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Neural Regeneration Research 2021年第1期16卷 110-112页

作者： Marcel Naumann Julian Laubenthal andreas Hermann Translational Neurodegeneration Section“Albrecht-Kossel” Department of NeurologyUniversity Medical Center RostockUniversity of RostockRostockGermany German Center for Neurodegenerative Diseases(DZNE)Rostock/Greifswald Center for Transdisciplinary Neurosciences Rostock(CTNR)University Medical Center RostockUniversity of RostockRostockGermany

Accumulation of DNA damage and genomic instability are believed to have crucial effects in neurodegenerative conditions such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,premature aging diseases as well as amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD).Until recently these studies were largely correlative in nature,though raising the possibility that defects in the DNA damage response(DDR)underlie neurodegenerative diseases.

关键词： diseases Huntington amyotrophic

No evidence for female discrimination against male house mice carrying a selfish genetic element

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Current Zoology 2016年第6期62卷 675-685页

作者： andreas SUTTER Anna K. LINDHOLM Institute of Evolutionary Biology and Environmental Studies University of Zurich Winterthurerstrasse 190 Zurich 8057 Switzerland

Meiotic drivers distort transmission to the next generation in their favor, with detrimental effects on the fitness of their homologues and the rest of the genome. Male carriers of meiotic drivers commonly inflict costs on their mates through genetic incompatibility, reduced fecundity, or biased brood sex ratios. Given these costs, evidence for female discrimination against male carriers is surprisingly rare. One of few examples is the t haplotype in house mice, a meiotic driver that shows strong transmission distortion in males and is typically homozygote lethal. As a consequence, mating between 2 t heterozygous （＋/t） mice leads to high embryo mortality. Previous experiments showing that＋/t females avoid this incompatibility cost by preferring ＋/＋ versus ＋/t males have inferred preference based on olfactory cues or brief social interactions. Evidence from mating contexts in laboratory settings and semi-natural populations has been inconclusive. Here, we investigated female choice from a large number of no-choice mating trials. We found no evidence for discrimination against＋/t males based on mating, remating, and copulatory behavior. Further, we found no evidence for avoidance of incompatibility through selective interactions between game- tes. The likelihood of mating showed significant effects of female weight and genotype, suggesting that our test paradigm enabled females to exhibit mate choice. We discuss the strengths and limitations of our approach. By explicitly considering selection at both the individual and gene level, we argue why precopulatory female discrimination by＋/t females may be less evolutionarily stable than discrimination by all females based on postcopulatory mechanisms.

关键词： cryptic female choice female preference indirect benefits mate choice segregation distortion t haplotype

Cancer cells evade ferroptosis: sex hormone-driven membrane-bound O-acyltransferase domain-containing 1 and 2 (MBOAT1/2) expression

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4424-4425页

作者： Alexia Belavgeni Wulf Tonnus andreas Linkermann Division of Nephrology Department of Internal Medicine IUniversity Hospital Carl Gustav Carus at the Technische Universitat DresdenDresdenGermany Division of Nephrology Department of MedicineAlbert Einstein College of MedicineBronxNYUSA

In a recent manuscript published in Cell,Liang et *** novel ferroptosis regulators,membrane-bound O-acyltransferase domain-containing 1 and 2(MBOAT1/2).1 These findings may have implications for ferroptosis-based canc... 详细信息

关键词： al. T1/2 Cancer

Effect of pulsed magnetic field pre-treatment of AISI 52100 steel on the coefficient of sliding friction and wear in pin-on-disk tests

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Friction 2014年第4期2卷 310-316页

作者： Anatolii BABUTSKYI andreas CHRYSANTHOU Chuanli ZHAO School of Engineering and Technology University of HertfordshireHatfieldUK

Disc specimens manufactured from commercial bearing rollers(AISI 52100 steel,62−63 HRC)in initial state and after pre‐treatment by pulsed magnetic field(PMF)with a magnetic field strength of 1−7 MA/m were tested with sunflower oil using pin‐on‐disk *** to the obtained results the treatment causes a reduction in the coefficient of friction and *** explain the results,nano‐and microhardness tests as well as optical and atomic force microscopy were *** of the effect of PMF on the friction and wear were discussed.

关键词： bearing rollers pulsed magnetic field

Live-Cell Imaging of Dual-Labeled Golgi Stacks in Tobacco BY-2 Cells Reveals Similar Behaviors for Different Cisternae during Movement and Brefeldin A Treatment

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Molecular Plant 2011年第5期4卷 896-908页

作者： Stephanie L. Madison andreas Nebenfuhr Department of Biochemistry and Cellular and Molecular Biology University of Tennessee Knoxville TN 37996-0840 USA

In plant cells, the Golgi apparatus consists of numerous stacks that, in turn, are composed of several flattened cisternae with a clear cis-to-trans polarity. During normal functioning within living cells, this unusual organelle displays a wide range of dynamic behaviors such as whole stack motility, constant membrane flux through the cisternae, and Golgi enzyme recycling through the ER. In order to further investigate various aspects of Golgi stack dynamics and integrity, we co-expressed pairs of established Golgi markers in tobacco BY-2 cells to distinguish sub-compartments of the Golgi during monensin treatments, movement, and brefeldin A （BFA）-induced disassembly. A combination of cis and trans markers revealed that Golgi stacks remain intact as they move through the cytoplasm. The Golgi stack orientation during these movements showed a slight preference for the cis side moving ahead, but trans cisternae were also found at the leading edge. During BFA treatments, the different sub-compartments of about half of the observed stacks fused with the ER sequentially; however, no consistent order could be detected. In contrast, the ionophore monensin resulted in swelling of trans cisternae while medial and particularly cis cisternae were mostly unaffected. Our results thus demonstrate a re- markable equivalence of the different cisternae with respect to movement and BFA-induced fusion with the ER. In addi- tion, we propose that a combination of dual-label fluorescence microscopy and drug treatments can provide a simple alternative approach to the determination of protein localization to specific Golgi sub-compartments.

关键词： Golgi apparatus Golgi stack integrity brefeldin A monensin tobacco BY-2 cells live-cell imaging.

Energy band alignment at ferroelectric/electrode interface determined by photoelectron spectroscopy

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Chinese Physics B 2014年第1期23卷 1-16页

作者：陈峰吴文彬李舜怡 andreas Klein High Magnetic Field Laboratory Chinese Academy of Sciences (CAS) and Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China High Magnetic Field Laboratory Chinese Academy of Sciences (CAS) and Hefei National Laboratory for Physical Sciences at MicroscaleUniversity of Science and Technology of China TechnischeUniversitt Darmstadt Department of Materials and Earth Sciences

The most important interface-related quantities determined by band alignment are the barrier heights for charge trans- port, given by the Fermi level position at the interface. Taking Pb（Zr, Ti）O3 （PZT） as a typical ferroelectric material and applying X-ray photoelectron spectroscopy （XPS）, we briefly review the interface formation and barrier heights at the inter- faces between PZT and electrodes made of various metals or conductive oxides. Polarization dependence of the Schottky barrier height at a ferroelectric/electrode interface is also directly observed using XPS.

关键词： ferroelectric band alignment Schottky barrier X-ray photoelectron spectroscopy

Photoemission Spectroscopy and Electronic Structures of LiMn2O4

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Chinese Physics Letters 2006年第8期23卷 2202-2205页

作者：吴启辉 THISSEN andreas JAEGERMANN Wolfram Department of Physics and Semiconductor Photonics Research Center Xiamen University Xiamen 361005 Surface Science Institute Department of Materials Science Darmstadt University of Technology Petersenstr. 2364287 Darmstadt Germany

We study the electronic structures of LiMn2O4 by x-ray and ultraviolet photoelectron spectroscopy （XPS, UPS） and resonant photoelectron spectroscopy （RPES）. XPS data suggest that the average oxidation state of Mn ions is 3.55, probably due to the small amount of lithium oxides on the surface. UPS and RPES data imply that Mn ions are in a high spin state, and RPES results show strong Mn3d-O2p hybridization in the LiMn2O4 valence band.

关键词： RAY PHOTOELECTRON-SPECTROSCOPY PHASE-TRANSITION THIN-FILMS SPINELS LI LI(X)MN2O4 SYSTEMS CELLS

Estimation of particle dynamics in 2-D fluidized beds using particle tracking velocimetry

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Particuology 2015年第5期13卷 39-51页

作者： Thomas Hagemeier Christoph Roloff andreas Buck Evangelos Tsotsas NaWiTec Thermal Process EngineeringOtto-von-Guericke University MagdeburgUniversitaetsplatz 239106 MagdeburgGermany Fluid Dynamics and Technical Flow Otto-von-Guericke University MagdeburgUniversitaetsplatz 239106 MagdeburgGermany

The experimental characterization of particle dynamics in fluidized beds is of great importance in fostering an understanding of solid phase motion and its effect on particle properties in granulation processes, Commonly used techniques such as particle image velocimetry rely on the cross-correlation of illumination intensity and averaging procedures. It is not possible to obtain single particle velocities with such techniques. Moreover, the estimated velocities may not accurately represent the local particle velocities in regions with high velocity gradients. Consequently, there is a need for devices and methods that are capable of acquiring individual particle velocities. This paper describes how particle tracking velocimetry can be adapted to dense particulate flows. The approach presented in this paper couples high-speed imaging with an innovative segmentation algorithm for particle detection, and employs the Voronoi method to solve the assignment problem usually encountered in densely seeded fows. Lagrangian particle tracks are obtained as primary information, and these serve as the basis for calculating sophisticated quantities such as the solid-phase flow field, granular temperature, and solid volume fraction. We show that the consistency of individual trajectories is sufficient to recognize collision events.

关键词： Particle dynamics Particle tracking velocimetry Pseudo-2D Fluidized bed

Numerical Simulation of the Mechanical Properties of Sintered and Bonded Perforated Hollow Sphere Structures (PHSS)

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Journal of Materials Science & Technology 2010年第8期26卷 730-736页

作者： andreas chsner Seyed Mohammad Hossein Hosseini Markus Merkel Department of Applied Mechanics Technical University of Malaysia Centre for Mass and Mechanical Transport in Engineering Materials The University of Newcastle CallaghanNewSouth Wales 2308Australia Department of Mechanical Engineering University of Applied Sciences Aalen

This paper investigated the uniaxial mechanical properties of a new type of hollow sphere structures. For this new type, the sphere shell was perforated by several holes in order to open the inner sphere volume and surface. The mechanical properties, i.e. elastic properties and initial yield stress of perforated hollow sphere structures （PHSS） in a primitive cubic arrangement were numerically evaluated for different hole diameters and different joining techniques of the hollow spheres. The results are compared to classical configurations without perforation.

关键词： Mechanical properties Cellular material Porous structure Finite element method

Microcrack Formation During Gas Metal Arc Welding of High-Strength Fine-Grained Structural Steel

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Acta Metallurgica Sinica(English Letters) 2014年第1期27卷 140-148页

作者： Christoph Heinze Thomas Michael andreas Pittner Michael Rethmeier Division 9.3 "Welding Technology" BAM Federal Institute for Materials Research and TestingUnter den Eichen 8712205 BerlinGermany Joining and Coating Technology Fraunhofer-Institute for Production Systems and Design Technology IPKPascalstraβe 8-910587 BerlinGermany

The recent development of high-performance-modified spray arc processes in gas metal arc welding due to modern digital control technology and inverter power sources enables a focused spray arc, which results in higher penetration depths and welding speed. However, rnicrocracks occurred in the weld metal while approaching the process limits of the modified spray arc, represented by a 20-mm double layer DV-groove butt-weld, These cracks were detected in structural steel exhibiting a yield strength level of up to 960 MPa and are neither dependent on the used weld power source nor a consequence of the modified spray arc process itself. The metallographic and fractographic investigations of the rather exceptional fracture surface lead to the classification of the microcracks as hot cracks, The effects of certain welding parameters on the crack probability are clarified using a statistical design of experiment. However, these microcracks do not impact the design specification for toughness in the Charpy V-notch test （absorbed energy at -40 ℃ for the present material is 30 J）.

关键词： High-strength low-alloy steel Welding Fracture Design of experiments Microcracking