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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi andreas h.Teuschl-Woller David hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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A DIFFUSION–TRANSPORT hYBRID METhOD FOR ACCELERATING OPTICAL TOMOGRAPhY

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Journal of Innovative Optical health Sciences 2010年第4期3卷 293-305页

作者： hYUN KEOL KIM andreas h.hIELSChER Department of Biomedical Engineering Columbia University New YorkNY 10027USA Department of Radiology Columbia University New YorkNY 10032USA Department of Electrical Engineering Columbia University New YorkNY 10027USA

It is well acknowledged that the equation of radiative transfer(ERT)provides an accurate prediction of light propagation in biological tissues,while the diffusion approximation(DA)is of limited accuracy for the transport ***,ERT-based reconstruction codes require much longer computation times as compared to DA-based reconstruction *** introduce here a computationally efficient algorithm,called a diffusion–transport hybrid solver,that makes use of the DA-or low-order ERT-based inverse solution as an initial guess for the full ERT-based reconstruction *** evaluate the performance of this hybrid method,we present extensive studies involving numerical tissue phantoms and experimental *** a result,we show that the hybrid method reduces the reconstruction time by a factor of up to 23,depending on the physical character of the problem.

关键词： Optical tomography reconstruction time radiative transfer equation

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Structure-activity relationship of cyclic ADP-ribose, an update

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Journal of Chinese Pharmaceutical Sciences 2013年第2期22卷 127-136页

作者： andreas h. Guse The Calcium Signalling Group Department of Biochemistry and Signal Transduction and Department of Biochemistry and Molecular Cell Biology University Medical Center Hamburg-Eppendorf

Cyclic ADP-ribose (cADPR) is a universal Ca2+ mobilizing second messenger in many different cell types and organisms. cADPR activates Ca2+ release from endo/sarcoplasmic reticulum via ryanodine receptors. In addition, Ca2+ entry secondary to Ca2+ depletion is at least one of the mechanisms in which cADPR triggers Ca2+ inflow, too. Analogues of cADPR have been prepared by chemical and chemo-enzymatic routes. Most of the analogues were analyzed for biological activity in intact or permeabilized Jurkat T cells (a human T-lymphoma cell line). As a systematic approach, analogues were grouped according to alterations in the base, the northern ribose, the southern ribose, the pyrophosphate backbone, or in complex modifications, comprising more than one part of the molecule. Biological activity of the analogues is reviewed, with special emphasis on Jurkat T cells.

关键词： Cyclic ADP-ribose Calcium signaling Cyclic ADP-ribose analogue Ryanodine receptor TRPM2 Cellular signal transduction

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Structural Finite Element Software Coupling Using Adapter Elements

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Computer Modeling in Engineering & Sciences 2019年第9期120卷 719-737页

作者： andreas h.Schellenberg Yuli huang Stephen A.Mahin Senior Engineer Maffei Structural EngineeringSan FranciscoCA 94111USA Senior Structural Analyst ArupSan FranciscoCA 94111USA

This paper describes a versatile and computationally efficient method for coupling several finite element analysis(FEA)programs together so that the unique modeling and analysis capabilities of each code can be utilized simultaneously to simulate the static or dynamic response of a complete numerical *** arbitrary number of finite element analysis software packages can be coupled by adding two special types of elements,namely generic and adapter elements,to each of the finite element applications using their programming *** elements are inserted at the interfaces between the different sub-domains of the complete system modeled by each finite element analysis software *** of data between the coupled FEA codes is accomplished in a modular and synchronized manner using OpenFresco(Opensource Framework for Experimental Setup and Control).OpenFresco is an objectoriented,environment independent software framework initially developed for hybrid simulation in which certain aspects of a complete structure are simulated numerically and other aspects are simultaneously tested *** important practical advantage of this coupled analysis approach is that all of the connected FEA codes run concurrently and continuously,decreasing analysis time consumption by an order of magnitude or more compared to more traditional approaches that shut down and restart the coupled analysis codes at each integration time *** implementation and accuracy of this approach to FE software coupling are demonstrated using dynamic analyses of three simple structural models from the field of earthquake engineering.

关键词： Software coupling co-simulation adapter element OpenFresco

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Source-specific risk assessment for cadmium in wheat and maize:Towards an enrichment model for China

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Journal of Environmental Sciences 2023年第3期125卷 723-734页

作者： Zhong Zhuang Qiqi Wang Siyu huang Andrea Giovanna NinoSavala Yanan Wan huafen Li andreas h.Schweiger andreas Fangmeier Jürgen Franzaring Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation Key Laboratory of Plant-Soil Interactions of the Ministry of EducationCollege of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001China Institute of Landscape and Plant Ecology University of Hohenheim70599 StuttgartGermany

Cadmium (Cd) pollution of agricultural soil is of public concern due to its high potential toxicity and *** study aimed to reveal the risk of Cd accumulation in soil and wheat/maize systems,with a specific focus on the source-specific ecological risk,human health risk and Cd enrichment *** this we investigated more than 6100 paired soil and grain samples with 216 datasets including soil Cd contents,soil ph and grain Cd contents of 85 sites from *** results showed that mining activities,sewage irrigation,industrial activities and agricultural practices were the critical factors causing Cd accumulation in wheat and maize cultivated ***,mining activities contributed to a higher Cd accumulation risk in the southwest China and Middle Yellow River regions;sewage irrigation influenced the Cd accumulation in the North China *** addition,the investigated sites were classified into different categories by comparing their soil and grain Cd contents with the Chinese soil screening values and food safety values,*** enrichment models were developed to predict the Cd levels in wheat and maize *** results showed that the models exhibited a good performance for predicting the grain Cd contents among safe and warning sites of wheat (R2=0.61 and 0.72,respectively);while the well-fitted model for maize was prone to the overestimated sites (R2=0.77).This study will provide national viewpoints for the risk assessments and prediction of Cd accumulation in soil and wheat/maize systems.

关键词： Ecological risk Enrichment models Cadmium health risk assessment Pollution sources

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Liver Fat Scores for Noninvasive Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease in Epidemiological and Clinical Studies

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Journal of Clinical and Translational hepatology 2023年第5期11卷 1212-1227页

作者： Mona Reinshagen Stefan Kabisch andreas F.h.Pfeiffer Joachim Spranger Department of Endocrinology and Metabolism Campus Benjamin FranklinCharitéUniversity MedicineBerlinGermany Deutsches Zentrum für Diabetesforschung e.V. Geschäftsstelle am Helmholtz-Zentrum MünchenNeuherbergGermany

Nonalcoholic fatty liver disease(NAFLD)is strongly associated with the metabolic syndrome and type 2 diabetes and independently contributes to long-term *** often asymptomatic but reversible,it would require population-wide screening,but direct diagnostics are either too invasive(liver biopsy),costly(MRI)or depending on the examiner’s expertise(ultrasonography).hepatosteatosis is usually accommodated by features of the metabolic syndrome(***,disturbances in triglyceride and glucose metabolism),and signs of hepatocellular damage,all of which are reflected by biomarkers,which poorly predict NAFLD as single item,but provide a cheap diagnostic alternative when integrated into composite liver fat *** liver index,NAFLD LFS,and hepatic steatosis index are common and accurate indices for NAFLD prediction,but show limited accuracy for liver fat *** indices are rarely *** fibrosis scores are commonly used in clinical practice,but their mandatory reflection of fibrotic reorganization,hepatic injury or systemic sequelae reduces sensitivity for the diagnosis of simple ***-induced liver fat changes are poorly reflected by liver fat indices,depending on the intervention and its specific impact of weight loss on *** limited validity in longitudinal settings stimulates research for new ***,hepatokines,markers of cellular integrity,genetic variants but also simple and inexpensive routine parameters might be potential ***,liver fat indices lack precision for NAFLD prediction or monitoring in individual patients,but in large cohorts they may substitute nonexistent imaging data and serve as a compound biomarker of metabolic syndrome and its cardiometabolic sequelae.

关键词： NAFLD Liver fat indices Fatty liver index Prediction Dietary intervention

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Real-Time hybrid Simulation of Seismically Isolated Structures with Full-Scale Bearings and Large Computational Models

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Computer Modeling in Engineering & Sciences 2019年第9期120卷 693-717页

作者： Alireza Sarebanha andreas h.Schellenberg Matthew J.Schoettler Gilberto Mosqueda Stephen A.Mahin Arup 900 Wilshire BoulevardLos Angeles90017USA Maffei Structural Engineering 98 Battery StSan Francisco94111USA Department of Civil and Environmental Engineering UC BerkeleyRichmond94804USA Department of Structural Engineering UC San DiegoLa Jolla92093USA

hybrid simulation can be a cost effective approach for dynamic testing of structural components at full scale while capturing the system level response through interactions with a numerical *** dynamic response of a seismically isolated structure depends on the combined characteristics of the ground motion,bearings,and ***,dynamic full-scale system level tests of isolated structures under realistic dynamic loading conditions are desirable towards a holistic validation of this earthquake protection ***,bearing properties and their ultimate behavior have been shown to be highly dependent on rate-of-loading and scale size effects,especially under extreme loading *** laboratory facilities can test full-scale seismic isolation bearings under prescribed displacement and/or loading *** adaptation of a full-scale bearing test machine for the implementation of real-time hybrid simulation is presented here with a focus on the challenges encountered in attaining reliable simulation results for large scale dynamic *** advanced real-time hybrid simulations of large and complex hybrid models with several thousands of degrees of freedom are some of the first to use high performance parallel computing to rapidly execute the numerical *** in the experimental setup included measured forces contaminated by delay and other systematic control errors in applying desired *** and inertial forces generated by the large-scale loading apparatus can affect the accuracy of measured force *** results from real-time hybrid simulation requires implementation of compensation algorithms and correction of these various sources of ***,this research program confirms that real-time hybrid simulation is a viable testing method to experimentally assess the behavior of full-scale isolators while capturing interactions with the numerical models of the superstructure to evaluate

关键词： Real-time hybrid simulation seismic isolation parallel processing full scale bearing experimental testing

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IPAAm凝胶在丙酮水溶液中溶胀行为的关联与预报(英文)

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物理化学学报 2004年第3期20卷 244-250页

作者：许小平 andreas hüther Gerd Maurer 福州大学化学化工学院福州350002 Lehrstuhl für Technische Thermodynamik Universitt Kaiserslautern

基于Maurer和Prausnitz的凝胶相平衡条件,建立了凝胶的溶胀模型.模型假设凝胶是以凝胶组分及凝胶吸收的溶液为核心,以弹性半渗透膜为壳的复合体.并采用UNIQUAC方程计算凝胶相及与之共存液相的Gibbs过剩自由能,采用“phantomnetwork”理... 详细信息

基于Maurer和Prausnitz的凝胶相平衡条件,建立了凝胶的溶胀模型.模型假设凝胶是以凝胶组分及凝胶吸收的溶液为核心,以弹性半渗透膜为壳的复合体.并采用UNIQUAC方程计算凝胶相及与之共存液相的Gibbs过剩自由能,采用“phantomnetwork”理论计算凝胶的弹性自由能,采用“自由体积”计算分子的尺度效应.同时以N-异丙基丙烯酰胺(IPAAm)为单体合成了IPAAm凝胶.研究了25℃时IPAAm凝胶在丙酮水溶液中的溶胀行为,并测定了丙酮在胶体相和与之共存液相中的分配,以检验模型的关联与预报能力.结果表明,模型预报的单体总量和交联剂浓度对凝胶溶胀的影响与实验符合得很好.而且凝胶溶胀时,能很好地预测丙酮在两相中的分配,表明模型具有很好的关联和预报能力.

关键词：水凝胶溶胀模型 N-异丙基丙烯酰胺丙酮水溶液溶胀行为胶体相液相关联预报

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Current status of transarterial radioembolization

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World Journal of Radiology 2016年第5期8卷 449-459页

作者： andreas h Mahnken Department of Diagnostic and Inter- ventional Radiology University HospitalPhilipps--University

Unresectable primary and secondary liver malignancies present a major problem in the treatment of solid tumors. Transarterial radioembolization(TARE) is an increasingly used technique for treating various types of malignant liver tumors. This approach is appealing, as the mechanism of action is independent from other loco-regional treatments and potentially complementary to systemic therapies. There are two commercially available products in use for TARE: 90Y-resin and 90Y-glass microspheres. Currently available data indicates TARE so be safe and effective in hepatocellular carcinoma(hCC) and metastatic liver disease. In hCC the results compare well with chemoembolization, while the role of TARE in combination with kinase inhibitors has yet to be established. Current data on TARE in metastatic liver disease is promising, but there is a strong need for prospective randomized trials comparing TARE and modern chemotherapeutic regimen to support the growing role of TARE in metastatic liver disease.

关键词： hepatocellular carcinoma Selective internal radiation therapy Radioembolization Liver Neoplasm Metastasis

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红外靶标自动探测器的研制及试验

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农业工程学报 2012年第12期28卷 159-163页

作者：李丽李恒何雄奎 h.andreas 山东省滨州职业学院电气工程学院滨州256603 中国农业大学理学院北京100193 德联邦施药技术研究所布伦瑞克38104

当前红外靶标自动探测器对绿色作物喷药时,存在对作物和非作物(土壤、枯枝等)都施药的缺陷,造成了药液的浪费和环境的污染。该文探讨用红外探测技术实现对靶标的自动探测,同时以颜色传感器为辅助对绿色靶标进行识别,实现红外靶标自动探... 详细信息

当前红外靶标自动探测器对绿色作物喷药时,存在对作物和非作物(土壤、枯枝等)都施药的缺陷,造成了药液的浪费和环境的污染。该文探讨用红外探测技术实现对靶标的自动探测,同时以颜色传感器为辅助对绿色靶标进行识别,实现红外靶标自动探测器仅对绿色靶标进行喷雾的目的,试验结果表明:所建立的红外靶标自动探测器可对绿色作物靶标进行自动探测,探测的最远距离为85～88cm;探测距离的远近受叶片覆盖率与照度2因素的影响,植物冠层叶片覆盖率越大时,探测距离越远;叶片表面的照度越高时,探测距离越远;叶片覆盖率越大且照度越大时,探测距离越远且工作越稳定,为绿色作物精准施药提供了一种控制思路及方法。

关键词：传感器作物红外探测精准喷施颜色探测距离

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