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Neuroinflammation as a therapeutic target in Huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： andrea kwakowsky Thulani H.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： Huntington inflammation Medicine

Metabotropic glutamate receptor 1 alpha:a unique receptor variant with variable implications for Alzheimer’s disease pathogenesis

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Neural Regeneration Research 2023年第10期18卷 2196-2197页

作者： Jason HY Yeung andrea kwakowsky Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer’s disease (AD) is the leading neurodegenerative disorder *** this,there is minimal effective therapeutics proven to reduce or prevent the progression of this *** is the main excitatory neurotransmitter with... 详细信息

关键词： Alzheimer Metab pathogenesis

Is EAAT2 a potential therapeutic intervention target for Alzheimer's disease?

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Neural Regeneration Research 2023年第8期18卷 1721-1722页

作者： Oliver WG Wood Jason HY Yeung andrea kwakowsky Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreOllscoil na Gaillimhe-University of GalwayGalwayIreland

Alzheimer's disease(AD)is the most common form of dementia worldwide,impairing memory and cognitive functions due to widespread neuronal *** global incidence of this neurodegenerative disorder is predicted to increase... 详细信息

关键词： Alzheimer death EAAT2

The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression

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Neural Regeneration Research 2021年第7期16卷 1399-1401页

作者： andrea kwakowsky Henry J.Waldvogel Richard LM Faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative *** underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the ***,most investigation is directed towards the amyloid-beta(Aβ)and tau pathologies,中文标题:The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression中文关词:Glu;AMPAR;APP;The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression;中文摘要:The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative *** underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the disease.

关键词： Alzheimer tau Aβ treatment

iGluR expression in the hippocampal formation, entorhinal cortex, and superior temporal gyrus in Alzheimer’s disease

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Neural Regeneration Research 2022年第10期17卷 2197-2199页

作者： Jason HY Yeung Henry J Waldvogel Richard LM Faull andrea kwakowsky Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

Alzheimer’s disease(AD)constitutes the largest proportion of dementia worldwide,with a significant associated medical *** major pathological hallmarks of AD include the gradual accumulation and deposition of amyloid-beta(Aβ)plaques and hyperphosphorylated tau protein(Revett et al.,2013).Whilst investigations centered around the tau and Aβhypothesis have been the main focus for the previous decades,the lack of therapeutic solutions has pushed for research into other potential therapeutic targets.

关键词： Alzheimer Aβ tau

Therapeutic potential of alpha 5 subunit containing GABA_(A) receptors in Alzheimer's disease

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Neural Regeneration Research 2021年第8期16卷 1550-1551页

作者： andrea kwakowsky Henry J.Waldvogel Richard L.M.Faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

Alheimer's disease(AD) is a common neurodegenerative disorder and the leading cause of dementia. It has been estimated that over 50 million people worldwide were affected by dementia in 2019, and the prevalence of dementia is expected to double approximately once every 20 years(Govindpani et al., 2017). Most people who die with AD require high levels of care for long periods of time.

关键词： al. Alzheimer Therapeutic

Vascular dysfunction in Alzheimer’s disease: a biomarker of disease progression and a potential therapeutic target

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Neural Regeneration Research 2020年第6期15卷 1030-1032页

作者： Karan Govindpani Chitra Vinnakota Henry J.waldvogel Richard L.Faull andrea kwakowsky Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the predominant form of *** its initial description by Alois Alzheimer in 1906,several advances have been made in our understanding of the progression of the disease and its clinical consequences,yet the underlying etiology remains *** the stereotyped patterns of cortical and hippocampal neuronal loss and the progressive degeneration of key neurotransmitter pathways,research has traditionally been focused on factors affecting neuronal viability,including the contribution of glial dysfunction to neuronal *** a clinical perspective,the fruits of this work have been *** pathological markers of the disease,includingβ-amyloid(Aβ)plaque formation and tau hyperphosphorylation,have yielded no effective therapies,highlighted by the recent discontinuations of several high profile Aβimmunotherapy *** few current symptomatic therapies for AD are predicated on the amelioration of cholinergic or glutamatergic *** from underscoring the inadequacy of current therapeutic approaches,this also points to the importance of alternative contributors to AD *** recent years,there has been a growing appreciation for the multimodal and multifactorial nature of the condition;the case for combinatorial therapies is thus strong.

关键词： Alzheimer degeneration dysfunction

Gamma-aminobutyric acid A receptors in Alzheimer＇s disease： highly localized remodeling of a complex and diverse signaling pathway

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Neural Regeneration Research 2018年第8期13卷 1362-1363页

作者： andrea kwakowsky Beatriz Calvo-Flores Guzman Karan Govindpani Henry J. Waldvogel Richard L. Faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health Sciences University of Auckland AucklandNew Zealand

Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide （Prince et al., 2015）, and with 60-80% of cases attributable to AD.

关键词： AD highly localized remodeling of a complex and diverse signaling pathway Gamma-aminobutyric acid A receptors in Alzheimer’s disease