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The 2017 Oslo conference report on neglected tropical diseases and emerging/re-emerging infectious diseases-focus on populations underserved

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Infectious Diseases of Poverty 2019年第3期8卷 106-106页

作者： Katharina Klohe John Amuasi Joyce Moriku Kaducu Ingeborg Haavardsson Ekaterina Bogatyreva Kristine Husoy Onarheim Wendy Harrison Frederik Kristensen Clarissa Prazeres da Costa andrea s.winkler Department of Neurology Center for Global HealthTechnical University of MunichMunichGermany Center for Global Health Institute for Medical MicrobiologyImmunology and HygieneTechnical University of MunichMunichGermany 不详

Background:In 2017,the Centre for Global Health(CGH)at the University of Oslo in collaboration with the Coalition for Epidemic Preparedness Innovations(CEPI)and the Norwegian Agency for Development Cooperation(Norad)held a meeting to discuss together with leading figures in disease control,research and development the issue of neglected tropical diseases and emerging/re-emerging infectious *** commentary has taken up this discussion and the conclusions drawn at this meeting to make a case for the opportunity the sustainable Development Goals(sDGs)provide in highlighting the interconnectedness of factors that are relevant in the successful fight against neglected tropical diseases(NTDs)and emerging infectious diseases(EIDs).Main body:Despite NTDs being endemic and EIDs being epidemic,in order to prevent both disease groups effectively,it is important to appreciate that they share essential health determining faaors,namely:neglect,poverty,a lack of access to clean water and sanitation facilities and an absence of or severely limited provision of healthcare as well as in many cases a zoonotic *** of looking to"simple disease management for the answer,the sDGs help to understand the interplay of multiple priority areas and thereby help to promote a more holistic approach to addressing these two disease ***:Their commonalities mean that the Global Health community should leverage opportunities and efforts in the prevention and elimination of both NTDs and *** so using a One Health approach is considered to offer a"public health best-buy".Concrete solutions are proposed.

关键词： Neglected tropical diseases Emerging infeaious diseases One health sDGs Poverty Neglea

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Burden of onchocerciasis-associated epilepsy:first estimates and research priorities

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Infectious Diseases of Poverty 2018年第1期7卷 1064-1075页

作者： Natalie V.s.Vinkeles Melchers sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.siewe sake Jde Vlas andrea s.winkler Wilma A.stolk Department of Public Health Erasmus MCUniversity Medical Center RotterdamP.O.box 20403000CARotterdamThe Netherlands Institute for Health Metrics and Evaluation University of Washington23015th AvenueSuite 600SeattleWA 98121USA Global Health Institute University of AntwerpAntwerpBelgium Department of Medical statistics Informaticsand Health EconomicsMedical University InnsbruckViennaAustria Department of Public Health Institute of Tropical Medicine AntwerpNationalestraat 1552000 AntwerpBelgium Department of Tropical Medicine University of KinshasaKinshasaDemocratic Republic of the Congo Centre for Global Health Institute for Health and SocietyOsloNorway Center for Global Health Department of NeurologyTechnical University of MunichMunichGermany

Background:since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free *** the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an *** we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic *** body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health *** not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities *** used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE *** then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of *** estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated *** total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of *** burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to *** estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases wou

关键词： River blindness Onchocerciasis Epilepsy Burden estimates Years of life lived with disability Review Research priorities Prevalence Disability weight Case definition

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Glial response in the midcingulate cortex in Huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani H.Palpagama andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： Huntington degeneration cortex

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Neuroinflammation as a therapeutic target in Huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： andrea Kwakowsky Thulani H.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： Huntington inflammation Medicine

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Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： andrea Bartolomé-Nafría Javier García-Pardo salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-stafshede,2023).

关键词： structure amyloid

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Dynamics of freshwater snails and schistosoma infection prevalence in schoolchildren during the construction and operation of a multipurpose dam in central Côte d’Ivoire

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Infectious Diseases of Poverty 2017年第1期6卷 810-818页

作者： Nana R.Diakite Mirko s.winkler Jean T.Coulibaly Negnorogo Guindo-Coulibaly Jürg Utzinger Eliezer K.N’Goran Laboratoire de Zoologie et Biologie Animale Unitede Formation et de Recherche BiosciencesUniversite Felix Houphouët-Boigny22 BP 522Abidjan 22Cote d’Ivoire swiss Tropical and Public Health Institute P.O.BoxCH-4002BaselSwitzerland University of Basel P.O.BoxCH-4003BaselSwitzerland Departement Environnement et sante Centre Suisse de Recherches Scientifiques en Cote d’Ivoire01 BP 1303Abidjan 01Cote d’Ivoire

Background:The construction and operation of small multipurpose dams in Africa have a history of altering the transmission of water-based diseases,including *** current study was designed to investigate the abundance and dynamics of schistosomiasis intermediate host snails and schistosoma infections in humans during the construction and the first years of operation of a small multipurpose dam in Côte d’***:The study was carried out in Raffierkro and four neighbouring villages in central Côte d’Ivoire between 2007 and *** were collected by two experienced investigators using scoops and forceps for 15 min at each *** were identified at genera and,whenever possible,species level,and subjected to testing for cercarial *** aged 6-15 years were examined once every year for schistosoma haematobium and *** infection,using urine filtration and duplication Kato-Katz thick smears,***,551 adults were examined for schistosoma infection before(June 2007)and 359 individuals 2 years after dam construction(June 2009).Results:Overall,1700 snails belonging to nine different genera were collected from 19 sampling ***(potential intermediate host snails of ***)and Pila were the most common genera,whereas Biomphalaria(potential intermediate host snail of ***),Lymnaea,Physa and Melanoides were found in two *** the first-year sampling period,65 snails were collected,of which 13(20%)were schistosomiasis intermediate *** subsequent years,out of 1635 snails collected,1079(66%)were identified as potential intermediate host for schistosomiasis,but none were shedding *** prevalence of *** among adults in the study area was low(0.4%in 2007 and 0.3%in 2009),whereas the prevalence of *** declined from 13.9%to 2.9%in this two-year ***:The low prevalence of schistosomiasis in humans and the absence of infected intermediate host s

关键词： schistosomiasis Intermediate host snail Transmission Water resources development and management Multipurpose dam Cote d’Ivoire

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALs)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALs involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(sOD1)mutations represent a minority of ALs cases,the sOD1 gene remains a milestone in ALs research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALs mutations in sOD1(sOD1-ALs),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of sOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for sOD1-ALs.

关键词： amyotrophic lateral sclerosis(ALs) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory sOD1 superoxide dismutase 1 urinary vocal cord palsy

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Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano serena Boccella Carmela Belardo andrea Maria Morace Francesca Guida sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

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No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2

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Cellular & Molecular Immunology 2022年第3期19卷 449-452页

作者： Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Martin s.winkler Martin Lier sebastian schulz Hans-Martin Jäck stefan Pöhlmann Markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University GöttingenRobert-Koch-Straße 4037075GöttingenGermany Division of Molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University Erlangen-NürnbergGlückstraße 691054ErlangenGermany

since the beginning of the COVID-19 pandemic,multiple sARs-CoV-2 variants have *** some variants spread only locally,others,referred to as variants of concern,disseminated globally and became drivers of the *** sARs-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic,and mutations in the viral spike(s)protein are considered of particular relevance since the s protein mediates host cell entry and constitutes the key target of the neutralizing antibody *** a consequence,mutations in the s protein may increase sARs-CoV-2 infectivity and enable its evasion of neutralizing ***,mutations in the s protein can modulate viral transmissibility and pathogenicity.

关键词： sARs-CoV-2 AY.4.2 Delta Host cell entry Antibody evasion

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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