragile hearts:Unveiling the crucial layers of frailty in elderly patients undergoing percutaneous coronary interventions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第26期12卷 5998-6000页

作者： andreas Mitsis Michael Myrianthefs Department of Cardiology Nicosia General HospitalNicosia 2026Cyprus

Wang and Liu's systematic review of frailty among elderly patients undergoing percutaneous coronary intervention(PCI)revealed that patients with frailty have significantly higher risks of all-cause and in-hospital death,major undesirable cardiovascular events,and major *** is associated with adverse events,prolonged hospital stays,increased complications,and elevated mortality risk due to diminished physiological *** frailty into risk assessment tools is crucial,and gait speed has emerged as a key predictor of *** the impact of frailty leads to personalized and informed decisionmaking,and frailty assessments should be *** holistic approach can inform tailored interventions,thereby optimizing outcomes for this vulnerable population undergoing PCI.

关键词： Frailty Elderly Percutaneous coronary intervention Outcomes Risk assessment tools

High-Intensity Focused Ultrasound-Induced Disulfide Mechanophore Activation in Polymeric Nanostructures for Molecule Release

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCs Chemistry 2024年第8期6卷 1895-1907页

作者： Jilin Fan Kuan Zhang Mingjun Xuan Xiang Gao Rostislav Vinokur Robert Göstl Lifei Zheng andreas Herrmann DWI—Leibniz Institute for Interactive Materials 52056 Aachen Institute of Technical and Macromolecular Chemistry RWTH Aachen University52074 Aachen Wenzhou Institute University of Chinese Academy of Sciences325001 Wenzhou

Ultrasound(Us)activation of mechanophores in polymers that initiates cascade chemical reactions is a promising strategy for on-demand molecule ***,the typical Us frequency used for mechanochemistry is around 20 kHz,producing inertial cavitation that exceeds the tolerance threshold of biological ***,high-intensity focused Us(HIFU)as a mechanical stimulus is introduced to drive the activation of disulfide mechanophores in hyperbranched star polymers(HBsPs)and microgels(MGLs).The mechanism of molecular release is attributed to the thiol-disulfide exchange reaction and subsequent intramolecular *** reveal that HBsPs and MGLs effectively transduce HIFU as mechanical input to chemical output,demonstrated by the quantification of the release of fluorescent umbelliferone(UMB).Moreover,an in vitro study of drug release is carried out using camptothecin as the model drug,which is covalently loaded in MGLs,demonstrating the potential of our system for controlled drug delivery to cancer cells.

关键词： mechanophores polymer mechanochemistry polymeric nanostructures ultrasound drug release sonopharmacology