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Hemorrhagic colitis induced by trientine in a 51-year-old patient with Wilson's disease waiting for liver transplantation:A case report

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World Journal of Hepatology 2022年第8期14卷 1687-1691页

作者： andreas schult Matts Andersson Jorge Asin-Cayuela Karl Sigvard Olsson Transplant Institute Sahlgrenska University HospitalGothenburg 41345Sweden Department of Molecular and Clinical Medicine Institute of MedicineSahlgrenska AcademyUniversity of GothenburgGothenburg 41345Sweden Department of Medicine Örnsköldsvik HospitalÖrnsköldsvik 89145Sweden Department of Clinical Genetics Sahlgrenska University HospitalGothenburg 41345Sweden Section of Hematology and Coagulation Department of Medicine and Clinical NutritionInstitute of MedicineSahlgrenska AcademyUniversity of GothenburgGothenburg 41345Sweden

BACKGROUND Wilson's disease(WD)is a rare inherited disorder of copper *** consists of chelating agents,but side effects are *** describe a patient who developed colitis during trientine treatment leading to decompensation of liver *** SUMMARY A healthy 51-year-old woman was diagnosed with liver cirrhosis due to decompensation with *** evaluation raised suspicion of hereditary hemochromatosis because of compound heterozygosity HFE p.C282Y/p.H63D,and phlebotomy was ***-evaluation showed low ceruloplasmin,increased urinary copper excretion and the presence of Kayser-Fleischer *** was confirmed by genetic *** of decompensated cirrhosis,she was referred for liver transplant ***,treatment with trientine was *** function initially stabilized,and the patient was not accepted for a liver *** after this,she developed severe hemorrhagic colitis,most probably a side effect of *** that episode,she decompensated with hepatic *** of a second decompensating event,she was accepted for liver transplantation,and an uneventful transplantation was carried out after clinical improvement of *** Despite WD being a rare disorder,it is important to consider because it can present with a plethora of symptoms from childhood to an elderly *** should be recognized as a serious adverse drug reaction to trientine treatment that can result in decompensated liver disease.

关键词： Wilson's disease Colitis Trientine Liver transplantation Adverse effect Case report

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