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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Simulation of microswimmer hydrodynamics with multiparticle collision dynamics

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Chinese Physics B 2020年第7期29卷 55-61页

作者： andreas Zottl Institute for Theoretical Physics TU WienWiedner Hauptstraße 8-101040 WienAustria

In this review we discuss the recent progress in the simulation of soft active matter systems and in particular the hydrodynamics of microswimmers using the method of multiparticle collision dynamics,which solves the hydrodynamic flows around active objects on a coarse-grained *** first present a brief overview of the basic simulation method and the coupling between microswimmers and *** then review the current achievements in simulating flexible and rigid microswimmers using multiparticle collision dynamics,and briefly conclude and discuss possible future directions.

关键词： active matter multiparticle collision dynamics microswimmers coarse-grained hydrodynamic simulations

Tunable structural colors on display

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Light(Science & Applications) 2022年第6期11卷 1036-1037页

作者： andreas Tittl Chair in Hybrid Nanosystems Nanoinstitute MunichFaculty of PhysicsLudwig-Maximilians-Universitat MünchenKoniginstraβe 1080539 MünchenGermany

Structural coloration takes inspiration from the bright hues found in nature to control the reflection and transmission of light from artificially structured *** them with active electrical tuning heralds breakthrough... 详细信息

关键词： materials tuning breakthrough

Geoscience material structures prediction via CALYPSO methodology

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维普期刊数据库

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Chinese Physics B 2019年第10期28卷 38-49页

作者： andreas Hermann Centre for Science at Extreme Conditions and SUPA School of Physics and Astronomy The University of Edinburgh

Many properties of planets such as their interior structure and thermal evolution depend on the high-pressure properties of their constituent materials. This paper reviews how crystal structure prediction methodology can help shed light on the transformations materials undergo at the extreme conditions inside planets. The discussion focuses on three areas:(i) the propensity of iron to form compounds with volatile elements at planetary core conditions(important to understand the chemical makeup of Earth's inner core),(ii) the chemistry of mixtures of planetary ices(relevant for the mantle regions of giant icy planets), and(iii) examples of mantle minerals. In all cases the abilities and current limitations of crystal structure prediction are discussed across a range of example studies.

关键词： crystal structure prediction core materials planetary ices hydrous minerals

Plasma optics improving plasma accelerators

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Light(Science & Applications) 2022年第9期11卷 1954-1955页

作者： andreas Dopp Ludwig-Maximilians-Universit?t Munchen GarchingGermany

Plasma accelerators driven by high-power lasers can provide high-energy electron beams on a dramatically smaller scale than conventional radio-frequency ***,the performance of these accelerators is fundamentally limited by the diffraction of the ***-generated plasma waveguides can mitigate this problem and,combined with a controlled injection method for electrons,highlight the potential of novel laser-plasma optics.

关键词： optics Plasma conventional