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Updating the orbital ephemeris of the dipping source XB 1254–690 and the distance to the source

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Research in Astronomy and Astrophysics 2017年第10期17卷 97-108页

作者： Angelo F.Gambino rosario Iaria Tiziana Di Salvo Marco Matranga Luciano Burderi Fabio Pintore Alessandro Riggio andrea Sanna Universita degli Studi di Palermo Dipartimento di Fisica e Chimica Universita degli Studi di Cagliari Dipartimento di Fisica INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano

XB 1254-690 is a dipping low mass X-ray binary system hosting a neutron star and showing type I X-ray bursts. We aim at obtaining a more accurate orbital ephemeris and at constraining the orbital period derivative of the system for the first time. In addition, we want to better constrain the distance to the source in order to locate the system in a well defined evolutive scenario. We apply, for the first time, an orbital timing technique to XB 1254-690, using the arrival times of the dips present in the light curves that have been collected during 26 yr of X-ray pointed observations acquired from different space missions. We estimate the dip arrival times using a statistical method that weights the count-rate inside the dip with respect to the level of persistent emission outside the dip. We fit the obtained delays as a function of the orbital cycles both with a linear and a quadratic function. We infer the orbital ephemeris of XB 1254-690, improving the accuracy of the orbital period with respect to previous estimates. We infer a mass of M2 = 0.42 ± 0.04 M for the donor star, in agreement with estimations already present in literature, assuming that the star is in thermal equilibrium while it transfers part of its mass via the inner Lagrangian point, and assuming a neutron star mass of 1.4 Mo. Using these assumptions, we also constrain the distance to the source, finding a value of 7.6±0.8 kpc. Finally, we discuss the evolution of the system, suggesting that it is compatible with a conservative mass transfer driven by magnetic braking.

关键词： stars: neutron -- stars: individual (XB 1254-690) -- X-rays: binaries -- X-rays: stars --Astrometry and celestial mechanics: ephemerides

Role of the miR-301a/Fra-2/GLIPR1 axis in lung cancer cisplatin resistance

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Signal Transduction and Targeted Therapy 2023年第2期8卷 377-380页

作者： Gian Luca Rampioni Vinciguerra Marina Capece rosario Distefano Giovanni Nigita andrea Vecchione Francesca Lovat Carlo M.Croce Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbusOH43210USA Department of Clinical and Molecular Medicine University of Rome‘Sapienza’Sant’Andrea HospitalRome00189Italy

Non-small cell lung cancer(NSCLC)is the leading cause of cancer-related mortality ***-based chemotherapy represents the main treatment,despite about the 70%of tumors are intrinsically *** the mechanisms of platinum-re... 详细信息

关键词： lung cancer chemotherapy

Laparo-endoscopic “Rendezvous” to treat cholecysto-choledocolithiasis: Effective,safe and simplifies the endoscopist’s work

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World Journal of Gastroenterology 2008年第18期14卷 2844-2850页

作者： Gaetano La Greca Francesco Barbagallo Michele Di Blasi andrea Chisari rosario Lombardo rosario Bonaccorso Saverio Latteri andrea Di Stefano Domenico Russello Department of Surgical Sciences Transplantation and Advanced Technologies University of Catania Cannizzaro Hospital Via Messina 829 Catania 95126 Italy Endoscopic Unit Cannizzaro Hospital Via Messina 829 Catania 95126 Italy

AIM: To investigate our clinical experience with combined laparo-endoscopic Rendezvous (RV) for the treatment of patients affected by gallstones and common bile duct (CBD) stones and especially to study the never evaluated opinion of the endoscopist concerning the difficulty of the intraoperative endoscopic procedure during the RV in comparison with standard endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: Eighty consecutive patients affected by cholecystolithiasis and diagnosed or suspected CBD stones were treated with a standardized "tailored" RV. The relevant technical features, the feasibility, the effectiveness in stone clearance, the safety but also the simple evaluation of difficulty and agreement of the endoscopist were analyzed with a questionnaire. RESULTS: The feasibility was 97.5% and the effectiveness 100% concerning CBD clearance and solution of coexisting problems at the papilla. Minor morbidity was 3.3%, the operating time was prolonged by a mean of 14 min, the mean hospital stay was 3.8 d and only one stone’s recurrence occurred. The endoscopist evaluated the procedure to be simpler than standard ERCP-ES in 81.2% of the ***: Simultaneous RV carries higheffectiveness and safety at least comparable to those reported for other options. The endoscopist is very often satisfied with this approach because of the minimization of some steps of the endoscopic procedure and avoidance of relevant iatrogenic risk factors. If the mandatory collaboration between surgeons and endoscopists is guaranteed, this approach can often be preferable for the patient, the surgeon, the endoscopist and the hospital.

关键词： Gallstones Common bile duct Endoscopic retrograde cholangio-pancreatography Endoscopic sphincterotomy Rendezvous Intra-operative cholangiography Laparoscopic cholecystectomy

Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions

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World Journal of Gastroenterology 2017年第32期23卷 5875-5886页

作者： Guido Giordano Massimo Pancione Nunzio Olivieri Pietro Parcesepe Marianna Velocci Tania Di Raimo Luigi Coppola Giuseppe Toffoli Mario rosario D’andrea Medical Oncology Unit San Filippo Neri Hospital CRO Aviano National Cancer Institute Department of Sciences and Technologies University of Sannio Department of Biochemistry and Molecular Biology II Faculty of PharmacyComplutense University Department of Biology University of Naples Department of Pathology and Diagnostics University of Verona Strada Anatomic Pathology Unit San Filippo Neri00135 RomaItaly Experimental and Clinical Pharmacology Unit CRO-National Cancer Institute Via F

Pancreatic cancer(PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addressed as a potential therapeutic target. Nano albumin bound(Nab)-paclitaxel is an innovative molecule depleting tumor stroma, through interaction between albumin and secreted protein acidic and rich in cysteine. Addition of nab-paclitaxel to gemcitabine has showed activity and efficacy in metastatic PDAC first-line treatment improving survival and overall response rate vs gemcitabine alone in the MPACT phase Ⅲ study. This combination represents one of the standards of care in advanced PDAC therapy and is suitable to a broader spectrum of patients compared to other schedules. Nab-paclitaxel is under investigation as a backbone of chemotherapy in novel combinations with target agents or immunotherapy in locally advanced or metastatic PDAC. In this article, we provide an updated and critical overview about the role of nab-paclitaxel in PDAC treatment based on the latest advances in preclinical and clinical research. Furthermore, we focus on the use of nab-paclitaxel within the context of metastatic PDAC treatment landscape and we discuss about future implications in the light of current clinical ongoing trials.

关键词： Nano albumin bound-paclitaxel Pancreatic cancer Metastatic disease Gemcitabine Folfirinox

Severe immune thrombocytopenia after peg-interferonalpha2a, ribavirin and telaprevir treatment completion: a case report and systematic review of literature

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World Journal of Hepatology 2015年第12期7卷 1718-1722页

作者： rosario Arena Paolo Cecinato andrea Lisotti Federica Buonfiglioli Claudio Calvanese Giuseppe Grande Marco Montagnani Francesco Azzaroli Giuseppe Mazzella Department of Medical and Surgical Science-DIMEC University of Bologna S.Orsola-Malpighi Hospital

Mild to moderate autoimmune thrombocytopenia(AITP) is a common finding in patients receiving interferonbased antiviral treatment, due to bone marrow suppression. Here we report the case of a patient with chronic genotype 1b hepatitis C virus(HCV) infection treated with pegylated-interferon alpha-2a, ribavirin and telaprevir for 24 wk; the patient developed severe AITP three weeks after treatment withdrawal. We performed a systematic literature search in order to review all published cases of AITP related to HCV antiviral treatment. To our knowledge, this is the second case of AITP observed after antiviral treatment withdrawal. In most published cases AITP occurred during treatment; in fact, among 24 cases of AITP related to interferonbased antiviral treatment, only one occurred after discontinuation. Early diagnosis of AITP is a key factor in order to achieve an early interferon discontinuation; in the era of new direct antiviral agents those patients have to be considered for interferon-free treatment regimens. Prompt prescription of immuno-suppressant treatment(i.e., corticosteroids, immunoglobulin infusion and even rituximab for unresponsive cases) leads to favourable prognosis in most of cases. Physicians using interferonbased treatments should be aware that AITP can occur both during and after treatment, specially in the new era of interferon-free antiviral treatment. Finally, in the case of suspected AITP, presence of anti-platelet antibodies should be checked not only during treatment but alsoafter discontinuation.

关键词： Autoimmune thrombocytopenia Pegylatedinterferon Chronic hepatitis C Viral hepatitis Antiplateletantibody

Long-term leukocyte natural α-interferon and ribavirin treatment in hepatitis C virus recurrence after liver transplantation

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World Journal of Gastroenterology 2013年第32期19卷 5278-5285页

作者： Mariarosa Tamè Federica Buonfiglioli Massimo Del Gaudio andrea Lisotti Paolo Cecinato Antonio Colecchia Francesco Azzaroli Antonietta D’Errico rosario Arena Claudio Calvanese Chiara Quarneti Giorgio Ballardini Antonio Daniele Pinna Giuseppe Mazzella Department of Digestive Diseases and Internal Medicine S. Orsola-Malpighi HospitalUniversity of Bologna Department of Liver and Multiorgan Transplant Unit S. Orsola-Malpighi HospitalUniversity of Bologna Department of Hematology Oncology and Laboratory MedicineS. Orsola-Malpighi HospitalUniversity of Bologna

AIM:To evaluate the effect of long-term treatment with leukocyte natural-interferon(ln-α-IFN)plus ribavirin(RBV).METHODS:Forty-six patients with hepatitis C virus(HCV)recurrence received 3 MU three times a week of ln-α-IFN plus RBV for 1 mo;then,patients with good tolerability(n=30)were switched to daily IFN administration,while the remaining were treated with the same *** have been treated for 12 mo after viral clearance while non-responders(NR)entered in the longterm treatment *** biopsies were planned at baseline,1 year after sustained virological response(SVR)and at 36 mo after start of therapy in *** software package was used for statistical ***:About 16.7%of genotype 1-4 and 70%of genotype 2-3 patients achieved *** patients withdrew therapy because of non-tolerance or noncompliance.A significant improvement in serum biochemistry and histological activity was observed in all SVR patients and long-term treated;100%of patients with SVR achieved a histological response(fibrosis stabilization or improvement)with a significant reduction in mean staging value(from 2.1 to 1.0;P=0.0031);histological response was observed in 84%of long-term treated patients compared to 57%of *** patients died during the entire study period(follow-up 40.6±7.7 mo);of them,5 presented with severe HCV recurrence on ***(OR=0.38,95%CI:0.08-0.59,P=0.01),leukopenia(OR=0.54,95%CI:0.03-0.57,P=0.03)and severe HCV recurrence(OR=0.51,95%CI:0.25-0.69,P=0.0003)were variables associated to ***-term treatment was well tolerated;no patients developed rejection or autoimmune ***:Long-term treatment improves histology in SVR patients and slows disease progression also in NR,leading to a reduction in liver decompensation,graft failure and liver-related death.

关键词： Hepatitis C virus Hepatitis C recurrence Interferon Ribavirin Liver transplantation

Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1132-1146页

作者： Gian Luca Rampioni Vinciguerra Marina Capece Luca Reggiani Bonetti Giovanni Nigita Federica Calore Sydney Rentsch Paolo Magistri Roberto Ballarin Fabrizio Di Benedetto rosario Distefano Roberto Cirombella andrea Vecchione Barbara Belletti Gustavo Baldassarre Francesca Lovat Carlo M.Croce Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State UniversityColumbus 43210 OHUSA Department of Clinical and Molecular Medicine Faculty of Medicine and PsychologySant’Andrea HospitalUniversity of Rome“Sapienza”Rome 00189Italy Department of Diagnostic Clinic and Public Health MedicineUniversity of Modena and Reggio EmiliaModena 41100Italy Hepato-pancreato-biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41100Italy Division of Molecular Oncology Centro di Riferimento Oncologico di Aviano(CRO)Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)National Cancer InstituteAviano 33081Italy

Pancreatic ductal adenocarcinoma(PDAC)is a lethal disease,characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient *** aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor *** of the onco-suppressor miR-15a has been extensively documented in ***,we identified the transcription factor Fos-related antigen-2(Fra-2)as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient *** report that the IGF1 signaling pathway was enhanced in nutrient deprived PDAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PDAC ***,we discovered that miR-15a repressed IGF1R expression via Fra-2 *** miR-15a-low context,IGF1R hyperactivated mTOR,modulated the autophagic flux and sustained PDAC growth in nutrient *** a genetic mouse model,Mir15aKO PDAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet ***,nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent ***,our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.

关键词： IGF1R Fra miR

Circulating tumor cells and the metastatic process: the complexity of malignancy

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 628-641页

作者： Tania Di Raimo Elena De Santis Luigi Coppola Mario rosario D’andrea Francesco Angelini Medical Oncology and Anatomic Pathology Unit San Filippo Neri HospitalRome 00135Italy Experimental&Clinical Pharmacology Centro Di Riferimento Oncologico-National Cancer CenterAviano(PN)33081Italy Department of Anatomical HistologicalLegal Medical and of the Locomotor Apparatus SciencesSapienza UniversityRome 00135Italy Anatomic Pathology Unit Sandro Pertini HospitalRome 00157Italy

Despite improvements achieved in terms of early detection and therapeutic approach,metastatic breast cancer remains one of the principal worldwide causes of *** recent years,due to the heterogeneous response of each patient to chemotherapy,clinical research highlights the need of a personalized *** tumor cells(CTCs)represents a promising tool for this ***,even if their correlation with sever-ity,outcome and metastatic nature of the tumor has been established,several issues,mainly concerning their characterization and isolation,need to be *** this review,latest knowledge on CTCs and metastatic pro-cess in breast cancer were analyzed,aiming to understand their clinical utility and validity for a prospective ther-apeutic scenario.

关键词： Breast cancer metastasis circulating tumor cells personalized therapy

Endoscopic retrieval of a duodenal perforating teaspoon

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World Journal of Gastrointestinal Endoscopy 2013年第4期5卷 186-188页

作者： Ivo Bokoski andrea Tringali rosario Landi Pietro Familiari Anna Chiara Iolanda Contini Claudio Pintus Guido Costamagna Digestive Endoscopy Unit Catholic University of Rome Pediatrics Department Catholic University of Rome Digestive Endoscopy Unit Catholic University of Rome

Foreign objects ingestion occur commonly in pediatric patients. The majority of ingested foreign bodies pass spontaneously the gastrointestinal tract and surgery is rarely required for extraction. Endoscopic removal of foreign bodies larger than 10 cm has not yet been described. We present the case of a 16 years old bulimic girl that swallowed a 12 cm long teaspoon in order to provoke vomiting. The teaspoon perforated the duodenum. However, it was removed during gastroscopy and the site of perforation was closed endoscopically. This particular case shows the importance of endoscopy for retrieval of large foreign bodies, and the possibility to endoscopically close a perforated duodenal wall.

关键词： Foreign body ingestion Upper endoscopy Bowel perforation Bulimia