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Targeted nanopore sequencing for the identification of novel PRMT1 circRNAs unveils a diverse transcriptional profile of this gene in breast cancer cells

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Genes & Diseases 2024年第2期11卷 589-592页

作者： Maria Papatsirou andreas Scorilas Diamantis C.Sideris Christos K.Kontos Department of Biochemistry and Molecular Biology National and Kapodistrian University of AthensPanepistimiopolisAthens GR 15701Greece

Long-read sequencing with nanopore technology has been widely utilized for the identification of the full-length sequence of RNA molecules."It is especially suitable for the identification of circular RNAs(circRNAs),which are regulatory molecules that are regarded as promising non-invasive biomarkers for various human malignancies,including breast cancer.2 The impact of circRNAs derived from the protein arginine methyltransferase 1(PRMT1)gene has not been clarified yet,even though the effect of PRMT1-mediated methylation on breast cancer cell characteristics has been well established.

关键词： PRMT1 breast cancer

EVA NEXUS-Phaco performance study

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1447-1452页

作者： Lukas Feldhaus andreas Ohlmann Stefan Kassumeh Siegfried Priglinger Wolfgang Mayer Department of Ophthalmology University HospitalLudwig-Maximilians-University MunichMunich 80336Germany

AIM:To investigate a novel phacoemulsification system“EVA NEXUS”(D.O.R.C.,Dutch Opthalmic Research Center)in comparison to the existing system“EVA”in clinical *** to compare both phacoemulsification systems in terms of efficiency,safety and postoperative inflammatory ***:In this study standardized cataract surgery was performed on both eyes of the study participant,using the“EVA system”(control group,n=20)on one eye and the“EVA NEXUS system”(intervention group,n=20)on the other *** patients with cataract LOCS Grading 1-3 and no accompanying eye diseases were included in this study.A total of 20 patients were included in this study,with each treatment arm including 20 *** surgery a 0.1 mL aqueous humor sample was collected 1min after phacoemulsification to measure the total prostaglanin E2 concentrations using an enzyme-linked immunosorbent *** endothelial cell count,visual and refractive outcomes,and anterior chamber flare were evaluated preoperatively,and 1d,1wk,and 3mo ***:There were no statistically significant differences between both groups regarding intraoperative safety parameters including effective phacoemulsification time(P=0.904),balanced saline solution flow(P=0.701)and total surgery time(P=0.565).Postoperative prostaglandin E2 levels,anterior chamber flare as well as endothelial cell loss tended to be lower in the NEXUS-Group,however not being statistically significant(P=0.718;0.164;0.486).Both systems provided similar clinical outcomes,regarding best corrected visual acuity and refractive parameters,showing no statistically significant differences between both ***:Both systems show a high level of safety and efficency with similar results in terms of safety parameters including postoperative inflammatory activity and endothelial cell loss as well as visual and refractive *** statistically not significant,the EVA NEXUS system tends to cause less postoperative inflammatio

关键词： cataract surgery phacoemulsification fluidics instrument

Deep learning-based prediction of 3-dimensional silver contact shapes enabling improved quality control in solar cell metallization

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Energy and AI

Energy and AI 2024年第3期17卷 513-524页

作者： Marius Singler Akshay Patil Linda Ney andreas Lorenz Sebastian Tepner Florian Clement Fraunhofer Institute for Solar Energy Systems(ISE) Heidenhofstr.279110 FreiburgGermany EKRA Automatisierungstechnik GmbH Zeppelinstraße 1674357 BonnigheimGermany

The industrial metallization of Si solar cells predominantly relies on screen printing,with silver as the preferred electrode ***,the design of commercial screens often leads to suboptimal silver usage and increased electrical resistance due to print-related inhomogeneities like mesh marks,constrictions and ***-time monitoring of quality parameters during production has thus become increasingly *** inline optical quality control systems usually only include 2D visualizations of the printed layout,which limits their effectiveness in quality *** that allow 3D measurements are usually slow,expensive,and therefore not worth considering in most *** research focuses on the development of a model that can estimate the three-dimensional shape of printed contact fingers from a single 2D image without the need of additional hardware using deep ***,a workflow for the generation of training data,which involves the creation of image pairs from a 2D microscope and a 3D confocal laser scanning microscope(CLSM)to accurately represent solar cell fingers,is *** model training,the predicted height maps are compared with the ground truth height maps,and the robustness of the model with respect to a paste variation and screen parameter variation is *** results confirm the feasibility and reliability of deep learning-based 3D shape estimation,extending its applicability to new,previously unseen data from screen-printed contact *** a structural similarity index(SSIM)score of 0.76,a strong correlation between the estimated and ground truth height maps is *** summary,our deep learning-based approach for height map estimation offers an effective and reliable solution for fast inline detection and analysis of the cross-sectional area of the printed contact fingers.

关键词： Deep Learning Front-side metallization Image2Heigth Solar cell Screen-printing

MXene-Based Elastomer Mimetic StretchableSensors: Design, Properties, and Applications

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Nano-Micro Letters 2024年第7期16卷 295-342页

作者： Poushali Das Parham Khoshbakht Marvi Sayan Ganguly Xiaowu(Shirley)Tang Bo Wang Seshasai Srinivasan Amin Reza Rajabzadeh andreas Rosenkranz School of Biomedical Engineering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnology(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W Booth School of Engineering Practice and Technology McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexible sensors based on MXene-polymer composites are highly prospective for next-generation wearable electronics used in human-machine *** of the motivating factors behind the progress of flexible sensors is the steady arrival of new conductive ***,a new family of 2D nanomaterials,have been draw-ing attention since the last decade due to their high electronic conduc-tivity,processability,mechanical robustness and chemical *** this review,we encompass the fabrication of MXene-based polymeric nanocomposites,their structure-property relationship,and applications in the flexible sensor ***,our discussion is not only lim-ited to sensor design,their mechanism,and various modes of sensing platform,but also their future perspective and market throughout the *** our article,we intend to fortify the bond between flexible matrices and MXenes thus promoting the swift advancement of flexible MXene-sensors for wearable technologies.

关键词： Flexible sensor 2D nanomaterials MXene Wearable and conductive Applications

Treatment of intermediate-risk prostate cancer with active surveillance in the routine care—Long-term outcomes of a prospective noninterventional study(HAROW)

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Current Urology 2024年第2期18卷 115-121页

作者： Lothar Weissbach andreas Schwarte Edith A.Boedefeld Jan Herden Health Research for Men GmbH BerlinGermany Urological practice Borken BorkenGermany Department of Urology Uro-OncologyRobot-Assisted and Reconstructive UrologyFaculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany PAN Clinic Urological practiceCologneGermany

Background:We report here the long-term outcomes of patients with intermediate-risk prostate cancer(PCa)treated with active surveillance(AS)in a daily routine *** andmethods:HAROW(2008–2013)was a noninterventional,health service research study investigating themanagement of localized PCa in a community setting.A substantial proportion of the study centers were office-based urologists.A follow-up examination of all intermediate-risk patients with AS was ***,cancer-specific,metastasis-free,and treatment-free survival rates,as well as reasons for discontinuation,were determined and ***:Of the 2957 patients enrolled,52 with intermediate-risk PCa were managed with AS and were available for *** median follow-up was 6.8 years(interquartile range,3.4–8.6 years).Seven patients(13.5%)died of causes unrelated to PCa,of whom 4 were under AS or under watchful *** patients(3.8%)developed *** estimated 8-year overall,cancer-specific,metastasis-free,and treatment-free survival rates were 85%(95%confidence interval[CI],72%–96%),100%,93%(95%CI,82%–100%),and 31%(95%CI,17%–45%),*** analysis,prostate-specific antigen density of≥0.2 ng/mL2 was significantly predictive of receiving invasive treatment(hazard ratio,3.29;p=0.006).Reasons for discontinuation were more often due to patient's or physician's concerns(36%)than due to observed clinical ***:Although survival outcome data for intermediate-risk patients managed with AS in real-life health care conditions were promising,rates of discontinuation were high,and discontinuation was often a patient's decision,even when the signs of disease progression were *** might be an indication of higher levels of mental burden and anxiety in this specific subgroup of patients,which should be considered when making treatment *** a psychological perspective,not all intermediate-risk patients are optimal candidates for A

关键词： Active surveillance Intermediate-risk prostate cancer HAROW study Conservative management Outcomes research

Adaptive optimisation of explosive reactive armour for protection against kinetic energy and shaped charge threats

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Defence Technology（防务技术） 2024年第10期40卷 1-12页

作者： Philipp Moldtmann Julian Berk Shannon Ryan andreas Klavzar Jerome Limido Christopher Lange Santu Rana Svetha Venkatesh University of the Federal Armed Forces Hamburg Holstenhofweg 85Hamburg 22043Germany Applied Artificial Intelligence Institute(A2I2) Deakin University75 Pigdons RdWaurn PondsVIC 3216Australia French-German Research Institute of Saint-Louis(ISL) 5 Rue de General CassagnouSaint-Louis 68300France ABSTRAO 16 Rue de Isaac NewtonPlaisance-du-Touch 31830France

We evaluate an adaptive optimisation methodology,Bayesian optimisation(BO),for designing a minimum weight explosive reactive armour(ERA)for protection against a surrogate medium calibre kinetic energy(KE)long rod projectile and surrogate shaped charge(SC)*** perform the optimisation using a conventional BO methodology and compare it with a conventional trial-and-error approach from a human expert.A third approach,utilising a novel human-machine teaming framework for BO is also *** for the optimisation is generated using numerical simulations that are demonstrated to provide reasonable qualitative agreement with reference *** human-machine teaming methodology is shown to identify the optimum ERA design in the fewest number of evaluations,outperforming both the stand-alone human and stand-alone BO *** a design space of almost 1800 configurations the human-machine teaming approach identifies the minimum weight ERA design in 10 samples.

关键词： Terminal ballistics Armour Explosive reactive armour Optimisation Bayesian optimisation

Zeno and the Wrong Understanding of Motion—A Philosophical-Mathematical Inquiry into the Concept of Finitude as a Peculiarity of Infinity

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Journal of Applied Mathematics and Physics 2024年第3期12卷 912-929页

作者： andreas Herberg-Rothe Faculty of Social and Cultural Studies University of Applied Sciences Fulda Hesse Germany

In contrast to the solutions of applied mathematics to Zeno’s paradoxes, I focus on the concept of motion and show that, by distinguishing two different forms of motion, Zeno’s apparent paradoxes are not paradoxical at all. Zeno’s paradoxes indirectly prove that distances are not composed of extensionless points and, in general, that a higher dimension cannot be completely composed of lower ones. Conversely, lower dimensions can be understood as special cases of higher dimensions. To illustrate this approach, I consider Cantor’s only apparent proof that the real numbers are uncountable. However, his widely accepted indirect proof has the disadvantage that it depends on whether there is another way to make the real numbers countable. Cantor rightly assumes that there can be no smallest number between 0 and 1, and therefore no beginning of counting. For this reason he arbitrarily lists the real numbers in order to show with his diagonal method that this list can never be complete. The situation is different if we start with the largest number between 0 and 1 (0.999…) and use the method of an inverted triangle, which can be understood as a special fractal form. Here we can construct a vertical and a horizontal stratification with which it is actually possible to construct all real numbers between 0 and 1 without exception. Each column is infinite, and each number in that column is the starting point of a new triangle, while each row is finite. Even in a simple sine curve, we experience finiteness with respect to the y-axis and infinity with respect to the x-axis. The first parts of this article show that Zeno’s assumptions contradict the concept of motion as such, so it is not surprising that this misconstruction leads to contradictions. In the last part, I discuss Cantor’s diagonal method and explain the method of an inverted triangle that is internally structured like a fractal by repeating this inverted triangle at each column. The consequence is that we encounter t

关键词： Zeno False Assumptions about Motion Finitude Infinity Cantor’s Diagonal Method Inverted Triangle as a Different Method Vertical and Horizontal Dimensions Quantum Theory Relativity of Space and Time Depending on Velocity

An illustrated guide to:Parsimonious multi-scale full-waveform inversion

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Earthquake Science 2024年第6期37卷 574-583页

作者： andreas Fichtner Solvi Thrastarson Dirk-Philip van Herwaarden Sebastian Noe Department of Earth Sciences ETH ZürichZürich 8049Switzerland

Having been a seemingly unreachable ideal for decades,3-D full-waveform inversion applied to massive seismic datasets has become reality in recent *** achieving unprecedented resolution,it has provided new insight into the structure of the Earth,from the upper few metres of soil to the entire *** by these successes,the technology is now being translated to medical ultrasound and non-destructive *** remarkable progress,the computational cost of fullwaveform inversion continues to be a major *** limits the amount of data that can be exploited,and it largely inhibits quantitative and comprehensive uncertainty *** notes complement a presentation on recent developments in full-waveform inversion that are intended to reduce computational cost and assimilate more data,thereby improving tomographic *** suite of strategies includes flexible and user-friendly spectral-element simulations,the design of wavefieldadapted meshes that harness prior information on wavefield geometry,dynamic mini-batch optimisation that naturally takes advantage of data redundancies,and collaborative multi-scale updating to jointly constrain crustal and mantle structure.

关键词： Earth model seismology full-waveform inversion

Endoscopic submucosal dissection and endoscopic mucosal resection for esophageal and gastric lesions:A comparison of procedures

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 66-71页

作者： Gustav Holm Schæbel andreas Weise Mucha Charlotte Egeland Michael Patrick Achiam Department of Surgery and Transplantation Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esophageal and gastric lesions are effectively managed with minimally invasive upper endoscopic procedures such as endoscopic mucosa resection(EMR)and endoscopic submucosal dissection(ESD),offering patients alternatives to invasive *** ESD is well established in Eastern Asia,its adoption in Denmark for superficial esophageal cancer is *** study presents real-world data on the feasibility,safety,and hospitalization duration associated with ESD and EMR for esophageal and gastric *** A retrospective analysis was conducted on patients who underwent ESD or EMR at a specialized center in Denmark from October 2016 to June *** on treatment,indication,lesion location,hospitalization duration,procedure duration,specimen size,complications,recurrence,and one-year overall survival were *** comparisons utilized the Mann-Whitney U test,independent sample median test,and chi-squared *** The study included 130 patients(144 procedures):72 underwent ESD and 58 underwent *** with EMR,ESD resulted in greater percentages of en bloc and R0 resections(98.8%vs.64.1%,p<0.001;and 83.9%vs.23.8%,p<0.001),greater complication rates(28.7%vs.3.1%,p<0.001)and longer procedure times(119.5 min vs.37.0 min,p<0.001).The ESD procedure time significantly decreased over time(p=0.01).The local recurrence rates were 14.5%for ESD and 23.8%for EMR(p=0.767).The one-year overall survival rates were similar between the groups(95.8%vs.94.8%,p=0.553).Conclusion Both ESD and EMR are safe and viable for treating esophageal and gastric *** offers advantages but requires more time and *** findings support the literature,emphasizing the importance of considering patient-specific factors and surgeon proficiency in selecting the appropriate procedure.

关键词： Endoscopic submucosal dissection Endoscopic mucosa resection Gastroesophageal cancer Real-world data