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Stem cells' centrosomes: How can organelles identified 130 years ago contribute to the future of regenerative medicine?

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World Journal of Stem Cells 2021年第9期13卷 1177-1196页

作者： andreas Goutas Varvara Trachana Department of Biology Faculty of MedicineUniversity of ThessalyLarisa 41500BiopolisGreece

At the core of regenerative medicine lies the expectation of repair or replacementof damaged tissues or whole organs. Donor scarcity and transplant rejection aremajor obstacles, and exactly the obstacles that stem cell􀀀based therapy promisesto overcome. These therapies demand a comprehensive understanding of theasymmetric division of stem cells, i.e. their ability to produce cells with identicalpotency or differentiated cells. It is believed that with better understanding,researchers will be able to direct stem cell differentiation. Here, we describeextraordinary advances in manipulating stem cell fate that show that we need tofocus on the centrosome and the centrosome-derived primary cilium. This beliefcomes from the fact that this organelle is the vehicle that coordinates theasymmetric division of stem cells. This is supported by studies that report thesignificant role of the centrosome/cilium in orchestrating signaling pathways thatdictate stem cell fate. We anticipate that there is sufficient evidence to place thisorganelle at the center of efforts that will shape the future of regenerativemedicine.

关键词： Centrosome Primary cilium Asymmetry Self-renewal Differentiation Stemness

Tribological behaviour of Ti_(3)C_(2)T_(x) nano-sheets: Substrate-dependent tribo-chemical reactions

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Friction 2023年第8期11卷 1522-1533页

作者： Alberto ROTA Nicolas BELLINA Bo WANG andreas ROSENKRANZ Dipartimento di Scienze Fisiche Informatiche e MatematicheUniversitàdi Modena e Reggio EmiliaModena 41125Italy CNR-Istituto di Nanoscienze Centro S3Modena 41125Italy Centro Interdipartimentale per la Ricerca Applicata e i Servizi nel settore della Meccanica Avanzata e della Motoristica Universitàdi Modena e Reggio EmiliaModena 41125Italy Key Laboratory of Marine New Materials and Related Technology Zhejiang Key Laboratory of Marine Materials and Protection TechnologyNingbo Institute of Material Technology&EngineeringChinese Academy of SciencesNingbo 315201China Department of Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiago 8370456Chile

MXenes,a newly emerging class of layered two dimensional(2D)materials,are promising solid lubricants due to their 2D structure consisting of weakly-bonded layers with a low shear strength and ability to form beneficial *** work aims at evaluating for the first time MXenes lubrication performance and tribofilm formation ability on different metallic substrates(mirror-lapped Fe and Cu discs).After depositing MXenes via ethanol(1 wt%)on the substrates,pronounced differences in the resulting substrate-dependent frictional evolution are *** MXenes are capable to reduce friction for both substrates after the full evaporation of ethanol,MXenes lubricating effect on Cu is long-lasting,with a 35-fold increased lifetime compared to *** spectra acquired in the wear-tracks of the substrates and counter-bodies reveal notable differences in the friction-induced chemical changes depending on the substrate *** case of Fe,the progressive failure of MXenes lubrication generates different Fe oxides on both the substrate and the ball,resulting in continuously increasing friction and a poor lubrication *** Cu,sliding induces the formation of a Ti_(3)C_(2)-based tribofilm on both rubbing surfaces,enabling a long-lasting lubricating *** work boosts further experimental and theoretical work on MXenes involved tribo-chemical processes.

关键词： Mxenes Ti_(3)C_(2)T_(x) nano-sheets coefficient of friction Raman spectroscopy tribochemistry

Extracting commuter-specific destination hotspots from trip destination data-comparing the boro taxi service with Citi Bike in NYC

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Geo-Spatial Information Science 2020年第2期23卷 141-152页

作者： andreas Keler Jukka M.Krisp Linfang Ding Department of Civil Geo and Environmental EngineeringTechnical University of MunichMunichGermany Applied Geoinformatics Institute of GeographyUniversity of Augsburg(UniA)AugsburgGermany The KRDB Research Centre for Knowledge and Data Free University of Bozen-BolzanoBozen-BolzanoItaly Department of Cartography Technical University of MunichMunichGermany

Taxi trajectories from urban environments allow inferring various information about the transport service qualities and commuter *** is possible to associate starting and end points of taxi trips with requirements of individual groups of people and even social *** research shows that due to service restrictions,boro taxis have typical customer destination locations on selected Saturdays:many drop-off clusters appear near the restricted zone,where it is not allowed to pick up customers and only few drop-off clusters appear at complicated *** crossings imply recent infrastructural *** want to follow up on these results and add one additional group of commuters:Citi Bike *** selected Saturdays in June 2015,we want to compare the destinations of boro taxi and Citi Bike *** is challenging due to manifold differences between active mobility and motorized road users,and,due to the fact that station-based bike sharing services are restricted to *** and end points of trips,as well as the volumes in between rely on specific numbers of bike sharing ***,we introduce a novel spatiotemporal assigning procedure for areas of influence around static bike sharing stations for extending available computational methods.

关键词： Urban transportation spatial analysis mobility patterns boro taxis vehicle fleets bicycle-sharing service

Data-driven prediction of plate velocities and plate deformation of explosive reactive armor

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Defence Technology（防务技术） 2022年第12期18卷 2141-2149页

作者： Marvin Becker andreas Klavzar Thomas Wolf Melissa Renck Institute of Saint-Louis 5 Rue du Général Cassagnou68330Saint LouisCedexFrance Ecole Centrale de Lille CitéScientifique59651Villeneuve d'AscqCedexFrance

Explosive reactive armor(ERA)is currently being actively developed as a protective system for mobile devices against ballistic threats such as kinetic energy penetrators and shaped-charge *** mobility,the aim is to design a protection system with a minimal amount of required *** efficiency of an ERA is sensitive to the impact position and the timing of the ***,different designs have to be tested for several impact scenarios to identify the best *** analytical models are not predicting the behavior of the ERA accurately enough and experiments,as well as numerical simulations,are too time-consuming,a data-driven model to estimate the displacements and deformation of plates of an ERA system is proposed *** ground truth for the artificial neural network(ANN)is numerical simulation results that are validated with *** ANN approximates the plate positions for different materials,plate sizes,and detonation point positions with sufficient accuracy in *** a future investigation,the results from the model can be used to estimate the interaction of the ERA with a given ***,a measure for the effectiveness of an ERA can be ***,an optimal ERA can be designed and analyzed for any possible impact scenario in negligible time.

关键词： Artificial neural network Explosive reactive armor Finite element simulation Particle simulation Flash X-ray

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Diverging rationalities between forest fire management services and the general public after the 21st-century mega-fires in Greece

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Journal of Forestry Research 2022年第2期33卷 553-564页

作者： andreas Y.Troumbis Kostas Kalabokidis Palaiologos Palaiologou Department of Environment University of the Aegean81100 MytileneLesvos IslandGreece Department of Geography University of the Aegean81100 MytileneLesvos IslandGreece

Wildfire risk related to hazards on people and assets is expected to increase in the face of climate change,especially in fire-prone environments such as the Mediterranean *** rationalities,i.e.,the complex profile of multi-thematic,wildfire-related perceptions that collectively characterize and quantify all of a society’s responses,its interrelations,and influence on its insights,are of primary importance to understand the degree of preparedness and the direction that wildfire management policies are *** is a country that suffered mega-wildfire events during the first years of the twenty-first *** paper presents a scheme of advanced multivariate statistical procedures applied on standard social survey questionnaires to uncover different or similar rationalities between fire management services and the general ***-centered versus message-oriented rationalities is *** differ mainly on the priorities attributed to strengthening personnel and equipment capacities versus the need for public education and *** are evaluated against the needs of long-term risk assessment and forest management policies in *** main conclusion is that Greek society,although traumatized by recent fire disasters,is not yet prepared for long-term strategic forestry adaptation and planning.

关键词： Wildfire Qualitative research Rationality Fire governance Public Perception Risk assessment

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Performance analysis of deep borehole heat exchangers for decarbonization of heating systems

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Deep Underground Science and Engineering 2024年第3期3卷 349-357页

作者： andreas E.D.Lund Department of Electrical Engineering and Automation Aalto UniversityEspooFinland

Meeting the climate change mitigation targets will require a substantial shift from fossil to clean fuels in the heating *** pumps with deep borehole exchangers are a promising solution to reduce *** the thermal behavior of deep borehole exchangers(DBHEs)ranging from 1 to 2 km was analyzed for various heat flow profiles.A strong correlation between thermal energy extraction and power output from DBHEs was found,also influenced by the heating profile *** operating time over the year typically resulted in higher energy production,while shorter one yielded higher average thermal power output,highlighting the importance of the choice of heating strategy and system design for optimal performance of *** breaks in operation for regenerating the borehole,for example,with waste heat,proved to be favorable for the performance yielding an overall heat output close to the same as with continuous extraction of *** results demonstrate the usefulness of deep boreholes for dense urban areas with less available *** the heat production from a single DBHE in Finnish conditions ranges from half up to even a few GWh a year,the technology is best suitable for larger heat loads.

关键词： clean energy deep borehole exchangers energy transition geothermal heat ground-coupled heat pump

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Extendible and Efcient Python Framework for Solving Evolution Equations with Stabilized Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2022年第2期4卷 657-696页

作者： andreas Dedner Robert Klöfkorn University of Warwick Coventry CV47ALUK Lund University Box 11822100 LundSweden

This paper discusses a Python interface for the recently published Dune-Fem-DG module which provides highly efcient implementations of the discontinuous Galerkin(DG)method for solving a wide range of nonlinear partial diferential equations(PDEs).Although the C++interfaces of Dune-Fem-DG are highly fexible and customizable,a solid knowledge of C++is necessary to make use of this powerful *** this work,easier user interfaces based on Python and the unifed form language are provided to open Dune-Fem-DG for a broader *** Python interfaces are demonstrated for both parabolic and frst-order hyperbolic PDEs.

关键词： Dune Dune-Fem Discontinuous Galerkin Finite volume Python Advection-difusion Euler Navier-Stokes

Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4151-4153页

作者： andreas Krämer Stefan Knapp Institute of Pharmaceutical Chemistry Goethe University FrankfurtMax-von-Laue-Str.960438Frankfurt am MainGermany Structural Genomics Consortium Buchmann Institute for Molecular Life SciencesGoethe-University FrankfurtMax-von-Laue-Str.1560438Frankfurt am MainGermany German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)DTKT Site Frankfurt-Mainz69120HeidelbergGermany

A recent study published in Nature by Radko-Juettner and colleagues reports an unexpected mutant-specific synthetic lethality in which the E3 protein ubiquitin ligase DCAF5 specifically degrades mutant but not wild-type SWI/SNF chromatin remodeling complexes.1 DCAF5 contains a likely druggable WDR domain,providing a new avenue for the development of novel therapeutics for aggressive cancers with SMARCB1 loss of function mutations.

关键词： tumour likely complexes

Holocene climate change in the Central Tibetan Plateau inferred by lacustrine sediment geochemical records

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Science China Earth Sciences 2007年第10期50卷 1548-1555页

作者： andreas LüCKE Bernd WüNNEMANN Institute of Chemistry and Dynamics of the Geosphere V: Sedimentary Systems Research Centre Jülich D-52425 Jülich Ger- many Interdisciplinary Centre Ecosystem Dynamics in Central Asia Freie Universitaet Berlin 12249 Berlin Germany

Multi-proxies of lacustrine sediments, such as total carbon (TC), total organic carbon (TOC), total inorganic carbon (TIC), total nitrogen (TN), total sulfur (TS), hydrogen index (HI), oxygen index (OI) and stable carbon isotopic composition of organic matter (δ^(13)C_(org)), were analyzed using a 7.3 m core from Zige Tangco. The source of the organic matter in the sediment was mainly from autochthonous phyto-plankton, therefore the significances of proxies can be interpreted as that high TOC, TOC/TS, HI and δ^(13)C_(org) values, low TC, TIC values corresponded to warm and wet climatic condition, and vice versa. The process of climatic development in the Zige Tangco region was hence recovered. During the early and Mid-Holocene, the climate was warm and wet and intensive cold events occurred during the periods of 8600 to 8400 cal a BP and 7400 to 7000 cal a BP. In the second half of Holocene, the climate became cold and dry gradually. The palaeoclimatic process during Holocene in Zige Tangco region matched well with that in Co Ngoin region which is ca 40 km to the south-east. Therefore this palaeoclimatic process represents the Holocene climatic feature in the Central Tibetan Plateau which has the same pattern in the Northern Tibetan Plateau, but the time and duration of some climatic events might be different. We can conclude that in Holocene solar insolation controlled the climatic pattern on the central Tibetan Plateau.

关键词： lacustrine sediment hydrogen index (HI) stable carbon isotopic composition (δ^(13)C_(org)) palaeoclimate Central Tibetan Plateau

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