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Fecal microbiota transplantation for the treatment of irritable bowel syndrome:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第20期29卷 3185-3202页

作者： Sofie Ingdam Halkjaer Bobby Lo Frederik Cold Alice Hojer Christensen Savanne Holster Julia Konig Robert Jan Brummer Olga C Aroniadis Perttu Lahtinen Tom Holvoet Lise Lotte Gluud andreas munk petersen Gastro Unit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark Copenhagen IBD Center Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Gastroenterology Aleris-Hamlet Hospitals CopenhagenSøborg 2860Denmark Nutrition-Gut-Brain Interactions Research Centre Faculty of Medicine and HealthSchool of Medical SciencesÖrebro UniversityÖrebro 70362Sweden Department of Internal Medicine Division of GastroenterologyRenaissance School of MedicineStony Brook University HospitalNew YorkNY 11794-8434United States Department of Internal Medicine Päijät-Häme Central HospitalLahti 15850Finland Department of Medicine University of HelsinkiHelsinki 00014Finland Department of Gastroenterology University Hospital GhentGhent 9000Belgium Department of Clinical Medicine University of CopenhagenCopenhagen 2200Denmark Department of Clinical Microbiology Copenhagen University Hospital HvidovreHvidovre 2650Denmark

BACKGROUND Irritable bowel syndrome(IBS)is the most prevalent gastrointestinal disorder in developed countries and reduces patients’quality of life,hinders their ability to work,and increases health care costs.A growing number of trials have demonstrated an aberrant gut microbiota composition in IBS,also known as‘gut dysbiosis’.Fecal microbiota transplantation(FMT)has been suggested as a treatment for *** To assess the efficacy and safety of FMT for the treatment of *** We searched Cochrane Central,MEDLINE,EMBASE and Web of Science up to 24 October 2022 for randomised controlled trials(RCTs)investigating the effectiveness of FMT compared to placebo(including autologous FMT)in treating *** primary outcome was the number of patients with improvements of symptoms measured using a validated,global IBS symptoms *** outcomes were changes in quality-of-life scores,non-serious and serious adverse *** ratios(RR)and corresponding 95%CI were calculated for dichotomous outcomes,as were the mean differences(MD)and 95%CI for continuous *** Cochrane risk of bias tool was used to assess the quality of the *** criteria were used to assess the overall quality of the *** Eight RCTs(484 participants)were included in the *** resulted in no significant benefit in IBS symptoms three months after treatment compared to placebo(RR 1.19,95%CI:0.68-2.10).Adverse events were reported in 97 participants in the FMT group and in 45 participants in the placebo group(RR 1.17,95%CI:0.63-2.15).One serious adverse event occurred in the FMT group and two in the placebo group(RR 0.42,95%CI:0.07-2.60).Endoscopic FMT delivery resulted in a significant improvement in symptoms,while capsules did *** did not improve the quality of life of IBS patients but,instead,appeared to reduce it,albeit non significantly(MD-6.30,95%CI:-13.39-0.79).The overall quality of the evidence was low due to moderate-high inconsistency,the small number of

关键词： Fecal microbiota transplantation Irritable bowel syndrome Meta-analysis Systematic review

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Can fecal microbiota transplantation cure irritable bowel syndrome?

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World Journal of Gastroenterology 2017年第22期23卷 4112-4120页

作者： Sofie Ingdam Halkjar Anders Watt Boolsen Stig Günther Alice Hojer Christensen andreas munk petersen Department of Gastroenterology Copenhagen University Hospital Hvidovre Department of Gastroenterology Aleris-Hamlet Hospitals Copenhagen Department of Clinical Microbiology Copenhagen University Hospital Hvidovre Faculty of Health and Medical Sciences University of Copenhagen

AIM To verify the utility of treatment with fecal microbiota transplantation(FMT) in patients with irritable bowel syndrome(IBS).METHODS We searched EMBASE, Cochrane Library and Pub Med in March, 2017. The reviewed literature was based on two systematic searches in each of the databases. The Me SH terms used were IBS and fecal microbiota transplantation and the abbreviations IBS and FMT. Reference lists from the articles were reviewed to identify additional pertinent articles. RESULTS A total of six conference abstracts, one case report, one letter to the editor, and one clinical review were included. In the final analysis, treatment of 48 patients was evaluated. Treatment revealed an improvement in 58% of cases. The varying structure of the nine included studies must be taken into *** Data on FMT and IBS are too limited to draw sufficientconclusions. Standardized double blinded randomized clinical trials need to be carried out to evaluate the effect of FMT on IBS.

关键词：烘便的 microbiota 移植 Microbiota 急躁的肠症候群

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Analysis of a Simple Probe for <i>In-Situ</i>Resistivity Measurements

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Journal of Water Resource and Protection 2017年第1期9卷 1-10页

作者： Jens munk Todd petersen Matt Cullin William Schnabel Department of Electrical Engineering University of Alaska Anchorage Anchorage AK USA Department of Mechanical Engineering University of Alaska Anchorage Anchorage AK USA University of Alaska Fairbanks Fairbanks AK USA

We present a probe factor for a simple measurement device, which can be used to determine in-situ electrical resistivity in soils or other penetrable bodies. The probe is primarily sensitive to the material immediately surrounding it and therefore is ideal for determining localized conductivities. The geometry of the probe can be scaled to effectively adjust the region of interest. The calibration, or “probe factor” is a function of the geometry, as well as the electrode configuration. Results are presented assuming a Wenner array configuration, however they can easily be extended to other geometries, such as the Schlumberger or dipole-dipole array.

关键词： Electrical Resistivity Measurements Soil Moisture Electrical Conductivity Geophysical Measurement

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Clinical outcome after surgery on schwannomas in the extremities

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World Journal of Orthopedics 2021年第10期12卷 760-767页

作者： andreas Saine Granlund Michala Skovlund Sørensen Claus Lindkær Jensen Birthe Højlund Bech Michael Mørk petersen Musculoskeletal Tumor Section Department of Orthopedic SurgeryCopenhagen University HospitalRigshospitaletCopenhagen 2100Denmark Department of Orthopedic Surgery Copenhagen University HospitalCopenhagen 2200Denmark Musculoskeletal Tumor Section Department of Orthopedic SurgeryUniversity of CopenhagenCopenhagen 2100Denmark Department of Radiology RigshospitaletUniversity of CopenhagenCopenhagen 2100Denmark

BACKGROUND Schwannoma is a benign,encapsulated and slowly growing tumor originating from Schwann cells and is rarely seen in the peripheral nerve *** symptoms are soreness,radiating pain and sensory loss combined with a soft tissue *** To evaluate pre-and postoperative symptoms in patients operated for schwannomas in the extremities and investigate the rate of malignant *** In this single center retrospective study design,all patients who had surgery for a benign schwannoma in the extremities from May 1997 to January 2018 were *** location of the tumor in the extremities was divided into five groups;forearm,arm,shoulder,thigh and leg including *** locations of the tumor in the nerves were also categorized as either;proximal,distal,minor or major *** the pre-and postoperative clinical evaluation,symptoms were classified as paresthesia,local pain,radiating pain,swelling,impairment of mobility/strength and asymptomatic tumors that were found incidentally(with magnetic resonance imaging).The patients were evaluated after surgery using the following categories:Asymptomatic or symptomatic patients(radiating and/or local pain)and those with *** follow up period was from the time of surgery until last examination of the particular *** logistic regression analysis was performed to identify independent prognostic factors for postoperative significant symptoms at *** We identified 858 cases from the institutional pathology *** excluded cases with duplicate diagnoses(n=407),pathology not including schwannomas(n=157),lesions involving the torso,spine and neck(n=150)leaving 144 patients for further *** this group 99 patients underwent surgery and there were five complications recorded:2 infections(treated with antibiotics)and 3 nerve palsies(2 involving the radial nerve and one involving the median nerve)that recovered *** the end of follow-up,1.4

关键词： Schwannoma Extremities Surgery Removal Symptoms Outcome

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Haemorrhagic septicaemia type B associated outbreak of fowl cholera in turkeys

Haemorrhagic septicaemia type B associated outbreak of fowl ...

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The 15th World Veterinary Poultry Congress

作者： Magne Bisgaard andreas petersen Anders M Bojesen Jens P Christensen Henrik Christensen Department of Veterinary Pathology Faculty of Life SciencesUniversity of CopenhagenDenmark Department of Veterinary Pathology Faculty of Life SciencesUniversity of CopenhagenDenmark Department of Veterinary Pathology Faculty of Life SciencesUniversity of CopenhagenDenmark Department of Veterinary Pathology Faculty of Life SciencesUniversity of CopenhagenDenmark Department of Veterinary Pathology Faculty of Life SciencesUniversity of CopenhagenDenmark

＜正＞Haemorrhagic septicaemia is an acute disease principally affecting cattle and water buffaloes character- ized by edematous swelling in the head-throat-brisket region,swollen and haemorrhagic lymph nodes and nu- ...

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Genetic diversity and persistance of Enterococcus faecalis obtained from different pathological lesiones in adult chickens as demonstrated by PFGE and MLST

Genetic diversity and persistance of Enterococcus faecalis o...

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The 15th World Veterinary Poultry Congress

作者： Magne Bisgaard Lise Hedegaard andreas petersen Henrik Christensen Jens P.Christensen Mark S.Chadfield Department of Veterinary Pathobiology-Faculty of Life Sciences-University of Copenhagen.Denmark Department of Veterinary Pathobiology-Faculty of Life Sciences-University of Copenhagen.Denmark Department of Veterinary Pathobiology-Faculty of Life Sciences-University of Copenhagen.Denmark Department of Veterinary Pathobiology-Faculty of Life Sciences-University of Copenhagen.Denmark Department of Veterinary Pathobiology-Faculty of Life Sciences-University of Copenhagen.Denmark Department of Veterinary Pathobiology-Faculty of Life Sciences-University of Copenhagen.Denmark

＜正＞Enterococcus faecalis affects avian species of all ***,the most serious infections have been associated with embryos and very young birds.E,faecalis has also been associated with pulmonary hyperten- sion syndrom...

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去势难治性前列腺癌骨转移患者223Ra治疗间隔延长对疗效的影响

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中华核医学与分子影像杂志 2018年第7期38卷 515-516页

作者：唐军 Marie ?bro Fosbφl Peter Meidahl petersen Gedske Daugaard Sφren Holm andreas Kjaer Jann Mortensen 上海交通大学医学院附属苏州九龙医院核医学科 Department of Clinical Physiology Nuclear Medicine & PET and Cluster for Molecular ImagingRigshospitalet and University of Copenhagen

目的二氯化镭(223Ra)是获批用于治疗去势难治性前列腺癌（mCRPC）骨转移的发射α粒子的亲骨性放射性药物。2014年秋天,由于生产上的原因,全球223Ra缺供了2个月。该研究分析非疾病原因造成的223Ra治疗间隔延长对疗效是否有负面影响。方... 详细信息

目的二氯化镭(223Ra)是获批用于治疗去势难治性前列腺癌（mCRPC）骨转移的发射α粒子的亲骨性放射性药物。2014年秋天,由于生产上的原因,全球223Ra缺供了2个月。该研究分析非疾病原因造成的223Ra治疗间隔延长对疗效是否有负面影响。方法单中心回顾性分析了2014年3月至2015年2月间开始行223Ra治疗的mCRPC患者。记录并计算各患者的疗程数、总生存时间（OS）和放射影像学无进展生存时间（rPFS）。首次治疗前和第3次、第6次治疗后患者行骨显像、胸腹部CT、血常规检查及前列腺特异性抗原（PSA）、碱性磷酸酶测定。随访期为首次223Ra治疗后18个月。结果共50例接受223Ra治疗的mCRPC患者,其中17例（34%）因供货原因治疗间隔延长,中位延长时间为4周（范围3～9周）。治疗间隔延长患者的rPFS也显著增加[rPFS为7.1（95%CI:4.9-9.3）个月],治疗间隔未延长患者的rPFS为4.5（95%CI:2.8～6.3）个月。完成的疗程数或OS间未见明显差异。结论因非疾病相关原因造成的223Ra治疗间隔的延长对OS、rPFS或完成的疗程数均无负面影响。

关键词： 223Ra 前列腺癌骨转移放射性核素治疗

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SUPERKILEN

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建筑技艺 2012年第2期18卷 44-49页

作者： Ondrej Tichy Jonas Lehmann Rune Hansen Jan Borgstrφm Lacin Karaoz Jonas Barre Nicklas Antoni Rasch Gabrielle Nadeau Jennifer Dahm petersen Richard Howis andreas Castberg Armen Menendian Jens Majdal Kaarsholm Jan Magasanik Toni Offenberger Katia Steckemetz Cristian Bohne Karoline Liedtke Jakob Fenger Rasmus Nielsen Bjφrnstjerne Christiansen 张岩 Superflex BIG Topotek1

正Superkilen是BIG、Topotek1和SUPERFLEX之间创造性合作的成果,从早期的概念设计到施工设计阶段的密切配合,成就了建筑、景观和艺术的完美融合。该项目是将半英里长的城市空间嵌入到丹麦种族最多样化和最具社会挑战性的一个街区中去。... 详细信息

正Superkilen是BIG、Topotek1和SUPERFLEX之间创造性合作的成果,从早期的概念设计到施工设计阶段的密切配合,成就了建筑、景观和艺术的完美融合。该项目是将半英里长的城市空间嵌入到丹麦种族最多样化和最具社会挑战性的一个街区中去。设计师们有一个总体的想法。

关键词：设计师概念设计密切配合城市空间广场设计阶段景观创造性公园多样化

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