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Better understanding of c-reactive protein and leukocytes in psychiatric inpatients with affective disorders:A biopsychosocial approach

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World Journal of Clinical Cases 2024年第19期12卷 3824-3836页

作者： Felix Kölblinger Elena md Schönthaler andreas Baranyi Tatjana Stross Frederike T Fellendorf Dirk von Lewinski Robert Queissner Eva Z Reininghaus Nina Dalkner Clinical Department of Psychiatry and Psychotherapeutic Medicine Medical University of GrazGraz 8036Austria Clinical Department of Cardiology Medical University of GrazGraz 8036Austria

BACKGROUND Affective disorders(AD)have been linked to inflammatory processes,although the underlying mechanisms of this relationship are still not fully *** is hypothesized that demographic,somatic,lifestyle,and personality variables predict inflammatory parameters in *** To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters,C-reactive protein(CRP)and *** This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters,serum inflammatory markers,somatic variables,psychological questionnaires,and lifestyle *** regression analyses were used to predict inflammatory markers from demographic,somatic,lifestyle,and personality *** Analyses showed that 33.8%of the variance of CRP was explained by body mass index and other somatic medication(***-diabetics),age and education,and age of affective disorder *** leukocytes,20.1%of the variance was explained by smoking,diet,metabolic syndrome(MetS),and anti-inflammatory medication(***-steroidal anti-inflammatory drugs).Other psychiatric or behavioural variables did not reach *** Metabolic components seem important,with mounting evidence for a metabolic affective disorder *** modifications and psychoeducation should be employed to prevent or treat MetS in AD.

关键词： Affective disorders C-reactive protein Leukocytes Metabolic syndrome Health behaviour Personality

Small scale adeno-associated virusvector production for preclinical gene delivery based on chloroform precipitation

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Neural Regeneration Research 2022年第1期17卷 99-100页

作者： Marcus Davidsson andreas Heuer Molecular Neuromodulation Department of Experimental Medical SciencesLund UniversityLundSweden Behavioural Neuroscience Laboratory Department of Experimental Medical SciencesLund UniversityLundSweden

Gene therapy aims to introduce genetic information into a cell-type of interest to replace,correct,silence,or modify defective *** therapy in its broadest sense can theoretically prevent,halt,or cure any condition that affects *** addition to that,the introduction and/or manipulation of genes is one of the major research areas in biological sciences,aimed to deepen our knowledge on how biological systems *** advances have made it possible to induce changes ranging from manipulations of large stretches of the genome to the change of single *** gold-standard vehicles to bring this genetic information into the target cells are viral vectors.

关键词： replace Small mankind

Molecular Dynamics Simulations of Nanoparticle Interactions with a Planar Wall:Does Shape Matter?

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Communications in Computational Physics 2013年第3期13卷 900-915页

作者： andreas Fuchs David Kauzlaric andreas Greiner Sauro Succi Jan.G.Korvink Laboratory for Simulation Department of Microsystems Engineering(IMTEK)University of FreiburgGeorges-Kohler-Allee 10379110 FreiburgGermany School of Soft Matter Research Freiburg Institute for Advanced StudiesUniversity of FreiburgAlbertstr.1979104 FreiburgGermany Istituto Applicazioni Calcolo CNRvia dei Taurini 900185RomaItaly

We investigate the hydrodynamic interactions of spherical colloidal nano particles and nano tetrahedra near a planar wall by means of molecular dynamics(md)simulations of rigid particles within an all-atom *** both spherical and nano-tetrahedral particles,we find that the parallel and perpendicular components of the local diffusion coefficient and viscosity,show good agreement with hydrodynamic theory of Fax´en and *** provides further evidence that low perturbations from sphericality of a nanoparticle’s shape has little influence on its local diffusive behaviour,and that for this particular case,the continuum theory fluid dynamics is valid even down to molecular scales.

关键词： Molecular dynamics simulation nanoparticle hydrodynamic interaction

Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care

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Virologica Sinica 2021年第6期36卷 1284-1302页

作者： Haoru Dong Xinhua Shu Qiang Xu Chen Zhu andreas M.Kaufmann Zhi-Ming Zheng andreas E.Albers Xu Qian Department of Clinical Laboratory Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Department of Cancer Prevention Cancer Hospital University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Clinic for Gynecology Berlin Institute of HealthCharité-Universitätsmedizin BerlinFreie Universität BerlinHumboldt-Universität Zu BerlinBerlin12203Germany Tumor Virus RNA Biology Section HIV Dynamics and Replication ProgramNational Cancer InstituteNational Institutes of HealthFrederickMD21702USA Department of Otolaryngology Head and Neck SurgeryBerlin Institute of HealthCharité-Universitätsmedizin BerlinFreie Universität BerlinHumboldt-Universität Zu BerlinBerlin13353Germany

Human papillomavirus(HPV)infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human *** to 38%–80%of head and neck squamous cell carcinoma(HNSCC)in oropharyngeal location(OPSCC)and nearly all cervical cancers contain the HPV genome which is implicated in causing cancer through its oncoproteins E6 and *** by the biologically distinct HPV-related OPSCC and a more favorable prognosis compared to HPV-negative tumors,clinical trials on de-escalation treatment strategies for these patients have been *** is therefore raised the questions for the patient stratification if treatment de-escalation is ***,understanding the crosstalk of HPV-mediated malignancy and immunity with clinical insights from the proportional response rate to immune checkpoint blockade treatments in patients with HNSCC is of importance to substantially improve the treatment *** review discusses the biology of HPV-related HNSCC as well as successful clinically findings with promising candidates in the pipeline for future *** the advent of various sequencing technologies,further biomolecules associated with HPV-related HNSCC progression are currently being identified to be used as potential biomarkers or targets for clinical decisions throughout the continuum of cancer care.

关键词： Human papillomavirus(HPV)integration Molecular diagnostics Oropharyngeal cancer De-Escalation treatment Immunotherapy

Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

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Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier--Chebbah Carsten Claussen Christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas Lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski Francesco Parino Gery Pruvost andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal Crépey PascalCrepey Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada Department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland Department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA Departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des Deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance Decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occurred during the *** workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data,social media,and wastewater *** advancements were noted in the development of predictive models,with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease *** role of open collaboration between various stakeholders in modelling was stressed,advocating for the continuation of such partnerships beyond the pandemic.A major gap identified was the absence of a common international framework for data sharing,which is crucial for global pandemic ***,the workshop underscored the need for robust,adaptable modelling frameworks and the integration of different data sources and collaboration across sectors,as key elements in enhancing future pandemic response and preparedness.

关键词： Modelling Covid-19 Infectious diseases Pandemic preparedness Workshop

Characterization and genetic manipulation of primed stem cells into a functional na?ve state with ESRRB

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World Journal of Stem Cells 2016年第10期8卷 355-366页

作者： Ricardo Antonio Rossello andreas Pfenning Jason T Howard Ute Hochgeschwender Department of Science and Technology Sistema Universitario Ana G. Méndez Metropolitan University San Juan 00928 Puerto Rico Department of Biochemistry University of Puerto Rico - Medical Sciences Campus San Juan 00921 Puerto Rico Massachusetts Institute of Technology Cambridge MA 02139 United States Howard Hughes Medical Institute Chevy Chase MD 20815-6789 United States Duke Neurotransgenic Laboratory Duke University Medical Center Durham NC 27710 United States

AIM To identify differences between primed mouse embryonic stem cells(ESCs) and fully functional naive ESCs; to manipulate primed cells into a naive state. METHODS We have cultured 3 lines of cells from different mouse strains that have been shown to be naive or primed as determined by generating germline-transmitting *** were put through a battery of tests to measure the different features. RNA from cells was analyzed using microarrays, to determine a priority list of the differentially expressed genes. These were later validated by quantificational real-time polymerase chain reaction. Viral cassettes were created to induce expression of differentially expressed genes in the primed cells through lentiviral transduction. Primed reprogrammed cells were subjected to in-vivo incorporation *** Most results show that both primed and naive cells have similar features(morphology, proliferation rates, stem cell genes expressed). However, there were some genes that were differentially expressed in the na?ve cells relative to the primed cells. Key upregulated genes in na?ve cells include ESRRB, ERAS, ATRX, RNF17, KLF-5, and MYC. After over-expressing some of these genes the primed cells were able to incorporate into embryos in-vivo, re-acquiring a feature previously absent in these cells. CONCLUSION Although there are no notable phenotypic differences, there are key differences in gene expression between these na?ve and primed stem cells. These differences can be overcome through overexpression.

关键词： ESRRB ERAS Induced stem cells Overexpression C-myc

Accuracy of combined PET/CT in image-guided interventions of liver lesions: An ex-vivo study

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World Journal of Gastroenterology 2006年第15期12卷 2388-2393页

作者： Patrick Veit Christiane Kuehle Thomas Beyer Hilmar Kuehl andreas Bockisch Gerald Antoch Department of Diagnostic and Interventional Radiology and Neuroradiology Department of Nuclear Medicine University Hospital Essen

AIM： Positioning of interventional devices in liver lesions is a challenging task if only CT is available. We investigated the potential benefit of combined PET/CT images for localization of interventional devices in interventional liver studies. METHODS： Thirty lesions each of hyperdense, isodense and hypodense attenuation compared to normal liver parenchyma were injected into 15 ex-vivo pig livers. All lesions were composed of the same amounts of gelatine containing 0.5 MBq of ^18F-FDG. Following lesion insertion, an interventional needle was placed in each lesion under CT-guidance solely. After that, a PET/CT study was performed. The localization of the needle within the lesion was assessed for CT alone and PET/CT and the root mean square （RMS） was calculated. Results were compared with macroscopic measurements after lesion dissection serving as the standard of reference. RESULTS： In hypo- and isodense lesions PET/CT proved more accurate in defining the position of the interventional device when compared with CT alone. The mean RMS for CT and PET/CT differed significantly in isodense and hypodense lesions. No significant difference was found for hyperdense lesions. CONCLUSION： Combined FDG-PET/CT imaging provides more accurate information than CT alone concerning the needle position in FDG-PET positive liver lesions. Therefore combined PET/CT might be potentially beneficial not only for localization of an interventional device, but may also be beneficial for guidance in interventional liver procedures.

关键词： Liver biopsy Radiofrequency ablation Combined PET/CT ex-vivo study Image guided interventions

Multi-slice and Dual-source CT in Cardiac Imaging: Principles — Protocols — Indications — Outlook 2nd ed.

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Risk of second primary cancers after testicular cancer in East and West Germany： a focus on contralateral testicular cancers

2007年

作者： Bernd M. Ohnesorge PhD, Thomas G. Flohr PhD, Christoph R. Becker md, andreas Knez md, Maximilian F. Reiser md (auth.)

来源：畅想之星图书光盘版（南... 评论

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Asian Journal of Andrology 2014年第2期16卷 285-289,I0010,I0011页

作者： Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts andreas Stang Institute of Clinical Epidemiology Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Common Cancer Registry of Berlin Berlin Saarland Cancer Registry Saarbrucken Institute of Medical Epidemiology Biostatistics and Informatics Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Germany Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD Department of Epidemiology Scfloof of Public Heaftfl Boston University Boston MA USA.

Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and Saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （SIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual SIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （SIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （SIR： 1.7; 95% Ch 1.4-2.0）. The SIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in Saarland to 13.9 in East Germany. The SIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based SIRs for contralateral testicular cancers. The majority of reported SIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. Testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.

关键词： cancer registry incidence neoplasms second primary testicular neoplasms