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Cardiac arrest and cardiopulmonary resuscitation in“hostile”environments:Using automated compression devices to minimize the rescuers’danger

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World Journal of Cardiology 2023年第2期15卷 45-55页

作者： George Latsios Marianna Leopoulou andreas synetos Antonios Karanasos Angelos Papanikolaou Pavlos Bounas Evangelia Stamatopoulou Konstantinos Toutouzas Kostas Tsioufis 1^(st)University Department of Cardiology "Hippokration"University HospitalAthens Medical SchoolAthens 11527Greece 1^(st)Cardiology Clinic 'Hippokration'University HospitalNational and Kapodistrian University of AthensSchool of MedicineAthens 11527Greece Department of Cardiology "Elpis"Athens General HospitalAthens 11522Greece 1^(st)Department of Cardiology Athens Medical SchoolUniversity AthensHippokrat HospitalAthens 11527Greece 1^(st)Cardiology Department Athens Medical School Hippokration General HospitalAthens 11527Greece Department of Cardiology “Thriasio”General HospitalThriasio General HospitalElefsina 19600Greece CathLab 2nd Department of CardiologyMedical SchoolNational and Kapodistrian University of Athens“Attikon”University HospitalAttikon University HospitalAthens 12462Greece The First Department of Cardiology Athens Medical SchoolAthens 11527Greece 1^(st)Department of Cardiology Medical SchoolNational and Kapodistrian University of Athens“Hippokration”General Hospital"Hippokration"University HospitalAthens 11527Greece

Mechanical automated compression devices are being used in cardiopulmonary resuscitation instead of manual,“hands-on”,rescuer-delivered chest ***-theoretical-advantages include high-quality non-stop compressions,thus freeing the rescuer performing the compressions and additionally the ability of the rescuer to stand reasonably away from a potentially“hazardous”victim,or from hazardous and/or difficult resuscitation *** circumstances involve cardiopulmonary resuscitation(CPR)in the Cardiac Catheterization Laboratory,especially directly under the fluoroscopy panel,where radiation is well known to cause detrimental effects to the rescuer,and CPR during/after land or air transportation of cardiac arrest ***,CPR in a coronavirus disease 2019 patient/ward,where the danger of contamination and further serious illness of the health provider is very *** scope of this review is to review and present literature and current guidelines regarding the use of mechanical compressions in these“hostile”and dangerous settings,while comparing them to manual compressions.

关键词： Automated compression devices Cardiopulmonary resuscitation Cathlab Computed tomography Transfer COVID-19

Takotsubo cardiomyopathy complicating transcatheter mitral valve-in-valve replacement

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Journal of Geriatric Cardiology 2022年第7期19卷 559-561页

作者： Maria Drakopoulou George Oikonomou George Latsios andreas synetos George Benetos Chrysavgi Simopoulou Anastasios Apostolos Stergios Soulaidopoulos Konstantina Aggeli Vasilios Lozos Dimitrios Lymperiadis Costas Tsioufis Konstantinos Toutouzas First Department of Cardiology Medical SchoolNational and Kapodistrian University of AthensHippokration General Hospital of AthensAthensGreece Department of Cardiac Surgery Hippokration General Hospital of AthensAthensGreece

A 73-year-old female presented with symp-tomatic heart failure(NYHA class Ⅲ)due to a failed 29-mm Sorin(*** Medical,***,MN)bioprosthetic heart valve surgically implanted 10-year before for severe primary mitral valve regurgitation(flail of the anterior mitral leaf-let at A2 scallop).Preprocedural echocardiography showed preserved left ventricular function with severe bioprosthetic valve stenosis and concomit-ant moderate regurgitation(Video 1 in Supplement).Because of prohibitive surgical risk,a transeptal mitral valve-in-valve(ViV)replacement was planned.

关键词： valve mitral replacement

Pressure and temperature effects resulting from impact onto materials of different reactivity

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Defence Technology(防务技术) 2025年第2期44卷 221-230页

作者： andreas Heine Matthias Wickert Fraunhofer Institute for High-Speed Dynamics Ernst-Mach-InstitutEMIErnst-Zermelo-Str.4Freiburg im Breisgau79104Germany

The pressure and temperature increase resulting from the impact of different threats onto target materials is analyzed with a unified laboratory-scale *** allows deriving qualitative information on the occurring phenomenology as well as quantitative statements about the relative effects sizes as a function of target material and *** considered target materials are steel,aluminum,and *** threats,kinetic energy penetrator,explosively formed projectile,and shaped charge jet are *** the investigated combinations,the measured overpressures vary by a factor of up to 5 for a variation of the material,by a factor of up to 7 for a variation of the threat,and by a factor larger than 15for a simultaneous variation of *** obtained results as well as the experimental approach are relevant for the basic understanding of impact effects and risks due to material *** paper combines two main ***,to provide a summary of own prior work in a coherent journal article and,secondly,to review and discuss these earlier results with a new perspective.

关键词： Impact effects Pressure Temperature Risk assessment Material reactivity

WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma:Role of Calculus bovis

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World Journal of Gastroenterology 2025年第3期31卷 130-133页

作者： Tryfonas Mpektsis Anastasios Manolakis andreas Kapsoritakis Department of Gastroenterology University Hospital of LarisaLarisa 41100Greece

Liver cancer,and in particular hepatocellular carcinoma(HCC)is a disease of rising prevalence and *** date,definitive treatment options include either surgical excision or ablation of the affected *** increasing research on several pathways that could be involved in the progression of HCC,new elements within these pathways emerge as potential targets for novel *** WNT/β-catenin pathway favors the presence of M2 tumor-associated macrophages which in turn promote tumor growth and *** inhibition of this pathway is considered a good candidate for such targeted therapeutic ***,as Huang et al show in their recently published article,Calculus bovis which is used in traditional Chinese medicine can exert an inhibitory effect on theβ-catenin pathway and become a potential candidate for targeted pharmacotherapy against liver cancer.

关键词： Hepatocellular carcinoma Calculus bovis WNT/β-catenin pathway Tumorassociated macrophages

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Evaluating the Potential of Birch Bark Suberinic Acids for Solid Wood Impregnation

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Journal of Renewable Materials 2025年第1期13卷 147-161页

作者： Daniela Godina Guntis Sosins Aigars Paze Janis Rizikovs Raimonds Makars andreas Treu Latvian State Institute of Wood Chemistry Biorefinery LaboratoryRigaLV-1006Latvia Norwegian Institute of Bioeconomy Research Department Wood TechnologyHøgskoleveien 8Ås1433Norway

Instead of the traditional linear model of taking,making,and disposing,the circular bio-economy promotes a regenerative *** there is potential to create valuable products like betulin,lupeol,and suberinic acids(SA)from outer birch bark,many industries,such as plywood and pulp,often choose to incinerate substan-tial amounts of leftover birch bark to meet their energy *** highlights the importance of obtaining valu-able products from *** objective of this study was to examine various fractions of SA and assess their potential for wood *** fractions included SA potassium salts in ethanol(SAK-EtOH)and water(SAK-H2O),SA suspension in water(SAS-H2O)and dried SA,which was subsequently diluted in ethanol(DSA-EtOH).There is signiﬁcant potential for utilizing SA in wood treatment formulations as a sustainable alternative to harmful petroleum-derived *** approach not only addresses environmental concerns but also enhances the functionality of wood in construction applications,such as improving impregnation for moisture and fungal *** the solutions tested,the ethanol solution of SA,speciﬁcally DSA-EtOH,showed the highest weight percent gain(WPG)and the greatest leaching *** analysis showed that SA salts in ethanol(SAK-EtOH)and water(SAK-H2O)predominantly consist of low molecular fractions and each process(acidiﬁcation and drying)reduces the low molecular content in the *** suggests that SA polymerizes after drying,making it necessary to dissolve it in ethanol to meet the requirements for *** opti-mization,including adjustments in the concentration of the SA ethanol solution and the curing temperature,is essential to identify the optimal conditions for more in-depth impregnation studies.

关键词： Birch bark suberinic acids solid wood impregnation

Contribution of fungal biomass to persistent soil carbon across natural ecosystems

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Science China Earth Sciences 2025年第2期68卷 444-456页

作者： Xiang WANG Guang-Hui YU Yakov KUZYAKOV Bo-Hao YIN andreas KAPPLER Cong-Qiang LIU Bohai Coastal Critical Zone National Observation and Research Station Institute of Surface-Earth System ScienceSchool of Earth System ScienceTianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai RimTianjin UniversityTianjin 300072China Department of Soil Science of Temperate Ecosystems Department of Agricultural Soil ScienceUniversity of GöttingenGöttingen 37077Germany Agro-Technological Institute Peoples Friendship University of Russia(RUDN University)Moscow 117198Russia Geomicrobiology Center for Applied GeosciencesUniversity of TübingenTübingen 72076Germany Cluster of Excellence EXC 2124 Controlling Microbes to Fight InfectionUniversity of TübingenTübingen 72076Germany

Fungi are known to be crucial in the formation and stabilization of soil organic matter through their exudates and dead residues(necromass).Yet,it remains unclear how fungi contribute to the persistence of carbon in soils over millennial scales across ***,this study fills the knowledge gap by linking fungal carbon stocks with minerals-associated carbon stocks across major biomes.A strong correlation between fungal biomass and reactive mineral-associated carbon stocks in soils across six biomes supports the substantial role of fungi in soil carbon persistence at the global *** spatial resolution nanoscale secondary ion mass spectrometry revealed that fungi may stabilize carbon by forming organo-mineral associations through their close physical connection to reactive minerals and weathered *** propose a conceptual model that emphasizes the dualistic role of hypha-mineral interactions:(i)fungi accelerate organic matter decomposition by producing reactive oxygen species on the hypha-mineral interfaces,and(ii)fungi stabilize their residues on mineral surfaces,leading to millennial scale persistence of soil ***,fungi play a fundamental role in ecosystems that extends beyond the decomposition of persistent *** are crucial in stabilizing carbon on mineral surfaces,thereby facilitating the long-term removal of carbon from rapid biotic cycling.

关键词： Biogeography Fungi Mineral-associated organic matter(MAOM) Reactive minerals Soil carbon stability NanoSIMS

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Integration of a hybrid vibration prediction model for railways into noise mapping software:methodology,assumptions and demonstration

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Railway Engineering Science 2025年第1期33卷 1-26页

作者： Pieter Reumers Geert Degrande Geert Lombaert David JThompson Evangelos Ntotsios Pascal Bouvet Brice Nélain andreas Nuber Department of Civil Engineering KU LeuvenKasteelpark Arenberg 403001 LeuvenBelgium ISVR University of SouthamptonHighfieldSouthampton SO171BJUK Vibratec 28 Chemin du petit bois69131 EcullyFrance Woelfel Engineering GmbH+Co.KMax‑Planck Strasse 1597204 HoechbergGermany

Within the SILVARSTAR project,a user-friendly frequency-based hybrid prediction tool has been developed to assess the environmental impact of railway-induced *** tool is integrated in existing noise mapping *** modern vibration standards and guidelines,the vibration velocity level in a building in each frequency band is expressed as the sum of a force density(source term),line source transfer mobility(propagation term)and building correction factor(receiver term).A hybrid approach is used that allows for a combination of experimental data and numerical predictions,providing increased flexibility and *** train and track properties can be selected from a database or entered as numerical *** user can select soil impedance and transfer functions from a database,pre-computed for a wide range of parameters with state-of-the-art *** experimental database of force densities,transfer functions,free field vibration and input parameters is also *** building response is estimated by means of building correction *** within the modelling approach are made to reduce computation time but these can influence prediction accuracy;this is quantified for the case of a nominal intercity train running at different speeds on a ballasted track supported by homogeneous soil of varying *** paper focuses on the influence of these parameters on the compliance of the track–soil system and the free field *** also demonstrate the use and discuss the validation of the vibration prediction tool for the case of a high-speed train running on a ballasted track in Lincent(Belgium).

关键词： Railway-induced vibration Hybrid vibration prediction model Experimental validation Low-speed approximation

Feasibility study on the suitability of dielectric barrier discharge plasma treatment of desert sand for concrete production purposes

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Plasma Science and Technology 2025年第1期27卷 111-117页

作者： Yorick FENNER Martin BELLMANN andreas TUMMEL Christoph GERHARD Faculty of Engineering and Health University of Applied Sciences and ArtsGöttingen 37085Germany Application Center for Plasma and Photonics Fraunhofer Institute for Surface Engineering and Thin FilmsGöttingen 37085Germany School of Industrial and Information Engineering Politecnico di MilanoMilano 20133Italy

Due to the continuously increasing building and construction industry,sand has become one of the most questioned raw materials ***,the available amount of sand suitable for concrete production is orders of magnitude lower that the demand and *** though desert sand is sufficiently available,it is not usable for realizing stable concrete due to its surface *** this background,the suitability of energy-efficient‘cold'dielectric barrier discharge plasma operated at atmospheric pressure for improving the properties of concrete produced from desert sand was investigated in this *** is shown that such plasma treatment allows for a certain roughening and re-shaping of sand *** a result,the mass flow of treated sand is decreased due to an improved wedging of sand *** leads to a certain increase in compressive strength of concrete *** though this increase is marginal,the suitability of the applied type of plasma for modification of the geometry and surface chemistry of sand grains was proven,showing its basic potential for the treatment and preconditioning of sand used for concrete,mortar or plastering.

关键词： plasma treatment atmospheric pressure plasma sand concrete surface roughening mass flow compressive strength