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Weighted individual-resource networks in prey–predator systems: the role of prey availability on the emergence of modular structures

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Integrative Zoology 2022年第1期17卷 115-127页

作者： andrea costa Antonio ROMANO Giacomo ROSA Sebastiano SALVIDIO Department of Earth Environment and Life Sciences(DISTAV)University of GenovaGenovaItaly Italian National Research Council(CNR) Agriculture and Food Sciences Department(IBE)Institute of Bioeconomy–BiologyRomaRMItaly

Ecological networks,usually depicting interactions among species,have been recently down-scaled to the individual level,permitting description of patterns of inter-individual resource variation that are usually hindered at the species *** diet theory(ODT)models,applied to prey–predator systems,predict different patterns of nestedness and modularity in the network,depending on the available resources and intra-specific *** effect of resource availability on the emergence of networks structures,and ODT framework,has not yet fully been ***,we analyzed the structural patterns of individual-resource networks in 3 species of Mediterranean salamanders,in relation to changes in prey *** used weighted individual-resource network metrics to interpret the observed patterns,according to 3 ODT *** found significant nestedness recurring in our study system,indicating that both selective and opportunistic individuals occur in the same *** diversity,rather than abundance,was apparently related to inter-individual resource variation and promoted the emergence of significant modularity within all *** observed patterns of nestedness and modularity,together with the variation in resource diversity and intra-specific competition,are in agreement with the distinct preferences model of *** findings suggest that in the focal prey–predator systems,individuals were able to perceive changes in prey diversity and to exploit in different ways the variations in composition of available resources,shifting their diet assembly rules *** findings also confirm that the use of weighted individual-resource networks,in prey–predator systems,allows to disclose dynamics that are masked at the species or population level.

关键词： inter-individual resource variation network-analysis optimal diet theory prey availability salamanders

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Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

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Journal of Sport and Health Science 2024年第3期13卷 398-408页

作者： Pedro L.Valenzuela Alfredo Santalla Lidia B.Alejo andrea Merlo Asuncion Bustos Laura Castellote-Belles Roser Ferrer-costa Nicola A.Maffiuletti David Barranco-Gil Tomas Pinos Alejandro Lucia Physical Activity and Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain Department of Sport and Computer Science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis Laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance Lab Schulthess ClinicZurich 8008Switzerland Biomedical Research Networking Center on Rare Disorders(CIBERER) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/L).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all p<0.05)and an impaired endurance exercise capacity(-51%ventilatory threshold and55%peak power output,both p<0.001).Regardless of the CHO dose(p<0.05 for both doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis Nutrition Supplement

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木刻吊灯

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设计 2013年第7期26卷 22-22页

作者： Jacob andrea costa

这是设计师Jandreacosta为意大利制造商ILIDE设计制作的TICK吊灯系列。ILIDE品牌善于将现代艺术的审美和古典风格相结合，利用新技术和新材料，也偏爱手工制作的灯具。TICK集合代表一个历史悠久的手工制作工艺。粗糙的木材先由设计师制... 详细信息

这是设计师Jandreacosta为意大利制造商ILIDE设计制作的TICK吊灯系列。ILIDE品牌善于将现代艺术的审美和古典风格相结合，利用新技术和新材料，也偏爱手工制作的灯具。TICK集合代表一个历史悠久的手工制作工艺。粗糙的木材先由设计师制造出整体造型，再送到意大利当地的老匠人手中进行装饰。在没有机器的拚助下，工匠师傅用传统的木刻工艺在木质灯罩上留下或深或浅的刻痕，就像是刻上了旧时光，作品富有美感，散发出浓郁的温暖氛围。它是意大利木雕工艺世代传承的缩影，从一道道刻痕上也能看到设计者的用心。

关键词：吊灯制作工艺手工制作意大利设计制作古典风格现代艺术整体造型

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The importance of glutathione and phytochelatins on the selenite and arsenate detoxification in Arabidopsis thaliana

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Journal of Environmental Sciences 2016年第11期28卷 150-161页

作者： Fatai Adigun Aborode andrea Raab Matthias Voigt Leticia Malta costa Eva M.Krupp Joerg Feldmann Trace Element Spedation Laboratory Department of Chemistry University of Aberdeen Aberdeen AB24 3UE Scotland UK Departamento de Quimica Uniuersidade Federal de Minas Gerais Belo Horizonte MG CEP： 31270-901 Brazil

We investigated the role of glutathione（GSH） and phytochelatins（PCs） on the detoxification of selenite using Arabidopsis thaliana. The wild-type（WT） of Arabidopsis thaliana and its mutants（glutathione deficient Cad 2–1 and phytochelatins deficient Cad 1–3） were separately exposed to varying concentrations of selenite and arsenate and jointly to both toxicants to determine their sensitivities. The results of the study revealed that, the mutants were about 20-fold more sensitive to arsenate than the WT, an indication that the GSH and PCs affect arsenate detoxification. On the contrary, the WT and both mutants showed a similar level of sensitivity to selenite, an indication that the GSH and PCs do not significantly affect selenite detoxification. However, the WT is about 8 times more sensitive to selenite than to arsenate, and the mutants were more resistant to selenite than arsenate by a factor of 2. This could not be explained by the accumulation of both elements in roots and shoots in exposure experiments. The co-exposure of the WT indicates a synergistic effect with regards to toxicity since selenite did not induce PCs but arsenic and selenium compete in their PC binding as revealed by speciation analysis of the root extracts using HPLC–ICP–MS/ESI–MS. In the absence of PCs an antagonistic effect has been detected which might suggest indirectly that the formation of Se glutathione complex prevent the formation of detrimental selenopeptides. This study, therefore, revealed that PC and GSH have only a subordinate role in the detoxification of selenite.

关键词： Toxicity Phytochelatins Glutathione Selenopeptides ICP–MS ESI–MS Arabidopsis thaliana

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Using Support Vector Machines and neural networks to classify Merlot wines from South America

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Information Processing in Agriculture 2019年第2期6卷 265-278页

作者： Nattane Luı´za costa Laura andrea Garcı´a Llobodanin Inar Alves Castro Rommel Barbosa Instituto de Informa´tica Universidade Federal de Goia´sGoiaˆnia-GoBrazil LADAF-Laboratory of Functional Foods Department of Food and Experimental NutritionFaculty of Pharmaceutical SciencesUniversity of Sa˜o PauloAv.Lineu Prestes580B1405508-900 Sa˜o PauloBrazil

Wines with a clear geographical origin are an issue of interest for consumers and food *** paper presents a data mining study of Merlot wines from South America to identify the fingerprint of their geographical origin.A group of samples from Argentina(n=17),Brazil(n=12),Chile(n=48),and Uruguay(n=6)was *** chemical compounds were determined by high-performance liquid chromatography(HPLC).These compounds include antioxidant activity,total polyphenols,total anthocyanins,individual anthocyanins and *** binary classification problems were performed(Brazil versus non-Brazil,Argentina versus non-Argentina,Chile versus non-Chile,and Uruguay versus non-Uruguay)to investigate the geographic characteristics of each *** the evaluation of binary classifications in our dataset it was possible to identify the main variables(chemical compounds)that discriminate between the *** used the following algorithms:Synthetic Minority over-sample Technique and under-sampling to balance the dataset of each classification approach,the Relief algorithm to obtain a variable importance ranking and the classifiers Support Vector Machines,Multilayer Perceptron and Radial Basis Function Network with dynamic decay *** model obtained the highest performance measures among the classifiers for each dataset(93.73%of accuracy for the Brazil versus non-Brazil,91.18%for the Argentina versus non-Argentina,79.16%for the Chile versus non-Chile,and 91.67%for the Uruguay versus non-Uruguay classification).These accuracies were achieved by the search of the possible variable subsets according to Relief for each classification *** found that some variables,such as DPPH,wine color and individual anthocyanins,are among the most important variables in the characterization of Merlot wines.

关键词： Support Vector Machine Multilayer Perceptron Anthocyanins Feature selection Merlot wines South America wines

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Stable NiO-CeO_(2) nanoparticles with improved carbon resistance for methane dry reforming

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Journal of Rare Earths 2022年第1期40卷 57-62页

作者： andrea Cárdenas-Arenas Esther Bailón-García Dolores Lozano-Castelló Patrick Da costa Agustín Bueno-López Department of Inorganic Chemistry University of AlicanteCarretera de San Vicente s/nE03080AlicanteSpain Sorbonne Universite Institut Jean Le Rond d'AlembertCNRS UMR 71902 place de la gare de ceinture78210Saint Cyr L'EcoleFrance

High surface area mixed oxide 8.7%NiO-CeO_(2) nanoparticles(122 m2/g;6-7 nm)were prepared using a reversed microemulsion method,and were tested for dry methane reforming(DRM).The catalytic activity of these nanoparticles remains stable under the severe conditions of DRM(700℃),and they show better carbon resistance than conventional NiO-CeO_(2) catalysts prepared without control of the *** activity and selectivity of nanoparticles and reference catalyst are similar,but nanoparticles reduce the accumulation of carbon by 63%during the DRM tests,which is a key feature for this *** and H_(2)-TPR suggest that the improved carbon resistance of the nanoparticles is due to the better interaction and cooperation between NiO and CeO_(2) mixed *** nanoparticles,the participation of cerium cations in the redox processes taking place during DRM stabilizes cationic species of *** the contrary,the catalyst prepared without control of the size suffers segregation of Ni during DRM reaction,and segregated Ni explains the higher catalytic formation of carbon.

关键词： Methane dry reforming Nickel Ceria Nanoparticle Rare earths

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Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple

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Horticulture Research 2020年第1期7卷 889-902页

作者： Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra andrea Patocchi Fabrizio costa Plant Breeding Research Division AgroscopeWädenswilZurichSwitzerland IRHS INRAEAgrocampus-OuestUniversitéd’AngersSFR 4207 QuaSaVBeaucouzéFrance Department of Genomics and Biology of Fruit Crops Research and Innovation CentreFondazione Edmund Mach(FEM)Via E.Mach 138010 San Michele all’AdigeItaly Department of Agriculture Food and Environment(Di3A)University of CataniaCataniaItaly Research Centre Laimburg Laimburg 639040 AuerItaly Center Agriculture Food Environment University of TrentoVia Mach 138010 San Michele all’AdigeItaly Present address:GAFL INRAE84140 MontfavetFrance

Texture is a complex trait and a major component of fruit quality in *** the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly *** further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore *** this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit *** of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP *** best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family *** adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation *** allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’×‘Pink Lady’*** results therefore identified key genetic parameters to consider when deploying genomic selection for texture in *** particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population.

关键词： prediction optimization fir

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Endoscopic management of difficult common bile duct stones:Where are we now?A comprehensive review

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World Journal of Gastroenterology 2021年第44期27卷 7597-7611页

作者： Alberto Tringali Deborah costa Alessandro Fugazza Matteo Colombo Kareem Khalaf Alessandro Repici andrea Anderloni Gastroenterology and Endoscopy Unit Department of MedicineConegliano HospitalULSS 2 Marca TrevigianaConegliano 31015Italy Digestive Endoscopy Unit Department of GastroenterologyHumanitas Research Hospital IRCCSRozzano 20089MilanItaly Department of Biomedical Sciences Humanitas UniversityPieve Emanuele 20072MilanItaly

Endoscopic management for difficult common bile duct(CBD)stones still presents a challenge for several reasons,including anatomic anomalies,patients’individual conditions and stone *** recent years,variable methods have emerged that have attributed to higher stone removal success rates,reduced cost and lower adverse *** this review,we outline a stepwise approach in CBD stone *** first line therapy,endoscopic sphincterotomy and large balloon dilation are recommended,due to a 30%-50%reduction of the use of mechanical *** the other hand,cholangioscopy-assisted lithotripsy has been increasingly reported as an effective and safe alternative technique to mechanical lithotripsy but remains to be reserved in special settings due to limited large-scale *** discussed,findings suggest that management needs to be tailored to the patient’s characteristics and anatomical ***,we evaluate the management of CBD stones in various surgical altered anatomy(Billroth II,Roux-en-Y and Roux-en-Y gastric bypass).Moreover,we could conclude that cholangioscopy-assisted lithotripsy needs to be evaluated for primary use,rather than following a failed management *** addition,we discuss the importance of dissecting other techniques,such as the primary use of interventional endoscopic ultrasound for the management of CBD stones when other techniques have *** conclusion,we recognize that endoscopic sphincterotomy and large balloon dilation,mechanical lithotripsy and intraductal lithotripsy substantiate an indication to the management of difficult CBD stones,but emerging techniques are in rapid evolution with encouraging results.

关键词： Common bile duct stones Balloon dilation Endoscopic retrograde cholangiopancreatography Endoscopic ultrasonography Anastomoses,Roux en y Double balloon enteroscopy Mechanical lithotripsy Cholangioscopy

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Gender inequalities in physical activity among adolescents from 64 Global South countries

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Journal of Sport and Health Science 2022年第4期11卷 509-520页

作者： Luiza Isnardi Cardoso Ricardo andrea Wendt Caroline dos Santos costa Gregore Iven Mielke Javier Brazo-Sayavera Asaduzzaman Khan Tracy L Kolbe-Alexander Inacio Crochemore-Silva Federal University of Pelotas PelotasRS 96010-040Brazil University of Sao Paulo Sao PauloSP 01153-000Brazil School of Public Health The University of QueenslandHerstonQLD 4006Australia University of the Republic MontevideoMontevideo 11200Uruguay

Purpose:The aims of this study were to(a)describe gender inequalities in physical activity(PA)among adolescents from Global South countries,and(b)investigate the relationship between gender inequalities in PA and contextual factors,such as geographic region,human development index,gender inequality index,and unemployment ***:We analyzed cross-sectional data from the Global School-Based Student Health Survey conducted in Global South countries between 2010 and 2020 among 13-to 17-year-old ***-context variables were retrieved from secondary data sources(World Health Organization,World Bank,and Human Development Reports).PA was assessed by a self-administered questionnaire querying the number of days in the past week in which participants were physically active for a total of at least 60 *** absolute gender inequalities were evaluated by the differences in the prevalence between boys and girls,95%confidence intervals(95%CIs)were estimated using the bootstrap *** inequalities were obtained through Poisson ***-analyses with random effects were used to calculate pooled estimates of absolute and relative ***:Based on 64 Global South countries/surveys,the prevalence of PA was 6.7 percentage points(p.p.)higher in boys than in girls,ranging from 0.5 *** Afghanistan to 15.6 *** Laos(I^(2)=85.1%).The pooled ratio for all countries showed that boys presented a PA prevalence 1.58 times higher than girls(95%CI:1.47-1.70)on *** highest absolute and relative inequalities were observed in high income *** with higher Human Development Index rankings and lower Gender Inequality Index rankings also presented greater gender ***:Given that girls are overall less active than boys across the globe,the findings of this study reinforce that macro-and micro-level changes should be actively sought if we aim to increase population levels of PA in adolescents and promote equity i

关键词： Adolescents Gender differences Physical activity Social inequalities Students

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Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features

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World Journal of Gastroenterology 2017年第37期23卷 6854-6867页

作者： Diego Marques Layse Raynara Ferreira-costa Lorenna Larissa Ferreira-costa Romualdo da Silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito Carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger Laboratório de Bioanálise e Biotecnologia Molecular Universidade Federal do Rio Grande do Norte Programa de Pós-graduacao em Ciências Farmacêutica Universidade Federal do Rio Grande do Norte Laboratório de Genética Humana e Médica Universidade Federal do Pará Departamento de Cirurgia Oncológica Liga Norte Riograndense Contra o Cancer Laboratório de Patologia eCitopatologia Liga Norte Riograndense Contra o Cancer Depart-amento de Análises Clínicas e Toxicológicas Universidade Federal do Rio Grande do Norte Núcleo de Pesquisas em Oncologia Universidade Federal do Pará

AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed *** O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology *** Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death *** The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings.

关键词： Colorectal cancer Ins-del polymorphism Admixed population Potential biomarker Diagnostic Risk stratification Prognostic Clinical features

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