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Batch Active learning for Multispectral and Hyperspectral Image Segmentation Using Similarity Graphs

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1013-1033页

作者： Bohan Chen Kevin Miller andrea l.bertozzi Jon Schwenk Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLosAngeles90095CAUSA Oden Institute for Computational Engineering and Sciences University of Texas at Austin201 E 24th StAustin 78712TXUSA los Alamos National laboratory Los AlamosNM 87545USA

Graph learning,when used as a semi-supervised learning(SSl)method,performs well for classification tasks with a low label *** provide a graph-based batch active learning pipeline for pixel/patch neighborhood multi-or hyperspectral image *** batch active learning approach selects a collection of unlabeled pixels that satisfy a graph local maximum constraint for the active learning acquisition function that determines the relative importance of each pixel to the *** work builds on recent advances in the design of novel active learning acquisition functions(e.g.,the Model Change approach in arXiv:2110.07739)while adding important further developments including patch-neighborhood image analysis and batch active learning methods to further increase the accuracy and greatly increase the computational efficiency of these *** addition to improvements in the accuracy,our approach can greatly reduce the number of labeled pixels needed to achieve the same level of the accuracy based on randomly selected labeled pixels.

关键词： Image segmentation Graph learning Batch active learning Hyperspectral image

Targeted NGS analysis reveals a complex genetic background of idiopathic erythrocytosis in a large Venetian family

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Genes & Diseases 2024年第2期11卷 561-563页

作者： bertozzi Irene Benetti andrea Regazzo Daniela Polese Francesca Biagetti Giacomo Ceolotto Giulio Randi Maria luigia First Medical Clinic University of Padua Department of Medicine – DIMEDVia Giustiniani 2Padova 35123Italy Transfusion Medicine Department Ospedale dell'Angelo - Venezia MestreVia Paccagnella 1Venice 30174Italy Emergency Medicine University of Padua Department of Medicine – DIMEDVia Giustiniani 2Padova 35123Italy

Absolute erythrocytosis,due to an increased production of red blood cells,becomes manifest with hemoglobin(Hb)levels above 165 or 160 g/l or with a hematocrit(HCT)above 51%and 48%in males and females,respectively.1 A minority of patients have polycythemia vera(PV);acquired secondary erythrocytosis frequently occurs due to appropriate or inappropriate erythropoietin(EPO)excess,while congenital secondary erythrocytosis may derive from genetic defects causing tissue *** erythrocytosis occurs in patients with genetic mutations of the oxygen-sensing pathway(VHl,PHD2,_HIF-1-alpha)or the erythropoietin receptor(EPOR)genes.2 Recently,HFE gene variants have been described in sporadic erythrocytoses.3 In a high proportion(about 70%)of patients with erythrocytosis,a specific etiology remains elusive despite extensive testing,and the diagnosis of idiopathic erythrocytosis(IE)is ruled out.

关键词： diagnosis patients congenital

Corrosion Investigation by Scanning Electrochemical Microscopy of AISI 446 and Ti-Coated AISI 446 Ferritic Stainless Steel as Potential Material for Bipolar Plate in PEMWE

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Acta Metallurgica Sinica(English letters) 2024年第4期37卷 607-619页

作者： andrea Kellenberger Nicolae Vaszilcsin Mircea laurentiu Dan Ion Mitelea Alexandru Adrian Geana Sigrid lædre Corneliu M.Craciunescu Faculty of Industrial Chemistry and Environmental Engineering Politehnica University TimisoaraPiata Victoriei 2300006TimisoaraRomania Faculty of Mechanical Engineering Politehnica University TimisoaraPiata Victoriei 2300006TimisoaraRomania SINTEF Industry 7465TrondheimNorway

The components of proton exchange membrane water electrolysers frequently experience corrosion issues, especially at high anodic polarization, that restrict the use of more affordable alternatives to titanium. Here, we investigate localized corrosion processes of bare and Ti-coated AISI 446 ferritic stainless steel under anodic polarization by scanning electrochemical microscopy (SECM) in sodium sulphate and potassium chloride solutions. SECM approach curves and area scans measured at open-circuit potential (OCP) of the samples in the feedback mode using a redox mediator evidence a negative feedback effect caused by the surface passive film. For the anodic polarization of the sample, the substrate generation-tip collection mode enables to observe local generation of iron (II) ions, as well as formation of molecular oxygen. For the uncoated AISI 446 sample, localized corrosion is detected in sodium sulphate solution simultaneously with oxygen formation at anodic potentials of 1.0 V vs. Ag/AgCl, whereas significant pitting corrosion is observed even at 0.2 V vs. Ag/AgCl in potassium chloride solution. The Ti-coated AISI 446 sample reveals enhanced corrosion resistance in both test solutions, without any evidence of iron (II) ions generation at anodic potentials of 1.2 V vs. Ag/AgCl, where only oxygen formation is observed.

关键词： Ferritic stainless steel Corrosion Ti coating Scanning electrochemical microscopy(SECM) Magnetron sputtering Proton exchange membrane water electrolysis(PEMWE)

laser-optimized Pt-Y alloy nanoparticles embedded in Pt-Y oxide matrix for high stability and ORR electrocatalytic activity

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Journal of Energy Chemistry 2024年第5期92卷 508-520页

作者： Riccardo Brandiele andrea Guadagnini Mattia Parnigotto Federico Pini Vito Coviello Denis Badocco Paolo Pastore Gian andrea Rizzi andrea Vittadini Daniel Forrer Vincenzo Amendola Christian Durante Department of Chemical Sciences University of PaduaVia Marzolo 135131 PadovaItaly Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia ICMATE-CNR via Marzolo 1 I-35131 PadovaItaly

The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday *** nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating *** this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ***_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in *** novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(l Pt catalysts,yet resulting remarkably more active with E_(1/2)=0.943 V ***,specific activity=1095μA cm^(-2) and mass activity>1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.

关键词： Electrocatalysis GDE ORR Pt_(2)Y Pt_(3)Y lAl lFl Oxide support Pto Nanoalloys

Application of flame-formed carbon nanoparticle films for ethanol sensing Author links open overlay panel

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Particuology 2024年第8期91卷 202-210页

作者： Pegah Darvehi luca Basta Mario Commodo Patrizia Minutolo andrea D'Anna Istituto di Scienze e Tecnologie per l’Energia e la MobilitàSostenibili Consiglio Nazionale delle RicercheP.le Tecchio 8080125NapoliItaly Dipartimento di Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversitàdegli Studi di Napoli Federico IIP.le Tecchio 8080125NapoliItaly

Carbon nanoparticles(CNPs)have received considerable attention due to their exceptional qualities and *** unique physical and chemical characteristics make them extremely intriguing as materials for numerous high-potential applications,such as electronics and gas *** study focused on producing carbon-based nanomaterial devices by deposition of flame-formed carbon nanoparticles on a suitable substrate and investigating their gas-sensing *** were produced in a fuel-rich laminar premixed ethylene/air flame and the collected CNP film was morphologically and electrically *** electrical conductivity of the film was investigated as a function of ethanol concentration and amount of deposited ***,CNP films exhibited high sensitivity to ambient ethanol gas concentrations,and rapid recovery times at room temperature,and showed a sensitivity increasing with the amount of deposited material and the surface *** findings demonstrate the high potential of combustion-generated CNPs as building materials for low-cost and portable ethanol sensors.

关键词： Flame synthesis Carbon nanoparticles Soot Nanostructured thin film Optical and electrical characterization Atomic force microscopy Sensors

The Behavior of Solutions of Multidimensional Aggregation Equations with Mildly Singular Interaction Kernels

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Chinese Annals of Mathematics,Series B 2009年第5期30卷 463-482页

作者： andrea l.bertozzi Thomas lAURENT Department of Mathematics University of California-Los AngelesLos Angeles

The authors consider the multidimensional aggregation equation tp-div（p K＊ ρ） = 0 in which the radially symmetric attractive interaction kernel has a mild singularity at the origin （lipschitz or better）, and review recent results on this problem concerning well-posedness of nonnegative solutions and finite time blowup in multiple space dimensions depending on the behavior of the kernel at the origin. The problem with bounded initial data, data in l^p ∩ l^1, and measure solutions are also considered.

关键词： Well-posedness Blowup Osgood condition

Epidemicity indices and reproduction numbers from infectious disease data in connected human populations

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Infectious Disease Modelling 2024年第3期9卷 875-891页

作者： Cristiano Trevisin lorenzo Mari Marino Gatto andrea Rinaldo laboratory of Ecohydrology École Polytechnique Fédérale de LausanneStation 2Lausanne1015Switzerland Dipartimento di Elettronica Informazione e BioingegneriaPolitecnico di MilanoVia Ponzio 34/5Milano20133Italy Dipartimento di Ingegneria Civile Edile e Ambientale(ICEA)Universitàdi PadovaStation 2Padova35131Italy

We focus on distinctive data-driven measures of the fate of ongoing *** relevance of our pursuit is suggested by recent results proving that the short-term temporal evolution of infection spread is described by an epidemicity index related to the maximum instantaneous growth rate of new infections,echoing concepts and tools developed to study the reactivity of *** epidemicity indices can showcase the dynamics of infections,together with commonly employed effective reproduction numbers,especially when the latter assume values less than *** particular,epidemicity evaluates the short-term reactivity to perturbations of a disease-free ***,we show that sufficient epidemicity thresholds to prevent transient epidemic outbreaks in a spatially connected setting can be estimated by generalizing existing analogues derived when spatial effects are *** specifically account for the discrete nature,in both space and time,of surveillance data of the type typically employed to estimate effective reproduction numbers that formed the bulk of the communication of the state of the COVID-19 pandemic and its *** analyzing the effects of spatial heterogeneity on the considered prognostic indicators,we perform a short-and long-term analysis on the COVID-19 pandemic in Italy,showing that endemic conditions were maintained throughout the duration of our simulation despite stringent control *** method provides a portfolio of prognostic indices that are essential to pinpoint the ongoing pandemic in both a qualitative and quantitative manner,as our results *** base our conclusions on extended investigations of the effects of spatial fragmentation of communities of different sizes owing to connectivity by human mobility and contact scenarios,within real geographic contexts and synthetic setups designed to test our framework.

关键词： COVID-19 Ecological reactivity Epidemicity Reproduction numbersleslie matrix Metapopulation Mobility

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

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Journal of Sport and Health Science 2024年第3期13卷 398-408页

作者： Pedro l.Valenzuela Alfredo Santalla lidia B.Alejo andrea Merlo Asuncion Bustos laura Castellote-Belles Roser Ferrer-Costa Nicola A.Maffiuletti David Barranco-Gil Tomas Pinos Alejandro lucia Physical Activity and Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain Department of Sport and Computer Science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance lab Schulthess ClinicZurich 8008Switzerland Biomedical Research Networking Center on Rare Disorders(CIBERER) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/l).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all platory threshold and55%peak power output,both pless of the CHO dose(placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis Nutrition Supplement

Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages

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Engineered Regeneration 2024年第1期5卷 80-91页

作者： Francesco Fontana andrea Cafarelli Francesco Iacoponi Soria Gasparini Tiziano Pratellesi Abigail NKoppes leonardo Ricotti The BioRobotics Institute Scuola Superiore Sant’Anna56127 PisaItaly Department of Excellence in Robotics&AI Scuola Superiore Sant’Anna56127 PisaItaly BAC Technology s.r.l. 50063 FlorenceItaly Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Department of Bioengineering Northeastern UniversityBostonMA 02115USA Department of Biology Northeastern UniversityBostonMA 02115USA

Nerve regeneration following traumas remains an unmet *** application of pulsed electromagnetic field(PEMF)stimulation has gained traction for a minimally invasive regeneration of ***,a sys-tematic exploration of different PEMF parameters influencing neuron function at a cellular level is not *** this study,we exposed neuroblastoma F11 cells to PEMF to trigger beneficial effects on neurite *** carrier frequencies,pulse repetition frequencies,and duty cycles were screened with a custom ad hoc setup to find the most influential parameters values.A carrier frequency of 13.5 MHz,a pulse repetition frequency of 20 Hz,and a duty cycle of 10%allowed maximal neurite outgrowth,with unaltered viability with respect to non-stimulated ***,in a longer-term analysis,such optimal conditions were also able to in-crease the gene expression of neuronal expression markers NeuN and Tuj-1 and transcription factor ***,the same optimal stimulation conditions were also applied to THP-1 macrophages,and both pro-inflammatory(TNF-α,Il-1β,Il-6,Il-8)and anti-inflammatory cytokines(Il-10,CD206)were *** optimal PEMF stimulation parameters did not induce differentiation towards an M1 macrophage phenotype,decreased Il-1β and Il-8 gene expression,decreased TNF-α and Il-8 cytokine release in M1-differentiated cells,increased Il-10 and CD206 gene expression,as well as Il-10 cytokine release in M0 *** specific PEMF stimulation regime,which is optimal in vitro,might have a high potential for a future in vivo translation targeting neural regeneration and anti-inflammatory action for treating peripheral nerve injuries.

关键词： Nerve regeneration Biophysical stimulation Pulsed electromagnetic fields(PEMF) Neurite outgrowth Anti-inflammatory Peripheral nerve injuries