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Prevalence of Mental Disorders and Health Service Utilization among Individuals with Turkish Migration Backgrounds in Germany: A Study Protocol for an Epidemiological Investigation

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Open Journal of Psychiatry 2016年第3期6卷 237-252页

作者： Mike Mösko Demet Dingoyan Simone Penka Azra Vardar Holger Schulz Uwe Koch andreas heinz Ulrike Kluge Department of Medical Psychology University Medical Center Hamburg-Eppendorf Hamburg Germany Clinic for Psychiatry and Psychotherapy Charité—University Medicine Berlin Germany Department of Migration Mental and Physical Health and Health Promotion BIM—Berlin Institute for Empirical Integration and Migration Research Humboldt University zu Berlin Berlin Germany

Background: There is a lack of reliable epidemiological data on prevalence and comorbidity rates of mental disorders in the migrant population in Germany. Despite existing national and international data on the extent of psychosocial burdens in migrant populations the prevalence among the study population remains unclear. The aim of this study was to collect prevalence data for the largest migrant population in Germany-individuals with Turkish migration backgrounds—using a culturally and linguistically sensitive approach. Methods: The study employs a cross-sectional design. The multi-centre study (Hamburg, Berlin) is based on a sample of individuals with Turkish migration backgrounds living in the two cities stratified by age, gender, and education. The study programme consists of three phases: 1) a qualitative focus group to collect information on how to increase the participation rate of the target population as a minority group in Germany;2) a translation phase to create culture and linguistic sensitive versions of the assessment tools (e.g., the Composite International Diagnostic Interview (CIDI) for Turkish speaking individuals;and 3) a baseline community study to assess the lifetime, 12-month and four-week prevalence and comorbidity rates of mental disorder, health care utilization and help-seeking behaviour in individuals of Turkish migration backgrounds living in Germany. Discussion: The study provides important data on the lifetime prevalence of mental disorders and health care utilization of individuals with Turkish migration backgrounds. Furthermore, the study is an important step towards gaining a better understanding of potential barriers to participation, creating resources for difficult-to- reach minorities, and understanding the need for assessing mental disorders in migrant populations. These results can offer a starting point for the initiation of the necessary structural changes for mental health care services and policies for groups with migratio

关键词： Mental Health Mental Disorder Migration Turkish Germany Prevalence Comorbidity Health Care Utilization Composite International Diagnostic Interview (CIDI) Epidemiology

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准确到一点一滴——利用夹管式定量控制阀准确实现微小剂量药液的定量控制

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现代包装 2012年第6期 24-24,26页

作者： andreas Loth heinz Lehr

在那些对微量定量控制有精细要求的生产领域中，往往“一滴”的偏差可导致最终的结果出现惊人差异，而对这些偏差起到决定性作用的，当属定量控制阀。夹管式定量控制阀的工作原理在小剂量液体介质药品的灌装定量控制过程中拥有许多技术... 详细信息

在那些对微量定量控制有精细要求的生产领域中，往往“一滴”的偏差可导致最终的结果出现惊人差异，而对这些偏差起到决定性作用的，当属定量控制阀。夹管式定量控制阀的工作原理在小剂量液体介质药品的灌装定量控制过程中拥有许多技术优势，利用它便可更好地实现药企针对药品灌装定量控制的严格要求。

关键词：定量控制控制阀小剂量管式利用药液控制过程液体介质

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准确到一点一滴

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流程工业 2012年第6期 74-75页

作者： andreas Loth heinz Lehr 德国柏林技术大学微流量技术系微技术和医药技术研究所

在那些有微量定量控制要求的生产领域中，往往会因“一滴”的偏差而导致最终结果出现惊人差异，而对于这些起到决定性作用的，当属定量控制阀。

关键词：控制要求决定性控制阀

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Anxiety and depression in adult patients with celiac disease on a gluten-free diet

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World Journal of Gastroenterology 2010年第22期16卷 2780-2787页

作者： Winfried Huser Karl-heinz Janke Bodo Klump Michael Gregor andreas Hinz Department of Internal Medicine I Klinikum Saarbrücken Winterberg 1 D-66119 Saarbrücken and Department of Psychosomatic Medicine and Psychotherapie Technische Universitt München Baden-Württemberg State Health Office District Government Stuttgart Gastroenterology and Gastrointestinal Cancer St. Anna Hospital Obere Waiblinger Starβe 101 D-70374 Stuttgart Germany and Department of Internal Medicine 1 Universittskliniken Tübingen Department of Internal Medicine 1 Universittskliniken Tübingen Department of Medical Psychology and Medical Sociology Universitt Leipzig

AIM: To compare anxiety and depression levels in adult patients with celiac disease (CD) on a gluten-free diet (GFD) with ***: The levels of anxiety, depression and of a probable anxiety or depressive disorder were assessed by the Hospital Anxiety and Depression Scale in 441 adult patients with CD recruited by the German Celiac Society, in 235 age-and sex-matched patients with inflammatory bowel disease (IBD) in remission or with slight disease activity, and in 441 adult persons of a representative German general population sample (GP). Potential demographic (age, sex, social class, family status) and disease-related (latency to diagnosis, duration of GFD, compliance with GFD, thyroid disease) predictors of anxiety and depression in CD were tested for by regression analyses. RESULTS: The level of anxiety in CD patients was predicted (R 2 = 0.07) by female gender (P = 0.01). Female sex (OR = 3.6, 95% CI: 1.3-9.4, P = 0.01) was associated with a probable anxiety disorder. Living alone (OR = 0.5, 95% CI: 0.2-0.9, P = 0.05) was associated with a reduced risk of an anxiety disorder. The level of depression and a probable depressive disorder were not predicted by any of the demographic and medical variables tested for. The levels of anxiety in patients with CD (6.6 ± 3.4) and with IBD (6.9 ± 3.7) were higher than those of persons in the GP (4.6 ± 3.3) (both P < 0.001). The levels of depression in persons with CD (4.2 ± 3.4), IBD (4.6 ± 3.4) and of the GP (4.2 ± 3.8) did not differ (P = 0.3). The prevalence of a probable anxiety disorder in persons with CD (16.8%) and IBD (14.0%) was higher than that of the GP (5.7%) (P < 0.001). The prevalence of a probable depressive disorder did not differ significantly between the three groups (P = 0.1). CONCLUSION: Anxiety in adult German female celiacs on a GFD is higher than in persons of the GP. Female celiacs on a GFD should be screened for anxiety.

关键词： Celiac disease Anxiety Depression Gender

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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A Setup for a Scenario-Driven Water Balance at Landscape Scale—Assessment with AKWA-M~-Embedded in a Model Framework for Land-Use Planning’s Decision Support in Mountainous Southwest China

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Journal of Earth Science 2010年第6期21卷 974-978页

作者： andreas Wahren Karin Berkhoff Albrecht Münch Sylvia Herrmann Karl-heinz Feger Insitute of Soil Science and Site Ecology Technische Universitt Dresden Dr. Dittrich & Partner Hydro-Consult GmbH Institute of Environmental Planning Leibniz University Hannover

Land-cover changes cause a loss of natural vegetation in many parts of the world. In the Xishuangbanna （西双版纳） district （Yunnan （云南） Province）, rubber plantations replace tropical rainforests covering already an area of about 10% of the study area （2007）. There, land-use allocation is mostly driven by economic considerations. Thus, local planning authorities need decision support for land-use planning issues, which integrate socio-economic and ecological aspects. Within the NabanFrame, an agro-economic, ecological and social model was applied, which, altogether, interacted with a land allocation model via defined interfaces. Effects on the water cycle, ecological conditions as well as socio-economic should be considered by integrating the spatially distributed rainfali-runoff and water balance model AKWA-M in the model setup.

关键词： land-use water balance model rubber integrated land-use planning land-use prognosis.

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Extremely severe hypochloremic metabolic alkalosis after ileorectal anastomosis in a patient with chronic intestinal pseudo-obstruction

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Gastroenterology Report 2023年第1期11卷 563-565页

作者： Peter heinz-Erian andreas RJanecke Thomas Muller Peter Rehder Elisabeth Bruder Thomas Menter heinz Zoller Markus Pirklbauer Michael Rieger Department of Pediatric and Adolescent Medicine Medical University of InnsbruckInnsbruckTyrolAustria Department of Urology Medical University of InnsbruckInnsbruckTyrolAustria Institute of Pathology University Hospital BaselBaselBaselSwitzerland Department of Internal Medicine I Medical University of InnsbruckInnsbruckTyrolAustria Department of Internal Medicine IV Medical University of InnsbruckInnsbruckTyrolAustria Department of Radiology District Hospital HallHallTyrolAustria

Introduction Chronic intestinal pseudo-obstruction(CIPO),defined as chronic constipation without mechanical obstruction of the gastrointestinal tract[1,2],often presents with a truly chameleon-like symptomatology including irregular defecation,abdominal pain and distension,nausea,vomiting,and sometimes fluid/electrolyte *** diarrhea was found in17%of CIPO cases,its nature,however,has not been precisely *** deviations of electrolyte and acid–base status,to the best of our knowledge,have not been reported.

关键词： obstruction diarrhea chronic

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Repeated Multiview Imaging for Estimating Seedling Tiller Counts of Wheat Genotypes Using Drones

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Plant Phenomics 2020年第1期2卷 279-298页

作者： Lukas Roth Moritz Camenzind Helge Aasen Lukas Kronenberg Christoph Barendregt Karl-heinz Camp Achim Walter Norbert Kirchgessner andreas Hund ETH Zurich Institute of Agricultural SciencesUniversitätstrasse 28092 ZurichSwitzerland Delley Samen und Pflanzen AG Route de Portalban 401567 DelleySwitzerland

Early generation breeding nurseries with thousands of genotypes in single-row plots are well suited to capitalize on high throughput ***,methods to monitor the intrinsically hard-to-phenotype early development of wheat are yet *** aimed to develop proxy measures for the rate of plant emergence,the number of tillers,and the beginning of stem elongation using drone-based *** used RGB images(ground sampling distance of 3mm pixel-1)acquired by repeated flights(≥2 flights per week)to quantify temporal changes of visible leaf *** exploit the information contained in the multitude of viewing angles within the RGB images,we processed them to multiview ground cover images showing plant pixel *** on these images,we trained a support vector machine for the beginning of stem elongation(GS30).Using the GS30 as key point,we subsequently extracted plant and tiller counts using a watershed algorithm and growth modeling,*** results show that determination coefficients of predictions are moderate for plant count(R^(2)=0:52),but strong for tiller count(R^(2)=0:86)and GS30(R^(2)=0:77).Heritabilities are superior to manual measurements for plant count and tiller count,but inferior for GS30 *** the selection intensity due to throughput may overcome this *** image traits can replace hand measurements with high efficiency(85-223%).We therefore conclude that multiview images have a high potential to become a standard tool in plant phenomics.

关键词： Wheat watershed breeding

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Simulation of microswimmer hydrodynamics with multiparticle collision dynamics

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Chinese Physics B 2020年第7期29卷 55-61页

作者： andreas Zottl Institute for Theoretical Physics TU WienWiedner Hauptstraße 8-101040 WienAustria

In this review we discuss the recent progress in the simulation of soft active matter systems and in particular the hydrodynamics of microswimmers using the method of multiparticle collision dynamics,which solves the hydrodynamic flows around active objects on a coarse-grained *** first present a brief overview of the basic simulation method and the coupling between microswimmers and *** then review the current achievements in simulating flexible and rigid microswimmers using multiparticle collision dynamics,and briefly conclude and discuss possible future directions.

关键词： active matter multiparticle collision dynamics microswimmers coarse-grained hydrodynamic simulations

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