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Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses

Cellular & Molecular Immunology 2021年第6期18卷 1463-1475页

作者： Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia sanna Rosengren andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel aTyr Pharma 3545 John Hopkins CourtSuite 250San DiegoCA92121USA Division of Rheumatology Department of MedicineSolnaKarolinska InstitutetKarolinska University HospitalSE-17176StockholmSweden IAS HKUST-Scripps R&D Laboratory Institute for Advanced StudyHong Kong University of Science and Technologyand Pangu BiopharmaHong KongChina The Scripps Laboratories for tRNA Synthetase Research 10650 North Torrey Pines RoadLa JollaCA92037USA The Scripps Laboratories for tRNA Synthetase Research Scripps Florida130 Scripps WayJupiterFL33458USA

His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome.

关键词： Immunology Autoimmunity Synthetase tRNA HARS

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IRFs as competing pioneers in T-cell differentiation

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Cellular & Molecular Immunology 2017年第8期14卷 649-651页

作者： andrea Kröger Institute for Medical Microbiology Molecular MicrobiologyOtto-von-Guericke University of MagdeburgMagdeburg D-39120Germany

CD4-expressing T lymphocytes are among of the best-characterized immune system cells.1 They develop in the thymus and acquire the potential to differentiate into distinct *** leaving the thymus,T helper cells further ... 详细信息

关键词： lymphocytes expressing pioneer

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Proximity to corridors benefits bird communities in vegetated interrow vineyards in Mendoza, Argentina

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Avian Research 2024年第2期15卷 147-155页

作者： andrea Paula Goijman Agustín Zarco EEA La Consulta Instituto Nacional de Tecnología Agropecuaria(INTA)San CarlosMendozaArgentina Instituto Argentino de Investigacion en las Zonas Aridas(IADIZA)CONICET 5500MendozaArgentina

Management under ecological schemes and increasing habitat heterogeneity,are essential for enhancing biodiversity in *** provide several contributions to agriculture,for example pest control,recreation and enhancing human mental health,and have intrinsic *** are also ideal model organisms because they are easy to survey,and species respond differently to agricultural land use at different *** borders of crops are key for many species of birds,and distance to the border have been found to be an important factor in vineyard-dominated *** evaluate if there are differences in the bird assemblage,between the interior compared to borders within vineyards,using a hierarchical community occupancy *** hypoth-esized that occupancy of birds is greater in environments with greater heterogeneity,which in this study was considered to be contributed by the proximity to vegetated *** expected that vineyard borders close to corridors will have higher bird occupancy than the center of the *** research was conducted in three vineyards with biodiversity-friendly management practices,in Gualtallary,Mendoza,*** surveys were conducted over three breeding seasons from 2018 to *** and richness of the bird community was more closely associated with the borders adjacent to the corridors than with the interior of the vineyards,as we initially predicted,although the assemblage of birds did not differ *** than 75%of the registered species consume exclusively or partially ***-friendly management and ecological schemes,together with vegetated corridors provide multiple benefits for biodiversity *** ap-proaches not only minimize the use of agrochemicals but also prioritize soil cover with spontaneous vegetation,which supports a diverse community of insectivorous bird species,potentially contributing to pest control.

关键词： Avian Bayesian analysis Field scale agroecosystem Management Multi-species occupancy model Nature’s contributions to people

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Thermal and chemical analysis of massive use of hot briquetted iron inside basic oxygen furnace

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Journal of Iron and Steel Research International 2017年第9期24卷 901-907页

作者： Cosmo Di Cecca Silvia Barella Carlo Mapelli andrea Gruttadauria andrea Francesco Ciuffini Davide Mombelli Enrico Bondi Depatment of Mechanical Engineering Politecnico di MilanoMilano 20156Italy Freelance Milano 20100Italy

The integrated steelmaking cycle based on the blast furnace-basic oxygen furnace（BOF）route plays an important role in the production of plain and ultra-low carbon steel,especially for deep drawing *** steelmaking is based on the conversion of cast iron in steel by impinging oxygen on the metal bath at supersonic *** order to avoid the addition of detrimental chemical elements owing to the introduction of uncontrolled scrap and in order to decrease environmental impact caused by the intensive use of coke for the production of cast iron,HBI（hot briquetted iron）can be used as a source of metal and a fraction of cast *** industrial experimental tests were performed to evaluate the viability of the use of HBI in *** experimental campaign was supported by a thermal prediction model and realized through the estimation of the oxidation ***,the process was thermodynamically analyzed based on oxygen potentials using the off-gas composition and the bath temperature evolution during the conversion as reference data.

关键词： Hot briquetted iron Basic oxygen furnace Thermal analysis Chemical analysis Oxygen potential

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A novel control solution for improved trajectory tracking and LVRT performance in DFIG-based wind turbines

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Control Theory and Technology 2020年第1期18卷 43-55页

作者： Ahmad HASHEMI Christian CONFICONI andrea TILLI The Center of Complex Automated Systems(CASY)at the Department of Electrical Electronic and Information Engineering(DEI)University of BolognaRisorgimento240136 BolognaItaly Sama Technical and Vocational training College Islamic Azad UniversityKermanshah BranchKermanshahIran

This paper presents a new control strategy for the rotor side converter of Doubly-Fed Induction Generator based Wind Turbine systems,under severe voltage *** main goal is to fulfill the Low Voltage Ride Through performance,required by modern grid *** this respect,the key point is to limit oscillations(particularly on rotor currents)triggered by line faults,so that the system keeps operating with graceful *** this aim,a suitable feedforward-feedback control solution is proposed for the DFIG rotor *** feedforward part exploits oscillation-free reference trajectories,analytically derived for the system internal *** feedback,designed accounting for control voltage limits,endows the system with robustness and further tame oscillations during ***,improved torque and stator reactive power tracking during faults is achieved,proposing an exact mapping between such quantities and rotor-side currents,which are conventionally used as controlled *** simulations are provided to validate the capability of the proposed approach to effectively cope with harsh faults.

关键词： Doubly-fed induction generator(DFIG) wind turbine(WT) feedforward-feedback control mapping solution low voltage ride through(LVRT)

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Analysis of Tonal Noise Generating Mechanisms in Low-Speed Axial-Flow Fans

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Journal of Thermal Science 2016年第4期25卷 302-311页

作者： Edward Canepa andrea Cattanei Fabio Mazzocut Zecchin DIME-Universita di Genova via Montallegro 1 1-16145 Genoa Italy

The present paper reports a comparison of experimental SPL spectral data related to the tonal noise generated by axial-flow fans.A nine blade rotor has been operated at free discharge conditions and in four geometrical configurations in which different kinds of tonal noise generating mechanisms are present:large-scale inlet turbulent structures,tip-gap flow,turbulent wakes,and rotor-stator *** measurements have been taken in a hemi-anechoic chamber at constant rotational speed and,in order to vary the acoustic source strength,during low angular acceleration,linear speed *** order to avoid erroneous quantitative evaluations if the acoustic propagation effects are not considered,the acoustic response functions of the different test configurations have been computed by means of the spectral decomposition ***,the properties of the tonal noise generating mechanisms have been *** this aim,the constant-Strouhal number SPL,obtained by means of measurements taken during the speed ramps,have been compared with the propagation ***,the analysis of the phase of the acoustic pressure has allowed to distinguish between random and deterministic tonal noise generating mechanisms and to collect information about the presence of important propagation effects.

关键词： Axial-flow fans Tonal noise Acoustic response

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Implications of butyrate and its derivatives for gut health and animal production

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Animal Nutrition 2018年第2期4卷 151-159页

作者： andrea Bedford Joshua Gong Guelph Research and Development Centre Agriculture and Agri-food Canada

Butyrate is produced by microbial fermentation in the large intestine of humans and *** serves as not only a primary nutrient that provides energy to colonocytes, but also a cellular mediator regulating multiple functions of gut cells and beyond, including gene expression, cell differentiation, gut tissue development, immune modulation, oxidative stress reduction, and diarrhea *** there are a large number of studies in human medicine using butyrate to treat intestinal disease, the importance of butyrate in maintaining gut health has also attracted significant research attention to its application for animal production, particularly as an alternative to in-feed *** to the difficulties of using butyrate in practice(i.e., offensive odor and absorption in the upper gut), different forms of butyrate,such as sodium butyrate and butyrate glycerides, have been developed and examined for their effects on gut health and growth performance across different *** and its derivatives generally demonstrate positive effects on animal production, including enhancement of gut development, control of enteric pathogens, reduction of inflammation, improvement of growth performance(including carcass composition), and modulation of gut *** benefits are more evident in young animals, and variations in the results have been *** present article has critically reviewed recent findings in animal research on butyrate and its derivatives in regard to their effects and mechanisms behind and discussed the implications of these findings for improving animal gut health and *** addition, significant findings of medical research in humans that are relevant to animal production have been cited.

关键词： Butyrate Butyrins Antibiotic alternatives Gut health Nutrition Animal production

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Cuscuta, the Merchant of Proteins

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Molecular Plant 2020年第4期13卷 533-535页

作者： andrea Paterlini Yka Helariutta Sainsbury Laboratory University of CambridgeCambridgeUK Institute of Biotechnology HiLIFEUniversity of HelsinkiHelsinkiFinland

"If thou wilt lend this money,lend it not As to thy friends,[...]But lend it rather to thine enemy,Who,if he break,thou mayst with better face Exact the penalty"The merchant Antonio speaking to the moneylender Shylock... 详细信息

关键词： money chant Shy

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Fruit ripeness classification:A survey

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Artificial Intelligence in Agriculture 2023年第1期7卷 44-57页

作者： Matteo Rizzo Matteo Marcuzzo Alessandro Zangari andrea Gasparetto andrea Albarelli Ca’Foscari Department of Environmental Sciences Informatics and StatisticsVia Torino 155Mestre(VE)30172Italy Ca’Foscari Department of Management Cannaregio 873Fondamenta San GiobbeVenice 30121Italy

Fruit is a key crop in worldwide agriculture feeding millions of *** standard supply chain of fruit products involves quality checks to guarantee freshness,taste,and,most of all,*** important factor that determines fruit quality is its stage of *** is usually manually classified by field experts,making it a labor-intensive and error-prone ***,there is an arising need for automation in fruit ripeness *** automatic methods have been proposed that employ a variety of feature descriptors for the food item to be *** learning and deep learning techniques dominate the top-performing ***,deep learning can operate on raw data and thus relieve the users from having to compute complex engineered features,which are often *** this survey,we review the latest methods proposed in the literature to automatize fruit ripeness classification,highlighting the most common feature descriptors they operate on.

关键词： Fruit ripeness classification Machine learning Deep learning

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Efficient object location determination and error analysis based on barycentric coordinates

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Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 195-201页

作者： andrea Bodonyi Roland Kunkli Faculty of Informatics University of DebrecenDebrecen H-4028Hungary Doctoral School of Informatics University of DebrecenDebrecen H-4028Hungary

In this paper,we propose an efficient computational method for converting local coordinates to world coordinates using specially structured coordinate *** problem in question is the computation of world coordinates of an object throughout a motion,assuming that we only know the changing coordinates of some fixed surrounding reference points in the local coordinate system of the *** proposed method is based on barycentric coordinates;by taking the aforementioned static positions as the vertices of a polyhedron,we can specify the coordinates of the object in each step with the help of barycentric *** approach can significantly help us to achieve more accurate results than by using other possible *** the paper,we describe the problem and barycentric coordinate-based solution in *** then compare the barycentric method with a technique based on transformation matrices,which we also tested for solving our *** also present various diagrams that demonstrate the efficiency of our proposed approach in terms of precision and performance.

关键词： Barycentric coordinates Conversion Transformation Coordinate systems Location

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